[go: up one dir, main page]

TWI799429B - 新穎氮喹啉衍生物 - Google Patents

新穎氮喹啉衍生物 Download PDF

Info

Publication number
TWI799429B
TWI799429B TW107122546A TW107122546A TWI799429B TW I799429 B TWI799429 B TW I799429B TW 107122546 A TW107122546 A TW 107122546A TW 107122546 A TW107122546 A TW 107122546A TW I799429 B TWI799429 B TW I799429B
Authority
TW
Taiwan
Prior art keywords
new
azaquinoline
derivatives
azaquinoline derivatives
new azaquinoline
Prior art date
Application number
TW107122546A
Other languages
English (en)
Other versions
TW201904961A (zh
Inventor
尼爾斯 葛瑞班紐
莊偉
艾德林 寇勒
丹尼爾 庫克
克勞迪雅 波恩
克絲汀 柏根
湯瑪士 伊格
漢斯 喬治 史瓦茲
渥納 哈倫拜區
奧瑞奇 高更斯
華特 胡比西
博恩德 阿力格
依玲 海斯勒
依莎 賈納 艾琳娜 傑森
Original Assignee
德商拜耳動物保健有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 德商拜耳動物保健有限公司 filed Critical 德商拜耳動物保健有限公司
Publication of TW201904961A publication Critical patent/TW201904961A/zh
Application granted granted Critical
Publication of TWI799429B publication Critical patent/TWI799429B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
TW107122546A 2017-06-30 2018-06-29 新穎氮喹啉衍生物 TWI799429B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
??17179149.4 2017-06-30
EP17179149.4 2017-06-30
EP17179149 2017-06-30

Publications (2)

Publication Number Publication Date
TW201904961A TW201904961A (zh) 2019-02-01
TWI799429B true TWI799429B (zh) 2023-04-21

Family

ID=59269946

Family Applications (1)

Application Number Title Priority Date Filing Date
TW107122546A TWI799429B (zh) 2017-06-30 2018-06-29 新穎氮喹啉衍生物

Country Status (22)

Country Link
US (1) US11485733B2 (zh)
EP (1) EP3615527B1 (zh)
JP (1) JP7210483B2 (zh)
KR (1) KR20200020911A (zh)
CN (1) CN110770227B (zh)
AR (1) AR112216A1 (zh)
AU (1) AU2018293627B2 (zh)
CA (1) CA3068350A1 (zh)
CL (1) CL2019003892A1 (zh)
CO (1) CO2019014484A2 (zh)
CR (1) CR20190595A (zh)
DK (1) DK3615527T3 (zh)
ES (1) ES2984497T3 (zh)
IL (1) IL271607B2 (zh)
MX (1) MX2019015895A (zh)
PE (1) PE20200608A1 (zh)
PH (1) PH12019502851A1 (zh)
PL (1) PL3615527T3 (zh)
TW (1) TWI799429B (zh)
UA (1) UA125800C2 (zh)
UY (1) UY37789A (zh)
WO (1) WO2019002132A1 (zh)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL279977B2 (en) * 2018-07-09 2024-06-01 Boehringer Ingelheim Animal Health Usa Inc Heterocyclic anthelmintic compounds
AU2019401442B2 (en) * 2018-12-18 2022-10-20 Elanco Tiergesundheit Ag Bicyclic derivatives
CN113490527B (zh) * 2018-12-18 2024-10-25 瑞士伊兰科动物保健有限公司 双环衍生物
US11560388B2 (en) 2019-03-19 2023-01-24 Boehringer Ingelheim Vetmedica Gmbh Anthelmintic aza-benzothiophene and aza-benzofuran compounds
AU2020289459A1 (en) * 2019-06-07 2022-01-06 Elanco Tiergesundheit Ag Bicyclic derivatives for treating endoparasites
TWI865563B (zh) * 2019-07-30 2024-12-11 德商拜耳動物保健有限公司 新穎異喹啉衍生物
JP7644121B2 (ja) * 2019-12-18 2025-03-11 インターベット インターナショナル ベー． フェー． アザインドール構造を含む駆虫剤化合物
AU2021253168A1 (en) * 2020-04-09 2022-11-03 Elanco Animal Health Gmbh Substituted condensed azines as anthelmintic compounds
CA3183100A1 (en) 2020-05-29 2021-12-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Anthelmintic heterocyclic compounds
WO2022106469A2 (en) 2020-11-18 2022-05-27 Elanco Tiergesundheit Ag N-(2,3-dihydro-1,4-benzoxazin-4-yl)-3-isopropyl-7-(2,3,5-trifluorophenyl)benzo-thiophene-2-carboxamide derivatives and similar compounds for the treatment of heartworm infections
CN116685584A (zh) * 2020-11-18 2023-09-01 礼蓝动物保健有限公司 用于治疗心丝虫感染的n-(2,3-二氢-1,4-苯并噁嗪-4-基)-3-异丙基-7-(2,3,5-三氟苯基)苯并噻吩-2-甲酰胺衍生物和类似化合物
CN116888124A (zh) * 2020-12-04 2023-10-13 礼蓝动物保健有限公司 二环衍生物
TW202237600A (zh) 2020-12-04 2022-10-01 瑞士商禮藍動物保健股份有限公司 雙環衍生物
EP4148052A1 (en) * 2021-09-09 2023-03-15 Bayer Animal Health GmbH New quinoline derivatives
AR127495A1 (es) 2021-11-01 2024-01-31 Boehringer Ingelheim Vetmedica Gmbh Compuestos de pirrolopiridazina como antihelmínticos
WO2024213752A1 (en) 2023-04-14 2024-10-17 Elanco Animal Health Gmbh Long-term prevention and/or treatment of a disease by slo-1 inhibitors
WO2025027117A1 (en) 2023-08-02 2025-02-06 Intervet International B.V. Carboxamide-4-quinoline compounds with anthelmintic activity

