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TNSN98035A1 - Atropisomeres de 3-aryl-4(3h)-quinazolinones, procede pour leur preparation et compositions les contenant - Google Patents

Atropisomeres de 3-aryl-4(3h)-quinazolinones, procede pour leur preparation et compositions les contenant

Info

Publication number
TNSN98035A1
TNSN98035A1 TNTNSN98035A TNSN98035A TNSN98035A1 TN SN98035 A1 TNSN98035 A1 TN SN98035A1 TN TNSN98035 A TNTNSN98035 A TN TNSN98035A TN SN98035 A TNSN98035 A TN SN98035A TN SN98035 A1 TNSN98035 A1 TN SN98035A1
Authority
TN
Tunisia
Prior art keywords
preparation
compositions containing
quinazolinones
atropisomers
aryl
Prior art date
Application number
TNTNSN98035A
Other languages
English (en)
Inventor
Michael Devries Keith
Mckowan Welch Willard Jr
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of TNSN98035A1 publication Critical patent/TNSN98035A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Adhesives Or Adhesive Processes (AREA)

Abstract

L'INVENTION CONCERNE UN ATROPISOMERE DE FORMULE DANS LAQUELLE R2,R3,R5,R6,R7 et R8 REPRESENTENT DIVERS RADICAUX ELLE CONCERNE EGALEMENT UN PROCEDE POUR SA PREPARATION ET DES COMPOSITIONS PHARMACEUTIQUES LE CONTENANT APPLICATION : UTILISATION DE CES COMPOSES ET COMPOSITIONS POUR LE TRAITEMENT DE MALADIES NEURODEGENERATIVES ET D'AFFECTIONS LIEES A UN TRAUMATISME DU SYSTEME NERVEUX CENTRAL.
TNTNSN98035A 1997-02-28 1998-02-25 Atropisomeres de 3-aryl-4(3h)-quinazolinones, procede pour leur preparation et compositions les contenant TNSN98035A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3890597P 1997-02-28 1997-02-28

Publications (1)

Publication Number Publication Date
TNSN98035A1 true TNSN98035A1 (fr) 2005-03-15

Family

ID=21902563

Family Applications (1)

Application Number Title Priority Date Filing Date
TNTNSN98035A TNSN98035A1 (fr) 1997-02-28 1998-02-25 Atropisomeres de 3-aryl-4(3h)-quinazolinones, procede pour leur preparation et compositions les contenant

Country Status (40)

Country Link
US (1) US6306864B1 (fr)
EP (1) EP0968194B1 (fr)
JP (1) JP2000509731A (fr)
KR (1) KR100358636B1 (fr)
CN (1) CN1248248A (fr)
AP (1) AP859A (fr)
AR (1) AR011170A1 (fr)
AT (1) ATE267817T1 (fr)
AU (1) AU744028B2 (fr)
BG (1) BG103689A (fr)
BR (1) BR9807872A (fr)
CA (1) CA2282277C (fr)
DE (1) DE69824157T2 (fr)
DK (1) DK0968194T3 (fr)
DZ (1) DZ2440A1 (fr)
EA (1) EA001963B1 (fr)
ES (1) ES2219866T3 (fr)
GT (1) GT199800038A (fr)
HR (1) HRP980106A2 (fr)
HU (1) HUP0000914A3 (fr)
ID (1) ID22711A (fr)
IL (1) IL130900A0 (fr)
IS (1) IS1952B (fr)
MA (1) MA24484A1 (fr)
NO (1) NO313630B1 (fr)
NZ (1) NZ336628A (fr)
OA (1) OA11089A (fr)
PA (1) PA8447001A1 (fr)
PE (1) PE58399A1 (fr)
PL (1) PL335418A1 (fr)
PT (1) PT968194E (fr)
SK (1) SK113299A3 (fr)
TN (1) TNSN98035A1 (fr)
TR (1) TR199902093T2 (fr)
TW (1) TW504508B (fr)
UA (1) UA61097C2 (fr)
UY (1) UY24897A1 (fr)
WO (1) WO1998038173A1 (fr)
YU (1) YU41299A (fr)
ZA (1) ZA981666B (fr)

