AP859A - Atropisomers of 3-Aryl-4-"Quinazolinones and use thereof for treating neorodegenerative conditions". - Google Patents

Atropisomers of 3-Aryl-4-"Quinazolinones and use thereof for treating neorodegenerative conditions". Download PDF

Info

Publication number: AP859A
Authority: AP; ARIPO
Prior art keywords: alkyl; fluoro; chloro; methyl; hydrogen
Prior art date: 1997-02-28

Application number

APAP/P/1998/001199A

Other languages

English (en)

Other versions

AP9801199A0 (en

Inventor

Jr Willard M Welch

Vries Keith Michael De

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-02-28

Filing date

1998-02-26

Publication date

2000-07-21

1998-02-26 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

1998-03-31 Publication of AP9801199A0 publication Critical patent/AP9801199A0/xx

2000-07-21 Application granted granted Critical

2000-07-21 Publication of AP859A publication Critical patent/AP859A/en

Links

238000000034 method Methods 0.000 claims abstract description 40
150000003839 salts Chemical class 0.000 claims abstract description 35
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239000008194 pharmaceutical composition Substances 0.000 claims abstract description 7
150000001875 compounds Chemical class 0.000 claims description 125
229920002554 vinyl polymer Polymers 0.000 claims description 56
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 50
-1 bromo, chloro, methyl Chemical group 0.000 claims description 50
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 48
229910052739 hydrogen Inorganic materials 0.000 claims description 46
239000001257 hydrogen Substances 0.000 claims description 43
125000000217 alkyl group Chemical group 0.000 claims description 41
125000005843 halogen group Chemical group 0.000 claims description 40
229910052792 caesium Inorganic materials 0.000 claims description 38
125000004093 cyano group Chemical group *C#N 0.000 claims description 36
229910052757 nitrogen Inorganic materials 0.000 claims description 33
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 30
229910052799 carbon Inorganic materials 0.000 claims description 25
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 24
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239000003814 drug Substances 0.000 claims description 24
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NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 18
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UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 17
125000003545 alkoxy group Chemical group 0.000 claims description 17
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QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 14
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QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 8
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125000004070 6 membered heterocyclic group Chemical group 0.000 claims description 7
RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims description 6
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NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims description 4
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JVQIKJMSUIMUDI-UHFFFAOYSA-N 3-pyrroline Chemical compound C1NCC=C1 JVQIKJMSUIMUDI-UHFFFAOYSA-N 0.000 claims description 2
229910052684 Cerium Inorganic materials 0.000 claims description 2
239000005864 Sulphur Chemical group 0.000 claims description 2
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208000012601 choreatic disease Diseases 0.000 claims 2
SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims 1
MGRVRXRGTBOSHW-UHFFFAOYSA-N (aminomethyl)phosphonic acid Chemical compound NCP(O)(O)=O MGRVRXRGTBOSHW-UHFFFAOYSA-N 0.000 claims 1
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OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 45
WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 42
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 39
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XHXFXVLFKHQFAL-UHFFFAOYSA-N phosphoryl trichloride Chemical compound ClP(Cl)(Cl)=O XHXFXVLFKHQFAL-UHFFFAOYSA-N 0.000 description 1
230000035790 physiological processes and functions Effects 0.000 description 1
239000003880 polar aprotic solvent Substances 0.000 description 1
239000002798 polar solvent Substances 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
235000011056 potassium acetate Nutrition 0.000 description 1
159000000001 potassium salts Chemical class 0.000 description 1
229920001592 potato starch Polymers 0.000 description 1
230000003389 potentiating effect Effects 0.000 description 1
238000002953 preparative HPLC Methods 0.000 description 1
230000002335 preservative effect Effects 0.000 description 1
230000008569 process Effects 0.000 description 1
239000003380 propellant Substances 0.000 description 1
235000019260 propionic acid Nutrition 0.000 description 1
WYVAMUWZEOHJOQ-UHFFFAOYSA-N propionic anhydride Chemical compound CCC(=O)OC(=O)CC WYVAMUWZEOHJOQ-UHFFFAOYSA-N 0.000 description 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
VTGOHKSTWXHQJK-UHFFFAOYSA-N pyrimidin-2-ol Chemical class OC1=NC=CC=N1 VTGOHKSTWXHQJK-UHFFFAOYSA-N 0.000 description 1
IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
239000000376 reactant Substances 0.000 description 1
230000029058 respiratory gaseous exchange Effects 0.000 description 1
238000012552 review Methods 0.000 description 1
230000021317 sensory perception Effects 0.000 description 1
239000012679 serum free medium Substances 0.000 description 1
239000000377 silicon dioxide Substances 0.000 description 1
239000000779 smoke Substances 0.000 description 1
235000017557 sodium bicarbonate Nutrition 0.000 description 1
229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
229910000029 sodium carbonate Inorganic materials 0.000 description 1
239000011775 sodium fluoride Substances 0.000 description 1
235000013024 sodium fluoride Nutrition 0.000 description 1
235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
235000019333 sodium laurylsulphate Nutrition 0.000 description 1
229910000162 sodium phosphate Inorganic materials 0.000 description 1
229940080313 sodium starch Drugs 0.000 description 1
239000004334 sorbic acid Substances 0.000 description 1
235000010199 sorbic acid Nutrition 0.000 description 1
229940075582 sorbic acid Drugs 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
235000010356 sorbitol Nutrition 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
230000000087 stabilizing effect Effects 0.000 description 1
239000008107 starch Substances 0.000 description 1
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235000019698 starch Nutrition 0.000 description 1
239000010959 steel Substances 0.000 description 1
230000000638 stimulation Effects 0.000 description 1
229960005322 streptomycin Drugs 0.000 description 1
UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Natural products CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 1
239000000829 suppository Substances 0.000 description 1
239000002511 suppository base Substances 0.000 description 1
230000000946 synaptic effect Effects 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
GJBRNHKUVLOCEB-UHFFFAOYSA-N tert-butyl benzenecarboperoxoate Chemical compound CC(C)(C)OOC(=O)C1=CC=CC=C1 GJBRNHKUVLOCEB-UHFFFAOYSA-N 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
125000004495 thiazol-4-yl group Chemical group S1C=NC(=C1)* 0.000 description 1
HPGGPRDJHPYFRM-UHFFFAOYSA-J tin(iv) chloride Chemical compound Cl[Sn](Cl)(Cl)Cl HPGGPRDJHPYFRM-UHFFFAOYSA-J 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
229940029284 trichlorofluoromethane Drugs 0.000 description 1
239000012588 trypsin Substances 0.000 description 1
230000002485 urinary effect Effects 0.000 description 1
238000010792 warming Methods 0.000 description 1
238000005406 washing Methods 0.000 description 1
239000003643 water by type Substances 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicinal Preparation (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Adhesives Or Adhesive Processes (AREA)

