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DE69909616D1 - 2-phenyl-1-[-(2-aminoethoxy)-benzyl -indol und estrogen als kombinationpräparate - Google Patents

2-phenyl-1-[-(2-aminoethoxy)-benzyl -indol und estrogen als kombinationpräparate

Info

Publication number
DE69909616D1
DE69909616D1 DE69909616T DE69909616T DE69909616D1 DE 69909616 D1 DE69909616 D1 DE 69909616D1 DE 69909616 T DE69909616 T DE 69909616T DE 69909616 T DE69909616 T DE 69909616T DE 69909616 D1 DE69909616 D1 DE 69909616D1
Authority
DE
Germany
Prior art keywords
aminoethoxy
indol
estrogen
benzyl
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69909616T
Other languages
English (en)
Other versions
DE69909616T2 (de
Inventor
Harrison Pickar
Samuel Komm
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
Wyeth LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22151320&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69909616(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth LLC filed Critical Wyeth LLC
Application granted granted Critical
Publication of DE69909616D1 publication Critical patent/DE69909616D1/de
Publication of DE69909616T2 publication Critical patent/DE69909616T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69909616T 1998-05-15 1999-05-11 2-phenyl-1-[-(2-aminoethoxy)-benzyl -indol und estrogen als kombinationpräparate Expired - Lifetime DE69909616T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7956198A 1998-05-15 1998-05-15
US79561 1998-05-15
PCT/US1999/010217 WO1999059581A1 (en) 1998-05-15 1999-05-11 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole in combination with estrogens

Publications (2)

Publication Number Publication Date
DE69909616D1 true DE69909616D1 (de) 2003-08-21
DE69909616T2 DE69909616T2 (de) 2004-06-17

Family

ID=22151320

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69909616T Expired - Lifetime DE69909616T2 (de) 1998-05-15 1999-05-11 2-phenyl-1-[-(2-aminoethoxy)-benzyl -indol und estrogen als kombinationpräparate

Country Status (41)

