TR200200553T2 - İkame edilen 3-fenil -5-alkoksi-1,3,4-oksdiazol-2-on ve lipaz önleyici olarak kullanımı - Google Patents
İkame edilen 3-fenil -5-alkoksi-1,3,4-oksdiazol-2-on ve lipaz önleyici olarak kullanımıInfo
- Publication number
- TR200200553T2 TR200200553T2 TR2002/00553T TR200200553T TR200200553T2 TR 200200553 T2 TR200200553 T2 TR 200200553T2 TR 2002/00553 T TR2002/00553 T TR 2002/00553T TR 200200553 T TR200200553 T TR 200200553T TR 200200553 T2 TR200200553 T2 TR 200200553T2
- Authority
- TR
- Turkey
- Prior art keywords
- alkyl
- substituted
- cycloalkyl
- oxdiazole
- alkoxy
- Prior art date
Links
- 229940086609 Lipase inhibitor Drugs 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 7
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 2
- -1 O-C6- C10-aryl Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000006763 (C3-C9) cycloalkyl group Chemical group 0.000 abstract 1
- 125000000041 C6-C10 aryl group Chemical group 0.000 abstract 1
- 102100026020 Hormone-sensitive lipase Human genes 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 102000000019 Sterol Esterase Human genes 0.000 abstract 1
- 108010055297 Sterol Esterase Proteins 0.000 abstract 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 230000003449 preventive effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
- C07D271/113—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Enzymes And Modification Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Formül 1'in ikame edilen 3-fenil-5-alkoksi-1,3,4 oksdiazol-2-on'lari ve bunlarin fizyolojik bakimdan hazmedilebilir tuzlari ve optik izomerleri tanimlanmaktadir, bunlarin içerisinde R1,C1-C6-alkil, C3-C9-sikloalkil anlamina gelmektedir, bunlarin her ikisi gerektiginde ikame edilmis olabilir, ve R2 ve R3, birbirinden bagimsiz olarak, hidrojen, C6-C10-aril, C3-C8-sikloalkil, C6-C10-ariloksimetil, O-benzil, O-C6-C10-aril, C3-C8-sikloalkil, O-C1-C6-alkil, SO2-NH-C1-C6-alkil, SO2-NH-(2,2,6,6-tetrametilpiperidin-4-il), SO2-NH-C3-C8-sikloalkil, SO2-N(C1-C6-alkil)2 ya da COX anlamina gelebilir, burada X O-C1-C6-alkil, NH-C1-C6-alkil, NH-C3-C8-sikloalkil ya da N(C1-C6-alkil)2 anlamina gelmektedir, su ölçüyle ki, R2 ve R3 gerektiginde ikame edilebilirler, ancak ayni anda hidrojen anlamina gelemezler. Ayrica, bunlarin imalatina yönelik yöntem tanimlanmistir. Bilesimler, hormona duyarli lipaz, HSL üzerinde önleyici etkiye sahiptir.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19942354A DE19942354A1 (de) | 1999-09-04 | 1999-09-04 | Substituierte 3-Phenyl-5-alkoxi-1,3,4-oxdiazol-2-one, ihre Herstellung und Verwendung in Arzneimitteln |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR200200553T2 true TR200200553T2 (tr) | 2002-06-21 |
Family
ID=7920884
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2002/00553T TR200200553T2 (tr) | 1999-09-04 | 2000-08-22 | İkame edilen 3-fenil -5-alkoksi-1,3,4-oksdiazol-2-on ve lipaz önleyici olarak kullanımı |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US6596742B1 (tr) |
| EP (1) | EP1214302B1 (tr) |
| JP (1) | JP2003508522A (tr) |
| KR (1) | KR100723817B1 (tr) |
| CN (1) | CN1152024C (tr) |
| AR (1) | AR032430A1 (tr) |
| AT (1) | ATE253059T1 (tr) |
| AU (1) | AU781330B2 (tr) |
