PE20020406A1 - 7-OXO-PYRIDO [2,3-d] PYRIMIDINES 2,6-DISUSTITUTED AS INHIBITORS OF PROTEIN KINASES - Google Patents
7-OXO-PYRIDO [2,3-d] PYRIMIDINES 2,6-DISUSTITUTED AS INHIBITORS OF PROTEIN KINASESInfo
- Publication number
- PE20020406A1 PE20020406A1 PE2001000860A PE2001000860A PE20020406A1 PE 20020406 A1 PE20020406 A1 PE 20020406A1 PE 2001000860 A PE2001000860 A PE 2001000860A PE 2001000860 A PE2001000860 A PE 2001000860A PE 20020406 A1 PE20020406 A1 PE 20020406A1
- Authority
- PE
- Peru
- Prior art keywords
- disustituted
- pyrido
- pyrimidines
- oxo
- inhibitors
- Prior art date
Links
- 102000001253 Protein Kinase Human genes 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 108060006633 protein kinase Proteins 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- -1 AMINO Chemical class 0.000 abstract 1
- 208000011231 Crohn disease Diseases 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- AIDS & HIV (AREA)
- Hospice & Palliative Care (AREA)
- Tropical Medicine & Parasitology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
SE REFIERE A 7-OXO-PIRIDO[2,3-d]PIRIMIDINAS 2,6 DISUSTITUIDAS DE FORMULA I DONDE R1 ES H, ALQUILO; R2 ES CICLOALQUILO, CICLOALQUILO HETEROSUSTITUIDO, ARALCOXI, ALCOXI, HETEROCICLICLO, ENTRE OTROS; R3 ES H, AMINO, MONOALQUILOAMINO, DIALQUILAMINO, ACILAMINO, ALQUILO, CICLOLAQUILO, -NRa-C(=O)-Rb, ENTRE OTROS DONDE Ra ES H, ALQUILO; Rb ES HETEROCICLILO, HETEROALQUILO; AR1 Y AR2 SON ARILO. SE REFIERE TAMBIEN A UN PROCEDIMIENTO PARA LA PREPARACION. SON COMPUESTOS PREFERIDOS LOS COMPUESTOS DE FORMULA II DONDE AR1 ES FENILO. LOS COMPUESTOS MENCIONADOS SON INHIBIDORES DE LAS PROTEINA CINASAS Y SON UTILES PARA EL TRATAMIENTO DE ARTRITIS, ENFERMEDAD DE CROHN, ALZHEIMERREFERS TO 7-OXO-PYRIDO [2,3-d] PYRIMIDINES 2,6 DISUSTITUTED OF FORMULA I WHERE R1 IS H, ALKYL; R2 IS CYCLOALKYL, HETEROSUSTITUTED CYCLOALKYL, ARALCOXI, ALCOXI, HETERO CYCLE, AMONG OTHERS; R3 IS H, AMINO, MONOALKYLAMINE, DIALKYLAMINE, ACILAMINE, ALKYL, CYCLOLAKYL, -NRa-C (= O) -Rb, AMONG OTHERS WHERE Ra IS H, ALKYL; Rb IS HETEROCYCLYL, HETEROALKYL; AR1 AND AR2 ARE ARYL. IT ALSO REFERS TO A PROCEDURE FOR PREPARATION. THE PREFERRED COMPOUNDS ARE THE COMPOUNDS OF FORMULA II WHERE AR1 IS PHENYL. THE MENTIONED COMPOUNDS ARE INHIBITORS OF PROTEIN KINASES AND ARE USEFUL FOR THE TREATMENT OF ARTHRITIS, CROHN'S DISEASE, ALZHEIMER
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22958400P | 2000-08-31 | 2000-08-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20020406A1 true PE20020406A1 (en) | 2002-05-17 |
Family
ID=22861859
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2001000860A PE20020406A1 (en) | 2000-08-31 | 2001-08-28 | 7-OXO-PYRIDO [2,3-d] PYRIMIDINES 2,6-DISUSTITUTED AS INHIBITORS OF PROTEIN KINASES |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1315726A1 (en) |
| JP (1) | JP4141830B2 (en) |
| KR (1) | KR100571339B1 (en) |
| CN (1) | CN1275964C (en) |
| AR (1) | AR033681A1 (en) |
| AU (2) | AU9378401A (en) |
| BR (1) | BR0113628A (en) |
| CA (1) | CA2420286A1 (en) |
| GT (1) | GT200100191A (en) |
| MX (1) | MXPA03001821A (en) |
| PA (1) | PA8527301A1 (en) |
| PE (1) | PE20020406A1 (en) |
| UY (1) | UY26918A1 (en) |
| WO (1) | WO2002018380A1 (en) |
| ZA (1) | ZA200301079B (en) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6518276B2 (en) | 2000-08-31 | 2003-02-11 | Syntex (U.S.A.) Llc | 7-oxo-pyridopyrimidines (II) |
