[go: up one dir, main page]

TW200716631A - Pyrido[2,3-d]pyrimidines useful as HCV inhibitors, and methods for the preparation thereof - Google Patents

Pyrido[2,3-d]pyrimidines useful as HCV inhibitors, and methods for the preparation thereof

Info

Publication number
TW200716631A
TW200716631A TW095116638A TW95116638A TW200716631A TW 200716631 A TW200716631 A TW 200716631A TW 095116638 A TW095116638 A TW 095116638A TW 95116638 A TW95116638 A TW 95116638A TW 200716631 A TW200716631 A TW 200716631A
Authority
TW
Taiwan
Prior art keywords
pyrido
preparation
methods
pyrimidines
hcv inhibitors
Prior art date
Application number
TW095116638A
Other languages
English (en)
Inventor
Kenneth Alan Simmen
Oliver Lenz
Dominique Louis Nestor Ghislain Surleraux
Pierre Jean-Marie Bernard Raboisson
Tse-I Lin
Original Assignee
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd
Publication of TW200716631A publication Critical patent/TW200716631A/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
TW095116638A 2005-05-12 2006-05-11 Pyrido[2,3-d]pyrimidines useful as HCV inhibitors, and methods for the preparation thereof TW200716631A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US68040505P 2005-05-12 2005-05-12
EP05106214 2005-07-07
EP06075855 2006-04-06

Publications (1)

Publication Number Publication Date
TW200716631A true TW200716631A (en) 2007-05-01

Family

ID=37198763

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095116638A TW200716631A (en) 2005-05-12 2006-05-11 Pyrido[2,3-d]pyrimidines useful as HCV inhibitors, and methods for the preparation thereof

Country Status (20)