Country Link
EP (1) EP1076558B1 (de)
JP (3) JP2002515431A (de)
KR (1) KR100620772B1 (de)
CN (1) CN1230163C (de)
AP (1) AP1424A (de)
AR (1) AR020074A1 (de)
AT (1) ATE245026T1 (de)
AU (1) AU760378B2 (de)
BE (1) BE2015C026I2 (de)
BG (1) BG64783B1 (de)
BR (1) BR9911040A (de)
CA (1) CA2329530A1 (de)
CU (1) CU23241B7 (de)
CY (1) CY2015020I1 (de)
CZ (1) CZ299334B6 (de)
DE (1) DE69909616T2 (de)
DK (1) DK1076558T3 (de)
EA (1) EA005932B1 (de)
EE (1) EE04262B1 (de)
ES (1) ES2203131T3 (de)
FR (1) FR15C0035I2 (de)
GE (1) GEP20033079B (de)
HR (1) HRP20000778B1 (de)
HU (2) HU226587B1 (de)
ID (1) ID26890A (de)
IL (1) IL139130A (de)
IN (1) IN192220B (de)
LT (1) LTC1076558I2 (de)
LU (1) LU92699I2 (de)
NO (2) NO328129B1 (de)
NZ (1) NZ508200A (de)
OA (1) OA11552A (de)
PL (1) PL194750B1 (de)
PT (1) PT1076558E (de)
SI (1) SI1076558T1 (de)
SK (1) SK284666B6 (de)
TR (1) TR200003377T2 (de)
TW (1) TW565554B (de)
UA (1) UA66861C2 (de)
WO (1) WO1999059581A1 (de)
ZA (1) ZA200006959B (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA66861C2 (uk) * 1998-05-15 2004-06-15 Уайт 2-феніл-1-[4-(2-аміноетокси)бензил]індол в комбінації з естрогенами, способи лікування та продукт для лікування
US7005428B1 (en) 1998-06-11 2006-02-28 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
US6465445B1 (en) 1998-06-11 2002-10-15 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
EP1196163B1 (de) 1999-07-06 2009-11-11 Endorecherche Inc. Pharmazeutische zubereitungen zur behandlung von insulinresitenz
US20020013327A1 (en) * 2000-04-18 2002-01-31 Lee Andrew G. Compositions and methods for treating female sexual dysfunction
AU2001271785A1 (en) * 2000-07-06 2002-01-21 American Home Products Corporation Combinations of statins, estrogenic agents and optionally estrogens
WO2002003992A2 (en) * 2000-07-06 2002-01-17 Wyeth Use of substituted indole compounds for treating prosthesis-related bone degeneration
AU2001271781A1 (en) * 2000-07-06 2002-01-21 Wyeth Use of substituted indole compounds for treating sphincter incontinence
BR0112364A (pt) * 2000-07-06 2003-07-29 Wyeth Corp Combinações de bisfosfonatos, agentes estrogênicos e opcionalmente estrogênios
US6376486B1 (en) 2000-07-06 2002-04-23 American Home Products Corporation Methods of inhibiting sphincter incontinence
US6455568B2 (en) 2000-07-06 2002-09-24 Wyeth Combination therapy for inhibiting sphincter incontinence
DE10117441A1 (de) * 2001-04-03 2002-10-10 Schering Ag 1-Indolylderivate, deren Verwendung zur Herstellung von Arzneimitteln, ein Verfahren zur Herstellung der 1-Indolylderivate sowie 1-Indolylderivate enthaltende pharmzeutische Präparate
HUP0401268A2 (hu) 2001-07-31 2004-11-29 Pfizer Products Inc. Ösztrogén agonisták/antagonisták, ösztrogének és progesztinek kombinációját tartalmazó gyógyszerkészítmények, valamint eljárás ezek előállítására
KR100470274B1 (ko) 2002-11-08 2005-02-05 진 장 덮개층을 이용한 비정질 물질의 상 변화 방법
US7781478B2 (en) 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
FR2880625B1 (fr) * 2005-01-07 2007-03-09 Sanofi Aventis Sa Derives de n-(heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique
SI2276732T1 (sl) 2008-04-16 2015-09-30 Karo Bio Ab Novi ligandi estrogenskega receptorja
AR072297A1 (es) * 2008-06-27 2010-08-18 Novartis Ag Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona.
GB201113538D0 (en) 2011-08-04 2011-09-21 Karobio Ab Novel estrogen receptor ligands
CN102690225B (zh) * 2012-04-11 2014-12-24 南京友杰医药科技有限公司 巴多昔芬的合成方法
CN103709090A (zh) * 2014-01-16 2014-04-09 江苏万特制药有限公司 醋酸巴多昔芬的制备方法及其关键中间体
CN103739540B (zh) * 2014-01-20 2016-05-04 华润赛科药业有限责任公司 一种醋酸巴多昔芬中间体的制备方法
CN105669518B (zh) * 2014-12-04 2019-06-04 上海医药集团股份有限公司 醋酸巴多昔芬及其a晶型的制备方法
BR112020011668A2 (pt) 2017-12-15 2020-11-17 Bristol-Myers Squibb Company compostos de éter de indol substituído
IT201800006562A1 (it) * 2018-06-21 2019-12-21 Procedimento e intermedi utili per la preparazione di indoli
CN115380026B (zh) * 2020-03-17 2023-11-07 南京明德新药研发有限公司 蛋白降解调节剂与其使用方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4729999A (en) * 1984-10-12 1988-03-08 Bcm Technologies Antiestrogen therapy for symptoms of estrogen deficiency
US5496844A (en) * 1992-05-08 1996-03-05 Otsuka Pharmaceutical Factory, Inc. Indole derivatives
TW366342B (en) * 1992-07-28 1999-08-11 Lilly Co Eli The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss
GB9326332D0 (en) * 1993-12-23 1994-02-23 Karo Bio Indole derivatives
DE4426625A1 (de) * 1994-07-27 1996-03-14 Schering Ag 2-Phenylindole, Verfahren zu deren Herstellung, diese enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
EP0802183B1 (de) * 1996-04-19 2001-10-10 American Home Products Corporation Östrogene Verbindungen
TW397821B (en) * 1996-04-19 2000-07-11 American Home Produits Corp 3-[4-(2-phenyl-indole-1-ylmethyl)-phenyl]-acrylamides and 2-phenyl-1-[4-(amino-1-yl-alk-1-ynyl)-benzyl]-1H-indol-5-ol as well as pharmaceutical compositions of estrogenic agents thereof
JP2000514074A (ja) * 1996-07-09 2000-10-24 スミスクライン・ビーチャム・ソシエタ・ペル・アチオニ 骨粗鬆症の治療のためのインドール誘導体
US5672609A (en) * 1996-07-18 1997-09-30 Eli Lilly And Company Pyridine compounds, intermediates compositions and methods of use
ES2281937T3 (es) * 1997-10-15 2007-10-01 Wyeth Nuevas ariloxi-alquil-dialquilaminas.
JP2001520997A (ja) * 1997-10-28 2001-11-06 メルク エンド カムパニー インコーポレーテッド 性腺刺激ホルモン放出ホルモン拮抗薬
UA68365C2 (en) * 1997-11-06 2004-08-16 Wyeth Corp Peroral contraception by combination of anti-estrogen and progestin
UA66861C2 (uk) * 1998-05-15 2004-06-15 Уайт 2-феніл-1-[4-(2-аміноетокси)бензил]індол в комбінації з естрогенами, способи лікування та продукт для лікування