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* Cited by examiner, † Cited by third party
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TR199802296T2 (xx) 1996-05-15 1999-02-22 Pfizer Inc. Yeni 2,3 dis�bstit�te-4 (3H)-kinazolinonlar
US6323208B1 (en) * 1997-09-05 2001-11-27 Pfizer Inc Atropisomers of 2,3-disubstituted-(5.6)-heteroaryl fused-pyrimidin-4-ones
JPH11279158A (ja) * 1998-02-09 1999-10-12 Pfizer Prod Inc キナゾリン―４―オン誘導体の製造方法
HRP20020838A2 (en) * 2000-04-25 2004-12-31 Icos Corp Inhibitors of human phosphatidyl-inositol 3-kinase delta
US6667300B2 (en) 2000-04-25 2003-12-23 Icos Corporation Inhibitors of human phosphatidylinositol 3-kinase delta
KR100850728B1 (ko) 2000-06-12 2008-08-06 에자이 알앤드디 매니지먼트 가부시키가이샤 1,2-디하이드로피리딘 화합물, 그의 제조 방법 및 그의 용도
RU2286340C2 (ru) 2000-08-18 2006-10-27 Адзиномото Ко., Инк. Новые производные фенилаланина
GB0129260D0 (en) 2001-12-06 2002-01-23 Eisai London Res Lab Ltd Pharmaceutical compositions and their uses
US6939968B2 (en) * 2002-12-23 2005-09-06 Bristol-Myers Squibb Company Atropisomers of 3-substituted-4-arylquinolin-2-one derivatives
US7410974B2 (en) * 2003-08-08 2008-08-12 Ulysses Pharmaceutical Products, Inc. Halogenated Quinazolinyl nitrofurans as antibacterial agents
US20080146562A1 (en) * 2003-08-08 2008-06-19 Ulysses Pharmaceutical Products Inc., Halogenated quinazolinyl nitrofurans as antibacterial agents
GB0325390D0 (en) * 2003-10-30 2003-12-03 Novartis Ag Organic compounds
EP1700850B1 (fr) 2003-12-22 2015-07-15 Ajinomoto Co., Inc. Derivé phenylalanine
RS55551B1 (sr) 2004-05-13 2017-05-31 Icos Corp Hinazolinoni kao inhibitori humane fosfatidilinozitol 3-kinaze delta
MY148809A (en) 2004-07-06 2013-05-31 Eisai R&D Man Co Ltd Crystals of 1,2-dihydropyridine compound and their production process
GB0416730D0 (en) * 2004-07-27 2004-09-01 Novartis Ag Organic compounds
US7893260B2 (en) 2005-11-04 2011-02-22 Hydra Biosciences, Inc. Substituted quinazolin-4-one compounds for antagonizing TRPV3 function
WO2008041118A2 (fr) 2006-10-04 2008-04-10 Pfizer Products Inc. Dérivés de pyrido[4,3-d]pyrimidin-4(3h)-one utilisés en tant qu'antagonistes du récepteur calcique
WO2008140750A1 (fr) * 2007-05-10 2008-11-20 Hydra Biosciences Inc. Composés modulant la fonction du trp v3
CN101429166B (zh) * 2007-11-07 2013-08-21 上海特化医药科技有限公司 喹唑啉酮衍生物及其制备方法和用途
KR101664511B1 (ko) 2008-11-13 2016-10-11 길리아드 칼리스토가 엘엘씨 혈액 종양에 대한 요법
US9492449B2 (en) 2008-11-13 2016-11-15 Gilead Calistoga Llc Therapies for hematologic malignancies
BRPI1012333A2 (pt) 2009-03-24 2016-03-29 Gilead Calistoga Llc atropisômeros de derivados de 2-purinil-3-tolil-quinazolinonas e métodos de uso
CN102647987A (zh) 2009-07-21 2012-08-22 吉里德卡利斯托加公司 使用pi3k抑制剂治疗肝脏障碍
PT2834241T (pt) 2012-03-05 2021-02-05 Gilead Calistoga Llc Formas polimórficas de (s)-2-(1-(9h-purin-6-ilamino)propil)-5-fluoro-3-fenil quinazolina-4(3h)-ona
CN103275086B (zh) * 2013-05-30 2015-04-15 温州大学 一种6-取代喹唑啉并喹唑啉酮化合物及其合成方法和用途
US9567337B2 (en) 2013-12-20 2017-02-14 Gilead Calistoga Llc Process methods for phosphatidylinositol 3-kinase inhibitors
US9708327B2 (en) 2013-12-20 2017-07-18 Gilead Calistoga Llc Polymorphic forms of a hydrochloride salt of (S)-2-(1-(9H-purin-6-ylamino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one
US9533909B2 (en) 2014-03-31 2017-01-03 Corning Incorporated Methods and apparatus for material processing using atmospheric thermal plasma reactor
HK1231476A1 (zh) 2014-06-13 2017-12-22 吉利德科学公司 磷脂酰肌醇3-激酶抑制剂
DE102014217021A1 (de) * 2014-08-27 2016-03-03 Skf Lubrication Systems Germany Ag Gehäuse für eine Vorrichtung zum dosierten Verteilen eines Mediums sowie eine Dosiereinrichtung zur Verwendung in dem Gehäuse
US12303499B2 (en) 2018-12-14 2025-05-20 Eisai R&D Management Co., Ltd. Aqueous based pharmaceutical formulations of 1,2-dihydropyridine compounds
HUE071972T2 (hu) 2020-01-29 2025-10-28 Kamari Pharma Ltd Vegyületek és készítmények bõrrendellenességek kezelésében történõ alkalmazásra

