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TNSN92073A1 - QUATERNARY AMMONIUM DERIVATIVES OF (+) AND (-) 10- (1-AZABICYCLO [2,2,2] OCT-3-YL-METHYL) -10-H-PHENOTHIAZINE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR THEIR PREPARATION - Google Patents

QUATERNARY AMMONIUM DERIVATIVES OF (+) AND (-) 10- (1-AZABICYCLO [2,2,2] OCT-3-YL-METHYL) -10-H-PHENOTHIAZINE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR THEIR PREPARATION

Info

Publication number
TNSN92073A1
TNSN92073A1 TNTNSN92073A TNSN92073A TNSN92073A1 TN SN92073 A1 TNSN92073 A1 TN SN92073A1 TN TNSN92073 A TNTNSN92073 A TN TNSN92073A TN SN92073 A TNSN92073 A TN SN92073A TN SN92073 A1 TNSN92073 A1 TN SN92073A1
Authority
TN
Tunisia
Prior art keywords
azabicyclo
phenothiazine
oct
methyl
preparation
Prior art date
Application number
TNTNSN92073A
Other languages
French (fr)
Inventor
Giorgi Raffaello
Subissi Alessandro
Turbanti Luigi
Original Assignee
Guidotti & C Spa Labor
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guidotti & C Spa Labor filed Critical Guidotti & C Spa Labor
Publication of TNSN92073A1 publication Critical patent/TNSN92073A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

LA DESCRIPTION A POUR OBJET LES DERIVES D'AMMONIUM QUATERNAIRE DE 10-(1-AZABICYCLO[2,2,2]OCT-3-YL-METHYL)-10-H-PHENOTHIAZINE ENANTIOMORPHES DEXTROGYRE (+) ET LEVOGYRE (-) PRESENTANT LA FORMULE SUIVANTE (I). DANS LA QUELLE R EST UN RADICAL ALKYLE EN C1-C4 OU CYCLOPROPYLE ; X EST UN HALOGENE, LE SULFATE DE DIMETHYLE OU L'ACIDE P- TOLUENESULFONIQUE, ET SE RAPPORTE EGALEMENT A LA PREPARATION DE CES COMPOSES AINSI QU'AUX COMPOSITIONS PHARMACEUTIQUES LES CONTENANTTHE DESCRIPTION RELATES TO QUATERNARY AMMONIUM DERIVATIVES OF 10- (1-AZABICYCLO [2,2,2] OCT-3-YL-METHYL) -10-H-PHENOTHIAZINE ENANTIOMORPHES DEXTROGYRE (+) AND LEVOGYRE (-) PRESENT THE FOLLOWING FORMULA (I). IN WHICH R IS A C1-C4 ALKYL OR CYCLOPROPYL RADICAL; X IS A HALOGEN, DIMETHYL SULFATE OR P-TOLUENESULFONIC ACID, AND ALSO RELATES TO THE PREPARATION OF THESE COMPOUNDS AS WELL AS THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

TNTNSN92073A 1991-08-07 1992-08-05 QUATERNARY AMMONIUM DERIVATIVES OF (+) AND (-) 10- (1-AZABICYCLO [2,2,2] OCT-3-YL-METHYL) -10-H-PHENOTHIAZINE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR THEIR PREPARATION TNSN92073A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI912225A IT1251161B (en) 1991-08-07 1991-08-07 QUATERNARY AMMONIUM DERIVATIVES OF (-) AND (+) - 3- (10 H-PHENOTHIAZIN-10-ILMETHYL) -L-AZABICYCLE (2.2.2.) OCT AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Publications (1)

Publication Number Publication Date
TNSN92073A1 true TNSN92073A1 (en) 1993-06-08

Family

ID=11360550

Family Applications (1)

Application Number Title Priority Date Filing Date
TNTNSN92073A TNSN92073A1 (en) 1991-08-07 1992-08-05 QUATERNARY AMMONIUM DERIVATIVES OF (+) AND (-) 10- (1-AZABICYCLO [2,2,2] OCT-3-YL-METHYL) -10-H-PHENOTHIAZINE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR THEIR PREPARATION

Country Status (19)

Country Link
EP (1) EP0599896A1 (en)
JP (1) JPH06509570A (en)
CN (1) CN1071667A (en)
AU (1) AU2417392A (en)
BG (1) BG98439A (en)
BR (1) BR9206339A (en)
CA (1) CA2114844A1 (en)
CZ (1) CZ24894A3 (en)
EC (1) ECSP920859A (en)
FI (1) FI940530L (en)
HU (1) HUT66570A (en)
IT (1) IT1251161B (en)
MA (1) MA22611A1 (en)
MX (1) MX9204539A (en)
PT (1) PT100765A (en)
SK (1) SK11594A3 (en)
TN (1) TNSN92073A1 (en)
WO (1) WO1993003029A1 (en)
ZA (1) ZA925852B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0837436A1 (en) * 1996-10-18 1998-04-22 Yamaha Corporation Musical performance teaching system and method, and machine readable medium containing program therefore
WO2003105811A2 (en) * 2002-01-31 2003-12-24 Southwest Research Institute Controlled release compositions and methods for using same
FR2910814B1 (en) * 2006-12-28 2011-06-17 Pf Medicament USE OF 10- (R3) -1-AZABICYCLO2.2.2-OCT-3-YLMETHYL-10H-PHENOTHIAZINE FOR THE PREPARATION OF A MEDICAMENT EXERCISING SELECTIVE INHIBITION OF M1,2,3 MUSCARINIC RECEPTORS
FR2911606B1 (en) * 2007-01-18 2009-04-17 Pierre Fabre Medicament Sa NEW QUINUCLIDINE DERIVATIVE USEFUL IN THE PREPARATION OF MEQUITAZINE
FR2924344B1 (en) * 2007-12-04 2010-04-16 Pf Medicament USE OF MEQUITAZINE IN THE FORM OF RACEMATE OR ENANTIOMERS FOR THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OR PREVENTION OF PATHOLOGIES INVOLVING HISTAMIC RECEPTORS H4.
FR2970255B1 (en) * 2011-01-10 2013-09-06 Pf Medicament VINYL QUINUCLIDINE USEFUL AS A SYNTHETIC INTERMEDIARY IN THE PREPARATION OF (R) -MEQUITAZINE
JP7599646B2 (en) * 2020-10-29 2024-12-16 国立大学法人金沢大学 Radioactive fluorine-labeled diagnostic imaging agents for measuring drug-metabolizing enzyme activities

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2522660A1 (en) * 1982-03-05 1983-09-09 Pharmuka Lab MEQUITAZINE LEVOGYER ISOMER, PROCESS FOR PREPARING THE SAME AND MEDICAMENTS CONTAINING THE SAME
FR2526433B1 (en) * 1982-05-04 1985-10-18 Pharmuka Lab DEXTROGYRIC ISOMERS OF AZA-1 BICYCLO (2,2,2) OCTANE DERIVATIVES, THEIR PREPARATION METHOD AND MEDICAMENTS CONTAINING THEM
IT1173445B (en) * 1984-03-16 1987-06-24 Guidotti & C Spa Labor AGENTS WITH ANTIBRONCOSPASTIC ACTIVITY AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM

Also Published As

Publication number Publication date
EP0599896A1 (en) 1994-06-08
CA2114844A1 (en) 1993-02-18
ECSP920859A (en) 1993-08-03
MA22611A1 (en) 1993-04-01
ITMI912225A1 (en) 1993-02-07
WO1993003029A1 (en) 1993-02-18
PT100765A (en) 1993-10-29
ZA925852B (en) 1993-03-05
FI940530A0 (en) 1994-02-04
BG98439A (en) 1994-09-30
FI940530A7 (en) 1994-02-04
BR9206339A (en) 1994-11-08
HUT66570A (en) 1994-12-28
CN1071667A (en) 1993-05-05
SK11594A3 (en) 1994-12-07
MX9204539A (en) 1993-02-01
FI940530L (en) 1994-02-04
JPH06509570A (en) 1994-10-27
ITMI912225A0 (en) 1991-08-07
IT1251161B (en) 1995-05-04
AU2417392A (en) 1993-03-02
HU9400273D0 (en) 1994-05-30
CZ24894A3 (en) 1994-07-13

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