Also Published As

Publication number Publication date
CZ20004254A3 (cs) 2001-12-12
EP1076558B1 (de) 2003-07-16
JP2002515431A (ja) 2002-05-28
PL345268A1 (en) 2001-12-03
ES2203131T3 (es) 2004-04-01
AP2000001970A0 (en) 2000-12-31
SK17202000A3 (sk) 2001-07-10
AP1424A (en) 2005-06-06
TW565554B (en) 2003-12-11
IL139130A0 (en) 2001-11-25
UA66861C2 (uk) 2004-06-15
EA005932B1 (ru) 2005-08-25
NO2015015I2 (no) 2015-06-02
JP2009019042A (ja) 2009-01-29
JP2014159472A (ja) 2014-09-04
PL194750B1 (pl) 2007-06-29
CN1230163C (zh) 2005-12-07
KR100620772B1 (ko) 2006-09-13
HK1031691A1 (en) 2001-06-22
NO20005770D0 (no) 2000-11-14
HU226587B1 (en) 2009-04-28
EE04262B1 (et) 2004-04-15
LU92699I2 (fr) 2015-06-24
BR9911040A (pt) 2001-02-13
NO2015015I1 (no) 2015-06-02
BG104930A (en) 2001-07-31
NZ508200A (en) 2003-09-26
DK1076558T3 (da) 2003-11-03
KR20010043641A (ko) 2001-05-25
DE69909616T2 (de) 2004-06-17
NO20005770L (no) 2001-01-12
LTC1076558I2 (lt) 2016-11-10
OA11552A (en) 2004-06-07
PT1076558E (pt) 2003-11-28
GEP20033079B (en) 2003-10-27
IN192220B (de) 2004-03-20
CY2015020I1 (el) 2020-05-29
SK284666B6 (sk) 2005-08-04
FR15C0035I1 (de) 2015-06-26
HUP0103096A2 (hu) 2002-05-29
CA2329530A1 (en) 1999-11-25
HRP20000778A2 (en) 2001-06-30
IL139130A (en) 2005-11-20
EE200000652A (et) 2002-04-15
BE2015C026I2 (en) 2018-08-24
CU23241B7 (es) 2007-10-17
BG64783B1 (bg) 2006-04-28
TR200003377T2 (tr) 2001-03-21
JP5607871B2 (ja) 2014-10-15
WO1999059581A1 (en) 1999-11-25
JP5872624B2 (ja) 2016-03-01
FR15C0035I2 (fr) 2015-08-28
AR020074A1 (es) 2002-04-10
AU760378B2 (en) 2003-05-15
ID26890A (id) 2001-02-15
EA200001193A1 (ru) 2001-12-24
CZ299334B6 (cs) 2008-06-25
ZA200006959B (en) 2001-11-27
NO328129B1 (no) 2009-12-14
EP1076558A1 (de) 2001-02-21
ATE245026T1 (de) 2003-08-15
HRP20000778B1 (en) 2004-10-31
SI1076558T1 (en) 2003-10-31
HUP0103096A3 (en) 2002-11-28
HUS1500023I1 (hu) 2017-03-28
AU3894499A (en) 1999-12-06
CN1326347A (zh) 2001-12-12

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Free format text: PRODUCT NAME: BAZEDOXIFEN, GEGEBENENFALLS IN FORM EINES PHARMAZEUTISCH ANNEHMBAREN SALZES DAVON UND KONJUGIERTE ESTROGENE; REGISTRATION NO/DATE: EU/1/14/960 20141216

Spc suppl protection certif: 122015000035

Filing date: 20150508

Expiry date: 20190512

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