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UA81660C2 - Биарилзамещённые триазолы как блокираторы натриевых каналов - Google Patents

Биарилзамещённые триазолы как блокираторы натриевых каналов

Info

Publication number
UA81660C2
UA81660C2 UAA200509759A UA2005009759A UA81660C2 UA 81660 C2 UA81660 C2 UA 81660C2 UA A200509759 A UAA200509759 A UA A200509759A UA 2005009759 A UA2005009759 A UA 2005009759A UA 81660 C2 UA81660 C2 UA 81660C2
Authority
UA
Ukraine
Prior art keywords
compounds
pain
alone
pharmaceutically acceptable
effective amount
Prior art date
Application number
UAA200509759A
Other languages
English (en)
Ukrainian (uk)
Inventor
Прасун К. Чакраварти
Майкл Х. Фишер
Бренда Палуки
Мин К. Парк
Уильям Х. Парсонз
Бишань Чжоу
Джеймс П. Кери
Дуглас Э. Франц
Майкл Х. Кресс
Деймиан Уивер
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of UA81660C2 publication Critical patent/UA81660C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Представлены биарилзамещенные производные триазола формул (І), (II) или (III) или их фармацевтически приемлемые соли и способ получения таких соединений и их солей. Фармацевтические композиции содержат эффективное количество данных соединений, или в чистом виде, или в комбинации с одной или несколькими другими терапевтически активными соединениями, и фармацевтически приемлемый наполнитель. Способы лечения состояний, связанных с или вызванных активностью натриевых каналов, которые включают, например, острую боль, хроническую боль, висцеральную боль, воспалительную �
UAA200509759A 2003-03-18 2004-03-12 Биарилзамещённые триазолы как блокираторы натриевых каналов UA81660C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45595203P 2003-03-18 2003-03-18
PCT/US2004/007830 WO2004083190A1 (en) 2003-03-18 2004-03-12 Biaryl substituted triazoles as sodium channel blockers

Publications (1)

Publication Number Publication Date
UA81660C2 true UA81660C2 (ru) 2008-01-25

Family

ID=33030073

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200509759A UA81660C2 (ru) 2003-03-18 2004-03-12 Биарилзамещённые триазолы как блокираторы натриевых каналов

Country Status (34)

Country Link
US (2) US7326726B2 (ru)
EP (1) EP1606269B1 (ru)
JP (1) JP4482554B2 (ru)
KR (1) KR100737721B1 (ru)
CN (2) CN1788002A (ru)
AR (1) AR044503A1 (ru)
AT (1) ATE412639T1 (ru)
AU (1) AU2004221885C1 (ru)
BR (1) BRPI0408407A (ru)
CA (1) CA2519252C (ru)
CL (1) CL2004000551A1 (ru)
CY (1) CY1108720T1 (ru)
DE (1) DE602004017438D1 (ru)
DK (1) DK1606269T3 (ru)
EC (1) ECSP056018A (ru)
EG (1) EG25994A (ru)
ES (1) ES2314387T3 (ru)
HR (1) HRP20050816A2 (ru)
IS (1) IS8001A (ru)
JO (1) JO2480B1 (ru)
MA (1) MA27665A1 (ru)
MX (1) MXPA05009847A (ru)
MY (1) MY142651A (ru)
NO (1) NO20054775L (ru)
NZ (1) NZ542205A (ru)
PE (1) PE20041066A1 (ru)
PL (1) PL1606269T3 (ru)
PT (1) PT1606269E (ru)
RU (1) RU2356897C2 (ru)
SI (1) SI1606269T1 (ru)
TW (1) TWI337605B (ru)
UA (1) UA81660C2 (ru)
WO (2) WO2004083189A1 (ru)
ZA (1) ZA200506906B (ru)

