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HUS1500023I1 - 2-Fenil-1-[4-(2-amino-etoxi)-benzil]-indol-származékok és ösztrogének kombinációját tartalmazó gyógyszerkészítmények - Google Patents

2-Fenil-1-[4-(2-amino-etoxi)-benzil]-indol-származékok és ösztrogének kombinációját tartalmazó gyógyszerkészítmények

Info

Publication number
HUS1500023I1
HUS1500023I1 HUS1500023C HUS1500023C HUS1500023I1 HU S1500023 I1 HUS1500023 I1 HU S1500023I1 HU S1500023 C HUS1500023 C HU S1500023C HU S1500023 C HUS1500023 C HU S1500023C HU S1500023 I1 HUS1500023 I1 HU S1500023I1
Authority
HU
Hungary
Prior art keywords
aminoethoxy
estrogens
indole
benzyl
phenyl
Prior art date
Application number
HUS1500023C
Other languages
English (en)
Original Assignee
Wyeth Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22151320&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUS1500023(I1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Llc filed Critical Wyeth Llc
Publication of HUS1500023I1 publication Critical patent/HUS1500023I1/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Reproductive Health (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HUS1500023C 1998-05-15 2015-04-17 2-Fenil-1-[4-(2-amino-etoxi)-benzil]-indol-származékok és ösztrogének kombinációját tartalmazó gyógyszerkészítmények HUS1500023I1 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US7956198A 1998-05-15 1998-05-15

Publications (1)

Publication Number Publication Date
HUS1500023I1 true HUS1500023I1 (hu) 2017-03-28

Family

ID=22151320

Family Applications (2)

Application Number Title Priority Date Filing Date
HU0103096A HU226587B1 (en) 1998-05-15 1999-05-11 Pharmaceutical composition containing 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole in combination with estrogens
HUS1500023C HUS1500023I1 (hu) 1998-05-15 2015-04-17 2-Fenil-1-[4-(2-amino-etoxi)-benzil]-indol-származékok és ösztrogének kombinációját tartalmazó gyógyszerkészítmények

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HU0103096A HU226587B1 (en) 1998-05-15 1999-05-11 Pharmaceutical composition containing 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole in combination with estrogens

Country Status (41)

Country Link
EP (1) EP1076558B1 (hu)
JP (3) JP2002515431A (hu)
KR (1) KR100620772B1 (hu)
CN (1) CN1230163C (hu)
AP (1) AP1424A (hu)
AR (1) AR020074A1 (hu)
AT (1) ATE245026T1 (hu)
AU (1) AU760378B2 (hu)
BE (1) BE2015C026I2 (hu)
BG (1) BG64783B1 (hu)
BR (1) BR9911040A (hu)
CA (1) CA2329530A1 (hu)
CU (1) CU23241B7 (hu)
CY (1) CY2015020I1 (hu)
CZ (1) CZ299334B6 (hu)
DE (1) DE69909616T2 (hu)
DK (1) DK1076558T3 (hu)
EA (1) EA005932B1 (hu)
EE (1) EE04262B1 (hu)
ES (1) ES2203131T3 (hu)
FR (1) FR15C0035I2 (hu)
GE (1) GEP20033079B (hu)
HR (1) HRP20000778B1 (hu)
HU (2) HU226587B1 (hu)
ID (1) ID26890A (hu)
IL (1) IL139130A (hu)
IN (1) IN192220B (hu)
LT (1) LTC1076558I2 (hu)
LU (1) LU92699I2 (hu)
NO (2) NO328129B1 (hu)
NZ (1) NZ508200A (hu)
OA (1) OA11552A (hu)
PL (1) PL194750B1 (hu)
PT (1) PT1076558E (hu)
SI (1) SI1076558T1 (hu)
SK (1) SK284666B6 (hu)
TR (1) TR200003377T2 (hu)
TW (1) TW565554B (hu)
UA (1) UA66861C2 (hu)
WO (1) WO1999059581A1 (hu)
ZA (1) ZA200006959B (hu)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1076558T3 (da) * 1998-05-15 2003-11-03 Wyeth Corp 2-Phenyl-1-[4-(2-aminoethoxy)benzyl]indol i kombination med østrogener
US7005428B1 (en) 1998-06-11 2006-02-28 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
US6465445B1 (en) 1998-06-11 2002-10-15 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
IL147485A0 (en) 1999-07-06 2002-08-14 Endorech Inc Pharmaceutical compositions containing a selective estrogen receptor modulator
US20020013327A1 (en) * 2000-04-18 2002-01-31 Lee Andrew G. Compositions and methods for treating female sexual dysfunction
EP1299093A2 (en) * 2000-07-06 2003-04-09 Wyeth Combinations of bisphosphonates, estrogenic agents and optionally estrogens
US6455568B2 (en) 2000-07-06 2002-09-24 Wyeth Combination therapy for inhibiting sphincter incontinence
AU2001271785A1 (en) * 2000-07-06 2002-01-21 American Home Products Corporation Combinations of statins, estrogenic agents and optionally estrogens
WO2002003992A2 (en) * 2000-07-06 2002-01-17 Wyeth Use of substituted indole compounds for treating prosthesis-related bone degeneration
US6376486B1 (en) 2000-07-06 2002-04-23 American Home Products Corporation Methods of inhibiting sphincter incontinence
AU2001271781A1 (en) * 2000-07-06 2002-01-21 Wyeth Use of substituted indole compounds for treating sphincter incontinence
DE10117441A1 (de) * 2001-04-03 2002-10-10 Schering Ag 1-Indolylderivate, deren Verwendung zur Herstellung von Arzneimitteln, ein Verfahren zur Herstellung der 1-Indolylderivate sowie 1-Indolylderivate enthaltende pharmzeutische Präparate
CZ2004118A3 (cs) 2001-07-31 2004-09-15 Pfizer Products Inc. Farmaceutický prostředek, kit a způsoby zahrnující kombinaci činidla estrogenový agonist/antagonist, estrogenu a progestinu
KR100470274B1 (ko) 2002-11-08 2005-02-05 진 장 덮개층을 이용한 비정질 물질의 상 변화 방법
US7781478B2 (en) 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
FR2880625B1 (fr) * 2005-01-07 2007-03-09 Sanofi Aventis Sa Derives de n-(heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique
ES2543599T3 (es) 2008-04-16 2015-08-20 Karo Bio Ab Nuevos ligandos de receptor de estrógeno
AR072297A1 (es) * 2008-06-27 2010-08-18 Novartis Ag Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona.
GB201113538D0 (en) 2011-08-04 2011-09-21 Karobio Ab Novel estrogen receptor ligands
CN102690225B (zh) * 2012-04-11 2014-12-24 南京友杰医药科技有限公司 巴多昔芬的合成方法
CN103709090A (zh) * 2014-01-16 2014-04-09 江苏万特制药有限公司 醋酸巴多昔芬的制备方法及其关键中间体
CN103739540B (zh) * 2014-01-20 2016-05-04 华润赛科药业有限责任公司 一种醋酸巴多昔芬中间体的制备方法
CN105669518B (zh) * 2014-12-04 2019-06-04 上海医药集团股份有限公司 醋酸巴多昔芬及其a晶型的制备方法
MX2020006093A (es) 2017-12-15 2020-08-24 Bristol Myers Squibb Co Compuestos de indol eter sustituidos.
IT201800006562A1 (it) * 2018-06-21 2019-12-21 Procedimento e intermedi utili per la preparazione di indoli
WO2021185291A1 (zh) * 2020-03-17 2021-09-23 南京明德新药研发有限公司 蛋白降解调节剂与其使用方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4729999A (en) * 1984-10-12 1988-03-08 Bcm Technologies Antiestrogen therapy for symptoms of estrogen deficiency
AU665690B2 (en) * 1992-05-08 1996-01-11 Otsuka Pharmaceutical Factory, Inc. Indole derivative
TW366342B (en) * 1992-07-28 1999-08-11 Lilly Co Eli The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss
GB9326332D0 (en) * 1993-12-23 1994-02-23 Karo Bio Indole derivatives
DE4426625A1 (de) * 1994-07-27 1996-03-14 Schering Ag 2-Phenylindole, Verfahren zu deren Herstellung, diese enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
TW397821B (en) * 1996-04-19 2000-07-11 American Home Produits Corp 3-[4-(2-phenyl-indole-1-ylmethyl)-phenyl]-acrylamides and 2-phenyl-1-[4-(amino-1-yl-alk-1-ynyl)-benzyl]-1H-indol-5-ol as well as pharmaceutical compositions of estrogenic agents thereof
ATE206701T1 (de) * 1996-04-19 2001-10-15 American Home Prod Östrogene verbindungen
EP0914321B1 (en) * 1996-07-09 2004-09-22 Nikem Research S.R.L. Indole derivatives for the treatment of osteoporosis
US5672609A (en) * 1996-07-18 1997-09-30 Eli Lilly And Company Pyridine compounds, intermediates compositions and methods of use
AU757630C (en) * 1997-10-15 2006-10-26 Wyeth Novel aryloxy-alkyl-dialkylamines
JP2001520997A (ja) * 1997-10-28 2001-11-06 メルク エンド カムパニー インコーポレーテッド 性腺刺激ホルモン放出ホルモン拮抗薬
UA68365C2 (en) * 1997-11-06 2004-08-16 Wyeth Corp Peroral contraception by combination of anti-estrogen and progestin
DK1076558T3 (da) * 1998-05-15 2003-11-03 Wyeth Corp 2-Phenyl-1-[4-(2-aminoethoxy)benzyl]indol i kombination med østrogener

Also Published As

Publication number Publication date
ZA200006959B (en) 2001-11-27
EE04262B1 (et) 2004-04-15
NO20005770L (no) 2001-01-12
SK284666B6 (sk) 2005-08-04
HUP0103096A2 (hu) 2002-05-29
CN1326347A (zh) 2001-12-12
JP2014159472A (ja) 2014-09-04
HRP20000778A2 (en) 2001-06-30
AP2000001970A0 (en) 2000-12-31
CU23241B7 (es) 2007-10-17
UA66861C2 (uk) 2004-06-15
AU760378B2 (en) 2003-05-15
FR15C0035I1 (hu) 2015-06-26
LU92699I2 (fr) 2015-06-24
HU226587B1 (en) 2009-04-28
CN1230163C (zh) 2005-12-07
LTC1076558I2 (lt) 2016-11-10
JP5607871B2 (ja) 2014-10-15
TR200003377T2 (tr) 2001-03-21
HUP0103096A3 (en) 2002-11-28
TW565554B (en) 2003-12-11
NZ508200A (en) 2003-09-26
OA11552A (en) 2004-06-07
JP2002515431A (ja) 2002-05-28
NO2015015I1 (no) 2015-06-02
AR020074A1 (es) 2002-04-10
SI1076558T1 (en) 2003-10-31
DK1076558T3 (da) 2003-11-03
JP5872624B2 (ja) 2016-03-01
NO2015015I2 (no) 2015-06-02
ATE245026T1 (de) 2003-08-15
DE69909616T2 (de) 2004-06-17
DE69909616D1 (de) 2003-08-21
ID26890A (id) 2001-02-15
CZ299334B6 (cs) 2008-06-25
AU3894499A (en) 1999-12-06
BE2015C026I2 (en) 2018-08-24
CY2015020I1 (el) 2020-05-29
NO328129B1 (no) 2009-12-14
FR15C0035I2 (fr) 2015-08-28
BR9911040A (pt) 2001-02-13
PL194750B1 (pl) 2007-06-29
GEP20033079B (en) 2003-10-27
CZ20004254A3 (cs) 2001-12-12
EA005932B1 (ru) 2005-08-25
BG104930A (en) 2001-07-31
HK1031691A1 (en) 2001-06-22
KR20010043641A (ko) 2001-05-25
IL139130A0 (en) 2001-11-25
EE200000652A (et) 2002-04-15
BG64783B1 (bg) 2006-04-28
JP2009019042A (ja) 2009-01-29
PL345268A1 (en) 2001-12-03
CA2329530A1 (en) 1999-11-25
EP1076558A1 (en) 2001-02-21
NO20005770D0 (no) 2000-11-14
EA200001193A1 (ru) 2001-12-24
KR100620772B1 (ko) 2006-09-13
SK17202000A3 (sk) 2001-07-10
HRP20000778B1 (en) 2004-10-31
IN192220B (hu) 2004-03-20
WO1999059581A1 (en) 1999-11-25
AP1424A (en) 2005-06-06
IL139130A (en) 2005-11-20
PT1076558E (pt) 2003-11-28
EP1076558B1 (en) 2003-07-16
ES2203131T3 (es) 2004-04-01

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