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MX2010009755A - Nuevos derivados de triarilo utiles como moduladores de receptores de acetilcolina nicotinicos. - Google Patents

Nuevos derivados de triarilo utiles como moduladores de receptores de acetilcolina nicotinicos.

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Publication number
MX2010009755A
MX2010009755A MX2010009755A MX2010009755A MX2010009755A MX 2010009755 A MX2010009755 A MX 2010009755A MX 2010009755 A MX2010009755 A MX 2010009755A MX 2010009755 A MX2010009755 A MX 2010009755A MX 2010009755 A MX2010009755 A MX 2010009755A
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Mexico
Prior art keywords
diseases
represent
disorders
modulators
nicotinic acetylcholine
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Application number
MX2010009755A
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English (en)
Inventor
Dan Peters
Jeppe Kejser Christensen
Antonio Nardi
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Neurosearch As
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Publication of MX2010009755A publication Critical patent/MX2010009755A/es

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Abstract

La presente invención se refiere a nuevos derivados de triarilo, de fórmula (I), un estereoisómero del mismo o una mezcla de sus estereoisómeros, o una sal del mismo farmacéuticamente aceptable, en donde todos de X, Y y Z representan CH; o uno o dos de X, Y y Z representan N; y los otros de X, Y y Z representan CH, y R1, R2, R3, R4 y R5, independientemente entre sí, representan hidrógeno, halo, trifluorometilo, trifluorometoxi, ciano, hidroxilo, alcoxi, alquilo, amino o sulfamoilo; o R1 y R2, junto con el anillo fenilo al cual están unidos forman un anillo indolilo o un anillo benzo-dioxolilo; y R3, R4 y R5 son como se definen anteriormente; y R6 representa amino o nitro, los cuales se encuentran por ser moduladores de los receptores de acetilcolina nicotínicos. Debido a su perfil farmacológico, los compuestos de la invención pueden ser útiles para el tratamiento de enfermedades o trastornos tan diversos como aquellos relacionados al sistema colinérgico del sistema nervioso central (SNC), el sistema nervioso periférico (SNP), enfermedades o trastornos relacionados a contracción del músculo liso, enfermedades y trastornos endócrinos, enfermedades o trastornos relacionados a neuro-degeneración, enfermedades o trastornos relacionados a inflamación, dolor y síntomas de abstinencia causados por la terminación del abuso de sustancias químicas.
MX2010009755A 2008-03-11 2009-03-09 Nuevos derivados de triarilo utiles como moduladores de receptores de acetilcolina nicotinicos. MX2010009755A (es)

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DKPA200800371 2008-03-11
US3591508P 2008-03-12 2008-03-12
PCT/EP2009/052733 WO2009112461A1 (en) 2008-03-11 2009-03-09 Novel triaryl derivatives useful as modulators of nicotinic acetylcholine receptors

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US (1) US20110105543A1 (es)
EP (1) EP2262767A1 (es)
JP (1) JP2011513460A (es)
KR (1) KR20100125304A (es)
CN (1) CN101970406A (es)
AU (1) AU2009224738A1 (es)
BR (1) BRPI0908837A2 (es)
CA (1) CA2718241A1 (es)
IL (1) IL207488A0 (es)
MX (1) MX2010009755A (es)
RU (1) RU2010135035A (es)
WO (1) WO2009112461A1 (es)
ZA (1) ZA201005691B (es)

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KR20100125304A (ko) 2010-11-30
JP2011513460A (ja) 2011-04-28
CA2718241A1 (en) 2009-09-17
IL207488A0 (en) 2010-12-30
EP2262767A1 (en) 2010-12-22
AU2009224738A1 (en) 2009-09-17
RU2010135035A (ru) 2012-04-20
CN101970406A (zh) 2011-02-09

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