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CL2019003892A1 - Nuevos derivados de azaquinolina. - Google Patents

Nuevos derivados de azaquinolina.

Info

Publication number
CL2019003892A1
CL2019003892A1 CL2019003892A CL2019003892A CL2019003892A1 CL 2019003892 A1 CL2019003892 A1 CL 2019003892A1 CL 2019003892 A CL2019003892 A CL 2019003892A CL 2019003892 A CL2019003892 A CL 2019003892A CL 2019003892 A1 CL2019003892 A1 CL 2019003892A1
Authority
CL
Chile
Prior art keywords
compounds
preparation
new
azaquinoline
pharmaceutical compositions
Prior art date
Application number
CL2019003892A
Other languages
English (en)
Inventor
Nils Griebenow
Wei Zhuang
Adeline Köhler
Daniel Kulke
Claudia Böhm
Kirsten Börngen
Thomas Ilg
Hans-Georg Schwarz
Werner Hallenbach
Ulrich Görgens
Walter Hübsch
Bernd Alig
Iring Heisler
Isa Jana Irina Janssen
Original Assignee
Bayer Animal Health Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Animal Health Gmbh filed Critical Bayer Animal Health Gmbh
Publication of CL2019003892A1 publication Critical patent/CL2019003892A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LA PRESENTE INVENCIÓN ABARCA COMPUESTOS DE AZAQUINOLINA DE LA FÓRMULA GENERAL (I): EN LA CUAL T, R1, R2, R3, R4, R5, R6, Y Q SON COMO SE DEFINEN EN EL PRESENTE, PROCEDIMIENTOS PARA LA PREPARACIÓN DE DICHOS COMPUESTOS, COMPUESTOS INTERMEDIOS ÚTILES PARA LA PREPARACIÓN DE DICHOS COMPUESTOS, COMPOSICIONES FARMACÉUTICAS Y COMBINACIONES QUE COMPRENDEN DICHOS COMPUESTOS Y EL USO DE DICHOS COMPUESTOS PARA LA ELABORACIÓN DE COMPOSICIONES FARMACÉUTICAS PARA EL TRATAMIENTO, CONTROL Y/O PREVENCIÓN DE ENFERMEDADES, EN ESPECIAL DE INFECCIONES CON HELMINTOS, COMO UN ÚNICO AGENTE O EN COMBINACIÓN CON OTROS INGREDIENTES ACTIVOS.
CL2019003892A 2017-06-30 2019-12-30 Nuevos derivados de azaquinolina. CL2019003892A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP17179149 2017-06-30

Publications (1)

Publication Number Publication Date
CL2019003892A1 true CL2019003892A1 (es) 2020-07-10

Family

ID=59269946

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2019003892A CL2019003892A1 (es) 2017-06-30 2019-12-30 Nuevos derivados de azaquinolina.

Country Status (22)

Country Link
US (1) US11485733B2 (es)
EP (1) EP3615527B1 (es)
JP (1) JP7210483B2 (es)
KR (1) KR20200020911A (es)
CN (1) CN110770227B (es)
AR (1) AR112216A1 (es)
AU (1) AU2018293627B2 (es)
CA (1) CA3068350A1 (es)
CL (1) CL2019003892A1 (es)
CO (1) CO2019014484A2 (es)
CR (1) CR20190595A (es)
DK (1) DK3615527T3 (es)
ES (1) ES2984497T3 (es)
IL (1) IL271607B2 (es)
MX (1) MX2019015895A (es)
PE (1) PE20200608A1 (es)
PH (1) PH12019502851A1 (es)
PL (1) PL3615527T3 (es)
TW (1) TWI799429B (es)
UA (1) UA125800C2 (es)
UY (1) UY37789A (es)
WO (1) WO2019002132A1 (es)

Cited By (1)

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US12312356B2 (en) 2020-05-29 2025-05-27 Boehringer Ingelheim Vetmedica Gmbh Anthelmintic heterocyclic compounds

