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TR200102135T2 - 5-Siyanoftalid hazırlama yöntemi - Google Patents

5-Siyanoftalid hazırlama yöntemi

Info

Publication number
TR200102135T2
TR200102135T2 TR2001/02135T TR200102135T TR200102135T2 TR 200102135 T2 TR200102135 T2 TR 200102135T2 TR 2001/02135 T TR2001/02135 T TR 2001/02135T TR 200102135 T TR200102135 T TR 200102135T TR 200102135 T2 TR200102135 T2 TR 200102135T2
Authority
TR
Turkey
Prior art keywords
cyanophthalide
preparation
sulfomide
citalopramine
carboxyphthalidine
Prior art date
Application number
TR2001/02135T
Other languages
English (en)
Inventor
Weber Beat
Original Assignee
H. Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H. Lundbeck A/S filed Critical H. Lundbeck A/S
Publication of TR200102135T2 publication Critical patent/TR200102135T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Furan Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

5-Karboksiftalidin, tiyonilklorür gibi bir dehidrate edici ajanla ve bir sülfonamidle, özellikle sülfomitle reaksiyona sokuldugu 5-siyanoftalid hazirlama yöntemi. Siyanoftalid, güvenilir bir yolla yüksek miktarlarda elde edilir. 5-Siyanoftalid, antidepresan ilaç sitalopramin hazirlanmasinda kullanilan bir ara üründür.
TR2001/02135T 1999-01-29 2000-01-26 5-Siyanoftalid hazırlama yöntemi TR200102135T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA199900128 1999-01-29

Publications (1)

Publication Number Publication Date
TR200102135T2 true TR200102135T2 (tr) 2002-01-21

Family

ID=8090069

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/02135T TR200102135T2 (tr) 1999-01-29 2000-01-26 5-Siyanoftalid hazırlama yöntemi

Country Status (31)

Country Link
US (1) US6441201B1 (tr)
EP (1) EP1150966B1 (tr)
JP (1) JP2002535397A (tr)
KR (1) KR100430327B1 (tr)
CN (1) CN1158271C (tr)
AR (1) AR022329A1 (tr)
AT (1) ATE222900T1 (tr)
AU (1) AU763666B2 (tr)
BG (1) BG64924B1 (tr)
BR (1) BR0008978A (tr)
CA (1) CA2361395C (tr)
CZ (1) CZ300257B6 (tr)
DE (1) DE60000364T2 (tr)
DK (1) DK1150966T3 (tr)
EA (1) EA003257B1 (tr)
ES (1) ES2180508T3 (tr)
HK (1) HK1044342B (tr)
HU (1) HUP0104976A3 (tr)
IL (2) IL144114A0 (tr)
IS (1) IS2223B (tr)
IT (1) IT1317741B1 (tr)
NO (1) NO326532B1 (tr)
NZ (1) NZ512775A (tr)
PL (1) PL198385B1 (tr)
PT (1) PT1150966E (tr)
SI (1) SI1150966T1 (tr)
SK (1) SK284367B6 (tr)
TR (1) TR200102135T2 (tr)
UA (1) UA70987C2 (tr)
WO (1) WO2000044738A1 (tr)
ZA (1) ZA200105549B (tr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ510858A (en) 1998-10-20 2003-11-28 H Method for the preparation of citalopram
TR200101796T2 (tr) 1998-12-23 2001-11-21 H. Lundbeck A/S 5-Siyanofitalitin preparasyonuna yönelik metot
AU759716B2 (en) 1999-04-14 2003-04-17 H. Lundbeck A/S Method for the preparation of citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
DE69920526T2 (de) 1999-10-25 2006-02-23 H. Lundbeck A/S Verfahren zur herstellung von citalopram
EP1228056B1 (en) 1999-10-25 2004-09-22 H. Lundbeck A/S Method for the preparation of citalopram
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
PT1246812E (pt) 1999-12-28 2004-08-31 Lundbeck & Co As H Metodo para a preparacao de citalopram
UA73336C2 (en) 1999-12-30 2005-07-15 Lundbeck & Co As H A method for the preparation of 5-cyano-phtalid
ES2206177T3 (es) 2000-01-14 2004-05-16 H. Lundbeck A/S Metodo para la preparacion de 5-cianoftalida.
FR2805812A1 (fr) 2000-02-24 2001-09-07 Lundbeck & Co As H Procede de preparation du citalopram
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
WO2001068629A1 (en) 2000-03-13 2001-09-20 H. Lundbeck A/S Stepwise alkylation of 5-substituted 1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
IL151490A0 (en) 2000-03-13 2003-04-10 Lundbeck & Co As H Method for the preparation of citalopram
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
DE60101786T2 (de) 2000-03-14 2004-07-15 H. Lundbeck A/S, Valby Verfahren zur herstellung von citalopram
PL360115A1 (en) * 2000-03-16 2004-09-06 H.Lundbeck A/S Method for the preparation of 5-cyano-1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
IL144816A (en) * 2000-08-18 2005-09-25 Lundbeck & Co As H Method for the preparation of citalopram
IL147226A (en) 2000-12-22 2006-04-10 Lundbeck & Co As H Process for the preparation of pure citalopram
PL353369A1 (en) 2000-12-28 2003-11-17 H.Lundbeck A/S Process for the preparation of pure citalopram
GR1004635B (el) * 2001-08-14 2004-07-14 H@Αlundbeckαa@Sαα Μεθοδοσαπαρασκευησατησασιταλοπραμης@αα
EP1321464A1 (en) * 2001-12-21 2003-06-25 ICROM S.p.A. Process for the preparation of 5-cyanophthalide and intermediates useful therein
PE20040991A1 (es) 2002-08-12 2004-12-27 Lundbeck & Co As H Separacion de intermediarios para la preparacion de escitalopram
CA2519629A1 (en) 2003-03-21 2004-09-30 H. Lundbeck A/S Intermediates for the preparation of citalopram and escitalopram
AU2003223105A1 (en) * 2003-03-24 2004-10-18 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
EP1777221A1 (en) * 2005-10-14 2007-04-25 Adorkem Technology SpA Process for the preparation of 5-cyanophthalide starting from 5-carboxyphthalide
CN119638868B (zh) * 2025-02-11 2025-05-13 济南市规划设计研究院 苯并呋喃酮壳聚糖复合物、其制备方法及其在历史街区更新领域的应用