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DE1195321B (de) * 1962-03-16 1965-06-24 Troponwerke Dinklage & Co Verfahren zur Herstellung von substituierten Chinazolon-(4)-derivaten
DE1670416A1 (de) * 1966-12-30 1971-02-11 Chem Fab Von Heyden Gmbh Muenc Verfahren zur Herstellung von aminosubstituierten Chinazolinonderivaten
GB1298603A (en) * 1970-04-06 1972-12-06 Karamchand Premchand Private Quinazolinone derivatives
US4183931A (en) * 1977-09-08 1980-01-15 Research Corporation 2-Ketoalkyl-4(3H)-quinazolinones
GB9022785D0 (en) * 1990-10-19 1990-12-05 Merck Sharp & Dohme Therapeutic agents
WO1992013535A1 (fr) * 1991-02-06 1992-08-20 Research Corporation Technologies, Inc. Quinazolones substituees a activite anticonvulsivante
US5777271A (en) * 1996-01-18 1998-07-07 Commscope, Inc. Cable having an at least partially oxidized armor layer
TR199802296T2 (xx) * 1996-05-15 1999-02-22 Pfizer Inc. Yeni 2,3 dis�bstit�te-4 (3H)-kinazolinonlar

Also Published As

Publication number Publication date
ATE267817T1 (de) 2004-06-15
US6306864B1 (en) 2001-10-23
NO994177L (no) 1999-08-27
TW504508B (en) 2002-10-01
DK0968194T3 (da) 2004-08-16
IS1952B (is) 2004-10-13
CN1248248A (zh) 2000-03-22
EA199900693A1 (ru) 2000-02-28
OA11089A (en) 2003-09-22
DZ2440A1 (fr) 2003-01-11
AP859A (en) 2000-07-21
CA2282277C (fr) 2005-10-11
WO1998038173A1 (fr) 1998-09-03
GT199800038A (es) 1999-08-13
IL130900A0 (en) 2001-01-28
SK113299A3 (en) 2001-05-10
MA24484A1 (fr) 1998-10-01
HRP980106A2 (en) 1999-02-28
IS5140A (is) 1999-07-30
ZA981666B (en) 1999-08-27
PL335418A1 (en) 2000-04-25
YU41299A (sh) 2002-09-19
UY24897A1 (es) 2000-12-29
NO313630B1 (no) 2002-11-04
CA2282277A1 (fr) 1998-09-03
AU744028B2 (en) 2002-02-14
BR9807872A (pt) 2000-03-21
NZ336628A (en) 2001-03-30
BG103689A (bg) 2000-11-30
ES2219866T3 (es) 2004-12-01
EP0968194A1 (fr) 2000-01-05
HUP0000914A3 (en) 2001-09-28
PE58399A1 (es) 1999-06-16
PT968194E (pt) 2004-08-31
HUP0000914A2 (hu) 2001-04-28
EP0968194B1 (fr) 2004-05-26
JP2000509731A (ja) 2000-08-02
AP9801199A0 (en) 1998-03-31
TR199902093T2 (xx) 1999-12-21
AU5676898A (en) 1998-09-18
ID22711A (id) 1999-12-09
NO994177D0 (no) 1999-08-27
DE69824157D1 (de) 2004-07-01
AR011170A1 (es) 2000-08-02
PA8447001A1 (es) 2000-05-24
DE69824157T2 (de) 2004-10-14
UA61097C2 (uk) 2003-11-17
EA001963B1 (ru) 2001-10-22
KR20000075814A (ko) 2000-12-26
KR100358636B1 (ko) 2002-10-31

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