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EA200900156A1 - Пиридазиновое соединение (варианты), способ его получения (варианты), способ лечения или профилактики инфекционного вирусного гепатита с с его помощью, композиция и лекарственное средство на его основе - Google Patents

Пиридазиновое соединение (варианты), способ его получения (варианты), способ лечения или профилактики инфекционного вирусного гепатита с с его помощью, композиция и лекарственное средство на его основе

Info

Publication number
EA200900156A1
EA200900156A1 EA200900156A EA200900156A EA200900156A1 EA 200900156 A1 EA200900156 A1 EA 200900156A1 EA 200900156 A EA200900156 A EA 200900156A EA 200900156 A EA200900156 A EA 200900156A EA 200900156 A1 EA200900156 A1 EA 200900156A1
Authority
EA
Eurasian Patent Office
Prior art keywords
variants
preparation
treatment
hepatitis
prevention
Prior art date
Application number
EA200900156A
Other languages
English (en)
Other versions
EA019452B1 (ru
Inventor
Стивн С. Бонди
Теренс К. Дал
Дэвид А. О
Ризэ Ольяй
Уинстон К. Тсе
Вахид Зиа
Original Assignee
Джилид Сайэнс, Инк.
К.Ю. Левен Рисеч Энд Дивелопмент
Пуэрштингер, Герхард
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Джилид Сайэнс, Инк., К.Ю. Левен Рисеч Энд Дивелопмент, Пуэрштингер, Герхард filed Critical Джилид Сайэнс, Инк.
Publication of EA200900156A1 publication Critical patent/EA200900156A1/ru
Publication of EA019452B1 publication Critical patent/EA019452B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Предложено пиридазиновое соединение формулы (1), его соли и сольваты, лечение или профилактика инфекционного вирусного гепатита С с его помощью, а также способы его получения.
EA200900156A 2006-07-07 2007-07-06 5-({6-[2,4-БИС-(ТРИФТОРМЕТИЛ)ФЕНИЛ]ПИРИДАЗИН-3-ИЛ}МЕТИЛ)-2-(2-ФТОРФЕНИЛ)-5Н-ИМИДАЗО[4,5-c]ПИРИДИН, СПОСОБ ЕГО ПОЛУЧЕНИЯ, СПОСОБ ЛЕЧЕНИЯ ИЛИ ПРОФИЛАКТИКИ ИНФЕКЦИОННОГО ВИРУСНОГО ГЕПАТИТА С С ЕГО ПОМОЩЬЮ, КОМПОЗИЦИЯ И ЛЕКАРСТВЕННОЕ СРЕДСТВО НА ЕГО ОСНОВЕ EA019452B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US81928906P 2006-07-07 2006-07-07
US83240306P 2006-07-21 2006-07-21
US83276906P 2006-07-24 2006-07-24
PCT/US2007/015553 WO2008005519A2 (en) 2006-07-07 2007-07-06 Novel pyridazine compound and use thereof

Publications (2)

Publication Number Publication Date
EA200900156A1 true EA200900156A1 (ru) 2009-06-30
EA019452B1 EA019452B1 (ru) 2014-03-31

Family

ID=38814329

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200900156A EA019452B1 (ru) 2006-07-07 2007-07-06 5-({6-[2,4-БИС-(ТРИФТОРМЕТИЛ)ФЕНИЛ]ПИРИДАЗИН-3-ИЛ}МЕТИЛ)-2-(2-ФТОРФЕНИЛ)-5Н-ИМИДАЗО[4,5-c]ПИРИДИН, СПОСОБ ЕГО ПОЛУЧЕНИЯ, СПОСОБ ЛЕЧЕНИЯ ИЛИ ПРОФИЛАКТИКИ ИНФЕКЦИОННОГО ВИРУСНОГО ГЕПАТИТА С С ЕГО ПОМОЩЬЮ, КОМПОЗИЦИЯ И ЛЕКАРСТВЕННОЕ СРЕДСТВО НА ЕГО ОСНОВЕ

Country Status (27)

Country Link
US (3) US7754720B2 (ru)
EP (1) EP2038275B1 (ru)
JP (1) JP4958974B2 (ru)
KR (1) KR101143596B1 (ru)
CN (1) CN102617571B (ru)
AP (1) AP3430A (ru)
AR (1) AR061969A1 (ru)
AT (1) ATE454384T1 (ru)
AU (1) AU2007269614B2 (ru)
CA (1) CA2656415C (ru)
CY (1) CY1112107T1 (ru)
DE (1) DE602007004220D1 (ru)
DK (1) DK2038275T3 (ru)
EA (1) EA019452B1 (ru)
ES (1) ES2339298T3 (ru)
HR (2) HRP20090078A2 (ru)
IL (1) IL195528A (ru)
MX (1) MX2009000235A (ru)
NO (1) NO20090595L (ru)
NZ (1) NZ574312A (ru)
PL (1) PL2038275T3 (ru)
PT (1) PT2038275E (ru)
RS (1) RS51336B (ru)
SG (1) SG175604A1 (ru)
SI (1) SI2038275T1 (ru)
TW (1) TWI360549B (ru)
WO (1) WO2008005519A2 (ru)

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BR112012014729A2 (pt) 2009-12-18 2016-03-29 Boehringer Ingelheim Int terapia combinada contra hcv
NZ603310A (en) 2010-05-21 2015-01-30 Gilead Sciences Inc Heterocyclic flaviviridae virus inhibitors
TW201211047A (en) * 2010-06-10 2012-03-16 Gilead Sciences Inc Methods for treating HCV
JP5891241B2 (ja) * 2010-12-20 2016-03-22 ギリアード サイエンシーズ， インコーポレイテッド Ｈｃｖを処置するための組合せ
CA2833500C (en) 2011-04-28 2019-01-08 Oncopeptides Ab Lyophilized preparation of cytotoxic dipeptides
JP6073897B2 (ja) 2011-09-16 2017-02-01 ギリアド ファーマセット エルエルシー Ｈｃｖを処置するための方法
MX365205B (es) * 2012-10-26 2019-05-27 Oncopeptides Ab Preparaciones liofilizadas de melfalán flufenamida.
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CN107427529A (zh) 2014-12-26 2017-12-01 埃莫里大学 N4‑羟基胞苷和衍生物及与其相关的抗病毒用途
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AP3430A (en) 2015-09-30
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ATE454384T1 (de) 2010-01-15
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HK1123803A1 (en) 2009-06-26
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CN102617571A (zh) 2012-08-01
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AU2007269614A1 (en) 2008-01-10
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