AR032430A1 - 3-fenil-5-alcoxi-1,3,4-oxadiazol-2-onas substituidas, un procedimiento para su preparacion, medicamento y empleo de dichos compuestos para la manufactura de un medicamento - Google Patents
3-fenil-5-alcoxi-1,3,4-oxadiazol-2-onas substituidas, un procedimiento para su preparacion, medicamento y empleo de dichos compuestos para la manufactura de un medicamentoInfo
- Publication number
- AR032430A1 AR032430A1 ARP000104589A ARP000104589A AR032430A1 AR 032430 A1 AR032430 A1 AR 032430A1 AR P000104589 A ARP000104589 A AR P000104589A AR P000104589 A ARP000104589 A AR P000104589A AR 032430 A1 AR032430 A1 AR 032430A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- plurisubstituted
- aryl
- mono
- cycloalkyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title abstract 3
- 229940079593 drug Drugs 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 229940126601 medicinal product Drugs 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 12
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 7
- -1 2,2,6,6-tetramethylpiperidin-4-yl Chemical group 0.000 abstract 3
- 125000000041 C6-C10 aryl group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
- 102100026020 Hormone-sensitive lipase Human genes 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 102000000019 Sterol Esterase Human genes 0.000 abstract 1
- 108010055297 Sterol Esterase Proteins 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000002483 medication Methods 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
- C07D271/113—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Se describen 3-fenil-5-alcoxi-1,3,4-oxdiazol-2-onas substituidas de la Formula (1), en la cual: R1 representa alquilo C1-6, cicloalquilo C3-9, pudiendo estos dos grupos estar mono- o plurisubstituidos eventualmente por fenilo, que a su vez puede estar mono- o plurisubstituido por halogeno, alquilo C1-4, O-alquilo C1-4, nitro, CF3; O-alquilo C1-4, S-alquilo C1-4 o N(alquilo C1-4)2; y R2 y R3 independientemente entre sí representan hidrogeno, arilo C6-10, cicloalquilo C3-8, ariloximetilo C6-10 eventualmente substituido por alquilo C1-4, O-bencilo, O-arilo C6-10 o O-cicloalquilo C3-8 eventualmente mono- o plurisubstituidos por halogeno, CF3 o alquilo C1-4; O-alquilo C1-6 mono- o plurisubstituido por fluor, arilo C6-10 o amino, pudiendo estar el amino a su vez mono- o plurisubstituido por alquilo C1-4; SO2-NH-alquilo C1-6, eventualmente substituido por N(alquilo C1-6)2, SO2-NH-(2,2,6,6-tetrametilpiperidin-4-ilo), SO2-NH-cicloalquilo C3-8, eventualmente mono- o plurisubstituido por alquilo C1-4, SO2-N(alquilo C1-6)2 o COX, representando X O-alquilo C1-6, NH-alquilo C1-6, NH-cicloalquilo C3-8 o N(alquilo C1-6)2, y pudiendo significar N(alquilo C1-6)2 también pirrolidino, piperidino, morfolino, tiomorfolino o piperazino, que pueden estar substituidos eventualmente por alquilo C1-4, bencilo, arilo C6-10, CO-alquilo C1-4, CO-arilo C6-10, CO-O-alquilo C1-4, SO2-alquilo C1-4 o SO2-arilo C6-10; con la condicion que R2 y R3 no pueden representar al mismo tiempo hidrogeno; así como sus sales fisiologicamente compatibles e isomeros opticos. Asimismo se describe un procedimiento para su preparacion. Los compuestos exhiben un efecto inhibidor sobre la lipasa sensible a hormonas, HSL. También se describen medicamentos y el empleo de dichos compuestos para la manufactura de un medicamento.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19942354A DE19942354A1 (de) | 1999-09-04 | 1999-09-04 | Substituierte 3-Phenyl-5-alkoxi-1,3,4-oxdiazol-2-one, ihre Herstellung und Verwendung in Arzneimitteln |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR032430A1 true AR032430A1 (es) | 2003-11-12 |