APAP/P/1998/001199A 1997-02-28 1998-02-26 Atropisomers of 3-Aryl-4-"Quinazolinones and use thereof for treating neorodegenerative conditions". AP859A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US3890597P	1997-02-28	1997-02-28
PCT/IB1998/000150 WO1998038173A1 (fr)	1997-02-28	1998-02-06	Atropisomeres de 3-aryl-4(3h)-quinazolinones et leur utilisation comme antagonistes des recepteurs de l'ampa

Publications (2)

Publication Number	Publication Date
AP9801199A0 AP9801199A0 (en)	1998-03-31
AP859A true AP859A (en)	2000-07-21

Family

ID=21902563

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
APAP/P/1998/001199A AP859A (en)	1997-02-28	1998-02-26	Atropisomers of 3-Aryl-4-"Quinazolinones and use thereof for treating neorodegenerative conditions".

Country Status (40)

Country	Link
US (1)	US6306864B1 (fr)
EP (1)	EP0968194B1 (fr)
JP (1)	JP2000509731A (fr)
KR (1)	KR100358636B1 (fr)
CN (1)	CN1248248A (fr)
AP (1)	AP859A (fr)
AR (1)	AR011170A1 (fr)
AT (1)	ATE267817T1 (fr)
AU (1)	AU744028B2 (fr)
BG (1)	BG103689A (fr)
BR (1)	BR9807872A (fr)
CA (1)	CA2282277C (fr)
DE (1)	DE69824157T2 (fr)
DK (1)	DK0968194T3 (fr)
DZ (1)	DZ2440A1 (fr)
EA (1)	EA001963B1 (fr)
ES (1)	ES2219866T3 (fr)
GT (1)	GT199800038A (fr)
HR (1)	HRP980106A2 (fr)
HU (1)	HUP0000914A3 (fr)
ID (1)	ID22711A (fr)
IL (1)	IL130900A0 (fr)
IS (1)	IS1952B (fr)
MA (1)	MA24484A1 (fr)
NO (1)	NO313630B1 (fr)
NZ (1)	NZ336628A (fr)
OA (1)	OA11089A (fr)
PA (1)	PA8447001A1 (fr)
PE (1)	PE58399A1 (fr)
PL (1)	PL335418A1 (fr)
PT (1)	PT968194E (fr)
SK (1)	SK113299A3 (fr)
TN (1)	TNSN98035A1 (fr)
TR (1)	TR199902093T2 (fr)
TW (1)	TW504508B (fr)
UA (1)	UA61097C2 (fr)
UY (1)	UY24897A1 (fr)
WO (1)	WO1998038173A1 (fr)
YU (1)	YU41299A (fr)
ZA (1)	ZA981666B (fr)

