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GT199800038A - Atropisomeros de 3-aril-4(3h)-quinazolinonas. - Google Patents

Atropisomeros de 3-aril-4(3h)-quinazolinonas.

Info

Publication number
GT199800038A
GT199800038A GT199800038A GT199800038A GT199800038A GT 199800038 A GT199800038 A GT 199800038A GT 199800038 A GT199800038 A GT 199800038A GT 199800038 A GT199800038 A GT 199800038A GT 199800038 A GT199800038 A GT 199800038A
Authority
GT
Guatemala
Prior art keywords
quinazolinones
atropisomers
treatments
aryl
3aril4
Prior art date
Application number
GT199800038A
Other languages
English (en)
Inventor
Willard Mckowan Welch Jr
Keith Michael Devries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GT199800038A publication Critical patent/GT199800038A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Adhesives Or Adhesive Processes (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A NUEVOS ATROPISOMEROS DE 2(ARIL O HETEROARIL)3ARIL4(3H)QUINAZOLINONAS DE LA FORMULA (I), A SUS SALES FARMACEUTICAMENTE ACEPTABLES, A COMPOSICIONES FARMACEUTICAS Y PROCEDIMIENTOS PARA EL TRATAMIENTO DE AFECCIONES NEURODEGENERATIVAS Y RELACIONADAS CON TRAUMAS DEL SNC. ESTOS COMPUESTOS TIENEN LA ESTRUCTURA QUIMICA (I), EN LA QUE R1, R2, R3, R4, R5, R6, R7 Y R8, SON GRUPOS FUNCIONALES DESCRITOS EN EL EXPEDIENTE.
GT199800038A 1997-02-28 1998-02-19 Atropisomeros de 3-aril-4(3h)-quinazolinonas. GT199800038A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3890597P 1997-02-28 1997-02-28

Publications (1)

Publication Number Publication Date
GT199800038A true GT199800038A (es) 1999-08-13

Family

ID=21902563

Family Applications (1)

Application Number Title Priority Date Filing Date
GT199800038A GT199800038A (es) 1997-02-28 1998-02-19 Atropisomeros de 3-aril-4(3h)-quinazolinonas.

Country Status (40)