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200640933A (en) * 2005-01-28 2006-12-01 Janssen Pharmaceutica Nv Anthelmintic compounds
US20130150414A1 (en) * 2010-08-31 2013-06-13 Meiji Seika Pharma Co., Ltd. Pest control agent
TW201617330A (zh) * 2014-07-25 2016-05-16 拜耳動物保健有限公司 用於抗蠕蟲治療之化合物

Family Cites Families (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4479955A (en) 1983-01-10 1984-10-30 Ciba-Geigy Corporation Heterocycle-fused pyrazolo[3,4-d]pyridin-3-ones as benzodiazepine receptor modulators
DE3639877A1 (de) 1986-11-21 1988-05-26 Bayer Ag Hetarylalkyl substituierte 5- und 6-ringheterocyclen
KR0169813B1 (ko) 1995-07-12 1999-01-15 김종인 4-아미노-3-아실나프티리딘 유도체
WO1998035967A2 (en) 1997-02-18 1998-08-20 Neurocrine Biosciences, Inc. Biazacyclic crf antagonists
DE19858253A1 (de) * 1998-12-17 2000-06-21 Aventis Pharma Gmbh Verwendung von Inhibitoren des KQt1-Kanals zur Herstellung eines Medikaments zur Behandlung von Krankheiten, die durch Helminthen und Ektoparasiten hervorgerufen werden
EP1254114A2 (en) * 2000-01-28 2002-11-06 Melacure Therapeutics AB Melanocortin receptor agonists and antagonists
US6559145B2 (en) 2000-07-12 2003-05-06 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
GB0213715D0 (en) 2002-06-14 2002-07-24 Syngenta Ltd Chemical compounds
SE0202461D0 (sv) 2002-08-14 2002-08-14 Astrazeneca Ab Novel compounds
TWI312272B (en) 2003-05-12 2009-07-21 Sumitomo Chemical Co Pyrimidine compound and pests controlling composition containing the same
GB0414438D0 (en) 2004-06-28 2004-07-28 Syngenta Participations Ag Chemical compounds
CA2581725C (en) 2004-10-20 2013-01-08 Kumiai Chemical Industry Co., Ltd. 3-triazolylphenyl sulfide derivative, and insecticide, miticide and nematicide containing it as an active ingredient
US7304074B2 (en) 2005-04-05 2007-12-04 Hoffmann-La Roche Inc. Substituted 1,5-naphthyridine azolinones
CA2608072A1 (en) 2005-05-24 2006-11-30 Astrazeneca Ab Aminopiperidine quinolines and their azaisosteric analogues with antibacterial activity
US7938851B2 (en) 2005-06-08 2011-05-10 Xtent, Inc. Devices and methods for operating and controlling interventional apparatus
CN102936221B (zh) 2005-10-06 2014-09-10 日本曹达株式会社 桥联环状胺化合物以及有害生物防除剂
US7465795B2 (en) * 2005-12-20 2008-12-16 Astrazeneca Ab Compounds and uses thereof
KR20080080206A (ko) * 2005-12-20 2008-09-02 아스트라제네카 아베 Ｇａｂａａ-수용체 조절제로서의 치환된 신놀린 유도체 및그의 합성 방법
SA08290245B1 (ar) * 2007-04-23 2012-02-12 استرازينيكا ايه بي مشتقات كربو كساميد جديدة من -n (8-اريل رباعي هيدرو نفثالين غير متجانس- 2- يل) أو -n (5-اريل كرومان غير متجانس -3-يل) لعلاج الألم
