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TNSN97060A1 - Procede pour preparer des acides cycloalcano - indole - et azaindole- et pyrimido (1,2-a) indole-carboxylique purs d'un point de vue enantiomere, et leurs derives actives - Google Patents

Procede pour preparer des acides cycloalcano - indole - et azaindole- et pyrimido (1,2-a) indole-carboxylique purs d'un point de vue enantiomere, et leurs derives actives

Info

Publication number
TNSN97060A1
TNSN97060A1 TNTNSN97060A TNSN97060A TNSN97060A1 TN SN97060 A1 TNSN97060 A1 TN SN97060A1 TN TNSN97060 A TNTNSN97060 A TN TNSN97060A TN SN97060 A TNSN97060 A TN SN97060A TN SN97060 A1 TNSN97060 A1 TN SN97060A1
Authority
TN
Tunisia
Prior art keywords
indole
pyrimido
cycloalcano
enantiomeric
preparing
Prior art date
Application number
TNTNSN97060A
Other languages
English (en)
Inventor
Jan-Bernd Lenfers Dr
Peter Fey Dr
Paul Naab Dr
Kai Van Laak Dr
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of TNSN97060A1 publication Critical patent/TNSN97060A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/612—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/612—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety
    • C07C69/616—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/62—Halogen-containing esters
    • C07C69/65—Halogen-containing esters of unsaturated acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'INVENTION CONCERNE UN PROCEDE ET DES INTERMEDIAIRES POUR PREPARER DES ACIDES CYCLOALCANO-INDOLECARBOXYLIQUE ET DES ACIDES AZAINDOLECARBOXYLIQUE ET DES ACIDES PYRIMIDO (1, 2-a) INDOLECARBOXYLIQUES PURS D’UN POINT DE VUE ENANTIOMERE, ET LEUR DERIVES ACTIVES, CARACTERISES EN CE QUE L’ACIDE TOLYLACETIQUE EST D’ABORD ESTERIFIE AVEC UN ALCOOL CHIRAL, PUIS ON PROCEDE A UNE SUBSTITUTION DIASTERIOSELECTIVE AU NIVEAU DES ATOMES DE CARBONE ل, CE PRODUIT ETANT HALOGENE DANS LE GROUPE TOLYLE PUIS ETANT MIS A REAGIR AVEC DES CYCLOALCANO-INDOLE, DES CYCLOALCANOLAZAINDOLE OU DES PYRIMIDO (1,2-a) INDOLES APPROPRIES. CE PROCEDE PERMET DE PREPARER PLUS PRECISEMENT ET AVEC UNE GRANDE PURETE LES ACIDES CARBOXYLIQUES PURS D’UN POINT DE VUE ENANTIOMERE, QUI SONT DES INTERMEDIAIRES POUR DES MEDICAMENTS DE GRANDE VALEUR.
TNTNSN97060A 1996-04-04 1997-04-02 Procede pour preparer des acides cycloalcano - indole - et azaindole- et pyrimido (1,2-a) indole-carboxylique purs d'un point de vue enantiomere, et leurs derives actives TNSN97060A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19613549A DE19613549A1 (de) 1996-04-04 1996-04-04 Verfahren zur Herstellung von enantiomerenreinen Cycloalkano-indol- und azaindol-carbonsäuren und deren aktivierte Derivate

Publications (1)

Publication Number Publication Date
TNSN97060A1 true TNSN97060A1 (fr) 2005-03-15

Family

ID=7790501

Family Applications (1)

Application Number Title Priority Date Filing Date
TNTNSN97060A TNSN97060A1 (fr) 1996-04-04 1997-04-02 Procede pour preparer des acides cycloalcano - indole - et azaindole- et pyrimido (1,2-a) indole-carboxylique purs d'un point de vue enantiomere, et leurs derives actives

Country Status (27)