Country Link
US (1) US6306864B1 (es)
EP (1) EP0968194B1 (es)
JP (1) JP2000509731A (es)
KR (1) KR100358636B1 (es)
CN (1) CN1248248A (es)
AP (1) AP859A (es)
AR (1) AR011170A1 (es)
AT (1) ATE267817T1 (es)
AU (1) AU744028B2 (es)
BG (1) BG103689A (es)
BR (1) BR9807872A (es)
CA (1) CA2282277C (es)
DE (1) DE69824157T2 (es)
DK (1) DK0968194T3 (es)
DZ (1) DZ2440A1 (es)
EA (1) EA001963B1 (es)
ES (1) ES2219866T3 (es)
GT (1) GT199800038A (es)
HR (1) HRP980106A2 (es)
HU (1) HUP0000914A3 (es)
ID (1) ID22711A (es)
IL (1) IL130900A0 (es)
IS (1) IS1952B (es)
MA (1) MA24484A1 (es)
NO (1) NO313630B1 (es)
NZ (1) NZ336628A (es)
OA (1) OA11089A (es)
PA (1) PA8447001A1 (es)
PE (1) PE58399A1 (es)
PL (1) PL335418A1 (es)
PT (1) PT968194E (es)
SK (1) SK113299A3 (es)
TN (1) TNSN98035A1 (es)
TR (1) TR199902093T2 (es)
TW (1) TW504508B (es)
UA (1) UA61097C2 (es)
UY (1) UY24897A1 (es)
WO (1) WO1998038173A1 (es)
YU (1) YU41299A (es)
ZA (1) ZA981666B (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU730503B2 (en) 1996-05-15 2001-03-08 Pfizer Inc. Novel 2,3 disubstituted-4(3H)-quinazolinones
US6323208B1 (en) 1997-09-05 2001-11-27 Pfizer Inc Atropisomers of 2,3-disubstituted-(5.6)-heteroaryl fused-pyrimidin-4-ones
JPH11279158A (ja) * 1998-02-09 1999-10-12 Pfizer Prod Inc キナゾリン―４―オン誘導体の製造方法
NZ522076A (en) * 2000-04-25 2005-08-26 Icos Corp Inhibitors of human phosphatidyl-inositol 3-kinase delta
US6667300B2 (en) 2000-04-25 2003-12-23 Icos Corporation Inhibitors of human phosphatidylinositol 3-kinase delta
CN1245386C (zh) 2000-06-12 2006-03-15 卫材株式会社 1,2－二氢吡啶化合物及其制备方法和用途
EP1288205B1 (en) 2000-08-18 2011-02-02 Ajinomoto Co., Inc. Novel phenylalanine derivatives
GB0129260D0 (en) 2001-12-06 2002-01-23 Eisai London Res Lab Ltd Pharmaceutical compositions and their uses
US6939968B2 (en) * 2002-12-23 2005-09-06 Bristol-Myers Squibb Company Atropisomers of 3-substituted-4-arylquinolin-2-one derivatives
MXPA06001552A (es) * 2003-08-08 2006-09-04 Ulysses Pharmaceutical Product Quinazolinil nitrofuranos halogenados como agentes antibacterianos.
US20080146562A1 (en) * 2003-08-08 2008-06-19 Ulysses Pharmaceutical Products Inc., Halogenated quinazolinyl nitrofurans as antibacterial agents
GB0325390D0 (en) * 2003-10-30 2003-12-03 Novartis Ag Organic compounds
RU2390520C2 (ru) 2003-12-22 2010-05-27 Адзиномото Ко., Инк. Новые производные фенилаланина
RS55551B1 (sr) 2004-05-13 2017-05-31 Icos Corp Hinazolinoni kao inhibitori humane fosfatidilinozitol 3-kinaze delta
MY148809A (en) 2004-07-06 2013-05-31 Eisai R&D Man Co Ltd Crystals of 1,2-dihydropyridine compound and their production process
GB0416730D0 (en) * 2004-07-27 2004-09-01 Novartis Ag Organic compounds
AU2006311883A1 (en) 2005-11-04 2007-05-18 Hydra Biosciences, Inc. Compounds for modulating TRPV3 function
MX2009003673A (es) 2006-10-04 2009-04-22 Pfizer Prod Inc Derivados de piridido[4,3-d]pirimidin-4(3h)-ona como antagonistas de los receptores de calcio.
WO2008140750A1 (en) 2007-05-10 2008-11-20 Hydra Biosciences Inc. Compounds for modulating trpv3 function
CN101429166B (zh) * 2007-11-07 2013-08-21 上海特化医药科技有限公司 喹唑啉酮衍生物及其制备方法和用途
US9492449B2 (en) 2008-11-13 2016-11-15 Gilead Calistoga Llc Therapies for hematologic malignancies
CN102271683B (zh) 2008-11-13 2014-07-09 吉里德卡利斯托加公司 恶性血液病的治疗
CA2756347A1 (en) 2009-03-24 2010-09-30 Gilead Calistoga Llc Atropisomers of 2-purinyl-3-tolyl-quinazolinone derivatives and methods of use
CA2768843A1 (en) 2009-07-21 2011-01-27 Gilead Calistoga Llc Treatment of liver disorders with pi3k inhibitors
AR090253A1 (es) 2012-03-05 2014-10-29 Gilead Calistoga Llc Formas polimorficas de (s)-2-(1-(9h-purin-6-ilamino)propil)-5-fluor-3-fenilquinazolin-4(3h)-ona
CN103275086B (zh) * 2013-05-30 2015-04-15 温州大学 一种6-取代喹唑啉并喹唑啉酮化合物及其合成方法和用途
JP2017500319A (ja) 2013-12-20 2017-01-05 ギリアード カリストガ エルエルシー （ｓ）−２−（１−（９ｈ−プリン−６−イルアミノ）プロピル）−５−フルオロ−３−フェニルキナゾリン−４（３ｈ）−オンの塩酸塩の多形形態
MX2016008259A (es) 2013-12-20 2016-10-13 Gilead Calistoga Llc Metodo de proceso para inhibidores de fosfatidilinositol 3-cinasa.
US9533909B2 (en) 2014-03-31 2017-01-03 Corning Incorporated Methods and apparatus for material processing using atmospheric thermal plasma reactor
AU2015274696B2 (en) 2014-06-13 2018-09-27 Gilead Sciences, Inc. Phosphatidylinositol 3-kinase inhibitors
DE102014217021A1 (de) * 2014-08-27 2016-03-03 Skf Lubrication Systems Germany Ag Gehäuse für eine Vorrichtung zum dosierten Verteilen eines Mediums sowie eine Dosiereinrichtung zur Verwendung in dem Gehäuse
KR102912861B1 (ko) 2018-12-14 2026-01-15 에자이 알앤드디 매니지먼트 가부시키가이샤 1,2-디하이드로피리딘 화합물의 수성 기반 약학적 제형
AU2021212754A1 (en) 2020-01-29 2022-08-04 Kamari Pharma Ltd. Compounds and compositions for use in treating skin disorders