| EP1315727B1 (en) * | 2000-08-31 | 2005-06-29 | F. Hoffmann-La Roche Ag | 7-oxo pyridopyrimidines |
| JP2006503802A (en) * | 2002-04-03 | 2006-02-02 | エフ．ホフマン−ラ ロシュ アーゲー | Imidazo condensation compounds |
| JP4603268B2 (en) * | 2002-04-19 | 2010-12-22 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | New compounds |
| US7084270B2 (en) | 2002-08-14 | 2006-08-01 | Hoffman-La Roche Inc. | Pyrimido compounds having antiproliferative activity |
| UY27939A1 (en) | 2002-08-21 | 2004-03-31 | Glaxo Group Ltd | COMPOUNDS |
| US7112676B2 (en) | 2002-11-04 | 2006-09-26 | Hoffmann-La Roche Inc. | Pyrimido compounds having antiproliferative activity |
| WO2004046152A1 (en) | 2002-11-18 | 2004-06-03 | F. Hoffmann La Roche Ag | Diazinopyrimidines |
| US7098332B2 (en) | 2002-12-20 | 2006-08-29 | Hoffmann-La Roche Inc. | 5,8-Dihydro-6H-pyrido[2,3-d]pyrimidin-7-ones |
| KR20050111636A (en) | 2003-04-10 | 2005-11-25 | 에프. 호프만-라 로슈 아게 | Pyrimido compounds |
| DE602004024536D1 (en) * | 2003-07-07 | 2010-01-21 | Van Andel Res Inst | INHIBITION OF TUMOR ANGIOGENESIS BY A COMBINATION OF THROMBOSPONDIN-1 AND INHIBITORS OF THE VASCULAR ENDOTHEL GROWTH FACTOR |
| EP1685131B1 (en) * | 2003-11-13 | 2007-03-07 | F. Hoffmann-La Roche AG | Hydroxyalkyl substituted pyrido-7-pyrimidin-7-ones |
| WO2005105097A2 (en) * | 2004-04-28 | 2005-11-10 | Gpc Biotech Ag | Pyridopyrimidines for treating inflammatory and other diseases |
| US20070054916A1 (en) * | 2004-10-01 | 2007-03-08 | Amgen Inc. | Aryl nitrogen-containing bicyclic compounds and methods of use |
| US20090131430A1 (en) * | 2004-11-23 | 2009-05-21 | Palle Venkata P | Pyrido'2,3-dipyrimidines as anti-inflammatory agents |
| WO2006082492A1 (en) * | 2005-02-02 | 2006-08-10 | Ranbaxy Laboratories Limited | Azabicyclo derivatives as anti-inflammatory agents |
| EP1931667A1 (en) * | 2005-09-28 | 2008-06-18 | Ranbaxy Laboratories Limited | Pyrido-pyridimidine derivatives useful as antiinflammatory agents |
| ES2329419T3 (en) | 2006-01-31 | 2009-11-25 | F. Hoffmann-La Roche Ag | 7H-PIRIDO (3,4-D) PIRIMIDIN-8-ONAS, ITS PREPARATION AND USE AS INHIBITORS OF KINASE PROTEINS. |
| KR100661523B1 (en) * | 2006-06-09 | 2006-12-26 | 주식회사 청용산기 | Improved torsion correction device mounted on carton manufacturing equipment |
| EP1914234A1 (en) | 2006-10-16 | 2008-04-23 | GPC Biotech Inc. | Pyrido[2,3-d]pyrimidines and their use as kinase inhibitors |
| WO2008055842A1 (en) | 2006-11-09 | 2008-05-15 | F. Hoffmann-La Roche Ag | Substituted 6-phenyl-pyrido [2,3-d] pyrimidin-7-one derivatives as kinase inhibitors and methods for using the same |
| WO2008078249A1 (en) * | 2006-12-21 | 2008-07-03 | Ranbaxy Laboratories Limited | Anti-inflammatory agents |
| EP2112150B1 (en) | 2008-04-22 | 2013-10-16 | Forma Therapeutics, Inc. | Improved raf inhibitors |
| KR101106162B1 (en) * | 2010-04-20 | 2012-01-20 | 주식회사 청용산기 | Unloading guide support unit in stitching device for packing box manufacturing equipment |
| IN2014MN02082A (en) * | 2012-03-22 | 2015-08-21 | Genosco | |
| US9321786B2 (en) | 2013-03-15 | 2016-04-26 | Celgene Avilomics Research, Inc. | Heteroaryl compounds and uses thereof |
| ES2892423T3 (en) | 2013-03-15 | 2022-02-04 | Celgene Car Llc | Heteroaryl compounds and uses thereof |
| AU2014228746B2 (en) | 2013-03-15 | 2018-08-30 | Celgene Car Llc | Heteroaryl compounds and uses thereof |
| JP6661606B2 (en) | 2014-09-12 | 2020-03-11 | バイオラブ・サヌス・ファーマセウティカ・エルティーディーエー． | New pyridopyrimidine derivative compounds |
