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TR200003377T2 - Estrojenler ile bütünleşik 2-fenil-1-[4-(2-aminoetoksi)benzil]-indol - Google Patents

Estrojenler ile bütünleşik 2-fenil-1-[4-(2-aminoetoksi)benzil]-indol

Info

Publication number
TR200003377T2
TR200003377T2 TR2000/03377T TR200003377T TR200003377T2 TR 200003377 T2 TR200003377 T2 TR 200003377T2 TR 2000/03377 T TR2000/03377 T TR 2000/03377T TR 200003377 T TR200003377 T TR 200003377T TR 200003377 T2 TR200003377 T2 TR 200003377T2
Authority
TR
Turkey
Prior art keywords
aminoethoxy
estrogens
benzyl
phenyl
indole
Prior art date
Application number
TR2000/03377T
Other languages
English (en)
Inventor
Harrison Pickar James
Samuel Komm Barry
Original Assignee
American Home Products Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22151320&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TR200003377(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by American Home Products Corporation filed Critical American Home Products Corporation
Publication of TR200003377T2 publication Critical patent/TR200003377T2/tr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Bu bulus, bir veya daha fazla estrojen ve 2-fenil-1-[4-(2-aminoetoksi)benzil]-indol bilesiklerini içeren, estrojenik ajanlar olarak yararli yeni formülasyonlar ve farmakolojik kompozisyonlar ile bilesikleri kullanan tedavi yöntemlerine iliskin olup burada (I) ve (II) genel yapilari söz konusudur.
TR2000/03377T 1998-05-15 1999-05-11 Estrojenler ile bütünleşik 2-fenil-1-[4-(2-aminoetoksi)benzil]-indol TR200003377T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US7956198A 1998-05-15 1998-05-15

Publications (1)

Publication Number Publication Date
TR200003377T2 true TR200003377T2 (tr) 2001-03-21

Family

ID=22151320

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/03377T TR200003377T2 (tr) 1998-05-15 1999-05-11 Estrojenler ile bütünleşik 2-fenil-1-[4-(2-aminoetoksi)benzil]-indol

Country Status (41)