CA2683392A1 (en) 2007-04-30 2008-11-06 Genentech, Inc. Inhibitors of iap
EP2166853B1 (en) 2007-06-08 2014-05-28 Dart Neuroscience (Cayman) Ltd Therapeutic pyrazolonaphthyridine derivatives
AU2008298545B2 (en) 2007-09-14 2013-12-12 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
CA2711500A1 (en) 2008-01-07 2009-07-16 Huanming Chen Novel hiv integrase inhibitors and methods of use
MX2010009755A (es) 2008-03-11 2010-09-30 Neurosearch As Nuevos derivados de triarilo utiles como moduladores de receptores de acetilcolina nicotinicos.
JP5268461B2 (ja) 2008-07-14 2013-08-21 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 Ｐｆ１３６４物質、その製造方法、生産菌株、及び、それを有効成分とする農園芸用殺虫剤
CN101337937B (zh) 2008-08-12 2010-12-22 国家农药创制工程技术研究中心 具有杀虫活性的n-苯基-5-取代氨基吡唑类化合物
CN101337940B (zh) 2008-08-12 2012-05-02 国家农药创制工程技术研究中心 具杀虫活性的含氮杂环二氯烯丙醚类化合物
CN101715774A (zh) 2008-10-09 2010-06-02 浙江化工科技集团有限公司 一个具有杀虫活性化合物制备及用途
EP2184273A1 (de) 2008-11-05 2010-05-12 Bayer CropScience AG Halogen-substituierte Verbindungen als Pestizide
GB0820344D0 (en) 2008-11-06 2008-12-17 Syngenta Ltd Herbicidal compositions
NZ593090A (en) * 2008-11-13 2013-06-28 Link Medicine Corp Azaquinolinone derivatives and uses thereof
CA2746394C (en) 2008-12-12 2017-08-29 Syngenta Limited Spiroheterocyclic n-oxypiperidines as pesticides
WO2011085575A1 (zh) 2010-01-15 2011-07-21 江苏省农药研究所股份有限公司 邻杂环甲酰苯胺类化合物及其合成方法和应用
AR081721A1 (es) 2010-02-25 2012-10-17 Nippon Soda Co Compuesto de amina ciclica y acaricida
CN102199152A (zh) 2010-03-25 2011-09-28 高大新 杂环咪唑类磷脂激酶抑制剂
BR112012030408A2 (pt) 2010-05-31 2015-09-29 Syngenta Participations Ag método de melhoramento de culturas
CN101967139B (zh) 2010-09-14 2013-06-05 中化蓝天集团有限公司 一种含一氟甲氧基吡唑的邻甲酰氨基苯甲酰胺类化合物、其合成方法及应用
EP2675440B1 (en) 2011-02-14 2020-03-25 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
CN103917525B (zh) 2011-05-23 2016-08-17 依兰制药公司 Lrrk2激酶活性的抑制剂
WO2013050317A1 (en) 2011-10-03 2013-04-11 Syngenta Limited Polymorphs of an isoxazoline derivative
CN102391261A (zh) 2011-10-14 2012-03-28 上海交通大学 一种n-取代噁二嗪类化合物及其制备方法和应用
US20140315857A1 (en) * 2011-11-28 2014-10-23 E I Du Pont De Nemours And Company N- (4 -quinolinylmethyl) sulfonamide derivatives and their use as anthelmintics
TWI566701B (zh) 2012-02-01 2017-01-21 日本農藥股份有限公司 芳烷氧基嘧啶衍生物及包含該衍生物作為有效成分的農園藝用殺蟲劑及其使用方法
CA2863892C (en) 2012-03-06 2016-08-30 Pfizer Inc. Macrocyclic derivatives for the treatment of proliferative diseases
WO2013148603A1 (en) 2012-03-27 2013-10-03 Takeda Pharmaceutical Company Limited Cinnoline derivatives as as btk inhibitors
