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MX2007014082A - Pirido[2,3-d]pirimidinas utiles como inhibidores del virus de la hepatitis c (hcv), y metodos para la preparacion de las mismas. - Google Patents

Pirido[2,3-d]pirimidinas utiles como inhibidores del virus de la hepatitis c (hcv), y metodos para la preparacion de las mismas.

Info

Publication number
MX2007014082A
MX2007014082A MX2007014082A MX2007014082A MX2007014082A MX 2007014082 A MX2007014082 A MX 2007014082A MX 2007014082 A MX2007014082 A MX 2007014082A MX 2007014082 A MX2007014082 A MX 2007014082A MX 2007014082 A MX2007014082 A MX 2007014082A
Authority
MX
Mexico
Prior art keywords
pyrido
preparation
methods
pyrimidines
hcv
Prior art date
Application number
MX2007014082A
Other languages
English (en)
Inventor
Pierre Jean-Marie Bernard Raboisson
Dominique Louis Nest Surleraux
Kenneth Alan Simmen
Tse-I Lin
Oliver Lenz
Original Assignee
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd
Publication of MX2007014082A publication Critical patent/MX2007014082A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invencion se refiere al uso de pirido[2,3-d]pirimidina s como inhibidores de replicacion de 10 HCV asi como tambien a su empleo en composiciones farmaceuticas destinadas a tratar o combatir infecciones con HCV; ademas, la presente invencion se refiere a los compuestos de prido[2,3-d]pirimidinas en si mismos y a su uso como medicinas; la presente invencion tambien se refiere a procesos para la preparacion de tales compuestos, a composiciones farmaceuticas que los comprenden, y a combinaciones de dichos compuestos 15 con otros agentes anti-HCV.
MX2007014082A 2005-05-12 2006-05-12 Pirido[2,3-d]pirimidinas utiles como inhibidores del virus de la hepatitis c (hcv), y metodos para la preparacion de las mismas. MX2007014082A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US68040505P 2005-05-12 2005-05-12
EP05106214 2005-07-07
EP06075855 2006-04-06
PCT/EP2006/062290 WO2006120252A2 (en) 2005-05-12 2006-05-12 Pyrido[2,3-d]pyrimidines useful as hcv inhibitors, and methods for the preparation thereof

Publications (1)

Publication Number Publication Date
MX2007014082A true MX2007014082A (es) 2008-04-17

Family

ID=37198763

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007014082A MX2007014082A (es) 2005-05-12 2006-05-12 Pirido[2,3-d]pirimidinas utiles como inhibidores del virus de la hepatitis c (hcv), y metodos para la preparacion de las mismas.

Country Status (20)

Country Link
US (1) US8022077B2 (es)
EP (1) EP1888580B1 (es)
JP (1) JP5464686B2 (es)
KR (1) KR20080007268A (es)
CN (1) CN101203515B (es)
AR (1) AR054122A1 (es)
AT (1) ATE459623T1 (es)
AU (1) AU2006245676B2 (es)
BR (1) BRPI0609098A2 (es)
CA (1) CA2608301C (es)
DE (1) DE602006012666D1 (es)
DK (1) DK1888580T3 (es)
ES (1) ES2341572T3 (es)
IL (1) IL186881A (es)
MX (1) MX2007014082A (es)
RU (1) RU2444522C2 (es)
SI (1) SI1888580T1 (es)
TW (1) TW200716631A (es)
WO (1) WO2006120252A2 (es)
ZA (1) ZA200709689B (es)