Family
ID=7920884
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP000104589A AR032430A1 (es) | 1999-09-04 | 2000-09-01 | 3-fenil-5-alcoxi-1,3,4-oxadiazol-2-onas substituidas, un procedimiento para su preparacion, medicamento y empleo de dichos compuestos para la manufactura de un medicamento |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US6596742B1 (es) |
| EP (1) | EP1214302B1 (es) |
| JP (1) | JP2003508522A (es) |
| KR (1) | KR100723817B1 (es) |
| CN (1) | CN1152024C (es) |
| AR (1) | AR032430A1 (es) |
| AT (1) | ATE253059T1 (es) |
| AU (1) | AU781330B2 (es) |
| BR (1) | BR0013765A (es) |
| CA (1) | CA2383731A1 (es) |
| CZ (1) | CZ2002772A3 (es) |
| DE (2) | DE19942354A1 (es) |
| DK (1) | DK1214302T3 (es) |
| EE (1) | EE04811B1 (es) |
| ES (1) | ES2204685T3 (es) |
| HK (1) | HK1048318B (es) |
| HR (1) | HRP20020187A2 (es) |
| HU (1) | HUP0202988A3 (es) |
| IL (2) | IL148275A0 (es) |
| MX (1) | MXPA02001834A (es) |
| NO (1) | NO323129B1 (es) |
| NZ (1) | NZ517551A (es) |
| PL (1) | PL197314B1 (es) |
| PT (1) | PT1214302E (es) |
| RU (1) | RU2265600C2 (es) |
| SK (1) | SK285924B6 (es) |
| TR (1) | TR200200553T2 (es) |
| WO (1) | WO2001017981A1 (es) |
| YU (1) | YU10402A (es) |
| ZA (1) | ZA200201594B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10102265C1 (de) * | 2001-01-18 | 2002-08-08 | Aventis Pharma Gmbh | Substituierte 3-Phenyl-5-alkoxi-1,3,4-oxdiazol-2-one, ihre Herstellung und Verwendung in Arzneistoffen |
| DE10208987A1 (de) * | 2002-02-28 | 2003-09-11 | Aventis Pharma Gmbh | Substituierte 3-Phenyl-5-alkoxi-1,3,4-oxidiazol-2-one, ihre Herstellung und Verwendung in Arzneistoffen |
| US6900233B2 (en) | 2002-02-28 | 2005-05-31 | Aventis Pharma Deutschland Gmbh | Substituted 3-phenyl-5-alkoxy-3H-(1,3,4)-oxadiazol-2-ones, pharmaceutical composition and method for treating obesity thereof |
| DE10208986A1 (de) * | 2002-02-28 | 2003-09-11 | Aventis Pharma Gmbh | Verwendung substituierter 3-Phenyl-5-alkoxi-1,3,4-oxdiazol-2-one zur Herstellung von Arzneimitteln mit hemmender Wirkung an der pankreatischen Lipase |
| US7208504B2 (en) | 2002-10-12 | 2007-04-24 | Sanofi-Aventis Deutschland Gmbh | Bicyclic inhibitors of hormone sensitive lipase |
| DE10247680B4 (de) * | 2002-10-12 | 2005-09-01 | Aventis Pharma Deutschland Gmbh | Neue bicyclische Inhibitoren der Hormon Sensitiven Lipase |
| CN101039919A (zh) * | 2004-10-13 | 2007-09-19 | 惠氏公司 | 经n－苯磺酰基取代的苯胺基嘧啶类似物 |
| CN101821227A (zh) * | 2007-07-12 | 2010-09-01 | 德维里斯公司 | 激素敏感性脂酶调节剂及使用方法 |
| KR20100111691A (ko) * | 2007-12-27 | 2010-10-15 | 바이알 - 포르텔라 앤드 씨에이 에스에이 | 의학 용도를 위한 5-ｏ-치환 3-ｎ-페닐-1,3,4-옥사디아졸론 |
| WO2010074587A2 (en) | 2008-12-23 | 2010-07-01 | Bial - Portela & Ca., S.A. | 5-o-substituted 3-n-aryl-1,3,4-oxadiazolones for medical use |
| US8501768B2 (en) * | 2011-05-17 | 2013-08-06 | Hoffmann-La Roche Inc. | Hexahydrocyclopentapyrrolone, hexahydropyrrolopyrrolone, octahydropyrrolopyridinone and octahydropyridinone compounds |
| CN114163351B (zh) * | 2020-09-11 | 2024-01-23 | 江苏优嘉植物保护有限公司 | 噁虫酮中间体2-(2-甲氧基)苯肼甲酸甲酯合成方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB518042A (en) | 1937-09-15 | 1940-02-15 | Ljungstroms Angturbin Ab | Improvements in elastic fluid turbines of the double rotation type |
| FR2299328A1 (fr) | 1975-02-03 | 1976-08-27 | Rhone Poulenc Ind | Derives de l'alcoyloxy-5 phenyl-3 oxyde azo |