Country Link
EP (1) EP1076558B1 (tr)
JP (3) JP2002515431A (tr)
KR (1) KR100620772B1 (tr)
CN (1) CN1230163C (tr)
AP (1) AP1424A (tr)
AR (1) AR020074A1 (tr)
AT (1) ATE245026T1 (tr)
AU (1) AU760378B2 (tr)
BE (1) BE2015C026I2 (tr)
BG (1) BG64783B1 (tr)
BR (1) BR9911040A (tr)
CA (1) CA2329530A1 (tr)
CU (1) CU23241B7 (tr)
CY (1) CY2015020I1 (tr)
CZ (1) CZ299334B6 (tr)
DE (1) DE69909616T2 (tr)
DK (1) DK1076558T3 (tr)
EA (1) EA005932B1 (tr)
EE (1) EE04262B1 (tr)
ES (1) ES2203131T3 (tr)
FR (1) FR15C0035I2 (tr)
GE (1) GEP20033079B (tr)
HR (1) HRP20000778B1 (tr)
HU (2) HU226587B1 (tr)
ID (1) ID26890A (tr)
IL (1) IL139130A (tr)
IN (1) IN192220B (tr)
LT (1) LTC1076558I2 (tr)
LU (1) LU92699I2 (tr)
NO (2) NO328129B1 (tr)
NZ (1) NZ508200A (tr)
OA (1) OA11552A (tr)
PL (1) PL194750B1 (tr)
PT (1) PT1076558E (tr)
SI (1) SI1076558T1 (tr)
SK (1) SK284666B6 (tr)
TR (1) TR200003377T2 (tr)
TW (1) TW565554B (tr)
UA (1) UA66861C2 (tr)
WO (1) WO1999059581A1 (tr)
ZA (1) ZA200006959B (tr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA66861C2 (uk) * 1998-05-15 2004-06-15 Уайт 2-феніл-1-[4-(2-аміноетокси)бензил]індол в комбінації з естрогенами, способи лікування та продукт для лікування
US7005428B1 (en) 1998-06-11 2006-02-28 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
US6465445B1 (en) 1998-06-11 2002-10-15 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
EP1196163B1 (en) 1999-07-06 2009-11-11 Endorecherche Inc. Pharmaceutical compositions for the treatment of insulin resistance
US20020013327A1 (en) * 2000-04-18 2002-01-31 Lee Andrew G. Compositions and methods for treating female sexual dysfunction
AU2001271785A1 (en) * 2000-07-06 2002-01-21 American Home Products Corporation Combinations of statins, estrogenic agents and optionally estrogens
WO2002003992A2 (en) * 2000-07-06 2002-01-17 Wyeth Use of substituted indole compounds for treating prosthesis-related bone degeneration
AU2001271781A1 (en) * 2000-07-06 2002-01-21 Wyeth Use of substituted indole compounds for treating sphincter incontinence
BR0112364A (pt) * 2000-07-06 2003-07-29 Wyeth Corp Combinações de bisfosfonatos, agentes estrogênicos e opcionalmente estrogênios
US6376486B1 (en) 2000-07-06 2002-04-23 American Home Products Corporation Methods of inhibiting sphincter incontinence
US6455568B2 (en) 2000-07-06 2002-09-24 Wyeth Combination therapy for inhibiting sphincter incontinence
DE10117441A1 (de) * 2001-04-03 2002-10-10 Schering Ag 1-Indolylderivate, deren Verwendung zur Herstellung von Arzneimitteln, ein Verfahren zur Herstellung der 1-Indolylderivate sowie 1-Indolylderivate enthaltende pharmzeutische Präparate
HUP0401268A2 (hu) 2001-07-31 2004-11-29 Pfizer Products Inc. Ösztrogén agonisták/antagonisták, ösztrogének és progesztinek kombinációját tartalmazó gyógyszerkészítmények, valamint eljárás ezek előállítására
KR100470274B1 (ko) 2002-11-08 2005-02-05 진 장 덮개층을 이용한 비정질 물질의 상 변화 방법
US7781478B2 (en) 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
FR2880625B1 (fr) * 2005-01-07 2007-03-09 Sanofi Aventis Sa Derives de n-(heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique
SI2276732T1 (sl) 2008-04-16 2015-09-30 Karo Bio Ab Novi ligandi estrogenskega receptorja
AR072297A1 (es) * 2008-06-27 2010-08-18 Novartis Ag Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona.
GB201113538D0 (en) 2011-08-04 2011-09-21 Karobio Ab Novel estrogen receptor ligands
CN102690225B (zh) * 2012-04-11 2014-12-24 南京友杰医药科技有限公司 巴多昔芬的合成方法
CN103709090A (zh) * 2014-01-16 2014-04-09 江苏万特制药有限公司 醋酸巴多昔芬的制备方法及其关键中间体
CN103739540B (zh) * 2014-01-20 2016-05-04 华润赛科药业有限责任公司 一种醋酸巴多昔芬中间体的制备方法
CN105669518B (zh) * 2014-12-04 2019-06-04 上海医药集团股份有限公司 醋酸巴多昔芬及其a晶型的制备方法
BR112020011668A2 (pt) 2017-12-15 2020-11-17 Bristol-Myers Squibb Company compostos de éter de indol substituído
IT201800006562A1 (it) * 2018-06-21 2019-12-21 Procedimento e intermedi utili per la preparazione di indoli
CN115380026B (zh) * 2020-03-17 2023-11-07 南京明德新药研发有限公司 蛋白降解调节剂与其使用方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4729999A (en) * 1984-10-12 1988-03-08 Bcm Technologies Antiestrogen therapy for symptoms of estrogen deficiency
US5496844A (en) * 1992-05-08 1996-03-05 Otsuka Pharmaceutical Factory, Inc. Indole derivatives
TW366342B (en) * 1992-07-28 1999-08-11 Lilly Co Eli The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss
GB9326332D0 (en) * 1993-12-23 1994-02-23 Karo Bio Indole derivatives
DE4426625A1 (de) * 1994-07-27 1996-03-14 Schering Ag 2-Phenylindole, Verfahren zu deren Herstellung, diese enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
EP0802183B1 (en) * 1996-04-19 2001-10-10 American Home Products Corporation Estrogenic agents
TW397821B (en) * 1996-04-19 2000-07-11 American Home Produits Corp 3-[4-(2-phenyl-indole-1-ylmethyl)-phenyl]-acrylamides and 2-phenyl-1-[4-(amino-1-yl-alk-1-ynyl)-benzyl]-1H-indol-5-ol as well as pharmaceutical compositions of estrogenic agents thereof
JP2000514074A (ja) * 1996-07-09 2000-10-24 スミスクライン・ビーチャム・ソシエタ・ペル・アチオニ 骨粗鬆症の治療のためのインドール誘導体
US5672609A (en) * 1996-07-18 1997-09-30 Eli Lilly And Company Pyridine compounds, intermediates compositions and methods of use
ES2281937T3 (es) * 1997-10-15 2007-10-01 Wyeth Nuevas ariloxi-alquil-dialquilaminas.
JP2001520997A (ja) * 1997-10-28 2001-11-06 メルク エンド カムパニー インコーポレーテッド 性腺刺激ホルモン放出ホルモン拮抗薬
UA68365C2 (en) * 1997-11-06 2004-08-16 Wyeth Corp Peroral contraception by combination of anti-estrogen and progestin
UA66861C2 (uk) * 1998-05-15 2004-06-15 Уайт 2-феніл-1-[4-(2-аміноетокси)бензил]індол в комбінації з естрогенами, способи лікування та продукт для лікування

