UY24913A1 - 2,4-diaminopirimidina substituida - Google Patents
2,4-diaminopirimidina substituidaInfo
- Publication number
- UY24913A1 UY24913A1 UY24913A UY24913A UY24913A1 UY 24913 A1 UY24913 A1 UY 24913A1 UY 24913 A UY24913 A UY 24913A UY 24913 A UY24913 A UY 24913A UY 24913 A1 UY24913 A1 UY 24913A1
- Authority
- UY
- Uruguay
- Prior art keywords
- preparation
- compounds
- substances
- drugs
- salts
- Prior art date
Links
- YAAWASYJIRZXSZ-UHFFFAOYSA-N pyrimidine-2,4-diamine Chemical group NC1=CC=NC(N)=N1 YAAWASYJIRZXSZ-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 4
- -1 2,4-diamino-pyrimidin-5-ylmethyl Chemical group 0.000 abstract 3
- 239000003814 drug Substances 0.000 abstract 3
- 229940079593 drug Drugs 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- 239000013543 active substance Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000004415 heterocyclylalkyl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000013067 intermediate product Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
La invención se refiere a compuestos derivados de 2,4-diamino pirimidina sustituida. El empleo de estos compuestos y sus sales como sustancias terapéuticamente activas, medicamentos basados en estas sustancias y su elaboración, el empleo de estas substancias como medicamentos y para la elaboración de medicamentos antibacterialmente activos, así como también la preparación de dichos compuestos y sus sales farmacéuticamente aceptables y productos intermedios para su preparación. Se trata de compuestos de fórmula l (como por ejemplo: (E)-(RS)-3-[5-(2,4-diamino-pirimidin-5-ilmetil)-2,3-dimetoxi-fenil]-1-(1-fenil-1H-ftalazin-2-il)-propenona), en donde R1 significa alcoxilo inferior; R2 significa hidroxilo o alcoxilo inferior; R3 se selecciona entre H, CN, alquilo, inferior, alquenilo, cicloalquilo, biciclilo, arilo, heterociclialquilo; así como sus sales farmacéuticamente aceptables de los mismos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97103436 | 1997-03-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY24913A1 true UY24913A1 (es) | 2001-01-31 |
Family
ID=8226543
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY24913A UY24913A1 (es) | 1997-03-03 | 1998-03-02 | 2,4-diaminopirimidina substituida |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6114330A (es) |
| JP (1) | JP4174077B2 (es) |
| KR (1) | KR20000075888A (es) |
| CN (1) | CN1091109C (es) |
| AR (1) | AR011879A1 (es) |
| AT (1) | ATE241618T1 (es) |
| AU (1) | AU726836B2 (es) |
| BR (1) | BR9808135A (es) |
| CA (1) | CA2281642C (es) |
| CO (1) | CO4940508A1 (es) |
| DE (1) | DE69815072T2 (es) |
| DK (1) | DK0966464T3 (es) |
| ES (1) | ES2198705T3 (es) |
| HR (1) | HRP980110A2 (es) |
| MA (1) | MA26475A1 (es) |
| PE (1) | PE59699A1 (es) |
| PT (1) | PT966464E (es) |
| TR (1) | TR199902140T2 (es) |
| TW (1) | TW464648B (es) |
| UY (1) | UY24913A1 (es) |
| ZA (1) | ZA981529B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006523620A (ja) * | 2003-02-19 | 2006-10-19 | バイオヴェイル ラボラトリーズ インコーポレイテッド | 急速吸収選択的５−ｈｔ作用剤製剤 |
| US8268825B2 (en) * | 2005-09-26 | 2012-09-18 | The Board Of Regents For Oklahoma State University | Method for the treatment of anthrax infections |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3117721B2 (ja) * | 1994-11-24 | 2000-12-18 | エフ・ホフマン−ラ ロシュ アーゲー | 新規なベンジルピリミジン類 |
| TW438796B (en) * | 1996-05-15 | 2001-06-07 | Hoffmann La Roche | 2,4-diaminopyrimidine derivatives, the manufacture process thereof, and the antibiotically-active pharmaceutical composition containing the same |
-
1998
- 1998-02-24 CA CA002281642A patent/CA2281642C/en not_active Expired - Fee Related
- 1998-02-24 TR TR1999/02140T patent/TR199902140T2/xx unknown
- 1998-02-24 ES ES98913585T patent/ES2198705T3/es not_active Expired - Lifetime
- 1998-02-24 AU AU68231/98A patent/AU726836B2/en not_active Ceased
- 1998-02-24 AT AT98913585T patent/ATE241618T1/de not_active IP Right Cessation
- 1998-02-24 DK DK98913585T patent/DK0966464T3/da active
- 1998-02-24 KR KR1019997007967A patent/KR20000075888A/ko not_active Ceased
- 1998-02-24 ZA ZA981529A patent/ZA981529B/xx unknown
- 1998-02-24 CN CN98803085A patent/CN1091109C/zh not_active Expired - Fee Related
- 1998-02-24 JP JP53811598A patent/JP4174077B2/ja not_active Expired - Fee Related
- 1998-02-24 PT PT98913585T patent/PT966464E/pt unknown
- 1998-02-24 DE DE69815072T patent/DE69815072T2/de not_active Expired - Lifetime
- 1998-02-24 BR BR9808135-7A patent/BR9808135A/pt not_active IP Right Cessation
- 1998-02-25 US US09/028,980 patent/US6114330A/en not_active Expired - Lifetime
- 1998-02-26 AR ARP980100859A patent/AR011879A1/es not_active Application Discontinuation
- 1998-02-27 CO CO98010856A patent/CO4940508A1/es unknown
- 1998-02-27 PE PE1998000142A patent/PE59699A1/es not_active Application Discontinuation
- 1998-03-02 MA MA24985A patent/MA26475A1/fr unknown
- 1998-03-02 UY UY24913A patent/UY24913A1/es not_active Application Discontinuation
- 1998-03-03 HR HR97103436.8A patent/HRP980110A2/hr not_active Application Discontinuation
- 1998-03-03 TW TW087103084A patent/TW464648B/zh active
Also Published As
| Publication number | Publication date |
|---|---|
| TR199902140T2 (en) | 2000-04-21 |
| JP2001513791A (ja) | 2001-09-04 |
| CO4940508A1 (es) | 2000-07-24 |
| AU6823198A (en) | 1998-09-22 |
| DE69815072T2 (de) | 2004-04-01 |
| ATE241618T1 (de) | 2003-06-15 |
| DE69815072D1 (de) | 2003-07-03 |
| AU726836B2 (en) | 2000-11-23 |
| CA2281642A1 (en) | 1998-09-11 |
| CA2281642C (en) | 2008-02-05 |
| US6114330A (en) | 2000-09-05 |
| BR9808135A (pt) | 2000-03-28 |
| HRP980110A2 (en) | 1998-12-31 |
| CN1091109C (zh) | 2002-09-18 |
| MA26475A1 (fr) | 2004-12-20 |
| TW464648B (en) | 2001-11-21 |
| ES2198705T3 (es) | 2004-02-01 |
| CN1249751A (zh) | 2000-04-05 |
| PE59699A1 (es) | 1999-06-16 |
| PT966464E (pt) | 2003-09-30 |
| ZA981529B (en) | 1998-09-03 |
| AR011879A1 (es) | 2000-09-13 |
| DK0966464T3 (da) | 2003-09-22 |
| KR20000075888A (ko) | 2000-12-26 |
| JP4174077B2 (ja) | 2008-10-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 109 | Application deemed to be withdrawn |
Effective date: 20130129 |