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AR006544A1 - Procedimiento para la preparacion de acidos cicloalcano-indol- y aza-indol y pirimido[1,2a]indol-carboxilicos enantiomeros puros y susderivados activados y compuestos intermediarios para dicho procedimiento - Google Patents

Procedimiento para la preparacion de acidos cicloalcano-indol- y aza-indol y pirimido[1,2a]indol-carboxilicos enantiomeros puros y susderivados activados y compuestos intermediarios para dicho procedimiento

Info

Publication number
AR006544A1
AR006544A1 ARP970101366A ARP970101366A AR006544A1 AR 006544 A1 AR006544 A1 AR 006544A1 AR P970101366 A ARP970101366 A AR P970101366A AR P970101366 A ARP970101366 A AR P970101366A AR 006544 A1 AR006544 A1 AR 006544A1
Authority
AR
Argentina
Prior art keywords
indol
procedure
aza
indoles
activated
Prior art date
Application number
ARP970101366A
Other languages
English (en)
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of AR006544A1 publication Critical patent/AR006544A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/612—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/612—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety
    • C07C69/616—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/62—Halogen-containing esters
    • C07C69/65—Halogen-containing esters of unsaturated acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Se refiere a un procedimiento y productos intermedios para la obtención de ácido cicloalcano-indol- y aza-indol y pirimido-[1,2a]-indol carboxílicosenantiómeros puros así como sus derivados activados, en el cual se esterifica un primer lugarel ácido tolil-acético con un alcohol quiral, se realiza acontinuación una sustitución distereoselectriva en los átomos de carbono en alfa- y este producto se halogena en el grupo tolilo y a continuación sehace reaccionar con loscorrespondientes c icloalcano-indoles, aza-indoles o pirimido-[1,2a]-indoles, aza-indoles o pirimido-[1,2a]-indoles. Con esteprocedimiento es posible obtener específicamente los ácidos carboxílicos enantiómeros puros, que constituyenproductos intermedios pa ra valiososmedicamentos, con alta pureza.
ARP970101366A 1996-04-04 1997-04-04 Procedimiento para la preparacion de acidos cicloalcano-indol- y aza-indol y pirimido[1,2a]indol-carboxilicos enantiomeros puros y susderivados activados y compuestos intermediarios para dicho procedimiento AR006544A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19613549A DE19613549A1 (de) 1996-04-04 1996-04-04 Verfahren zur Herstellung von enantiomerenreinen Cycloalkano-indol- und azaindol-carbonsäuren und deren aktivierte Derivate

Publications (1)

Publication Number Publication Date
AR006544A1 true AR006544A1 (es) 1999-09-08

Family

ID=7790501

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP970101366A AR006544A1 (es) 1996-04-04 1997-04-04 Procedimiento para la preparacion de acidos cicloalcano-indol- y aza-indol y pirimido[1,2a]indol-carboxilicos enantiomeros puros y susderivados activados y compuestos intermediarios para dicho procedimiento
ARP980101029A AR012048A2 (es) 1996-04-04 1998-03-06 Derivados del acido fenil cicloalquilcarboxilicos y el uso de los mismos

Family Applications After (1)

Application Number Title Priority Date Filing Date
ARP980101029A AR012048A2 (es) 1996-04-04 1998-03-06 Derivados del acido fenil cicloalquilcarboxilicos y el uso de los mismos

Country Status (27)