| BR (1) | BR0013765A (tr) |
| CA (1) | CA2383731A1 (tr) |
| CZ (1) | CZ2002772A3 (tr) |
| DE (2) | DE19942354A1 (tr) |
| DK (1) | DK1214302T3 (tr) |
| EE (1) | EE04811B1 (tr) |
| ES (1) | ES2204685T3 (tr) |
| HK (1) | HK1048318B (tr) |
| HR (1) | HRP20020187A2 (tr) |
| HU (1) | HUP0202988A3 (tr) |
| IL (2) | IL148275A0 (tr) |
| MX (1) | MXPA02001834A (tr) |
| NO (1) | NO323129B1 (tr) |
| NZ (1) | NZ517551A (tr) |
| PL (1) | PL197314B1 (tr) |
| PT (1) | PT1214302E (tr) |
| RU (1) | RU2265600C2 (tr) |
| SK (1) | SK285924B6 (tr) |
| TR (1) | TR200200553T2 (tr) |
| WO (1) | WO2001017981A1 (tr) |
| YU (1) | YU10402A (tr) |
| ZA (1) | ZA200201594B (tr) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10102265C1 (de) * | 2001-01-18 | 2002-08-08 | Aventis Pharma Gmbh | Substituierte 3-Phenyl-5-alkoxi-1,3,4-oxdiazol-2-one, ihre Herstellung und Verwendung in Arzneistoffen |
| US6900233B2 (en) | 2002-02-28 | 2005-05-31 | Aventis Pharma Deutschland Gmbh | Substituted 3-phenyl-5-alkoxy-3H-(1,3,4)-oxadiazol-2-ones, pharmaceutical composition and method for treating obesity thereof |
| DE10208987A1 (de) * | 2002-02-28 | 2003-09-11 | Aventis Pharma Gmbh | Substituierte 3-Phenyl-5-alkoxi-1,3,4-oxidiazol-2-one, ihre Herstellung und Verwendung in Arzneistoffen |
| DE10208986A1 (de) * | 2002-02-28 | 2003-09-11 | Aventis Pharma Gmbh | Verwendung substituierter 3-Phenyl-5-alkoxi-1,3,4-oxdiazol-2-one zur Herstellung von Arzneimitteln mit hemmender Wirkung an der pankreatischen Lipase |
| US7208504B2 (en) | 2002-10-12 | 2007-04-24 | Sanofi-Aventis Deutschland Gmbh | Bicyclic inhibitors of hormone sensitive lipase |
| DE10247680B4 (de) * | 2002-10-12 | 2005-09-01 | Aventis Pharma Deutschland Gmbh | Neue bicyclische Inhibitoren der Hormon Sensitiven Lipase |
| JP2008515986A (ja) * | 2004-10-13 | 2008-05-15 | ワイス | Ｎ−ベンゼンスルホニル置換アニリノ−ピリミジン類似物 |
| EP2178821A2 (en) * | 2007-07-12 | 2010-04-28 | Deviris Inc. | Hormone sensitive lipase modulators and methods of use |
| TW200932732A (en) * | 2007-12-27 | 2009-08-01 | Bial Portela & Companhia S A | 5-O-substituted 3-N-phenyl-1,3,4-oxadiazolones for medical use |
| WO2010074587A2 (en) | 2008-12-23 | 2010-07-01 | Bial - Portela & Ca., S.A. | 5-o-substituted 3-n-aryl-1,3,4-oxadiazolones for medical use |
| US8501768B2 (en) * | 2011-05-17 | 2013-08-06 | Hoffmann-La Roche Inc. | Hexahydrocyclopentapyrrolone, hexahydropyrrolopyrrolone, octahydropyrrolopyridinone and octahydropyridinone compounds |
| CN114163351B (zh) * | 2020-09-11 | 2024-01-23 | 江苏优嘉植物保护有限公司 | 噁虫酮中间体2-(2-甲氧基)苯肼甲酸甲酯合成方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB518042A (en) | 1937-09-15 | 1940-02-15 | Ljungstroms Angturbin Ab | Improvements in elastic fluid turbines of the double rotation type |
| US4076824A (en) | 1975-02-03 | 1978-02-28 | Rhone-Poulenc Industries | Anthelmintic oxadiazolinone derivatives |
| FR2299328A1 (fr) | 1975-02-03 | 1976-08-27 | Rhone Poulenc Ind | Derives de l'alcoyloxy-5 phenyl-3 oxyde azo |
| FR2299028A1 (fr) | 1975-02-03 | 1976-08-27 | Rhone Poulenc Ind | Nouvea |
| DK156439C (da) | 1980-09-15 | 1990-01-22 | Shell Int Research | 7-substituerede 2,3-dihydrobenzofuranderivater samt pesticidpraeparater indeholdende disse og en fremgangsmaade til bekaempelse af skadelige organismer |