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143702A (tr) 1965-03-18
GB1526331A (en) 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) * 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
US5296507A (en) 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
DE19626659A1 (de) 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
EA001728B1 (ru) 1997-07-08 2001-08-27 Х.Лундбекк А/С Способ получения циталопрама
UA62985C2 (en) 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
CZ292911B6 (cs) 1997-11-11 2004-01-14 H. Lundbeck A/S Způsob výroby citalopramu
NZ510858A (en) 1998-10-20 2003-11-28 H Method for the preparation of citalopram
TR200101796T2 (tr) * 1998-12-23 2001-11-21 H. Lundbeck A/S 5-Siyanofitalitin preparasyonuna yönelik metot
AU759716B2 (en) 1999-04-14 2003-04-17 H. Lundbeck A/S Method for the preparation of citalopram
ITMI991581A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
EP1228056B1 (en) 1999-10-25 2004-09-22 H. Lundbeck A/S Method for the preparation of citalopram
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
IES20010143A2 (en) 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
FR2805812A1 (fr) 2000-02-24 2001-09-07 Lundbeck & Co As H Procede de preparation du citalopram
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
IL144816A (en) 2000-08-18 2005-09-25 Lundbeck & Co As H Method for the preparation of citalopram
IL147226A (en) 2000-12-22 2006-04-10 Lundbeck & Co As H Process for the preparation of pure citalopram
PL353369A1 (en) 2000-12-28 2003-11-17 H.Lundbeck A/S Process for the preparation of pure citalopram

Also Published As

Publication number Publication date
IL144114A (en) 2006-06-11
AU763666B2 (en) 2003-07-31
CZ20012734A3 (cs) 2002-01-16
HK1044342B (zh) 2005-04-22
SK10562001A3 (sk) 2002-01-07
DE60000364D1 (de) 2002-10-02
CA2361395A1 (en) 2000-08-03
CN1337957A (zh) 2002-02-27
BG64924B1 (bg) 2006-09-29
ATE222900T1 (de) 2002-09-15
AR022329A1 (es) 2002-09-04
NO20013667D0 (no) 2001-07-26
CA2361395C (en) 2005-11-15
DK1150966T3 (da) 2002-12-30
EP1150966A1 (en) 2001-11-07
AU2278200A (en) 2000-08-18
KR100430327B1 (ko) 2004-05-03
JP2002535397A (ja) 2002-10-22
ZA200105549B (en) 2002-07-05
PL349908A1 (en) 2002-10-07
NO20013667L (no) 2001-07-26
EA003257B1 (ru) 2003-02-27
SK284367B6 (sk) 2005-02-04
SI1150966T1 (en) 2003-02-28
NZ512775A (en) 2003-11-28
IS2223B (is) 2007-03-15
WO2000044738A1 (en) 2000-08-03
ES2180508T3 (es) 2003-02-16
KR20010101432A (ko) 2001-11-14
EP1150966B1 (en) 2002-08-28
CZ300257B6 (cs) 2009-04-01
PL198385B1 (pl) 2008-06-30
BG105692A (en) 2002-02-28
NO326532B1 (no) 2008-12-29
US20020028956A1 (en) 2002-03-07
HUP0104976A2 (en) 2002-06-29
IL144114A0 (en) 2002-05-23
EA200100834A1 (ru) 2001-12-24
DE60000364T2 (de) 2003-04-03
US6441201B1 (en) 2002-08-27
UA70987C2 (uk) 2004-11-15
BR0008978A (pt) 2001-11-27
CN1158271C (zh) 2004-07-21
ITMI20000112A0 (it) 2000-01-27
IS5982A (is) 2001-06-28
PT1150966E (pt) 2003-01-31
ITMI20000112A1 (it) 2001-07-27
HK1044342A1 (en) 2002-10-18
HUP0104976A3 (en) 2002-09-30
IT1317741B1 (it) 2003-07-15

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