TWI360549B - Novel pyridazine compound and use thereof - Google Patents

Novel pyridazine compound and use thereof Download PDF

Info

Publication number: TWI360549B
Authority: TW; Taiwan
Prior art keywords: compound; acid; hcv; formula; fatty acid
Prior art date: 2006-07-07

Application number

TW096124777A

Other languages

English (en)

Chinese (zh)

Other versions

TW200811180A (en

Inventor

Steven S Bondy

Terrence C Dahl

David A Oare

Reza Oliyai

Winston C Tse

Vahid Zia

Original Assignee

Gilead Sciences Inc

Leuven K U Res & Dev

Puerstinger Gerhard

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-07-07

Filing date

2007-07-06

Publication date

2012-03-21

2007-07-06 Application filed by Gilead Sciences Inc, Leuven K U Res & Dev, Puerstinger Gerhard filed Critical Gilead Sciences Inc

2008-03-01 Publication of TW200811180A publication Critical patent/TW200811180A/zh

2012-03-21 Application granted granted Critical

2012-03-21 Publication of TWI360549B publication Critical patent/TWI360549B/zh

Links

-1 pyridazine compound Chemical class 0.000 title description 26
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238000000034 method Methods 0.000 claims description 21
239000002904 solvent Substances 0.000 claims description 20
235000014113 dietary fatty acids Nutrition 0.000 claims description 19
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WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims description 17
LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims description 17
QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims description 17
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ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims description 17
QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims description 17
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210000002845 virion Anatomy 0.000 description 1
229930003231 vitamin Natural products 0.000 description 1
239000011782 vitamin Substances 0.000 description 1
235000013343 vitamin Nutrition 0.000 description 1
229940088594 vitamin Drugs 0.000 description 1
235000019165 vitamin E Nutrition 0.000 description 1
229940046009 vitamin E Drugs 0.000 description 1
239000011709 vitamin E Substances 0.000 description 1
239000008215 water for injection Substances 0.000 description 1
239000001993 wax Substances 0.000 description 1
238000005303 weighing Methods 0.000 description 1
238000009736 wetting Methods 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1
229910052727 yttrium Inorganic materials 0.000 description 1
VWQVUPCCIRVNHF-UHFFFAOYSA-N yttrium atom Chemical compound [Y] VWQVUPCCIRVNHF-UHFFFAOYSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Communicable Diseases (AREA)
Virology (AREA)
Oncology (AREA)
Gastroenterology & Hepatology (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

TW096124777A 2006-07-07 2007-07-06 Novel pyridazine compound and use thereof TWI360549B (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date
US81928906P	2006-07-07	2006-07-07
US83240306P	2006-07-21	2006-07-21
US83276906P	2006-07-24	2006-07-24

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TW200811180A TW200811180A (en)	2008-03-01
TWI360549B true TWI360549B (en)	2012-03-21

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US (3)	US8569487B2 (es)
EP (1)	EP2038275B1 (es)
JP (1)	JP4958974B2 (es)
KR (1)	KR101143596B1 (es)
CN (1)	CN102617571B (es)
AP (1)	AP3430A (es)
AR (1)	AR061969A1 (es)
AT (1)	ATE454384T1 (es)
AU (1)	AU2007269614B2 (es)
CA (1)	CA2656415C (es)
CY (1)	CY1112107T1 (es)
DE (1)	DE602007004220D1 (es)
DK (1)	DK2038275T3 (es)
EA (1)	EA019452B1 (es)
ES (1)	ES2339298T3 (es)
HR (2)	HRP20100180T1 (es)
IL (1)	IL195528A (es)
MX (1)	MX2009000235A (es)
NO (1)	NO20090595L (es)
NZ (1)	NZ574312A (es)
PL (1)	PL2038275T3 (es)
PT (1)	PT2038275E (es)
RS (1)	RS51336B (es)
SG (1)	SG175604A1 (es)
SI (1)	SI2038275T1 (es)
TW (1)	TWI360549B (es)
WO (1)	WO2008005519A2 (es)

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CN101018843B (zh)	2004-09-13	2011-05-11	西巴特殊化学品控股有限公司	烷基氨基乙酰胺润滑添加剂
PT1841765E (pt) *	2004-12-21	2009-05-14	Gilead Sciences Inc	Anticorpos para mcp-1 humano
WO2007063744A1 (ja) *	2005-11-30	2007-06-07	Fujifilm Corporation	平版刷版の後露光方法、後露光装置、露光装置、露光用器具、現像方法、及び現像装置
CN101004515A (zh) *	2006-01-21	2007-07-25	鸿富锦精密工业（深圳）有限公司	直下式背光模组
CA2656415C (en)	2006-07-07	2012-05-22	Gilead Sciences, Inc.	Novel pyridazine compound and use thereof
UA99466C2 (en) *	2007-07-06	2012-08-27	Гилиад Сайенсиз, Инк.	Crystalline pyridazine compound
GB0718575D0 (en) *	2007-09-24	2007-10-31	Angeletti P Ist Richerche Bio	Nucleoside derivatives as inhibitors of viral polymerases