| EP0067471B1 (en) | 1981-06-15 | 1985-11-06 | Shell Internationale Researchmaatschappij B.V. | 7-substituted 2,3-dihydrobenzofurans, their preparation and their use as pesticides or as chemical intermediates |
| JPS60115502A (ja) * | 1983-11-28 | 1985-06-22 | Mitsubishi Chem Ind Ltd | 殺虫剤 |
| US5236939A (en) | 1989-09-23 | 1993-08-17 | Bayer Aktiengesellschaft | Substituted 1,3,4-oxa(thia)diazolinones process for their preparation and their use of combating endoparasites |
| DE3931843A1 (de) | 1989-09-23 | 1991-04-04 | Bayer Ag | Substituierte 1,3,4-oxa(thia)diazolinone verfahren zu ihrer herstellung und ihre verwendung der bekaempfung von endoparasiten |
| US5641796A (en) * | 1994-11-01 | 1997-06-24 | Eli Lilly And Company | Oral hypoglycemic agents |
-
1999
- 1999-09-04 DE DE19942354A patent/DE19942354A1/de not_active Withdrawn
-
2000
- 2000-08-22 ES ES00962346T patent/ES2204685T3/es not_active Expired - Lifetime
- 2000-08-22 MX MXPA02001834A patent/MXPA02001834A/es active IP Right Grant
- 2000-08-22 RU RU2002108509/04A patent/RU2265600C2/ru not_active IP Right Cessation
- 2000-08-22 PT PT00962346T patent/PT1214302E/pt unknown
- 2000-08-22 AT AT00962346T patent/ATE253059T1/de not_active IP Right Cessation
- 2000-08-22 HR HR20020187A patent/HRP20020187A2/hr not_active Application Discontinuation
- 2000-08-22 IL IL14827500A patent/IL148275A0/xx active IP Right Grant
- 2000-08-22 HU HU0202988A patent/HUP0202988A3/hu unknown
- 2000-08-22 NZ NZ517551A patent/NZ517551A/en unknown
- 2000-08-22 BR BR0013765-0A patent/BR0013765A/pt not_active Application Discontinuation
- 2000-08-22 EE EEP200200109A patent/EE04811B1/xx not_active IP Right Cessation
- 2000-08-22 EP EP00962346A patent/EP1214302B1/de not_active Expired - Lifetime
- 2000-08-22 PL PL353214A patent/PL197314B1/pl not_active IP Right Cessation
- 2000-08-22 DE DE50004274T patent/DE50004274D1/de not_active Expired - Lifetime
- 2000-08-22 HK HK03100568.9A patent/HK1048318B/zh not_active IP Right Cessation
- 2000-08-22 CZ CZ2002772A patent/CZ2002772A3/cs unknown
- 2000-08-22 YU YU10402A patent/YU10402A/sh unknown
- 2000-08-22 CA CA002383731A patent/CA2383731A1/en not_active Abandoned
- 2000-08-22 TR TR2002/00553T patent/TR200200553T2/tr unknown
- 2000-08-22 JP JP2001521728A patent/JP2003508522A/ja active Pending
- 2000-08-22 WO PCT/EP2000/008150 patent/WO2001017981A1/de not_active Ceased
- 2000-08-22 SK SK301-2002A patent/SK285924B6/sk not_active IP Right Cessation
- 2000-08-22 CN CNB008121346A patent/CN1152024C/zh not_active Expired - Fee Related
- 2000-08-22 AU AU74112/00A patent/AU781330B2/en not_active Ceased
- 2000-08-22 KR KR1020027002775A patent/KR100723817B1/ko not_active Expired - Fee Related
- 2000-08-22 DK DK00962346T patent/DK1214302T3/da active
- 2000-09-01 AR ARP000104589A patent/AR032430A1/es not_active Application Discontinuation
- 2000-09-05 US US09/655,373 patent/US6596742B1/en not_active Expired - Lifetime
-
2002
- 2002-02-20 IL IL148275A patent/IL148275A/en not_active IP Right Cessation
- 2002-02-26 ZA ZA200201594A patent/ZA200201594B/en unknown
- 2002-02-28 NO NO20021007A patent/NO323129B1/no not_active IP Right Cessation
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