US9334238B2 (en) 2012-03-30 2016-05-10 Basf Se N-substituted pyridinylidenes for combating animal pests
EP2647626A1 (en) 2012-04-03 2013-10-09 Syngenta Participations AG. 1-Aza-spiro[4.5]dec-3-ene and 1,8-diaza-spiro[4.5]dec-3-ene derivatives as pesticides
US9282739B2 (en) 2012-04-27 2016-03-15 Dow Agrosciences Llc Pesticidal compositions and processes related thereto
US8901153B2 (en) 2012-04-27 2014-12-02 Dow Agrosciences, Llc. Pesticidal compositions and processes related thereto
CN103109816B (zh) 2013-01-25 2014-09-10 青岛科技大学 硫代苯甲酰胺类化合物及其应用
CN103232431B (zh) 2013-01-25 2014-11-05 青岛科技大学 一种二卤代吡唑酰胺类化合物及其应用
US20140275503A1 (en) 2013-03-13 2014-09-18 Dow Agrosciences Llc Process for the preparation of certain triaryl rhamnose carbamates
JP2016512239A (ja) 2013-03-15 2016-04-25 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ Ａｔｒキナーゼの阻害剤として有用な化合物
US20140336182A1 (en) 2013-05-13 2014-11-13 Amgen Inc. Aurora Kinase Modulators and Method of Use
BR112015029268B1 (pt) 2013-05-23 2020-10-20 Syngenta Participations Ag composição pesticida, pacote de combinação, utilização, método de aumento da eficácia e redução da fitotoxicidade de compostos de ácido tetrâmico ativos em termos pesticidas, método não terapêutico para combater e controlar pragas
CN103265527B (zh) 2013-06-07 2014-08-13 江苏省农用激素工程技术研究中心有限公司 邻氨基苯甲酰胺化合物及其制备方法和应用
TWI529171B (zh) 2013-07-29 2016-04-11 赫孚孟拉羅股份公司 １，７－萘啶衍生物
CN103524422B (zh) 2013-10-11 2015-05-27 中国农业科学院植物保护研究所 苯并咪唑衍生物及其制备方法和用途
CA2925595A1 (en) 2013-10-17 2015-04-23 Dow Agrosciences Llc Processes for the preparation of pesticidal compounds
WO2015058021A1 (en) 2013-10-17 2015-04-23 Dow Agrosciences Llc Processes for the preparation of pesticidal compounds
JP6472444B2 (ja) * 2013-10-23 2019-02-20 バイエル・クロップサイエンス・アクチェンゲゼルシャフト 有害生物防除剤としての置換されているキノキサリン誘導体
MX2016010056A (es) * 2014-02-06 2016-11-15 Abbvie Inc 6-heteroariloxi o 6-ariloxi-quinolina-2-carboxamidas y metodos de uso.
NZ724691A (en) 2014-03-24 2018-02-23 Guangdong Zhongsheng Pharmaceutical Co Ltd Quinoline derivatives as smo inhibitors
TWI649307B (zh) 2014-05-07 2019-02-01 日商橘生藥品工業股份有限公司 Cyclohexylpyridine derivative
TW201613866A (en) 2014-07-07 2016-04-16 Bayer Cropscience Ag Process for preparing fluorinated iminopyridine compounds
PE20171735A1 (es) 2015-02-17 2017-12-04 Nippon Soda Co Composicion agroquimica
EP3325479B1 (en) 2015-06-03 2020-12-02 UWM Research Foundation, Inc. Ligands selective to alpha 6 subunit-containing gabaa receptors and their methods of use
ES2884073T3 (es) 2016-11-11 2021-12-10 Bayer Animal Health Gmbh Nuevos derivados antihelmínticos de quinolina-3-carboxamida

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200640933A (en) * 2005-01-28 2006-12-01 Janssen Pharmaceutica Nv Anthelmintic compounds
US20130150414A1 (en) * 2010-08-31 2013-06-13 Meiji Seika Pharma Co., Ltd. Pest control agent
TW201617330A (zh) * 2014-07-25 2016-05-16 拜耳動物保健有限公司 用於抗蠕蟲治療之化合物

Also Published As

Publication number Publication date
EP3615527B1 (en) 2024-03-06
US20200131175A1 (en) 2020-04-30
IL271607B1 (en) 2023-03-01
US11485733B2 (en) 2022-11-01
WO2019002132A1 (en) 2019-01-03
JP7210483B2 (ja) 2023-01-23
BR112019028181A2 (pt) 2020-07-07
UA125800C2 (uk) 2022-06-08
NZ759633A (en) 2024-05-31
AU2018293627B2 (en) 2022-07-21
CA3068350A1 (en) 2019-01-03
MX2019015895A (es) 2020-02-07
PE20200608A1 (es) 2020-03-10
DK3615527T3 (da) 2024-05-06
AU2018293627A1 (en) 2019-12-12
UY37789A (es) 2019-01-31
JP2020525444A (ja) 2020-08-27
CR20190595A (es) 2020-03-03
IL271607B2 (en) 2023-07-01
CN110770227B (zh) 2024-03-01
CN110770227A (zh) 2020-02-07
CL2019003892A1 (es) 2020-07-10
PH12019502851A1 (en) 2020-10-19
RU2020103733A (ru) 2021-07-30
AR112216A1 (es) 2019-10-02
TW201904961A (zh) 2019-02-01
CO2019014484A2 (es) 2020-01-17
EP3615527A1 (en) 2020-03-04
ES2984497T3 (es) 2024-10-29
IL271607A (en) 2020-02-27
RU2020103733A3 (zh) 2021-10-22
KR20200020911A (ko) 2020-02-26
PL3615527T3 (pl) 2024-07-01

Similar Documents

Publication Publication Date Title
TWI799429B (zh) 新穎氮喹啉衍生物
EP3688700A4 (en) BLOCKCHAINS REPORTED BY MESSAGES
EP3573975A4 (en) LINKS
EP3573976A4 (en) COMPOUNDS
EP3573956A4 (en) LINKS
EP3665276A4 (en) IMPROVED ENDOINULINASES
EP3630366B8 (en) Ablutionary fitting
EP3596929A4 (en) SHOUTCASTING
EP3585947A4 (en) BACKFILL LAYOUT
EP3573980A4 (en) LINKS
EP3595659A4 (en) AZA DIHYDRO ACRIDONE DERIVATIVES
EP3388425A4 (en) AMINOAZOLE DERIVATIVE
HK40058409A (zh) 咪唑幷嘧啶衍生物
EP3685644B8 (en) Rfid-carrel
HK40035532A (zh) 有消息憑證的區塊鏈
EP3730143A4 (en) OMIDENEPAG COMBINATION
HK40026010A (zh) 修饰的car-t
HK40024473A (zh) 多液体喷嘴
HK40030345A (zh) 吗啉基吡啶酮化合物
HK40030346A (zh) 吡啶基吡啶酮化合物
AU2017904707A0 (en) Humelove
AU2017904592A0 (en) Picaccia
HK40017252A (zh) 洗浴配件
AU2017904507A0 (en) foncph
AU2017904434A0 (en) LifeLessons