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AR056347A1 (es) 2005-05-12 2007-10-03 Tibotec Pharm Ltd Uso de compuestos de pteridina para fabricar medicamentos y composiciones farmaceuticas
RU2441010C2 (ru) * 2005-12-21 2012-01-27 Эбботт Лэборетриз Противовирусные соединения
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US8236950B2 (en) 2006-12-20 2012-08-07 Abbott Laboratories Anti-viral compounds
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EP2376514A2 (en) 2008-12-23 2011-10-19 Pharmasset, Inc. Nucleoside analogs
WO2010075554A1 (en) 2008-12-23 2010-07-01 Pharmasset, Inc. Synthesis of purine nucleosides
US8716262B2 (en) 2008-12-23 2014-05-06 Gilead Pharmasset Llc Nucleoside phosphoramidates
US8618076B2 (en) 2009-05-20 2013-12-31 Gilead Pharmasset Llc Nucleoside phosphoramidates
TWI583692B (zh) 2009-05-20 2017-05-21 基利法瑪席特有限責任公司 核苷磷醯胺
US20110312973A1 (en) * 2010-03-10 2011-12-22 Bernd Liepold Solid compositions
RS54368B1 (sr) 2010-03-31 2016-04-28 Gilead Pharmasset Llc Kristalni (s)-izopropil 2-(((s)-(((2r,3r,4r,5r)-5-(2,4-diokso-3,4-dihidropirimidin-1-(2h)-il)-4-fluoro-3-hidroksi-4-metiltetrahidrofuran-2-il)metoksi)(fenoksi)fosforil)amino)propanoat
WO2011123672A1 (en) 2010-03-31 2011-10-06 Pharmasset, Inc. Purine nucleoside phosphoramidate
PL3290428T3 (pl) 2010-03-31 2022-02-07 Gilead Pharmasset Llc Tabletka zawierająca krystaliczny (S)-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-diokso-3,4-dihydropirymidyn-1(2H)-ylo)-4-fluoro-3-hydroksy-4-metylotetrahydrofuran-2-ylo)metoksy)(fenoksy)fosforylo)amino)propanian izopropylu
CA2818853A1 (en) 2010-11-30 2012-06-07 Gilead Pharmasset Llc 2'-spirocyclo-nucleosides for use in therapy of hcv or dengue virus
JP6046694B2 (ja) 2011-04-08 2016-12-21 ヤンセン・サイエンシズ・アイルランド・ユーシー ウイルス感染治療用のピリミジン誘導体
ES2690082T3 (es) 2011-11-09 2018-11-19 Janssen Sciences Ireland Uc Derivados de purina para el tratamiento de infecciones virales
US8889159B2 (en) 2011-11-29 2014-11-18 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
SI2872515T1 (sl) 2012-07-13 2016-10-28 Janssen Sciences Ireland Uc Makrociklični purini za zdravljanje virusnih infekcij
TR201807076T4 (tr) 2012-10-10 2018-06-21 Janssen Sciences Ireland Uc Viral enfeksiyonların ve diğer hastalıkların tedavisine yönelik pirolo[3,2-d]pirimidin derivatları.
CA2886635C (en) 2012-11-16 2021-01-05 Janssen Sciences Ireland Uc Heterocyclic substituted 2-amino-quinazoline derivatives for the treatment of viral infections
EP2958900B1 (en) 2013-02-21 2019-04-10 Janssen Sciences Ireland Unlimited Company 2-aminopyrimidine derivatives for the treatment of viral infections
MX366481B (es) 2013-03-29 2019-07-09 Janssen Sciences Ireland Uc Deaza-purinonas macrociclicas para el tratamiento de infecciones virales.
EA034674B1 (ru) * 2013-05-24 2020-03-05 Янссен Сайенсиз Айрлэнд Юси Производные пиридона для лечения нарушений, в которое вовлечены модуляции tlr7 и/или tlr8
CN109369643B (zh) 2013-06-27 2021-05-18 爱尔兰詹森科学公司 用于治疗病毒感染和其他疾病的吡咯并[3,2-d]嘧啶衍生物
CN105492446B (zh) 2013-07-30 2018-08-03 爱尔兰詹森科学公司 用于治疗病毒性感染的噻吩并[3,2-d]嘧啶衍生物
SG11201600919UA (en) 2013-08-27 2016-03-30 Gilead Pharmasset Llc Combination formulation of two antiviral compounds
EP3089971B1 (en) 2014-01-01 2020-07-29 Medivation Technologies LLC Compounds and methods of use
EP2905024A1 (en) 2014-02-07 2015-08-12 Institut Quimic De Sarriá Cets, Fundació Privada Pyrido[2,3-d]pyrimidine-7(8H)-one derivatives for the treatment of infections caused by Flaviviridae
CA3027471A1 (en) 2016-07-01 2018-01-04 Janssen Sciences Ireland Unlimited Company Dihydropyranopyrimidines for the treatment of viral infections
EA038646B1 (ru) 2016-09-29 2021-09-28 Янссен Сайенсиз Айрлэнд Анлимитед Компани Пиримидиновые пролекарства для лечения вирусных инфекций и других заболеваний
TW202415645A (zh) 2018-03-01 2024-04-16 愛爾蘭商健生科學愛爾蘭無限公司 ２，４－二胺基喹唑啉衍生物及其醫學用途
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DK1869037T3 (da) * 2005-03-25 2011-10-24 Tibotec Pharm Ltd Heterobicykliske inhibitorer af HVC

Also Published As

Publication number Publication date
WO2006120252A3 (en) 2007-02-22
AU2006245676A1 (en) 2006-11-16
CA2608301A1 (en) 2006-11-16
TW200716631A (en) 2007-05-01
CN101203515A (zh) 2008-06-18
JP2008540494A (ja) 2008-11-20
BRPI0609098A2 (pt) 2010-02-17
EP1888580B1 (en) 2010-03-03
IL186881A0 (en) 2008-02-09
IL186881A (en) 2015-06-30
KR20080007268A (ko) 2008-01-17
EP1888580A2 (en) 2008-02-20
ES2341572T3 (es) 2010-06-22
WO2006120252A2 (en) 2006-11-16
AU2006245676B2 (en) 2012-08-02
JP5464686B2 (ja) 2014-04-09
RU2007146173A (ru) 2009-06-20
US20090131460A1 (en) 2009-05-21
US8022077B2 (en) 2011-09-20
ATE459623T1 (de) 2010-03-15
SI1888580T1 (sl) 2010-06-30
ZA200709689B (en) 2009-07-29
RU2444522C2 (ru) 2012-03-10
CN101203515B (zh) 2014-02-26
DK1888580T3 (da) 2010-06-14
CA2608301C (en) 2014-04-22
AR054122A1 (es) 2007-06-06
DE602006012666D1 (de) 2010-04-15

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