2007
- 2007-07-06 CA CA2656415A patent/CA2656415C/en not_active Expired - Fee Related
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- 2007-07-06 TW TW096124777A patent/TWI360549B/zh not_active IP Right Cessation
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- 2007-07-06 HR HR20100180T patent/HRP20100180T1/hr unknown
- 2007-07-06 SI SI200730208T patent/SI2038275T1/sl unknown
- 2007-07-06 AR ARP070103028A patent/AR061969A1/es unknown
- 2007-07-06 DK DK07796714.9T patent/DK2038275T3/da active
- 2007-07-06 RS RSP-2010/0150A patent/RS51336B/sr unknown
- 2007-07-06 KR KR1020097002417A patent/KR101143596B1/ko not_active Expired - Fee Related
- 2007-07-06 SG SG2011073590A patent/SG175604A1/en unknown
- 2007-07-06 WO PCT/US2007/015553 patent/WO2008005519A2/en not_active Ceased
- 2007-07-06 US US12/303,207 patent/US8569487B2/en not_active Expired - Fee Related
- 2007-07-06 AT AT07796714T patent/ATE454384T1/de active
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- 2007-07-06 CN CN201210099711.XA patent/CN102617571B/zh not_active Expired - Fee Related
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- 2008-11-26 IL IL195528A patent/IL195528A/en not_active IP Right Cessation
2009
- 2009-02-06 NO NO20090595A patent/NO20090595L/no not_active Application Discontinuation
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TWI447116B (zh) *	2007-07-06	2014-08-01	Gilead Sciences Inc	結晶性嗒化合物

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Publication number	Publication date
AU2007269614B2 (en)	2011-09-08
EP2038275A2 (en)	2009-03-25
US7956184B2 (en)	2011-06-07
US7754720B2 (en)	2010-07-13
JP2009542692A (ja)	2009-12-03
IL195528A0 (en)	2009-09-01
AR061969A1 (es)	2008-08-10
CA2656415C (en)	2012-05-22
EA200900156A1 (ru)	2009-06-30
WO2008005519A2 (en)	2008-01-10
DE602007004220D1 (de)	2010-02-25
EP2038275B1 (en)	2010-01-06
KR20090028813A (ko)	2009-03-19
SG175604A1 (en)	2011-11-28
NO20090595L (no)	2009-04-07
ES2339298T3 (es)	2010-05-18
RS51336B (sr)	2011-02-28
SI2038275T1 (sl)	2010-06-30
MX2009000235A (es)	2009-01-23
AU2007269614A1 (en)	2008-01-10
CN102617571A (zh)	2012-08-01
US8569487B2 (en)	2013-10-29
AP2008004717A0 (en)	2008-12-31
AP3430A (en)	2015-09-30
EA019452B1 (ru)	2014-03-31
HK1123803A1 (en)	2009-06-26
KR101143596B1 (ko)	2012-05-11
US20080199427A1 (en)	2008-08-21
ATE454384T1 (de)	2010-01-15
HRP20090078A2 (en)	2009-06-30
WO2008005519A3 (en)	2008-04-24
CY1112107T1 (el)	2015-11-04
PT2038275E (pt)	2010-04-08
US20100063059A1 (en)	2010-03-11
CA2656415A1 (en)	2008-01-10
IL195528A (en)	2014-07-31
NZ574312A (en)	2012-02-24
TW200811180A (en)	2008-03-01
US20100152444A1 (en)	2010-06-17
JP4958974B2 (ja)	2012-06-20
CN102617571B (zh)	2015-06-10
PL2038275T3 (pl)	2010-08-31
HRP20100180T1 (hr)	2010-06-30
DK2038275T3 (da)	2010-05-10

Publication	Publication Date	Title
TWI360549B (en)	2012-03-21	Novel pyridazine compound and use thereof
CN101778847B (zh)	2013-07-24	结晶哒嗪化合物
CN101484444B (zh)	2012-11-21	哒嗪化合物及其用途
AU2011253901B2 (en)	2013-08-29	Novel pyridazine compound and use thereof
HK1123803B (en)	2010-05-28	Novel pyridazine compound and use thereof

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2016-12-21	MM4A	Annulment or lapse of patent due to non-payment of fees

TWI360549B - Novel pyridazine compound and use thereof - Google Patents

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