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NZ547044A (en) * 2003-11-10 2010-05-28 Merck Sharp & Dohme Substituted triazoles as sodium channel blockers
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TW201837023A (zh) 2011-07-01 2018-10-16 美商基利科學股份有限公司 作為離子通道調節劑之稠合雜環化合物
NO3175985T3 (ru) 2011-07-01 2018-04-28
CN103781770B (zh) 2011-09-16 2016-04-13 辉瑞公司 转甲状腺素蛋白解离抑制剂的固体形式
WO2013131018A1 (en) * 2012-03-02 2013-09-06 Zalicus Pharmaceuticals Ltd. Biaryl inhibitors of the sodium channel
TWI568722B (zh) 2012-06-15 2017-02-01 葛蘭馬克製藥公司 作爲ｍＰＧＥＳ－１抑制劑之三唑酮化合物
JP6456909B2 (ja) 2013-03-15 2019-01-23 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Ｌｘｒ調節因子
ES2912881T3 (es) 2014-12-23 2022-05-30 Convergence Pharmaceuticals Procedimiento para preparar derivados de alfa-carboxamida pirrolidina
JP6616244B2 (ja) * 2015-05-29 2019-12-04 北興化学工業株式会社 新規なヒドロキシフェニルボロン酸エステルとその製造方法、およびヒドロキシビフェニル化合物の製造法
US11192856B2 (en) 2017-10-05 2021-12-07 Biogen Inc. Process for preparing alpha-carboxamide pyrrolidine derivatives
KR102512548B1 (ko) 2017-12-22 2023-03-22 삼성디스플레이 주식회사 유기 전계 발광 소자 및 유기 전계 발광 소자용 함질소 화합물
WO2019171234A1 (en) * 2018-03-09 2019-09-12 Pi Industries Ltd. Heterocyclic compounds as fungicides
CN108794413A (zh) * 2018-06-25 2018-11-13 青岛科技大学 一种1,2,4-三氮唑-3-甲酰胺的合成方法
CN108863965A (zh) * 2018-06-25 2018-11-23 青岛科技大学 一锅法制备1,2,4-三氮唑-3-甲酰胺的方法

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Also Published As

Publication number Publication date
SI1606269T1 (sl) 2009-02-28
PL1606269T3 (pl) 2009-04-30
JO2480B1 (en) 2009-01-20
NO20054775D0 (no) 2005-10-17
ES2314387T3 (es) 2009-03-16
CN101289428A (zh) 2008-10-22
JP4482554B2 (ja) 2010-06-16
MY142651A (en) 2010-12-15
RU2005132168A (ru) 2006-04-27
ATE412639T1 (de) 2008-11-15
ECSP056018A (es) 2006-01-27
KR20050109583A (ko) 2005-11-21
US20080171777A1 (en) 2008-07-17
EG25994A (en) 2012-11-28
NZ542205A (en) 2008-11-28
EP1606269B1 (en) 2008-10-29
MXPA05009847A (es) 2005-12-05
WO2004083189A1 (en) 2004-09-30
MA27665A1 (fr) 2005-12-01
AU2004221885C1 (en) 2010-09-23
US7326726B2 (en) 2008-02-05
KR100737721B1 (ko) 2007-07-11
JP2006520782A (ja) 2006-09-14
CA2519252A1 (en) 2004-09-30
EP1606269A1 (en) 2005-12-21
AU2004221885A1 (en) 2004-09-30
BRPI0408407A (pt) 2006-03-21
US20050119261A1 (en) 2005-06-02
DK1606269T3 (da) 2009-02-09
WO2004083190A1 (en) 2004-09-30
US7572822B2 (en) 2009-08-11
TWI337605B (en) 2011-02-21
IS8001A (is) 2005-08-29
CA2519252C (en) 2008-11-18
PE20041066A1 (es) 2005-01-22
DE602004017438D1 (de) 2008-12-11
HRP20050816A2 (hr) 2006-04-30
RU2356897C2 (ru) 2009-05-27
AU2004221885B2 (en) 2010-04-22
AR044503A1 (es) 2005-09-14
ZA200506906B (en) 2007-02-28
TW200505876A (en) 2005-02-16
CY1108720T1 (el) 2013-09-04
CN1788002A (zh) 2006-06-14
CL2004000551A1 (es) 2005-01-21
PT1606269E (pt) 2008-12-16
NO20054775L (no) 2005-12-16

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