| US4076824A (en) | 1975-02-03 | 1978-02-28 | Rhone-Poulenc Industries | Anthelmintic oxadiazolinone derivatives |
| FR2299028A1 (fr) | 1975-02-03 | 1976-08-27 | Rhone Poulenc Ind | Nouvea |
| DK156439C (da) | 1980-09-15 | 1990-01-22 | Shell Int Research | 7-substituerede 2,3-dihydrobenzofuranderivater samt pesticidpraeparater indeholdende disse og en fremgangsmaade til bekaempelse af skadelige organismer |
| EP0067471B1 (en) | 1981-06-15 | 1985-11-06 | Shell Internationale Researchmaatschappij B.V. | 7-substituted 2,3-dihydrobenzofurans, their preparation and their use as pesticides or as chemical intermediates |
| JPS60115502A (ja) * | 1983-11-28 | 1985-06-22 | Mitsubishi Chem Ind Ltd | 殺虫剤 |
| US5236939A (en) | 1989-09-23 | 1993-08-17 | Bayer Aktiengesellschaft | Substituted 1,3,4-oxa(thia)diazolinones process for their preparation and their use of combating endoparasites |
| DE3931843A1 (de) | 1989-09-23 | 1991-04-04 | Bayer Ag | Substituierte 1,3,4-oxa(thia)diazolinone verfahren zu ihrer herstellung und ihre verwendung der bekaempfung von endoparasiten |
| US5641796A (en) * | 1994-11-01 | 1997-06-24 | Eli Lilly And Company | Oral hypoglycemic agents |
-
1999
- 1999-09-04 DE DE19942354A patent/DE19942354A1/de not_active Withdrawn
-
2000
- 2000-08-22 NZ NZ517551A patent/NZ517551A/en unknown
- 2000-08-22 BR BR0013765-0A patent/BR0013765A/pt not_active Application Discontinuation
- 2000-08-22 DK DK00962346T patent/DK1214302T3/da active
- 2000-08-22 YU YU10402A patent/YU10402A/sh unknown
- 2000-08-22 RU RU2002108509/04A patent/RU2265600C2/ru not_active IP Right Cessation
- 2000-08-22 MX MXPA02001834A patent/MXPA02001834A/es active IP Right Grant
- 2000-08-22 IL IL14827500A patent/IL148275A0/xx active IP Right Grant
- 2000-08-22 CA CA002383731A patent/CA2383731A1/en not_active Abandoned
- 2000-08-22 WO PCT/EP2000/008150 patent/WO2001017981A1/de not_active Ceased
- 2000-08-22 KR KR1020027002775A patent/KR100723817B1/ko not_active Expired - Fee Related
- 2000-08-22 AU AU74112/00A patent/AU781330B2/en not_active Ceased
- 2000-08-22 AT AT00962346T patent/ATE253059T1/de not_active IP Right Cessation
- 2000-08-22 HU HU0202988A patent/HUP0202988A3/hu unknown
- 2000-08-22 EE EEP200200109A patent/EE04811B1/xx not_active IP Right Cessation
- 2000-08-22 PL PL353214A patent/PL197314B1/pl not_active IP Right Cessation
- 2000-08-22 EP EP00962346A patent/EP1214302B1/de not_active Expired - Lifetime
- 2000-08-22 HR HR20020187A patent/HRP20020187A2/hr not_active Application Discontinuation
- 2000-08-22 ES ES00962346T patent/ES2204685T3/es not_active Expired - Lifetime
- 2000-08-22 CN CNB008121346A patent/CN1152024C/zh not_active Expired - Fee Related
- 2000-08-22 PT PT00962346T patent/PT1214302E/pt unknown
- 2000-08-22 TR TR2002/00553T patent/TR200200553T2/xx unknown
- 2000-08-22 CZ CZ2002772A patent/CZ2002772A3/cs unknown
- 2000-08-22 JP JP2001521728A patent/JP2003508522A/ja active Pending
- 2000-08-22 HK HK03100568.9A patent/HK1048318B/zh not_active IP Right Cessation
- 2000-08-22 SK SK301-2002A patent/SK285924B6/sk not_active IP Right Cessation
- 2000-08-22 DE DE50004274T patent/DE50004274D1/de not_active Expired - Lifetime
- 2000-09-01 AR ARP000104589A patent/AR032430A1/es not_active Application Discontinuation
- 2000-09-05 US US09/655,373 patent/US6596742B1/en not_active Expired - Lifetime
-
2002
- 2002-02-20 IL IL148275A patent/IL148275A/en not_active IP Right Cessation
- 2002-02-26 ZA ZA200201594A patent/ZA200201594B/en unknown
- 2002-02-28 NO NO20021007A patent/NO323129B1/no not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |