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TNSN99056A1 - Composes azabicycliques substitues nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant - Google Patents

Composes azabicycliques substitues nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant

Info

Publication number
TNSN99056A1
TNSN99056A1 TNTNSN99056A TNSN99056A TNSN99056A1 TN SN99056 A1 TNSN99056 A1 TN SN99056A1 TN TNSN99056 A TNTNSN99056 A TN TNSN99056A TN SN99056 A TNSN99056 A TN SN99056A TN SN99056 A1 TNSN99056 A1 TN SN99056A1
Authority
TN
Tunisia
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
novel substituted
azabicyclic compounds
Prior art date
Application number
TNTNSN99056A
Other languages
English (en)
Inventor
Michael Bright Gene
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of TNSN99056A1 publication Critical patent/TNSN99056A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Addiction (AREA)
  • Gynecology & Obstetrics (AREA)
  • Child & Adolescent Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Luminescent Compositions (AREA)

Abstract

-L'INVENTION CONCERNE DES COMPOSES DE FORMULE I : DANS LAQUELLE R3, R4, Z ET W REPRESENTENT DIVERS RADICAUX. ELLE CONCERNE EGALEMENT UN PROCEDE POUR LEUR PREPARATION ET DES COMPOSITIONS PHARMACEUTIQUES LES CONTENANT. APPLICATION : UTILISATION DE CES COMPOSES ET COMPOSITIONS, COMME AGONISTES OU ANTAGONISTES DES RECEPTEURS DE SEROTONINE 1, POUR LE TRAITEMENT OU LA PREVENTION DE DIVERS TROUBLES DU SYSTEME NERVEUX CENTRAL.
TNTNSN99056A 1998-04-09 1999-04-07 Composes azabicycliques substitues nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant TNSN99056A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8123798P 1998-04-09 1998-04-09

Publications (1)

Publication Number Publication Date
TNSN99056A1 true TNSN99056A1 (fr) 2005-11-10

Family

ID=22162936

Family Applications (1)

Application Number Title Priority Date Filing Date
TNTNSN99056A TNSN99056A1 (fr) 1998-04-09 1999-04-07 Composes azabicycliques substitues nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant

Country Status (40)

Country Link
US (2) US6525048B1 (fr)
EP (1) EP1070065B1 (fr)
JP (1) JP3496759B2 (fr)
KR (1) KR100378931B1 (fr)
CN (1) CN1117092C (fr)
AP (1) AP1175A (fr)
AR (1) AR015751A1 (fr)
AT (1) ATE248838T1 (fr)
AU (1) AU749254B2 (fr)
BG (1) BG104915A (fr)
BR (1) BR9909522A (fr)
CA (1) CA2327782A1 (fr)
CO (1) CO5080727A1 (fr)
CZ (1) CZ20003684A3 (fr)
DE (1) DE69910997T2 (fr)
DK (1) DK1070065T3 (fr)
DZ (1) DZ2756A1 (fr)
EA (1) EA003400B1 (fr)
ES (1) ES2204154T3 (fr)
HR (1) HRP20000653A2 (fr)
HU (1) HUP0102400A3 (fr)
ID (1) ID26086A (fr)
IL (1) IL138629A0 (fr)
IS (1) IS5641A (fr)
MA (1) MA26619A1 (fr)
MY (1) MY133390A (fr)
NO (1) NO20005004L (fr)
NZ (1) NZ507010A (fr)
OA (1) OA11496A (fr)
PA (1) PA8469101A1 (fr)
PE (1) PE20000413A1 (fr)
PL (1) PL343408A1 (fr)
PT (1) PT1070065E (fr)
SK (1) SK14782000A3 (fr)
TN (1) TNSN99056A1 (fr)
TR (1) TR200002932T2 (fr)
TW (1) TW555758B (fr)
WO (1) WO1999052907A1 (fr)
YU (1) YU59400A (fr)
ZA (1) ZA992596B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6231833B1 (en) 1999-08-05 2001-05-15 Pfizer Inc 2,7-substituted octahydro-1H-pyrido[1,2-A]pyrazine derivatives as ligands for serotonin receptors
UA62015C2 (en) 1998-12-28 2003-12-15 Pfizer Prod Inc Benzoizoxazol derivatives, a pharmaceutical composition (variants) based thereon (variants) and a method for treatment (variants)
BR0014166A (pt) * 1999-09-03 2002-05-14 Lilly Co Eli Método de utilização de inibidores de reabsorção de serotonina seletivo de rápido ataque para tratamento de disfunção sexual
GB2362826A (en) * 2000-06-02 2001-12-05 Lilly Co Eli A pharmaceutical composition comprising a serotonin transport inhibitor and a serotonin recptor antagonist
EP1383496B1 (fr) * 2001-02-20 2008-10-01 Dinan, Timothy Gerard Pindolol pour le traitement de la fibromyalgie
PL378749A1 (pl) * 2003-03-12 2006-05-15 Pfizer Products Inc. Azabicykliczne pochodne pirydyloksymetylowe i benzoizoksazolowe
WO2005082370A1 (fr) * 2004-01-29 2005-09-09 Pfizer Products Inc. Combinaisons d'un antipsychotique atypique et de derives azabicycliques d'aminomethylpyridyloxy- methyle/benzisoxazole pour le traitement de troubles du systeme nerveux central
JP4559749B2 (ja) * 2004-02-16 2010-10-13 あすか製薬株式会社 ピペラジニルピリジン誘導体
AR048112A1 (es) * 2004-03-25 2006-03-29 Solvay Pharm Bv Derivados de 1-(2h-1-benzopiran-2-on-8-il)-piperazina para el tratamiento de dolor
AR049478A1 (es) 2004-03-25 2006-08-09 Solvay Pharm Bv Un procedimiento para la preparacion de 3-amino-8-(1-piperazinil)-2h-1-benzopiran-2-ona. sales e hidratos y composiciones farmaceuticas.
BRPI0512567A (pt) * 2004-06-22 2008-03-25 Pfizer Prod Inc compostos antagonistas de receptor de histamina-3 diazabicìclico e respectivas composições farmacêuticas
US8685924B2 (en) 2004-08-25 2014-04-01 Takeda Pharmaceutical Company Limited Preventives/remedies for stress urinary incontinence and method of screening the same
CA2580042A1 (fr) * 2004-09-10 2006-03-16 Pfizer Products Inc. Methodes destinees a traiter des troubles cognitifs au moyen de derives azabicycliques de pyridyloxymethyle et de benzisoxazole
RU2417082C2 (ru) * 2009-07-14 2011-04-27 Учреждение Российской Академии Наук Институт Физиологически Активных Веществ Ран (Ифав Ран) Средство для восстановления утраченной памяти в норме и патологии у пациентов всех возрастных групп на основе n, n'-замещенных 3, 7-диазабицикло[3.3.1]нонанов, фармацевтическая композиция на его основе и способ ее применения
JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物
WO2020087031A1 (fr) 2018-10-26 2020-04-30 The Research Foundation For The State University Of New York Combinaison d'un inhibiteur de réabsorption spécifique de la sérotonine et d'un agoniste partiel du récepteur de la sérotonine 1a pour réduire la dyskinésie induite par l-dopa
WO2020183011A1 (fr) 2019-03-14 2020-09-17 Institut Curie Inhibiteurs de htr1d et leurs utilisations dans le traitement du cancer

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5106849A (en) * 1988-05-24 1992-04-21 American Home Products Corporation Use of aryl- and heteroaryl piperazinyl carboxamides in the treatment of various central nervous system disorders
MX19222A (es) * 1989-01-23 1993-12-01 Pfizer Agentes ansioliticos bis-aza-biciclicos
US5157034A (en) * 1991-02-27 1992-10-20 Pfizer Inc. Neuroleptic perhydro-1H-pyrido[1,2-a]pyrazines
ES2096099T3 (es) * 1991-09-25 1997-03-01 Pfizer Perhidro-1h-pirido(1,2,a)pirazinas 2-sustituidas neurolepticas.
US5262428A (en) * 1992-03-13 1993-11-16 Wake Forest University Biologically active tropane derivatives
CA2138018C (fr) * 1992-06-16 1998-01-27 Frank J. Urban Procede et intermediaires pour agents anxiolytiques bi-aza-bicycliques
GB9410512D0 (en) * 1994-05-25 1994-07-13 Smithkline Beecham Plc Novel treatment
WO1996010570A1 (fr) * 1994-09-30 1996-04-11 Pfizer Inc. PERHYDRO-1H-PYRIDO[1,2-a] PYRAZINES DISUBSTITUEES EN 2,7 A ACTION NEUROLEPTIQUE
US5614523A (en) * 1995-01-17 1997-03-25 Eli Lilly And Company Compounds having effects on serotonin-related systems

Also Published As

Publication number Publication date
JP3496759B2 (ja) 2004-02-16
AP9901502A0 (en) 1999-06-30
TW555758B (en) 2003-10-01
CO5080727A1 (es) 2001-09-25
HRP20000653A2 (en) 2001-04-30
AP1175A (en) 2003-06-04
CN1305477A (zh) 2001-07-25
PA8469101A1 (es) 2000-09-29
ID26086A (id) 2000-11-23
JP2002511469A (ja) 2002-04-16
AU3268799A (en) 1999-11-01
SK14782000A3 (sk) 2002-06-04
EP1070065B1 (fr) 2003-09-03
MY133390A (en) 2007-11-30
ES2204154T3 (es) 2004-04-16
CZ20003684A3 (cs) 2002-03-13
PT1070065E (pt) 2003-12-31
KR20010042527A (ko) 2001-05-25
PL343408A1 (en) 2001-08-13
AU749254B2 (en) 2002-06-20
BG104915A (en) 2001-07-31
NO20005004L (no) 2000-11-27
PE20000413A1 (es) 2000-05-25
NO20005004D0 (no) 2000-10-04
TR200002932T2 (tr) 2001-01-22
EP1070065A1 (fr) 2001-01-24
IS5641A (is) 2000-09-26
US6887905B2 (en) 2005-05-03
US6525048B1 (en) 2003-02-25
HK1035719A1 (en) 2001-12-07
HUP0102400A3 (en) 2002-10-28
EA200000910A1 (ru) 2001-04-23
ZA992596B (en) 2000-10-08
NZ507010A (en) 2003-05-30
CA2327782A1 (fr) 1999-10-21
YU59400A (sh) 2003-10-31
DE69910997T2 (de) 2004-05-19
BR9909522A (pt) 2000-12-19
CN1117092C (zh) 2003-08-06
IL138629A0 (en) 2001-10-31
DZ2756A1 (fr) 2003-09-15
US20030181458A1 (en) 2003-09-25
ATE248838T1 (de) 2003-09-15
MA26619A1 (fr) 2004-12-20
DE69910997D1 (de) 2003-10-09
OA11496A (en) 2004-05-14
AR015751A1 (es) 2001-05-16
KR100378931B1 (ko) 2003-04-07
WO1999052907A1 (fr) 1999-10-21
DK1070065T3 (da) 2003-11-24
EA003400B1 (ru) 2003-04-24
HUP0102400A2 (hu) 2001-11-28

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