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JPH11279158A (ja) *	1998-02-09	1999-10-12	Pfizer Prod Inc	キナゾリン―４―オン誘導体の製造方法
NZ522076A (en) *	2000-04-25	2005-08-26	Icos Corp	Inhibitors of human phosphatidyl-inositol 3-kinase delta
US6667300B2 (en)	2000-04-25	2003-12-23	Icos Corporation	Inhibitors of human phosphatidylinositol 3-kinase delta
CN1245386C (zh)	2000-06-12	2006-03-15	卫材株式会社	1,2－二氢吡啶化合物及其制备方法和用途
EP1288205B1 (fr)	2000-08-18	2011-02-02	Ajinomoto Co., Inc.	Nouveaux derives de phenylalanine
GB0129260D0 (en)	2001-12-06	2002-01-23	Eisai London Res Lab Ltd	Pharmaceutical compositions and their uses
US6939968B2 (en) *	2002-12-23	2005-09-06	Bristol-Myers Squibb Company	Atropisomers of 3-substituted-4-arylquinolin-2-one derivatives
MXPA06001552A (es) *	2003-08-08	2006-09-04	Ulysses Pharmaceutical Product	Quinazolinil nitrofuranos halogenados como agentes antibacterianos.
US20080146562A1 (en) *	2003-08-08	2008-06-19	Ulysses Pharmaceutical Products Inc.,	Halogenated quinazolinyl nitrofurans as antibacterial agents
GB0325390D0 (en) *	2003-10-30	2003-12-03	Novartis Ag	Organic compounds
RU2390520C2 (ru)	2003-12-22	2010-05-27	Адзиномото Ко., Инк.	Новые производные фенилаланина
RS55551B1 (sr)	2004-05-13	2017-05-31	Icos Corp	Hinazolinoni kao inhibitori humane fosfatidilinozitol 3-kinaze delta
MY148809A (en)	2004-07-06	2013-05-31	Eisai R&D Man Co Ltd	Crystals of 1,2-dihydropyridine compound and their production process
GB0416730D0 (en) *	2004-07-27	2004-09-01	Novartis Ag	Organic compounds
AU2006311883A1 (en)	2005-11-04	2007-05-18	Hydra Biosciences, Inc.	Compounds for modulating TRPV3 function
MX2009003673A (es)	2006-10-04	2009-04-22	Pfizer Prod Inc	Derivados de piridido[4,3-d]pirimidin-4(3h)-ona como antagonistas de los receptores de calcio.
WO2008140750A1 (fr)	2007-05-10	2008-11-20	Hydra Biosciences Inc.	Composés modulant la fonction du trp v3
CN101429166B (zh) *	2007-11-07	2013-08-21	上海特化医药科技有限公司	喹唑啉酮衍生物及其制备方法和用途
US9492449B2 (en)	2008-11-13	2016-11-15	Gilead Calistoga Llc	Therapies for hematologic malignancies
CN102271683B (zh)	2008-11-13	2014-07-09	吉里德卡利斯托加公司	恶性血液病的治疗
CA2756347A1 (fr)	2009-03-24	2010-09-30	Gilead Calistoga Llc	Atropisomeres de derives de 2-purinyl-3-tolyl-quinazolinone et procedes d'utilisation
CA2768843A1 (fr)	2009-07-21	2011-01-27	Gilead Calistoga Llc	Traitement de troubles du foie par des inhibiteurs de pi3k
AR090253A1 (es)	2012-03-05	2014-10-29	Gilead Calistoga Llc	Formas polimorficas de (s)-2-(1-(9h-purin-6-ilamino)propil)-5-fluor-3-fenilquinazolin-4(3h)-ona
CN103275086B (zh) *	2013-05-30	2015-04-15	温州大学	一种6-取代喹唑啉并喹唑啉酮化合物及其合成方法和用途
JP2017500319A (ja)	2013-12-20	2017-01-05	ギリアードカリストガエルエルシー	（ｓ）−２−（１−（９ｈ−プリン−６−イルアミノ）プロピル）−５−フルオロ−３−フェニルキナゾリン−４（３ｈ）−オンの塩酸塩の多形形態
MX2016008259A (es)	2013-12-20	2016-10-13	Gilead Calistoga Llc	Metodo de proceso para inhibidores de fosfatidilinositol 3-cinasa.
US9533909B2 (en)	2014-03-31	2017-01-03	Corning Incorporated	Methods and apparatus for material processing using atmospheric thermal plasma reactor