Also Published As

Publication number Publication date
CZ20004254A3 (cs) 2001-12-12
EP1076558B1 (en) 2003-07-16
JP2002515431A (ja) 2002-05-28
PL345268A1 (en) 2001-12-03
ES2203131T3 (es) 2004-04-01
AP2000001970A0 (en) 2000-12-31
SK17202000A3 (sk) 2001-07-10
AP1424A (en) 2005-06-06
TW565554B (en) 2003-12-11
IL139130A0 (en) 2001-11-25
UA66861C2 (uk) 2004-06-15
EA005932B1 (ru) 2005-08-25
NO2015015I2 (no) 2015-06-02
JP2009019042A (ja) 2009-01-29
JP2014159472A (ja) 2014-09-04
PL194750B1 (pl) 2007-06-29
CN1230163C (zh) 2005-12-07
KR100620772B1 (ko) 2006-09-13
HK1031691A1 (en) 2001-06-22
NO20005770D0 (no) 2000-11-14
HU226587B1 (en) 2009-04-28
EE04262B1 (et) 2004-04-15
LU92699I2 (fr) 2015-06-24
BR9911040A (pt) 2001-02-13
NO2015015I1 (no) 2015-06-02
BG104930A (en) 2001-07-31
NZ508200A (en) 2003-09-26
DK1076558T3 (da) 2003-11-03
KR20010043641A (ko) 2001-05-25
DE69909616T2 (de) 2004-06-17
NO20005770L (no) 2001-01-12
LTC1076558I2 (lt) 2016-11-10
OA11552A (en) 2004-06-07
PT1076558E (pt) 2003-11-28
GEP20033079B (en) 2003-10-27
IN192220B (tr) 2004-03-20
CY2015020I1 (el) 2020-05-29
SK284666B6 (sk) 2005-08-04
FR15C0035I1 (tr) 2015-06-26
HUP0103096A2 (hu) 2002-05-29
CA2329530A1 (en) 1999-11-25
HRP20000778A2 (en) 2001-06-30
IL139130A (en) 2005-11-20
EE200000652A (et) 2002-04-15
BE2015C026I2 (en) 2018-08-24
CU23241B7 (es) 2007-10-17
BG64783B1 (bg) 2006-04-28
DE69909616D1 (de) 2003-08-21
JP5607871B2 (ja) 2014-10-15
WO1999059581A1 (en) 1999-11-25
JP5872624B2 (ja) 2016-03-01
FR15C0035I2 (fr) 2015-08-28
AR020074A1 (es) 2002-04-10
AU760378B2 (en) 2003-05-15
ID26890A (id) 2001-02-15
EA200001193A1 (ru) 2001-12-24
CZ299334B6 (cs) 2008-06-25
ZA200006959B (en) 2001-11-27
NO328129B1 (no) 2009-12-14
EP1076558A1 (en) 2001-02-21
ATE245026T1 (de) 2003-08-15
HRP20000778B1 (en) 2004-10-31
SI1076558T1 (en) 2003-10-31
HUP0103096A3 (en) 2002-11-28
HUS1500023I1 (hu) 2017-03-28
AU3894499A (en) 1999-12-06
CN1326347A (zh) 2001-12-12

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