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1195321B (de) * 1962-03-16 1965-06-24 Troponwerke Dinklage & Co Verfahren zur Herstellung von substituierten Chinazolon-(4)-derivaten
DE1670416A1 (de) * 1966-12-30 1971-02-11 Chem Fab Von Heyden Gmbh Muenc Verfahren zur Herstellung von aminosubstituierten Chinazolinonderivaten
GB1298603A (en) * 1970-04-06 1972-12-06 Karamchand Premchand Private Quinazolinone derivatives
US4183931A (en) * 1977-09-08 1980-01-15 Research Corporation 2-Ketoalkyl-4(3H)-quinazolinones
GB9022785D0 (en) * 1990-10-19 1990-12-05 Merck Sharp & Dohme Therapeutic agents
WO1992013535A1 (en) * 1991-02-06 1992-08-20 Research Corporation Technologies, Inc. Anticonvulsant substituted quinazolones
US5777271A (en) * 1996-01-18 1998-07-07 Commscope, Inc. Cable having an at least partially oxidized armor layer
AU730503B2 (en) * 1996-05-15 2001-03-08 Pfizer Inc. Novel 2,3 disubstituted-4(3H)-quinazolinones

Also Published As

Publication number Publication date
BR9807872A (pt) 2000-03-21
HRP980106A2 (en) 1999-02-28
DE69824157T2 (de) 2004-10-14
US6306864B1 (en) 2001-10-23
NO313630B1 (no) 2002-11-04
WO1998038173A1 (en) 1998-09-03
BG103689A (bg) 2000-11-30
DE69824157D1 (de) 2004-07-01
YU41299A (sh) 2002-09-19
CA2282277A1 (en) 1998-09-03
EP0968194B1 (en) 2004-05-26
OA11089A (en) 2003-09-22
TW504508B (en) 2002-10-01
IS1952B (is) 2004-10-13
JP2000509731A (ja) 2000-08-02
ZA981666B (en) 1999-08-27
AP859A (en) 2000-07-21
ES2219866T3 (es) 2004-12-01
PE58399A1 (es) 1999-06-16
HUP0000914A2 (hu) 2001-04-28
NZ336628A (en) 2001-03-30
PT968194E (pt) 2004-08-31
SK113299A3 (en) 2001-05-10
PA8447001A1 (es) 2000-05-24
AR011170A1 (es) 2000-08-02
NO994177D0 (no) 1999-08-27
NO994177L (no) 1999-08-27
KR20000075814A (ko) 2000-12-26
TNSN98035A1 (fr) 2005-03-15
AU744028B2 (en) 2002-02-14
PL335418A1 (en) 2000-04-25
AP9801199A0 (en) 1998-03-31
TR199902093T2 (xx) 1999-12-21
CN1248248A (zh) 2000-03-22
IL130900A0 (en) 2001-01-28
UA61097C2 (uk) 2003-11-17
EA199900693A1 (ru) 2000-02-28
CA2282277C (en) 2005-10-11
MA24484A1 (fr) 1998-10-01
HUP0000914A3 (en) 2001-09-28
EP0968194A1 (en) 2000-01-05
ID22711A (id) 1999-12-09
UY24897A1 (es) 2000-12-29
KR100358636B1 (ko) 2002-10-31
DK0968194T3 (da) 2004-08-16
IS5140A (is) 1999-07-30
DZ2440A1 (fr) 2003-01-11
AU5676898A (en) 1998-09-18
ATE267817T1 (de) 2004-06-15
EA001963B1 (ru) 2001-10-22

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