Country Link
US (1) US8022077B2 (zh)
EP (1) EP1888580B1 (zh)
JP (1) JP5464686B2 (zh)
KR (1) KR20080007268A (zh)
CN (1) CN101203515B (zh)
AR (1) AR054122A1 (zh)
AT (1) ATE459623T1 (zh)
AU (1) AU2006245676B2 (zh)
BR (1) BRPI0609098A2 (zh)
CA (1) CA2608301C (zh)
DE (1) DE602006012666D1 (zh)
DK (1) DK1888580T3 (zh)
ES (1) ES2341572T3 (zh)
IL (1) IL186881A (zh)
MX (1) MX2007014082A (zh)
RU (1) RU2444522C2 (zh)
SI (1) SI1888580T1 (zh)
TW (1) TW200716631A (zh)
WO (1) WO2006120252A2 (zh)
ZA (1) ZA200709689B (zh)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5046942B2 (ja) * 2004-09-30 2012-10-10 テイボテク・フアーマシユーチカルズ Ｈｃｖ阻害性の二環式ピリミジン類
EP1869037B1 (en) * 2005-03-25 2011-07-27 Tibotec Pharmaceuticals Heterobicylic inhibitors of hvc
AR056347A1 (es) 2005-05-12 2007-10-03 Tibotec Pharm Ltd Uso de compuestos de pteridina para fabricar medicamentos y composiciones farmaceuticas
WO2007081517A2 (en) * 2005-12-21 2007-07-19 Abbott Laboratories Anti-viral compounds
CN101384592A (zh) * 2005-12-21 2009-03-11 艾博特公司 抗病毒化合物
ATE475660T1 (de) 2005-12-21 2010-08-15 Abbott Lab Antivirale verbindungen
US7910595B2 (en) * 2005-12-21 2011-03-22 Abbott Laboratories Anti-viral compounds
EP2094276A4 (en) 2006-12-20 2011-01-05 Abbott Lab ANTIVIRAL COMPOUNDS
US7964580B2 (en) 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
US8716263B2 (en) 2008-12-23 2014-05-06 Gilead Pharmasset Llc Synthesis of purine nucleosides
EA201100851A1 (ru) 2008-12-23 2012-04-30 Фармассет, Инк. Аналоги нуклеозидов
EA019341B1 (ru) 2008-12-23 2014-02-28 Джилид Фармассет, Ллс. Фосфорамидаты нуклеозидов
US8618076B2 (en) 2009-05-20 2013-12-31 Gilead Pharmasset Llc Nucleoside phosphoramidates
TWI576352B (zh) 2009-05-20 2017-04-01 基利法瑪席特有限責任公司 核苷磷醯胺
MX2012010478A (es) * 2010-03-10 2013-02-01 Abbott Lab Composiciones solidas.
US8563530B2 (en) 2010-03-31 2013-10-22 Gilead Pharmassel LLC Purine nucleoside phosphoramidate
UY33312A (es) 2010-03-31 2011-10-31 Pharmasset Inc Fosforamidato de nucleosido de purina
MX2012011171A (es) 2010-03-31 2013-02-01 Gilead Pharmasset Llc Fosforamidatos de nucleosido.
JP6069215B2 (ja) 2010-11-30 2017-02-01 ギリアド ファーマセット エルエルシー 化合物
CN103608335B (zh) 2011-04-08 2018-02-23 爱尔兰詹森科学公司 用于治疗病毒感染的嘧啶衍生物
BR122019020718B1 (pt) 2011-11-09 2021-07-06 Janssen Sciences Ireland Uc Derivados purínicos para o tratamento de infecções virais e composição farmacêutica que os compreende
US8889159B2 (en) 2011-11-29 2014-11-18 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
MX360718B (es) 2012-07-13 2018-11-13 Janssen Sciences Ireland Uc Purinas macrocíclicas para el tratamiento de infecciones víricas.
TR201807076T4 (tr) 2012-10-10 2018-06-21 Janssen Sciences Ireland Uc Viral enfeksiyonların ve diğer hastalıkların tedavisine yönelik pirolo[3,2-d]pirimidin derivatları.
SG11201503042QA (en) 2012-11-16 2015-06-29 Janssen Sciences Ireland Uc Heterocyclic substituted 2-amino-quinazoline derivatives for the treatment of viral infections
EA035174B1 (ru) 2013-02-21 2020-05-12 Янссен Сайенсиз Айрлэнд Юси Производные 2-аминопиримидина в качестве модуляторов толл-подобных рецепторов tlr7 и/или tlr8
HRP20170654T1 (hr) 2013-03-29 2017-06-30 Janssen Sciences Ireland Uc Makrociklički deaza-purinoni za liječenje virusnih infekcija
DK3004074T3 (da) * 2013-05-24 2018-01-29 Janssen Sciences Ireland Uc Pyridonderivater til behandling af virusinfektioner og yderligere sygdomme
HRP20171720T1 (hr) 2013-06-27 2017-12-29 Janssen Sciences Ireland Uc Derivati pirolo [3,2-d] pirimidina za liječenje virusnih infekcija i drugih bolesti
EP3027624B1 (en) 2013-07-30 2018-09-12 Janssen Sciences Ireland UC Thieno[3,2-d]pyrimidines derivatives for the treatment of viral infections
EP3038601B1 (en) 2013-08-27 2020-04-08 Gilead Pharmasset LLC Combination formulation of two antiviral compounds
HUE050761T2 (hu) 2014-01-01 2021-01-28 Medivation Tech Llc Vegyületek és alkalmazási eljárások
EP2905024A1 (en) 2014-02-07 2015-08-12 Institut Quimic De Sarriá Cets, Fundació Privada Pyrido[2,3-d]pyrimidine-7(8H)-one derivatives for the treatment of infections caused by Flaviviridae
US11053256B2 (en) 2016-07-01 2021-07-06 Janssen Sciences Ireland Unlimited Company Dihydropyranopyrimidines for the treatment of viral infections
MA46340A (fr) 2016-09-29 2019-08-07 Janssen Sciences Ireland Unlimited Co Promédicaments de pyrimidine pour le traitement d'infections virales et d'autres maladies
TW202415645A (zh) 2018-03-01 2024-04-16 愛爾蘭商健生科學愛爾蘭無限公司 ２，４－二胺基喹唑啉衍生物及其醫學用途
WO2024243025A1 (en) * 2023-05-19 2024-11-28 Ikena Oncology, Inc. Naphthyl-substituted pyrido[4,3-d]pyrimidines and related compounds and their use in treating medical conditions

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE789496A (zh) * 1971-10-05 1973-03-29 S M B Anciens Ets J Muelberger
IL112249A (en) 1994-01-25 2001-11-25 Warner Lambert Co Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds
US6184226B1 (en) * 1998-08-28 2001-02-06 Scios Inc. Quinazoline derivatives as inhibitors of P-38 α
AU2003202263A1 (en) 2002-01-10 2003-07-30 Bayer Healthcare Ag Roh-kinase inhibitors
JP2003321472A (ja) 2002-02-26 2003-11-11 Takeda Chem Ind Ltd Ｇｒｋ阻害剤
EP1511738A4 (en) * 2002-05-17 2007-05-09 Scios Inc TREATMENT OF FIBROPROLIFERATIVE DISEASES USING TGF BETA INHIBITORS
AU2003260072A1 (en) 2002-08-27 2004-03-19 Bristol-Myers Squibb Company Antagonists of chemokine receptors
US7148226B2 (en) * 2003-02-21 2006-12-12 Agouron Pharmaceuticals, Inc. Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same
US7232824B2 (en) 2003-09-30 2007-06-19 Scios, Inc. Quinazoline derivatives as medicaments
CN101189234B (zh) * 2005-03-25 2011-08-17 泰博特克药品有限公司 Hcv的杂二环抑制剂
EP1869037B1 (en) * 2005-03-25 2011-07-27 Tibotec Pharmaceuticals Heterobicylic inhibitors of hvc

