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UA96284C2 - Производные пиримидина, которые применяют как ингибиторы pi-3 киназы, и способы их применения - Google Patents

Производные пиримидина, которые применяют как ингибиторы pi-3 киназы, и способы их применения

Info

Publication number
UA96284C2
UA96284C2 UAA200809431A UAA200809431A UA96284C2 UA 96284 C2 UA96284 C2 UA 96284C2 UA A200809431 A UAA200809431 A UA A200809431A UA A200809431 A UAA200809431 A UA A200809431A UA 96284 C2 UA96284 C2 UA 96284C2
Authority
UA
Ukraine
Prior art keywords
kinase inhibitors
pyrimidine derivatives
derivatives used
alone
pharmaceutically acceptable
Prior art date
Application number
UAA200809431A
Other languages
English (en)
Ukrainian (uk)
Inventor
Метью Бюргер
Жи-джи Ни
Сабина Пекки
Гордана Аталла
Сара Бартулис
Келли Фрейзер
Аарон Смит
Жоэль Верхаген
Янчен Жанг
Аллан Вагмен
Саймон Нг
Кит Пфистер
Дениэл Пун
Алисия Луи
Тереза Пик
Пол Барсанти
Эдвин Иванович
Уэнди Фентл
Томас Хендриксон
Марк Кнапп
Ханне Меритт
Чарльз Волива
Мерион Визманн
Ксихуа Ксин
Original Assignee
Новартис Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37951939&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA96284(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Новартис Аг filed Critical Новартис Аг
Publication of UA96284C2 publication Critical patent/UA96284C2/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

В заявке описаны новые ингибиторы фосфатидилинозит (PI) 3-киназы, их фармацевтически приемлемые соли и пролекарства; композиции новых соединений, отдельно или в комбинации по меньшей мере с одним дополнительным терапевтическим средством, с фармацевтически приемлемым носителем; и применение новых соединений, отдельно или в комбинации по меньшей мере с одним дополнительным терапевтическим средством, для профилактики или лечения пролиферативных заболеваний, которые характеризуются аномальной активностью факторов роста, протеинсерон/треонинкиназ и фосфолипидкиназ.
UAA200809431A 2006-01-20 2007-01-22 Производные пиримидина, которые применяют как ингибиторы pi-3 киназы, и способы их применения UA96284C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US76078906P 2006-01-20 2006-01-20

Publications (1)

Publication Number Publication Date
UA96284C2 true UA96284C2 (ru) 2011-10-25

Family

ID=37951939

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200809431A UA96284C2 (ru) 2006-01-20 2007-01-22 Производные пиримидина, которые применяют как ингибиторы pi-3 киназы, и способы их применения

Country Status (40)

Country Link
US (2) US8217035B2 (ru)
EP (2) EP1984350B1 (ru)
JP (1) JP5161110B2 (ru)
KR (1) KR101353829B1 (ru)
CN (1) CN101389622B (ru)
AR (2) AR059087A1 (ru)
AT (1) ATE478064T1 (ru)
AU (1) AU2007206048B2 (ru)
BR (1) BRPI0707189B1 (ru)
CA (1) CA2636993C (ru)
CR (1) CR10163A (ru)
CY (1) CY1111091T1 (ru)
DE (1) DE602007008529D1 (ru)
DK (2) DK1984350T3 (ru)
EA (1) EA018083B1 (ru)
EC (1) ECSP088630A (ru)
ES (2) ES2351172T3 (ru)
GE (1) GEP20115147B (ru)
GT (1) GT200800143A (ru)
HN (1) HN2008001144A (ru)
HR (2) HRP20100603T1 (ru)
IL (1) IL192763A (ru)
JO (1) JO2660B1 (ru)
MA (1) MA30208B1 (ru)
ME (2) MEP3908A (ru)
MY (1) MY144233A (ru)
NO (1) NO342183B1 (ru)
NZ (1) NZ569771A (ru)
PE (1) PE20071322A1 (ru)
PL (2) PL1984350T3 (ru)
PT (2) PT2261223E (ru)
RS (2) RS52928B (ru)
SI (2) SI2261223T1 (ru)
SM (1) SMP200800048B (ru)
SV (1) SV2008002984A (ru)
TN (1) TNSN08305A1 (ru)
TW (2) TW201315723A (ru)
UA (1) UA96284C2 (ru)
WO (1) WO2007084786A1 (ru)
ZA (1) ZA200806017B (ru)

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