Country Link
US (1) US5952498A (es)
EP (1) EP0799829B1 (es)
JP (2) JP4235268B2 (es)
KR (1) KR970069988A (es)
CN (2) CN1067394C (es)
AR (2) AR006544A1 (es)
AT (1) ATE246193T1 (es)
AU (1) AU722592B2 (es)
BR (1) BR9701672A (es)
CA (1) CA2201435C (es)
CZ (1) CZ102197A3 (es)
DE (2) DE19613549A1 (es)
DZ (1) DZ2202A1 (es)
EE (1) EE9700079A (es)
ES (1) ES2202506T3 (es)
HR (1) HRP970178A2 (es)
HU (1) HU218494B (es)
ID (1) ID16794A (es)
IL (1) IL120591A (es)
MA (1) MA24130A1 (es)
NO (2) NO308301B1 (es)
NZ (1) NZ314498A (es)
PL (1) PL319269A1 (es)
SG (1) SG60050A1 (es)
SK (1) SK42897A3 (es)
TN (1) TNSN97060A1 (es)
ZA (1) ZA972831B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4435477A1 (de) 1994-10-04 1996-04-11 Bayer Ag Cycloalkano-indol- und -azaindol-derivate
WO2001074817A1 (en) * 2000-03-30 2001-10-11 Yamanouchi Pharmaceutical Co., Ltd. Hydrazide derivatives
WO2005051382A1 (ja) * 2003-11-28 2005-06-09 Astellas Pharma Inc. 脂質低下作用増強剤
JP5697296B2 (ja) 2004-03-05 2015-04-08 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 高脂血症および高コレステロール血症に関連する障害または疾患を、副作用を最小限にしつつ処置するための方法
WO2005097131A2 (en) * 2004-04-09 2005-10-20 Janssen Pharmaceutica N.V. Intermittent dosing regimen for the treatment of overweight with mtp-inhibitors
US20070088089A1 (en) * 2005-10-18 2007-04-19 Wisler Gerald L Methods for treating disorders associated with hyperlipidemia in a mammal
AU2007252994A1 (en) * 2006-05-18 2007-11-29 Bayer Healthcare Ag Pharmaceutical compositions comprising implitapide and methods of using same
AU2007338625A1 (en) * 2006-12-21 2008-07-03 Aegerion Pharmaceuticals, Inc. Methods for treating obesity with a combination comprising a MTP inhibitor and a cholesterol absorption inhibitor
WO2008124384A2 (en) * 2007-04-03 2008-10-16 Aegerion Pharmaceuticals, Inc. Combinations of mtp inhibitors with cholesterol absorption inhibitors or interferon for treating hepatitis c
PL2968284T3 (pl) 2013-03-14 2021-09-27 Osteoqc Inc. Pochodne alkilo-amino harminy wspierające wzrost kości
CA3109104A1 (en) 2018-08-14 2020-02-20 Osteoqc Inc. Fluoro .beta.-carboline compounds
CN112996506A (zh) 2018-08-14 2021-06-18 奥斯特克有限公司 吡咯并二吡啶化合物
CN116322682A (zh) 2020-07-29 2023-06-23 艾米琳制药有限责任公司 在治疗儿科患者的高脂血症和高胆固醇血症的方法中使用的洛美他派

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3900261A1 (de) * 1988-05-31 1989-12-07 Bayer Ag Substituierte 4-(chinolin-2-yl-methoxy) phenyl-essigsaeure-derivate
DE4200954A1 (de) * 1991-04-26 1992-10-29 Bayer Ag Heterocyclisch substituierte phenylessigsaeurederivate
DE4208051A1 (de) * 1992-03-13 1993-09-16 Bayer Ag Substituierte phenylessigsaeureamide
DE4302956A1 (de) * 1993-02-03 1994-08-04 Bayer Ag Substituierte Imidazo(4,5-b)pyridine und Benzimidazole
DE4435477A1 (de) * 1994-10-04 1996-04-11 Bayer Ag Cycloalkano-indol- und -azaindol-derivate

Also Published As

Publication number Publication date
ES2202506T3 (es) 2004-04-01
NO971513L (no) 1997-10-06
HU9700698D0 (en) 1997-05-28
NO20003784L (no) 1997-10-06
EP0799829B1 (de) 2003-07-30
NO971513D0 (no) 1997-04-03
SG60050A1 (en) 1999-02-22
ZA972831B (en) 1997-10-31
DE59710487D1 (de) 2003-09-04
NO308301B1 (no) 2000-08-28
MX9702446A (es) 1997-10-31
AU722592B2 (en) 2000-08-10
IL120591A0 (en) 1997-08-14
CA2201435C (en) 2006-12-12
IL120591A (en) 2000-11-21
HUP9700698A1 (hu) 1998-01-28
CN1184109A (zh) 1998-06-10
KR970069988A (ko) 1997-11-07
SK42897A3 (en) 1997-10-08
JP4235268B2 (ja) 2009-03-11
CA2201435A1 (en) 1997-10-04
US5952498A (en) 1999-09-14
CN1067394C (zh) 2001-06-20
BR9701672A (pt) 1998-11-03
TNSN97060A1 (fr) 2005-03-15
JPH1045759A (ja) 1998-02-17
AR012048A2 (es) 2000-09-27
DZ2202A1 (fr) 2002-12-03
ID16794A (id) 1997-11-13
CZ102197A3 (en) 1997-10-15
ATE246193T1 (de) 2003-08-15
AU1660297A (en) 1997-10-09
HU218494B (hu) 2000-09-28
CN1330065A (zh) 2002-01-09
PL319269A1 (en) 1997-10-13
NZ314498A (en) 1999-09-29
EP0799829A1 (de) 1997-10-08
HRP970178A2 (en) 1998-04-30
DE19613549A1 (de) 1997-10-09
MA24130A1 (fr) 1997-10-01
NO20003784D0 (no) 2000-07-24
EE9700079A (et) 1997-10-15
JP2008169218A (ja) 2008-07-24

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