AR011879A1 - 2,4-diaminopirimidinas substituidas, su empleo, procedimiento para obtenerlas, y medicamentos y preparaciones farmaceuticas que las contienen - Google Patents
2,4-diaminopirimidinas substituidas, su empleo, procedimiento para obtenerlas, y medicamentos y preparaciones farmaceuticas que las contienenInfo
- Publication number
- AR011879A1 AR011879A1 ARP980100859A ARP980100859A AR011879A1 AR 011879 A1 AR011879 A1 AR 011879A1 AR P980100859 A ARP980100859 A AR P980100859A AR P980100859 A ARP980100859 A AR P980100859A AR 011879 A1 AR011879 A1 AR 011879A1
- Authority
- AR
- Argentina
- Prior art keywords
- aryl
- alkyl
- drugs
- signifies
- diaminopyrimidines
- Prior art date
Links
- 229940058936 antimalarials diaminopyrimidines Drugs 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 3
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000013543 active substance Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- -1 aryl-Q-alkyl Chemical group 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- YAAWASYJIRZXSZ-UHFFFAOYSA-N pyrimidine-2,4-diamine Chemical class NC1=CC=NC(N)=N1 YAAWASYJIRZXSZ-UHFFFAOYSA-N 0.000 abstract 1
- MISVBCMQSJUHMH-UHFFFAOYSA-N pyrimidine-4,6-diamine Chemical class NC1=CC(N)=NC=N1 MISVBCMQSJUHMH-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
2,4-diaminopirimidinas substituidas de formula general (I), en donde R1 significa alcoxilo inferior, R2 significa hidroxilo o alcoxilo inferior, R3significa hidrogeno, ciano, alquilo, alquenilo, cicloalquilo, arilo, hetrociclilo, aralquilo, aril-Q-alquilo, heterocicloalquilo o un grupo deformula: -(CH2)n-, Q significa -SO-; R4, R4 significan independientemente entre sí, hidrogeno, alquilo, arilo o heterocicloalquilo; R5 significahidrogeno, alquilo, alcoxilo, arilo o heterociclilo, o R4 y R5 juntos, pueden formar un grupo -(CH2)n-, y n es un numero entero de 2 a 5, así comotambién las sales farmacéuticamente aceptables de las mismas; el empleo de estas 2,4-diaminopirimidinas substituidas y sus sales comosustanciasterapéuticamente activas, medicamentos y preparaciones farmacéuticas, utiles como antibacterianos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97103436 | 1997-03-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR011879A1 true AR011879A1 (es) | 2000-09-13 |
Family
ID=8226543
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980100859A AR011879A1 (es) | 1997-03-03 | 1998-02-26 | 2,4-diaminopirimidinas substituidas, su empleo, procedimiento para obtenerlas, y medicamentos y preparaciones farmaceuticas que las contienen |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6114330A (es) |
| JP (1) | JP4174077B2 (es) |
| KR (1) | KR20000075888A (es) |
| CN (1) | CN1091109C (es) |
| AR (1) | AR011879A1 (es) |
| AT (1) | ATE241618T1 (es) |
| AU (1) | AU726836B2 (es) |
| BR (1) | BR9808135A (es) |
| CA (1) | CA2281642C (es) |
| CO (1) | CO4940508A1 (es) |
| DE (1) | DE69815072T2 (es) |
| DK (1) | DK0966464T3 (es) |
| ES (1) | ES2198705T3 (es) |
| HR (1) | HRP980110A2 (es) |
| MA (1) | MA26475A1 (es) |
| PE (1) | PE59699A1 (es) |
| PT (1) | PT966464E (es) |
| TR (1) | TR199902140T2 (es) |
| TW (1) | TW464648B (es) |
| UY (1) | UY24913A1 (es) |
| ZA (1) | ZA981529B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006523620A (ja) * | 2003-02-19 | 2006-10-19 | バイオヴェイル ラボラトリーズ インコーポレイテッド | 急速吸収選択的５−ｈｔ作用剤製剤 |
| US8268825B2 (en) * | 2005-09-26 | 2012-09-18 | The Board Of Regents For Oklahoma State University | Method for the treatment of anthrax infections |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT793656E (pt) * | 1994-11-24 | 2003-07-31 | Basilea Pharmaceutica Ag | Novas benzil-pirimidinas |
| TW438796B (en) * | 1996-05-15 | 2001-06-07 | Hoffmann La Roche | 2,4-diaminopyrimidine derivatives, the manufacture process thereof, and the antibiotically-active pharmaceutical composition containing the same |
-
1998
- 1998-02-24 DE DE69815072T patent/DE69815072T2/de not_active Expired - Lifetime
- 1998-02-24 KR KR1019997007967A patent/KR20000075888A/ko not_active Ceased
- 1998-02-24 JP JP53811598A patent/JP4174077B2/ja not_active Expired - Fee Related
- 1998-02-24 PT PT98913585T patent/PT966464E/pt unknown
- 1998-02-24 CN CN98803085A patent/CN1091109C/zh not_active Expired - Fee Related
- 1998-02-24 ES ES98913585T patent/ES2198705T3/es not_active Expired - Lifetime
- 1998-02-24 CA CA002281642A patent/CA2281642C/en not_active Expired - Fee Related
- 1998-02-24 TR TR1999/02140T patent/TR199902140T2/xx unknown
- 1998-02-24 DK DK98913585T patent/DK0966464T3/da active
- 1998-02-24 ZA ZA981529A patent/ZA981529B/xx unknown
- 1998-02-24 AU AU68231/98A patent/AU726836B2/en not_active Ceased
- 1998-02-24 AT AT98913585T patent/ATE241618T1/de not_active IP Right Cessation
- 1998-02-24 BR BR9808135-7A patent/BR9808135A/pt not_active IP Right Cessation
- 1998-02-25 US US09/028,980 patent/US6114330A/en not_active Expired - Lifetime
- 1998-02-26 AR ARP980100859A patent/AR011879A1/es not_active Application Discontinuation
- 1998-02-27 PE PE1998000142A patent/PE59699A1/es not_active Application Discontinuation
- 1998-02-27 CO CO98010856A patent/CO4940508A1/es unknown
- 1998-03-02 UY UY24913A patent/UY24913A1/es not_active Application Discontinuation
- 1998-03-02 MA MA24985A patent/MA26475A1/fr unknown
- 1998-03-03 HR HR97103436.8A patent/HRP980110A2/hr not_active Application Discontinuation
- 1998-03-03 TW TW087103084A patent/TW464648B/zh active
Also Published As
| Publication number | Publication date |
|---|---|
| HRP980110A2 (en) | 1998-12-31 |
| KR20000075888A (ko) | 2000-12-26 |
| PE59699A1 (es) | 1999-06-16 |
| UY24913A1 (es) | 2001-01-31 |
| JP2001513791A (ja) | 2001-09-04 |
| CA2281642C (en) | 2008-02-05 |
| DE69815072D1 (de) | 2003-07-03 |
| ZA981529B (en) | 1998-09-03 |
| CN1249751A (zh) | 2000-04-05 |
| PT966464E (pt) | 2003-09-30 |
| DK0966464T3 (da) | 2003-09-22 |
| JP4174077B2 (ja) | 2008-10-29 |
| CN1091109C (zh) | 2002-09-18 |
| ATE241618T1 (de) | 2003-06-15 |
| BR9808135A (pt) | 2000-03-28 |
| TR199902140T2 (en) | 2000-04-21 |
| TW464648B (en) | 2001-11-21 |
| ES2198705T3 (es) | 2004-02-01 |
| US6114330A (en) | 2000-09-05 |
| CO4940508A1 (es) | 2000-07-24 |
| DE69815072T2 (de) | 2004-04-01 |
| MA26475A1 (fr) | 2004-12-20 |
| CA2281642A1 (en) | 1998-09-11 |
| AU726836B2 (en) | 2000-11-23 |
| AU6823198A (en) | 1998-09-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CO4810373A1 (es) | Compuestos azapoliciclicos condensados con arilo | |
| ECSP23095485A (es) | N-(hidroxialquil (hetero)aril) tetrahidrofurano carboxamidas como moduladores de canales de sodio | |
| NO963053D0 (no) | Kosmetiske eller farmasöytiske preparater inneholdende mangiferin eller derivater derav | |
| GT199800046A (es) | Compuestos de pirazina. | |
| IL149163A0 (en) | Piperazine derivatives of carbazole, their preparation and pharmaceutical compositions containing them | |
| DK1263730T3 (da) | Aminderivater til behandling af apoptose | |
| ECSP045229A (es) | Piridinonas sustituidas como moduladores de la p38 map quinasa | |
| ES2053508T3 (es) | Compuestos de acidos 3-pirrolidinil-tio-1-azabiciclo(3.2.0)hept-2-eno-2-carboxilicos. | |
| CO4810375A1 (es) | Derivados de 9-amino-3-ceto eritromicina | |
| ES2190396T3 (es) | Nuevos compuestos amino-triazoles, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen. | |
| ES2169147T3 (es) | Derivados de beta-carbolina agonistas de la melatonina, sus procedimientos de preparacion y su utilizacion a titulo de medicamento. | |
| ES2175161T3 (es) | Derivados de piperazina como antagonistas de taquiquinina. | |
| AR007118A1 (es) | 4(3h)-quinazolinonas 2,3 disustituidas y composiciones farmaceuticas que las contienen | |
| TR200201509T2 (tr) | Farmasötik olarak aktif benzazol türevleri. | |
| AR004516A1 (es) | Derivados de pirimidina, su uso, procedimientos para prepararlos y medicamentos que los contienen | |
| AR033594A1 (es) | Un compuesto derivado de 3-aroilindol, su utilizacion, procedimientos para prepararlo, una composicion farmaceutica que lo contiene, un medicamento constituido por dicho compuesto, y compuestos intermediarios | |
| CO4840509A1 (es) | 2,4 diaminopirimidinas sustituidas, medicamento que contiene dichos compuestos para el control o la prevencion de enfermedades infecciosas y procedimiento para la preparacion de dichos compuestos" | |
| MX9605218A (es) | Amidas aciclicas y ciclicas novedosas como mejoradores de liberacion de neurotransmisores. | |
| AR027578A1 (es) | Derivados de indano | |
| EA200300044A1 (ru) | Новые замещенные фталиды, способ их получения и содержащие их фармацевтические композиции | |
| GT199800039A (es) | Atropisomeros de 3-heteroaril-4(3h)-quinazolinonas. | |
| ES2103440T3 (es) | Nuevas amidas y sulfonamidas naftalenicas, procedimiento de preparacion y composiciones farmaceuticas que las contienen. | |
| AR011879A1 (es) | 2,4-diaminopirimidinas substituidas, su empleo, procedimiento para obtenerlas, y medicamentos y preparaciones farmaceuticas que las contienen | |
| ES2125963T3 (es) | Nuevos derivados espiranicos del 3-amino-cromano, sus procedimientos de preparacion y las composiciones farmaceuticas que los contienen. | |
| ES2189072T3 (es) | Nuevo benzo-cicloalquenos heterociclicos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |