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MA27665A1 - Triazoles substitues diaryle comme bloqueurs des canaux sodiques - Google Patents

Triazoles substitues diaryle comme bloqueurs des canaux sodiques

Info

Publication number
MA27665A1
MA27665A1 MA28481A MA28481A MA27665A1 MA 27665 A1 MA27665 A1 MA 27665A1 MA 28481 A MA28481 A MA 28481A MA 28481 A MA28481 A MA 28481A MA 27665 A1 MA27665 A1 MA 27665A1
Authority
MA
Morocco
Prior art keywords
compounds
pain
relates
alone
pharmaceutically acceptable
Prior art date
Application number
MA28481A
Other languages
English (en)
Inventor
James P Carey
Prasun K Chakravarty
Michael H Fisher
Brenda Palucki
Min K Park
William H Parsons
Bishan Zhou
Douglas E Frantz
Michael H Kress
Damian Weaver
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of MA27665A1 publication Critical patent/MA27665A1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00Anaesthetics
    • A61P23/02Local anaesthetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/101,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Anesthesiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne des composés triazole substitués par du biaryle, représentés par la formule (I), (II) ou (III), ou des sels acceptables sur le plan pharmaceutique de ceux-ci. L'invention concerne également un procédé de préparation de tels composés et des sels de ceux-ci, ainsi que des compositions pharmaceutiques renfermant une quantité efficace des composés selon l'invention, soit seuls, soit avec un ou plusieurs autres composés actifs sur le plan thérapeutique, et un excipient acceptable sur le plan pharmaceutique. L'invention concerne, en outre, des méthodes de traitement d'états associés à l'activité des canaux sodiques ou engendrés par celle-ci, notamment, par exemple, des douleurs aigues, des douleurs chroniques, des douleurs viscérales, des douleurs inflammatoires, des douleurs neuropathiques, l'épilepsie, le syndrome du côlon irritable, la dépression, l'anxiété, la sclérose en plaques et un trouble polaire, consistant à administrer une quantité efficace des composés selon l'invention, soit seuls, soit conjointement avec un ou plusieurs autres composés actifs sur le plan thérapeutique. L'invention concerne enfin un procédé d'anesthésie locale consistant à administrer une quantité efficace d'un composé selon l'invention, soit seul, soit conjointement avec un ou plusieurs composés actifs sur le plan thérapeutique, et un excipient acceptable sur le plan pharmaceutique.
MA28481A 2003-03-18 2005-09-06 Triazoles substitues diaryle comme bloqueurs des canaux sodiques MA27665A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US45595203P 2003-03-18 2003-03-18

Publications (1)

Publication Number Publication Date
MA27665A1 true MA27665A1 (fr) 2005-12-01

Family

ID=33030073

Family Applications (1)

Application Number Title Priority Date Filing Date
MA28481A MA27665A1 (fr) 2003-03-18 2005-09-06 Triazoles substitues diaryle comme bloqueurs des canaux sodiques

Country Status (34)

Country Link
US (2) US7326726B2 (fr)
EP (1) EP1606269B1 (fr)
JP (1) JP4482554B2 (fr)
KR (1) KR100737721B1 (fr)
CN (2) CN101289428A (fr)
AR (1) AR044503A1 (fr)
AT (1) ATE412639T1 (fr)
AU (1) AU2004221885C1 (fr)
BR (1) BRPI0408407A (fr)
CA (1) CA2519252C (fr)
CL (1) CL2004000551A1 (fr)
CY (1) CY1108720T1 (fr)
DE (1) DE602004017438D1 (fr)
DK (1) DK1606269T3 (fr)
EC (1) ECSP056018A (fr)
EG (1) EG25994A (fr)
ES (1) ES2314387T3 (fr)
HR (1) HRP20050816A2 (fr)
IS (1) IS8001A (fr)
JO (1) JO2480B1 (fr)
MA (1) MA27665A1 (fr)
MX (1) MXPA05009847A (fr)
MY (1) MY142651A (fr)
NO (1) NO20054775L (fr)
NZ (1) NZ542205A (fr)
PE (1) PE20041066A1 (fr)
PL (1) PL1606269T3 (fr)
PT (1) PT1606269E (fr)
RU (1) RU2356897C2 (fr)
SI (1) SI1606269T1 (fr)
TW (1) TWI337605B (fr)
UA (1) UA81660C2 (fr)
WO (2) WO2004083190A1 (fr)
ZA (1) ZA200506906B (fr)

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ES2373639T3 (es) 2002-12-19 2012-02-07 The Scripps Research Institute Composiciones y usos para estabilizar la transtiretina e inhibir el plegamiento anómalo de la transtiretina.
MY142651A (en) * 2003-03-18 2010-12-15 Merck Sharp & Dohme Biaryl substituted triazoles as sodium channel blockers
NZ547044A (en) * 2003-11-10 2010-05-28 Merck Sharp & Dohme Substituted triazoles as sodium channel blockers
CN101198598A (zh) 2004-05-20 2008-06-11 弗尔德里克斯制药股份有限公司 2-((杂)芳基)-苯并噁唑化合物及其衍生物、组合物以及用于稳定和抑制甲状腺素转运蛋白错重叠的方法
TW200728258A (en) 2005-10-10 2007-08-01 Glaxo Group Ltd Novel compounds
JP5139307B2 (ja) 2005-10-10 2013-02-06 グラクソ グループ リミテッド ナトリウムチャネルモジュレーターとしてのプロリンアミド誘導体
TW200730494A (en) 2005-10-10 2007-08-16 Glaxo Group Ltd Novel compounds
KR20090112722A (ko) * 2007-01-24 2009-10-28 글락소 그룹 리미티드 3,5-디아미노-6-(2,3-디클로로페닐)-1,2,4-트리아진 또는 r(-)-2,4-디아미노-5-(2,3-디클로로페닐)-6-플루오로메틸 피리미딘 및 nk1을 포함하는 제약 조성물
CA2677481C (fr) 2007-02-08 2015-07-07 Synta Pharmaceuticals Corp. Composes a base de triazole modulant l'activite de hsp90
EP2532643A1 (fr) 2007-06-08 2012-12-12 MannKind Corporation Inhibiteurs IRE-1A
DK2464645T3 (en) 2009-07-27 2017-10-23 Gilead Sciences Inc CONDENSED, HETEROCYCLIC COMPOUNDS AS IRON CHANNEL MODULATORS
US8703759B2 (en) 2010-07-02 2014-04-22 Gilead Sciences, Inc. Fused heterocyclic compounds as ion channel modulators
PL2707361T3 (pl) 2011-05-10 2018-01-31 Gilead Sciences Inc Skondensowane związki heterocykliczne stosowane jako modulatory kanału sodowego
TWI622583B (zh) 2011-07-01 2018-05-01 基利科學股份有限公司 作為離子通道調節劑之稠合雜環化合物
NO3175985T3 (fr) 2011-07-01 2018-04-28
SG2014013270A (en) 2011-09-16 2014-05-29 Pfizer Solid forms of a transthyretin dissociation inhibitor
WO2013131018A1 (fr) * 2012-03-02 2013-09-06 Zalicus Pharmaceuticals Ltd. Inhibiteurs biaryle du canal sodique
TWI568722B (zh) 2012-06-15 2017-02-01 葛蘭馬克製藥公司 作爲mPGES-1抑制劑之三唑酮化合物
JP6456909B2 (ja) 2013-03-15 2019-01-23 ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company Lxr調節因子
WO2016102967A1 (fr) 2014-12-23 2016-06-30 Convergence Pharmaceuticals Limited Procédé de préparation de dérivés d'alpha-carboxamide de pyrrolidine
JP6616244B2 (ja) * 2015-05-29 2019-12-04 北興化学工業株式会社 新規なヒドロキシフェニルボロン酸エステルとその製造方法、およびヒドロキシビフェニル化合物の製造法
MX2020003811A (es) 2017-10-05 2021-01-15 Biogen Inc Proceso para preparar derivados de alfa-carboxamida pirrolidina.
KR102512548B1 (ko) 2017-12-22 2023-03-22 삼성디스플레이 주식회사 유기 전계 발광 소자 및 유기 전계 발광 소자용 함질소 화합물
US20210002232A1 (en) * 2018-03-09 2021-01-07 Pi Industries Ltd. Heterocyclic compounds as fungicides
CN108863965A (zh) * 2018-06-25 2018-11-23 青岛科技大学 一锅法制备1,2,4-三氮唑-3-甲酰胺的方法
CN108794413A (zh) * 2018-06-25 2018-11-13 青岛科技大学 一种1,2,4-三氮唑-3-甲酰胺的合成方法

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Also Published As

Publication number Publication date
ATE412639T1 (de) 2008-11-15
EG25994A (en) 2012-11-28
CN101289428A (zh) 2008-10-22
US7572822B2 (en) 2009-08-11
WO2004083190A1 (fr) 2004-09-30
ZA200506906B (en) 2007-02-28
TWI337605B (en) 2011-02-21
AU2004221885C1 (en) 2010-09-23
DK1606269T3 (da) 2009-02-09
MY142651A (en) 2010-12-15
WO2004083189A1 (fr) 2004-09-30
JP4482554B2 (ja) 2010-06-16
EP1606269A1 (fr) 2005-12-21
US20080171777A1 (en) 2008-07-17
MXPA05009847A (es) 2005-12-05
RU2356897C2 (ru) 2009-05-27
US7326726B2 (en) 2008-02-05
NZ542205A (en) 2008-11-28
BRPI0408407A (pt) 2006-03-21
US20050119261A1 (en) 2005-06-02
JO2480B1 (en) 2009-01-20
SI1606269T1 (sl) 2009-02-28
PL1606269T3 (pl) 2009-04-30
ES2314387T3 (es) 2009-03-16
CA2519252A1 (fr) 2004-09-30
CN1788002A (zh) 2006-06-14
NO20054775D0 (no) 2005-10-17
HRP20050816A2 (hr) 2006-04-30
DE602004017438D1 (de) 2008-12-11
KR20050109583A (ko) 2005-11-21
UA81660C2 (ru) 2008-01-25
PE20041066A1 (es) 2005-01-22
PT1606269E (pt) 2008-12-16
IS8001A (is) 2005-08-29
AR044503A1 (es) 2005-09-14
CL2004000551A1 (es) 2005-01-21
AU2004221885A1 (en) 2004-09-30
ECSP056018A (es) 2006-01-27
NO20054775L (no) 2005-12-16
EP1606269B1 (fr) 2008-10-29
JP2006520782A (ja) 2006-09-14
TW200505876A (en) 2005-02-16
AU2004221885B2 (en) 2010-04-22
RU2005132168A (ru) 2006-04-27
KR100737721B1 (ko) 2007-07-11
CA2519252C (fr) 2008-11-18
CY1108720T1 (el) 2013-09-04

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