Country Link
US (1) US5952498A (fr)
EP (1) EP0799829B1 (fr)
JP (2) JP4235268B2 (fr)
KR (1) KR970069988A (fr)
CN (2) CN1067394C (fr)
AR (2) AR006544A1 (fr)
AT (1) ATE246193T1 (fr)
AU (1) AU722592B2 (fr)
BR (1) BR9701672A (fr)
CA (1) CA2201435C (fr)
CZ (1) CZ102197A3 (fr)
DE (2) DE19613549A1 (fr)
DZ (1) DZ2202A1 (fr)
EE (1) EE9700079A (fr)
ES (1) ES2202506T3 (fr)
HR (1) HRP970178A2 (fr)
HU (1) HU218494B (fr)
ID (1) ID16794A (fr)
IL (1) IL120591A (fr)
MA (1) MA24130A1 (fr)
NO (2) NO308301B1 (fr)
NZ (1) NZ314498A (fr)
PL (1) PL319269A1 (fr)
SG (1) SG60050A1 (fr)
SK (1) SK42897A3 (fr)
TN (1) TNSN97060A1 (fr)
ZA (1) ZA972831B (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4435477A1 (de) 1994-10-04 1996-04-11 Bayer Ag Cycloalkano-indol- und -azaindol-derivate
WO2001074817A1 (fr) * 2000-03-30 2001-10-11 Yamanouchi Pharmaceutical Co., Ltd. Derives d'hydrazide
WO2005051382A1 (fr) * 2003-11-28 2005-06-09 Astellas Pharma Inc. Agent renforçant l'effet hypolipidemiant
JP5697296B2 (ja) 2004-03-05 2015-04-08 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 高脂血症および高コレステロール血症に関連する障害または疾患を、副作用を最小限にしつつ処置するための方法
WO2005097131A2 (fr) * 2004-04-09 2005-10-20 Janssen Pharmaceutica N.V. Schema posologique intermittent destine a des sujets obeses ou en surpoids
US20070088089A1 (en) * 2005-10-18 2007-04-19 Wisler Gerald L Methods for treating disorders associated with hyperlipidemia in a mammal
AU2007252994A1 (en) * 2006-05-18 2007-11-29 Bayer Healthcare Ag Pharmaceutical compositions comprising implitapide and methods of using same
AU2007338625A1 (en) * 2006-12-21 2008-07-03 Aegerion Pharmaceuticals, Inc. Methods for treating obesity with a combination comprising a MTP inhibitor and a cholesterol absorption inhibitor
WO2008124384A2 (fr) * 2007-04-03 2008-10-16 Aegerion Pharmaceuticals, Inc. Méthodes de traitement de l'hépatite c
PL2968284T3 (pl) 2013-03-14 2021-09-27 Osteoqc Inc. Pochodne alkilo-amino harminy wspierające wzrost kości
CA3109104A1 (fr) 2018-08-14 2020-02-20 Osteoqc Inc. Composes .beta.-carboline fluores
CN112996506A (zh) 2018-08-14 2021-06-18 奥斯特克有限公司 吡咯并二吡啶化合物
CN116322682A (zh) 2020-07-29 2023-06-23 艾米琳制药有限责任公司 在治疗儿科患者的高脂血症和高胆固醇血症的方法中使用的洛美他派

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3900261A1 (de) * 1988-05-31 1989-12-07 Bayer Ag Substituierte 4-(chinolin-2-yl-methoxy) phenyl-essigsaeure-derivate
DE4200954A1 (de) * 1991-04-26 1992-10-29 Bayer Ag Heterocyclisch substituierte phenylessigsaeurederivate
DE4208051A1 (de) * 1992-03-13 1993-09-16 Bayer Ag Substituierte phenylessigsaeureamide
DE4302956A1 (de) * 1993-02-03 1994-08-04 Bayer Ag Substituierte Imidazo(4,5-b)pyridine und Benzimidazole
DE4435477A1 (de) * 1994-10-04 1996-04-11 Bayer Ag Cycloalkano-indol- und -azaindol-derivate

Also Published As

Publication number Publication date
ES2202506T3 (es) 2004-04-01
NO971513L (no) 1997-10-06
HU9700698D0 (en) 1997-05-28
NO20003784L (no) 1997-10-06
EP0799829B1 (fr) 2003-07-30
NO971513D0 (no) 1997-04-03
SG60050A1 (en) 1999-02-22
ZA972831B (en) 1997-10-31
DE59710487D1 (de) 2003-09-04
NO308301B1 (no) 2000-08-28
MX9702446A (es) 1997-10-31
AU722592B2 (en) 2000-08-10
IL120591A0 (en) 1997-08-14
CA2201435C (fr) 2006-12-12
IL120591A (en) 2000-11-21
HUP9700698A1 (hu) 1998-01-28
CN1184109A (zh) 1998-06-10
KR970069988A (ko) 1997-11-07
SK42897A3 (en) 1997-10-08
JP4235268B2 (ja) 2009-03-11
CA2201435A1 (fr) 1997-10-04
US5952498A (en) 1999-09-14
CN1067394C (zh) 2001-06-20
BR9701672A (pt) 1998-11-03
JPH1045759A (ja) 1998-02-17
AR012048A2 (es) 2000-09-27
DZ2202A1 (fr) 2002-12-03
ID16794A (id) 1997-11-13
CZ102197A3 (en) 1997-10-15
ATE246193T1 (de) 2003-08-15
AU1660297A (en) 1997-10-09
HU218494B (hu) 2000-09-28
CN1330065A (zh) 2002-01-09
PL319269A1 (en) 1997-10-13
NZ314498A (en) 1999-09-29
EP0799829A1 (fr) 1997-10-08
HRP970178A2 (en) 1998-04-30
DE19613549A1 (de) 1997-10-09
MA24130A1 (fr) 1997-10-01
AR006544A1 (es) 1999-09-08
NO20003784D0 (no) 2000-07-24
EE9700079A (et) 1997-10-15
JP2008169218A (ja) 2008-07-24

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