AU2015274696B2 (en)	2014-06-13	2018-09-27	Gilead Sciences, Inc.	Phosphatidylinositol 3-kinase inhibitors
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1998
- 1998-02-06 TR TR1999/02093T patent/TR199902093T2/xx unknown
- 1998-02-06 DE DE69824157T patent/DE69824157T2/de not_active Expired - Fee Related
- 1998-02-06 PL PL98335418A patent/PL335418A1/xx unknown
- 1998-02-06 YU YU41299A patent/YU41299A/sh unknown
- 1998-02-06 AT AT98900978T patent/ATE267817T1/de not_active IP Right Cessation
- 1998-02-06 ID IDW990937A patent/ID22711A/id unknown
- 1998-02-06 JP JP10537448A patent/JP2000509731A/ja active Pending
- 1998-02-06 ES ES98900978T patent/ES2219866T3/es not_active Expired - Lifetime
- 1998-02-06 NZ NZ336628A patent/NZ336628A/xx unknown
- 1998-02-06 IL IL13090098A patent/IL130900A0/xx unknown
- 1998-02-06 CA CA002282277A patent/CA2282277C/fr not_active Expired - Fee Related
- 1998-02-06 BR BR9807872A patent/BR9807872A/pt not_active Application Discontinuation
- 1998-02-06 US US09/367,960 patent/US6306864B1/en not_active Expired - Fee Related
- 1998-02-06 PT PT98900978T patent/PT968194E/pt unknown
- 1998-02-06 AU AU56768/98A patent/AU744028B2/en not_active Ceased
- 1998-02-06 HU HU0000914A patent/HUP0000914A3/hu unknown
- 1998-02-06 DK DK98900978T patent/DK0968194T3/da active
- 1998-02-06 KR KR1019997007887A patent/KR100358636B1/ko not_active Expired - Fee Related
- 1998-02-06 SK SK1132-99A patent/SK113299A3/sk unknown
- 1998-02-06 CN CN98802638A patent/CN1248248A/zh active Pending
- 1998-02-06 WO PCT/IB1998/000150 patent/WO1998038173A1/fr not_active Ceased
- 1998-02-06 EP EP98900978A patent/EP0968194B1/fr not_active Expired - Lifetime
- 1998-02-06 EA EA199900693A patent/EA001963B1/ru not_active IP Right Cessation
- 1998-02-17 PA PA19988447001A patent/PA8447001A1/es unknown
- 1998-02-19 GT GT199800038A patent/GT199800038A/es unknown
- 1998-02-20 UY UY24897A patent/UY24897A1/es not_active Application Discontinuation
- 1998-02-23 PE PE1998000126A patent/PE58399A1/es not_active Application Discontinuation
- 1998-02-25 TW TW087102714A patent/TW504508B/zh not_active IP Right Cessation
- 1998-02-25 DZ DZ980050A patent/DZ2440A1/fr active
- 1998-02-25 MA MA24978A patent/MA24484A1/fr unknown
- 1998-02-25 TN TNTNSN98035A patent/TNSN98035A1/fr unknown
- 1998-02-26 AR ARP980100871A patent/AR011170A1/es not_active Application Discontinuation
- 1998-02-26 AP APAP/P/1998/001199A patent/AP859A/en active
- 1998-02-27 HR HR60/038,905A patent/HRP980106A2/hr not_active Application Discontinuation
- 1998-02-27 ZA ZA9801666A patent/ZA981666B/xx unknown
- 1998-06-02 UA UA99084849A patent/UA61097C2/uk unknown
1999
- 1999-07-30 IS IS5140A patent/IS1952B/is unknown
- 1999-08-20 OA OA9900187A patent/OA11089A/en unknown
- 1999-08-24 BG BG103689A patent/BG103689A/bg unknown
- 1999-08-27 NO NO19994177A patent/NO313630B1/no not_active IP Right Cessation

Non-Patent Citations (1)

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BR9807872A (pt)	2000-03-21
HRP980106A2 (en)	1999-02-28
DE69824157T2 (de)	2004-10-14
US6306864B1 (en)	2001-10-23
NO313630B1 (no)	2002-11-04
WO1998038173A1 (fr)	1998-09-03
BG103689A (bg)	2000-11-30
DE69824157D1 (de)	2004-07-01
YU41299A (sh)	2002-09-19
CA2282277A1 (fr)	1998-09-03
EP0968194B1 (fr)	2004-05-26
OA11089A (en)	2003-09-22
TW504508B (en)	2002-10-01
IS1952B (is)	2004-10-13
JP2000509731A (ja)	2000-08-02
ZA981666B (en)	1999-08-27
ES2219866T3 (es)	2004-12-01
PE58399A1 (es)	1999-06-16
HUP0000914A2 (hu)	2001-04-28
NZ336628A (en)	2001-03-30
PT968194E (pt)	2004-08-31
SK113299A3 (en)	2001-05-10
PA8447001A1 (es)	2000-05-24
AR011170A1 (es)	2000-08-02
NO994177D0 (no)	1999-08-27
NO994177L (no)	1999-08-27
KR20000075814A (ko)	2000-12-26
TNSN98035A1 (fr)	2005-03-15
AU744028B2 (en)	2002-02-14
PL335418A1 (en)	2000-04-25
AP9801199A0 (en)	1998-03-31
TR199902093T2 (xx)	1999-12-21
CN1248248A (zh)	2000-03-22
IL130900A0 (en)	2001-01-28
UA61097C2 (uk)	2003-11-17
EA199900693A1 (ru)	2000-02-28
CA2282277C (fr)	2005-10-11
MA24484A1 (fr)	1998-10-01
HUP0000914A3 (en)	2001-09-28
EP0968194A1 (fr)	2000-01-05
ID22711A (id)	1999-12-09
UY24897A1 (es)	2000-12-29
KR100358636B1 (ko)	2002-10-31
DK0968194T3 (da)	2004-08-16
IS5140A (is)	1999-07-30
DZ2440A1 (fr)	2003-01-11
GT199800038A (es)	1999-08-13
AU5676898A (en)	1998-09-18
ATE267817T1 (de)	2004-06-15
EA001963B1 (ru)	2001-10-22

Publication	Publication Date	Title
AP859A (en)	2000-07-21	Atropisomers of 3-Aryl-4-"Quinazolinones and use thereof for treating neorodegenerative conditions".
US6303615B1 (en)	2001-10-16	2,3 disubstituded-4(3H)-quinazolinones
US6060479A (en)	2000-05-09	Quinazoline-4-one AMPA antagonists
EP0900799B1 (fr)	2005-06-08	Nouveaux atropismères de (5,6)-Pyrimidin-4-ones condensés à hétéroaryle, substitués en 2,3
US6380204B1 (en)	2002-04-30	Atropisomers of 3-heteroaryl-4(3H)-quinazolinones for the treatment of neurodegenerative and CNS-trauma related conditions
CZ9902994A3 (cs)	2000-11-15	Aťropoisomery 3-aryl-4(3H)-chinazolinonů a jejich použití jako antagonizujících činidel receptoru AMPA
MXPA99008012A (en)	2000-01-01	Atropisomers of 3-aryl-4(3h)-quinazolinones and their use as ampa-receptor antagonists
CZ9902995A3 (cs)	2000-12-13	Atropoisomery 3-heteroaryl-4(3H)-chinazolinonů I pro léčení neurodegenaritivních stavů a stavů odvozených od CNS-traumatu