| US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
| EP3691620B1 (en) | 2017-10-05 | 2022-07-27 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce dux4 and downstream gene expression for the treatment of fshd |
| TWI831829B (en) | 2018-09-12 | 2024-02-11 | 美商建南德克公司 | Phenoxy-pyridyl-pyrimidine compounds and methods of use |
| MA54608B1 (en) | 2018-12-27 | 2023-02-28 | Servier Lab | Aza-heterobicyclic mat2a inhibitors and methods of use for treating cancer |
| CN113508115A (en) * | 2019-01-03 | 2021-10-15 | 基因泰克公司 | Pyridopyrimidone and pteridone compounds as inhibitors of endoribonuclease myo-inositol requiring enzyme I (IRE I A) for the treatment of cancer diseases |
| BR112021023825A2 (en) * | 2019-05-31 | 2022-02-08 | Servier Lab | Heterobicyclic mat2a inhibitors and methods of use for cancer treatment |
| WO2022052924A1 (en) * | 2020-09-11 | 2022-03-17 | 上海凌达生物医药有限公司 | Preparation method for class of nitrogen-containing fused ring compounds and use thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE190978T1 (en) * | 1994-11-14 | 2000-04-15 | Warner Lambert Co | 6-ARYL-PYRIDO(2,3-D)PYRIMIDINES AND NAPHTHYRIDINES FOR INHIBITING CELL PRODUCTION CAUSED BY PROTEIN TYROSINE KINASE |
| IL117923A (en) * | 1995-05-03 | 2000-06-01 | Warner Lambert Co | Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds |
| KR20010043829A (en) * | 1998-05-26 | 2001-05-25 | 로즈 암스트롱, 크리스틴 에이. 트러트웨인 | Bicyclic Pyrimidines and Bicyclic 3,4-Dihydropyrimidines as Inhibitors of Cellular Proliferation |
-
2001
- 2001-08-22 EP EP01974206A patent/EP1315726A1/en not_active Withdrawn
- 2001-08-22 MX MXPA03001821A patent/MXPA03001821A/en active IP Right Grant
- 2001-08-22 JP JP2002523895A patent/JP4141830B2/en not_active Expired - Fee Related
- 2001-08-22 CN CNB018150306A patent/CN1275964C/en not_active Expired - Fee Related
- 2001-08-22 KR KR1020037002936A patent/KR100571339B1/en not_active Expired - Fee Related
- 2001-08-22 BR BR0113628-3A patent/BR0113628A/en not_active Application Discontinuation
- 2001-08-22 WO PCT/EP2001/009689 patent/WO2002018380A1/en not_active Ceased
- 2001-08-22 CA CA002420286A patent/CA2420286A1/en not_active Abandoned
- 2001-08-22 AU AU9378401A patent/AU9378401A/en active Pending
- 2001-08-22 AU AU2001293784A patent/AU2001293784B2/en not_active Ceased
- 2001-08-28 PE PE2001000860A patent/PE20020406A1/en not_active Application Discontinuation
- 2001-08-28 PA PA20018527301A patent/PA8527301A1/en unknown
- 2001-08-30 AR ARP010104132A patent/AR033681A1/en unknown
- 2001-08-30 UY UY26918A patent/UY26918A1/en not_active Application Discontinuation
- 2001-09-18 GT GT200100191A patent/GT200100191A/en unknown
-
2003
- 2003-02-07 ZA ZA200301079A patent/ZA200301079B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2001293784B2 (en) | 2007-08-30 |
| UY26918A1 (en) | 2002-02-28 |
| JP4141830B2 (en) | 2008-08-27 |
| WO2002018380A1 (en) | 2002-03-07 |
| CA2420286A1 (en) | 2002-03-07 |
| KR20030022422A (en) | 2003-03-15 |
| KR100571339B1 (en) | 2006-04-17 |
| AU9378401A (en) | 2002-03-13 |
| PA8527301A1 (en) | 2002-07-30 |
| BR0113628A (en) | 2003-07-01 |
| GT200100191A (en) | 2002-05-16 |
| AR033681A1 (en) | 2004-01-07 |
| EP1315726A1 (en) | 2003-06-04 |
| CN1275964C (en) | 2006-09-20 |
| MXPA03001821A (en) | 2003-06-04 |
| JP2004507541A (en) | 2004-03-11 |
| CN1451005A (en) | 2003-10-22 |
| ZA200301079B (en) | 2004-05-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |