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MX2015015130A - Compuestos de biheteroarilo y usos de los mismos. - Google Patents

Compuestos de biheteroarilo y usos de los mismos.

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Publication number
MX2015015130A
MX2015015130A MX2015015130A MX2015015130A MX2015015130A MX 2015015130 A MX2015015130 A MX 2015015130A MX 2015015130 A MX2015015130 A MX 2015015130A MX 2015015130 A MX2015015130 A MX 2015015130A MX 2015015130 A MX2015015130 A MX 2015015130A
Authority
MX
Mexico
Prior art keywords
compounds
biheteroarilo
same
formula
diseases
Prior art date
Application number
MX2015015130A
Other languages
English (en)
Inventor
Joseph P Lyssikatos
Terry Kellar
Anthony Estrada
Daniel Shore
Malcolm Huestis
Michael Siu
Snahel Patel
Wen Liu
Kevin X Chen
Liting Dong
Paul Gibbons
Changyou Ma
Alan Olivero
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2015015130A publication Critical patent/MX2015015130A/es

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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract

La presente invención proporciona compuestos de Fórmula I-I y modalidades y sales de los mismos para el tratamiento de enfermedades (por ejemplo, enfermedades neurodegenerativas) Las variables R1, R2, R3, X1, X2, A y Cy en la Fórmula I-I tienen todas los significados definidos en el presente documento. (ver Fórmula).
MX2015015130A 2013-05-01 2014-04-30 Compuestos de biheteroarilo y usos de los mismos. MX2015015130A (es)

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