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WO2020131631A1 (en) 2018-12-18 2020-06-25 Elanco Tiergesundheit Ag Bicyclic derivatives
US11560388B2 (en) * 2019-03-19 2023-01-24 Boehringer Ingelheim Vetmedica Gmbh Anthelmintic aza-benzothiophene and aza-benzofuran compounds
US12448391B2 (en) 2019-06-07 2025-10-21 Elanco Tiergesundheit Ag Bicyclic derivatives for treating endoparasites
TWI865563B (zh) * 2019-07-30 2024-12-11 德商拜耳動物保健有限公司 新穎異喹啉衍生物
JP7644121B2 (ja) * 2019-12-18 2025-03-11 インターベット インターナショナル ベー． フェー． アザインドール構造を含む駆虫剤化合物
WO2021204930A1 (en) 2020-04-09 2021-10-14 Bayer Animal Health Gmbh Substituted condensed azines as anthelmintic compounds
CN116685584A (zh) * 2020-11-18 2023-09-01 礼蓝动物保健有限公司 用于治疗心丝虫感染的n-(2,3-二氢-1,4-苯并噁嗪-4-基)-3-异丙基-7-(2,3,5-三氟苯基)苯并噻吩-2-甲酰胺衍生物和类似化合物
WO2022106469A2 (en) 2020-11-18 2022-05-27 Elanco Tiergesundheit Ag N-(2,3-dihydro-1,4-benzoxazin-4-yl)-3-isopropyl-7-(2,3,5-trifluorophenyl)benzo-thiophene-2-carboxamide derivatives and similar compounds for the treatment of heartworm infections
CN116888124A (zh) * 2020-12-04 2023-10-13 礼蓝动物保健有限公司 二环衍生物
TW202237600A (zh) 2020-12-04 2022-10-01 瑞士商禮藍動物保健股份有限公司 雙環衍生物
EP4148052A1 (en) * 2021-09-09 2023-03-15 Bayer Animal Health GmbH New quinoline derivatives
PE20250675A1 (es) 2021-11-01 2025-03-04 Boehringer Ingelheim Vetmedica Gmbh Compuestos de pirrolopiridazina como antihelminticos
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Cited By (1)

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US12312356B2 (en) 2020-05-29 2025-05-27 Boehringer Ingelheim Vetmedica Gmbh Anthelmintic heterocyclic compounds

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RU2020103733A3 (es) 2021-10-22
TW201904961A (zh) 2019-02-01
IL271607B1 (en) 2023-03-01
CO2019014484A2 (es) 2020-01-17
UA125800C2 (uk) 2022-06-08
EP3615527A1 (en) 2020-03-04
EP3615527B1 (en) 2024-03-06
UY37789A (es) 2019-01-31
TWI799429B (zh) 2023-04-21
RU2020103733A (ru) 2021-07-30
PH12019502851A1 (en) 2020-10-19
CN110770227B (zh) 2024-03-01
AU2018293627A1 (en) 2019-12-12
AR112216A1 (es) 2019-10-02
PE20200608A1 (es) 2020-03-10
DK3615527T3 (da) 2024-05-06
ES2984497T3 (es) 2024-10-29
KR20200020911A (ko) 2020-02-26
CR20190595A (es) 2020-03-03
IL271607A (en) 2020-02-27
JP7210483B2 (ja) 2023-01-23
MX2019015895A (es) 2020-02-07
JP2020525444A (ja) 2020-08-27
PL3615527T3 (pl) 2024-07-01
US20200131175A1 (en) 2020-04-30
CA3068350A1 (en) 2019-01-03
BR112019028181A2 (pt) 2020-07-07
IL271607B2 (en) 2023-07-01
WO2019002132A1 (en) 2019-01-03
NZ759633A (en) 2024-05-31
US11485733B2 (en) 2022-11-01
AU2018293627B2 (en) 2022-07-21
CN110770227A (zh) 2020-02-07

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