Also Published As

Publication number Publication date
RU2007146173A (ru) 2009-06-20
CN101203515A (zh) 2008-06-18
CN101203515B (zh) 2014-02-26
DE602006012666D1 (de) 2010-04-15
KR20080007268A (ko) 2008-01-17
IL186881A0 (en) 2008-02-09
ZA200709689B (en) 2009-07-29
JP5464686B2 (ja) 2014-04-09
AU2006245676A1 (en) 2006-11-16
IL186881A (en) 2015-06-30
EP1888580A2 (en) 2008-02-20
JP2008540494A (ja) 2008-11-20
CA2608301A1 (en) 2006-11-16
ES2341572T3 (es) 2010-06-22
CA2608301C (en) 2014-04-22
DK1888580T3 (da) 2010-06-14
BRPI0609098A2 (pt) 2010-02-17
WO2006120252A2 (en) 2006-11-16
US8022077B2 (en) 2011-09-20
AU2006245676B2 (en) 2012-08-02
EP1888580B1 (en) 2010-03-03
US20090131460A1 (en) 2009-05-21
ATE459623T1 (de) 2010-03-15
MX2007014082A (es) 2008-04-17
WO2006120252A3 (en) 2007-02-22
SI1888580T1 (sl) 2010-06-30
RU2444522C2 (ru) 2012-03-10
AR054122A1 (es) 2007-06-06

Similar Documents

Publication Publication Date Title
TW200716631A (en) Pyrido[2,3-d]pyrimidines useful as HCV inhibitors, and methods for the preparation thereof
TW200626157A (en) HCV inhibiting bi-cyclic pyrimidines
EP2431379A3 (en) HCV inhibitors
IL184898A0 (en) Pyrrolopyrimidine derivatives and pharmaceutical compositions containing the same
NO20081628L (no) Benzodiazepiner som HCV-inhibitorer
SG170828A1 (en) Deazapurines useful as inhibitors of janus kinases
SG151327A1 (en) Deazapurines useful as inhibitors of janus kinases
UA95940C2 (uk) Азаіндоли як інгібітори кіназ януса
MX2009006700A (es) Derivados de 5-ciano-4-(pirolo)[2,3b]piridina-3-il)-pirimidinas utiles como inhibidores de proteina-cinasas.
TW200604168A (en) Azaindoles useful as inhibitors of rock and other protein kinases
MY143795A (en) Tetrahydropyridoindole derivatives
CL2007002261A1 (es) Compuestos derivados de imidazo[1,2-b]piridazina, inhibidores de quinasa; composicion farmaceutica; y uso en el tratamiento o prevencion del cancer.
TW200633980A (en) Pyridones useful as inhibitors of kinases
MXPA06011327A (es) Azaindoles utiles como inhibidores de jak y otras proteinas cinasas.
TW200745128A (en) Pyrazolopyrimidines as protein kinase inhibitors
WO2007095223A3 (en) Pyrrolo(3,2-c) pyridines useful as inhibitors of protein kinases
MX2009004771A (es) Compuestos heteroaril triciclicos utiles como inhibidores de janus cinasa.
IL182893A0 (en) PYRAZOLO-[1,5-a] PYRIMIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
CL2008001122A1 (es) Compuestos derivados de imidazo[1,2,3-ij]-1,8-naftiridin-4,9-diona; compuestos intermediarios; composicion farmaceutica; y uso en el tratamiento de infecciones bacterianas.
WO2008040778A3 (en) Carboxamide 4-[(4-pyridyl)amino] pyrimidines for the treatment of hepatitis c
MX2009010127A (es) Compuestos utiles como inhibidores de janus cinasas.
TW200745127A (en) Pyrazolopyrimidines as protein kinase inhibitors
CL2008003659A1 (es) Compuestos derivados de 6-(4-bencilpiperazin-1-il)pirimidin-4-ona, moduladores de la enzima estearoil-coa-desaturasa 1; procedimiento de preparacion; composicin farmaceutica; y uso en el tratamiento y profilaxis de la obesidad.
MX2007011903A (es) Alquinil pirrolopirimidinas y analogos relacionados como inhibidores de hsp90.
WO2006116148A3 (en) (7-arlysubstituted 2, 3-dihydr0-1-benz0furan-2-yl) alkylamines in the treatment' of substance abuse