PE59699A1 - 2,4 diaminopirimidina sustituida - Google Patents
2,4 diaminopirimidina sustituidaInfo
- Publication number
- PE59699A1 PE59699A1 PE1998000142A PE00014298A PE59699A1 PE 59699 A1 PE59699 A1 PE 59699A1 PE 1998000142 A PE1998000142 A PE 1998000142A PE 00014298 A PE00014298 A PE 00014298A PE 59699 A1 PE59699 A1 PE 59699A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- alcoxyl
- aryl
- compound
- formula
- Prior art date
Links
- YAAWASYJIRZXSZ-UHFFFAOYSA-N pyrimidine-2,4-diamine Chemical class NC1=CC=NC(N)=N1 YAAWASYJIRZXSZ-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 101100134922 Gallus gallus COR5 gene Proteins 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- FDDDEECHVMSUSB-UHFFFAOYSA-N sulfanilamide Chemical compound NC1=CC=C(S(N)(=O)=O)C=C1 FDDDEECHVMSUSB-UHFFFAOYSA-N 0.000 abstract 1
- 229940124530 sulfonamide Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA (I) O SUS SALES DONDE, R1 ES ALCOXILO, R2 ES OH O ALCOXILO; R3 ES CN, H, ALQUILO, ALQUENILO, CICLOALQUILO, ARILO, HETEROCICLO, ARIL-Q-ALQUILO, -CR4R4`COR5; ENTRE OTROS; Q ES SO o SO2; R4 Y R4' SON H, ALQUILO, ARILO, HETEROCICLO; R5 ES H, ALQUILO, ALCOXILO, ENTRE OTROS; o R4 Y R5 FORMAN JUNTOS UN GRUPO CR4R4'COR5, n ES 2-5. SON COMPUESTOS PREFERIDOS (E)-(RS)-3-[5-(2,4-DIAMINO-PIRIMIDIN-5-ILMETIL)-2,3-DIMETOXIFENIL]-1-(1-FENIL-1H-FTALAZIN-2-IL)PROPENONA; (E)-(RS)-3-[5-(2,4-DIAMINO-PIRIMIDIN-5-ILMETIL)-2,3-DIMETOXI-FENIL]-1-(1-FURAN-2-IL-1H-FTALAZIN-2-IL)-PROPENONA; ENTRE OTROS. TAMBIEN SE REFIERE A PROCEDIMIENTOS PARA SU OBTENCION Y A UNA PREPARACION FARMACEUTICA QUE CONTIENE UN COMPUESTO DE FORMULA (I) Y UNA SULFONAMIDA, EN UNA PROPORCION PREFERIDA DE 1:10 A 1:2 PARTES EN PESO. EL COMPUESTO DE FORMULA (I) PUEDE SER UTIL PARA EL TRATAMIENTO DE INFECCIONES
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97103436 | 1997-03-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE59699A1 true PE59699A1 (es) | 1999-06-16 |
Family
ID=8226543
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1998000142A PE59699A1 (es) | 1997-03-03 | 1998-02-27 | 2,4 diaminopirimidina sustituida |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6114330A (es) |
| JP (1) | JP4174077B2 (es) |
| KR (1) | KR20000075888A (es) |
| CN (1) | CN1091109C (es) |
| AR (1) | AR011879A1 (es) |
| AT (1) | ATE241618T1 (es) |
| AU (1) | AU726836B2 (es) |
| BR (1) | BR9808135A (es) |
| CA (1) | CA2281642C (es) |
| CO (1) | CO4940508A1 (es) |
| DE (1) | DE69815072T2 (es) |
| DK (1) | DK0966464T3 (es) |
| ES (1) | ES2198705T3 (es) |
| HR (1) | HRP980110A2 (es) |
| MA (1) | MA26475A1 (es) |
| PE (1) | PE59699A1 (es) |
| PT (1) | PT966464E (es) |
| TR (1) | TR199902140T2 (es) |
| TW (1) | TW464648B (es) |
| UY (1) | UY24913A1 (es) |
| ZA (1) | ZA981529B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006523620A (ja) * | 2003-02-19 | 2006-10-19 | バイオヴェイル ラボラトリーズ インコーポレイテッド | 急速吸収選択的５−ｈｔ作用剤製剤 |
| US8268825B2 (en) * | 2005-09-26 | 2012-09-18 | The Board Of Regents For Oklahoma State University | Method for the treatment of anthrax infections |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3117721B2 (ja) * | 1994-11-24 | 2000-12-18 | エフ・ホフマン−ラ ロシュ アーゲー | 新規なベンジルピリミジン類 |
| TW438796B (en) * | 1996-05-15 | 2001-06-07 | Hoffmann La Roche | 2,4-diaminopyrimidine derivatives, the manufacture process thereof, and the antibiotically-active pharmaceutical composition containing the same |
-
1998
- 1998-02-24 CA CA002281642A patent/CA2281642C/en not_active Expired - Fee Related
- 1998-02-24 TR TR1999/02140T patent/TR199902140T2/xx unknown
- 1998-02-24 ES ES98913585T patent/ES2198705T3/es not_active Expired - Lifetime
- 1998-02-24 AU AU68231/98A patent/AU726836B2/en not_active Ceased
- 1998-02-24 AT AT98913585T patent/ATE241618T1/de not_active IP Right Cessation
- 1998-02-24 DK DK98913585T patent/DK0966464T3/da active
- 1998-02-24 KR KR1019997007967A patent/KR20000075888A/ko not_active Ceased
- 1998-02-24 ZA ZA981529A patent/ZA981529B/xx unknown
- 1998-02-24 CN CN98803085A patent/CN1091109C/zh not_active Expired - Fee Related
- 1998-02-24 JP JP53811598A patent/JP4174077B2/ja not_active Expired - Fee Related
- 1998-02-24 PT PT98913585T patent/PT966464E/pt unknown
- 1998-02-24 DE DE69815072T patent/DE69815072T2/de not_active Expired - Lifetime
- 1998-02-24 BR BR9808135-7A patent/BR9808135A/pt not_active IP Right Cessation
- 1998-02-25 US US09/028,980 patent/US6114330A/en not_active Expired - Lifetime
- 1998-02-26 AR ARP980100859A patent/AR011879A1/es not_active Application Discontinuation
- 1998-02-27 CO CO98010856A patent/CO4940508A1/es unknown
- 1998-02-27 PE PE1998000142A patent/PE59699A1/es not_active Application Discontinuation
- 1998-03-02 MA MA24985A patent/MA26475A1/fr unknown
- 1998-03-02 UY UY24913A patent/UY24913A1/es not_active Application Discontinuation
- 1998-03-03 HR HR97103436.8A patent/HRP980110A2/hr not_active Application Discontinuation
- 1998-03-03 TW TW087103084A patent/TW464648B/zh active
Also Published As
| Publication number | Publication date |
|---|---|
| TR199902140T2 (en) | 2000-04-21 |
| JP2001513791A (ja) | 2001-09-04 |
| CO4940508A1 (es) | 2000-07-24 |
| AU6823198A (en) | 1998-09-22 |
| DE69815072T2 (de) | 2004-04-01 |
| UY24913A1 (es) | 2001-01-31 |
| ATE241618T1 (de) | 2003-06-15 |
| DE69815072D1 (de) | 2003-07-03 |
| AU726836B2 (en) | 2000-11-23 |
| CA2281642A1 (en) | 1998-09-11 |
| CA2281642C (en) | 2008-02-05 |
| US6114330A (en) | 2000-09-05 |
| BR9808135A (pt) | 2000-03-28 |
| HRP980110A2 (en) | 1998-12-31 |
| CN1091109C (zh) | 2002-09-18 |
| MA26475A1 (fr) | 2004-12-20 |
| TW464648B (en) | 2001-11-21 |
| ES2198705T3 (es) | 2004-02-01 |
| CN1249751A (zh) | 2000-04-05 |
| PT966464E (pt) | 2003-09-30 |
| ZA981529B (en) | 1998-09-03 |
| AR011879A1 (es) | 2000-09-13 |
| DK0966464T3 (da) | 2003-09-22 |
| KR20000075888A (ko) | 2000-12-26 |
| JP4174077B2 (ja) | 2008-10-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |