ITMI912225A1 - QUATERNARY AMMONIUM DERIVATIVES OF (-) AND (+) - 3- (10 H-PHENOTHIAZIN-10- ILMETHYL) -L-AZABICYCLE (2. 2. 2.) OCT AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - Google Patents

QUATERNARY AMMONIUM DERIVATIVES OF (-) AND (+) - 3- (10 H-PHENOTHIAZIN-10- ILMETHYL) -L-AZABICYCLE (2. 2. 2.) OCT AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Info

Publication number: ITMI912225A1
Authority: IT; Italy
Prior art keywords: azabicycle; ilmethyl; phenothiazin; oct; pharmaceutical compositions
Prior art date: 1991-08-07

Application number

IT002225A

Other languages

Italian (it)

Inventor

Raffaello Giorgi

Alessandro Subissi

Luigi Turbanti

Original Assignee

Guidotti & C Spa Labor

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-08-07

Filing date

1991-08-07

Publication date

1993-02-07

1991-08-07 Application filed by Guidotti & C Spa Labor filed Critical Guidotti & C Spa Labor

1991-08-07 Publication of ITMI912225A0 publication Critical patent/ITMI912225A0/en

1991-08-07 Priority to ITMI912225A priority Critical patent/IT1251161B/en

1992-08-03 Priority to JP5503276A priority patent/JPH06509570A/en

1992-08-03 Priority to SK115-94A priority patent/SK11594A3/en

1992-08-03 Priority to HU9400273A priority patent/HUT66570A/en

1992-08-03 Priority to PCT/EP1992/001759 priority patent/WO1993003029A1/en

1992-08-03 Priority to AU24173/92A priority patent/AU2417392A/en

1992-08-03 Priority to CS94248A priority patent/CZ24894A3/en

1992-08-03 Priority to FI940530A priority patent/FI940530L/en

1992-08-03 Priority to MA22900A priority patent/MA22611A1/en

1992-08-03 Priority to EP92916942A priority patent/EP0599896A1/en

1992-08-03 Priority to BR9206339A priority patent/BR9206339A/en

1992-08-03 Priority to CA002114844A priority patent/CA2114844A1/en

1992-08-04 Priority to ZA925852A priority patent/ZA925852B/en

1992-08-04 Priority to EC1992000859A priority patent/ECSP920859A/en

1992-08-05 Priority to TNTNSN92073A priority patent/TNSN92073A1/en

1992-08-05 Priority to MX9204539A priority patent/MX9204539A/en

1992-08-06 Priority to CN92109021A priority patent/CN1071667A/en

1992-08-07 Priority to PT100765A priority patent/PT100765A/en

1993-02-07 Publication of ITMI912225A1 publication Critical patent/ITMI912225A1/en

1994-02-04 Priority to NO940366A priority patent/NO940366L/en

1994-02-07 Priority to BG98439A priority patent/BG98439A/en

1995-05-04 Application granted granted Critical

1995-05-04 Publication of IT1251161B publication Critical patent/IT1251161B/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pulmonology (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

ITMI912225A 1991-08-07 1991-08-07 QUATERNARY AMMONIUM DERIVATIVES OF (-) AND (+) - 3- (10 H-PHENOTHIAZIN-10-ILMETHYL) -L-AZABICYCLE (2.2.2.) OCT AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM IT1251161B (en)

Priority Applications (20)

Application Number	Priority Date	Filing Date	Title
ITMI912225A IT1251161B (en)	1991-08-07	1991-08-07	QUATERNARY AMMONIUM DERIVATIVES OF (-) AND (+) - 3- (10 H-PHENOTHIAZIN-10-ILMETHYL) -L-AZABICYCLE (2.2.2.) OCT AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
BR9206339A BR9206339A (en)	1991-08-07	1992-08-03	(-) and (+) 10- (1-azabicycles (2.2.2) OCT-3-IL-Methyl) -10 H- Ammonia derivatives of quaternary phenothiazine, pharmaceutical compositions containing them and process for obtaining them
SK115-94A SK11594A3 (en)	1991-08-07	1992-08-03	(+) and (-) 10-(1-azabicyclo (2.2.2.) oct-3-yl methyl)-10 h-phenothiazine quaternary ammonium derivatives, pharmaceutical compositions containing them and process for their preparation
HU9400273A HUT66570A (en)	1991-08-07	1992-08-03	(-) and (+) 10-(1-azabicyclo[2,2,2]oct-3-yl-methyl)-10 h-phenothiazine quaternary ammonium derivatives, pharmaceutical compositions containing them and process for producing them
PCT/EP1992/001759 WO1993003029A1 (en)	1991-08-07	1992-08-03	(-) and (+) 10-(1-azabicyclo[2.2.2.]oct-3-yl-methyl)-10 h-phenothiazine quaternary ammonium derivatives, pharmaceutical compositions containing them and process for their preparation
AU24173/92A AU2417392A (en)	1991-08-07	1992-08-03	(-) and (+) 10-(1-azabicyclo{2.2.2.}oct-3-yl-methyl)-10 h-phenothiazine quaternary ammonium derivatives, pharmaceutical compositions containing them and process for their preparation
CS94248A CZ24894A3 (en)	1991-08-07	1992-08-03	Quaternary ammonium derivatives (-) and (+)-10- (azabicyclo/2.2.2/-oct-3-yl-methyl)-10h-phenothiazine, process of their preparation and pharmaceutical preparations in which they are comprised
FI940530A FI940530L (en)	1991-08-07	1992-08-03	Quaternary ammonium derivatives of (-) and (+) 10-(1-azabicyclo(2.2.2.)oct-3-ylmethyl-10-phenothiazine, pharmaceutical compositions containing them and method of preparing them
MA22900A MA22611A1 (en)	1991-08-07	1992-08-03	QUATERNARY AMMONIUM DERIVATIVES OF (+) AND (-) 10- (1-AZABICYCLO (2,2,2) OCT-3-YL-METHYL) -10-H-PHENO-THIAZINE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND METHOD FOR THEIR PREPARATION.
EP92916942A EP0599896A1 (en)	1991-08-07	1992-08-03	(-) and (+) 10-(1-azabicyclo 2.2.2.]oct-3-yl-methyl)-10 h-phenothiazine quaternary ammonium derivatives, pharmaceutical compositions containing them and process for their preparation
JP5503276A JPH06509570A (en)	1991-08-07	1992-08-03	Pharmaceutical compositions having (-) and (+) 10-(1-azabicyclo[2.2.2.]oct-3-yl-methyl)-10H-phenothiazine quaternary ammonium derivatives and their formulation process
CA002114844A CA2114844A1 (en)	1991-08-07	1992-08-03	(-) and (+) 10-(1-azabicyclo[2.2.2.]oct-3-yl-methyl)-10 h-phenothiazine quaternary ammonium derivatives, pharmaceutical compositions containing them and process for their preparation
ZA925852A ZA925852B (en)	1991-08-07	1992-08-04	(-) and (+) 10-(1-azabicyclo(2.2.2.)oct-3-yl-methyl)-10 h-phenothiazine quaternary ammonium derivatives, pharmaceutical compositions containing them and process for their preparation.
EC1992000859A ECSP920859A (en)	1991-08-07	1992-08-04	QUATERNARY AMMONIUM DERIVATIVES (-) AND (+) 10- (1 - AZABICICLO [2.2.2] OCT - 3 - IL - METHYL) - 10 H- PHENOTIAZINE, PROCEDURE TO OBTAIN THEM AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM
TNTNSN92073A TNSN92073A1 (en)	1991-08-07	1992-08-05	QUATERNARY AMMONIUM DERIVATIVES OF (+) AND (-) 10- (1-AZABICYCLO [2,2,2] OCT-3-YL-METHYL) -10-H-PHENOTHIAZINE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR THEIR PREPARATION
MX9204539A MX9204539A (en)	1991-08-07	1992-08-05	QUATERNARY AMMONIUM DERIVATIVES (-) AND (+) 10- (1-AZABICICLO (2.2.2) OCT-3-IL-METHYL) -10 H-PHENOTIAZINE, PROCEDURE TO OBTAIN THEM AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.
CN92109021A CN1071667A (en)	1991-08-07	1992-08-06	Phenothiazine quaternary ammonium derivative and process for preparing composition thereof
PT100765A PT100765A (en)	1991-08-07	1992-08-07	(+) 10- (1-AZABICYCLO (2.2.2.) OCT-3-IL-METHYL) -10H-PHENOTIAZINE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR THEIR PREPARATION
NO940366A NO940366L (en)	1991-08-07	1994-02-04	Quaternary (-) and (+) 10- (1-azabicyclo (2.2.2. Oct-3-yl-methyl) -10-H-phenothiazine ammonium derivatives, pharmaceutical compositions containing them, and methods for their preparation
BG98439A BG98439A (en)	1991-08-07	1994-02-07	QUATERNERIC AMMONIUM PRODUCTS OF (-) AND (+) 10- (1-AZOBICYCLE /2.2.2/OCT-3-IL-METHYL) 10H- PHENOTHIAZINE, PHARMACEUTICAL COMPOSITIONS AND THEIR BASIS

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
ITMI912225A IT1251161B (en)	1991-08-07	1991-08-07	QUATERNARY AMMONIUM DERIVATIVES OF (-) AND (+) - 3- (10 H-PHENOTHIAZIN-10-ILMETHYL) -L-AZABICYCLE (2.2.2.) OCT AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Publications (3)

Publication Number	Publication Date
ITMI912225A0 ITMI912225A0 (en)	1991-08-07
ITMI912225A1 true ITMI912225A1 (en)	1993-02-07
IT1251161B IT1251161B (en)	1995-05-04

Family

ID=11360550

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ITMI912225A IT1251161B (en)	1991-08-07	1991-08-07	QUATERNARY AMMONIUM DERIVATIVES OF (-) AND (+) - 3- (10 H-PHENOTHIAZIN-10-ILMETHYL) -L-AZABICYCLE (2.2.2.) OCT AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Country Status (19)

Country	Link
EP (1)	EP0599896A1 (en)
JP (1)	JPH06509570A (en)
CN (1)	CN1071667A (en)
AU (1)	AU2417392A (en)
BG (1)	BG98439A (en)
BR (1)	BR9206339A (en)
CA (1)	CA2114844A1 (en)
CZ (1)	CZ24894A3 (en)
EC (1)	ECSP920859A (en)
FI (1)	FI940530L (en)
HU (1)	HUT66570A (en)
IT (1)	IT1251161B (en)
MA (1)	MA22611A1 (en)
MX (1)	MX9204539A (en)
PT (1)	PT100765A (en)
SK (1)	SK11594A3 (en)
TN (1)	TNSN92073A1 (en)
WO (1)	WO1993003029A1 (en)
ZA (1)	ZA925852B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0837436A1 (en) *	1996-10-18	1998-04-22	Yamaha Corporation	Musical performance teaching system and method, and machine readable medium containing program therefore
WO2003105811A2 (en) *	2002-01-31	2003-12-24	Southwest Research Institute	Controlled release compositions and methods for using same
FR2910814B1 (en) *	2006-12-28	2011-06-17	Pf Medicament	USE OF 10- (R3) -1-AZABICYCLO2.2.2-OCT-3-YLMETHYL-10H-PHENOTHIAZINE FOR THE PREPARATION OF A MEDICAMENT EXERCISING SELECTIVE INHIBITION OF M1,2,3 MUSCARINIC RECEPTORS
FR2911606B1 (en) *	2007-01-18	2009-04-17	Pierre Fabre Medicament Sa	NEW QUINUCLIDINE DERIVATIVE USEFUL IN THE PREPARATION OF MEQUITAZINE
FR2924344B1 (en) *	2007-12-04	2010-04-16	Pf Medicament	USE OF MEQUITAZINE IN THE FORM OF RACEMATE OR ENANTIOMERS FOR THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OR PREVENTION OF PATHOLOGIES INVOLVING HISTAMIC RECEPTORS H4.
FR2970255B1 (en) *	2011-01-10	2013-09-06	Pf Medicament	VINYL QUINUCLIDINE USEFUL AS A SYNTHETIC INTERMEDIARY IN THE PREPARATION OF (R) -MEQUITAZINE
JP7599646B2 (en) *	2020-10-29	2024-12-16	国立大学法人金沢大学	Radioactive fluorine-labeled diagnostic imaging agents for measuring drug-metabolizing enzyme activities

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2522660A1 (en) *	1982-03-05	1983-09-09	Pharmuka Lab	MEQUITAZINE LEVOGYER ISOMER, PROCESS FOR PREPARING THE SAME AND MEDICAMENTS CONTAINING THE SAME
FR2526433B1 (en) *	1982-05-04	1985-10-18	Pharmuka Lab	DEXTROGYRIC ISOMERS OF AZA-1 BICYCLO (2,2,2) OCTANE DERIVATIVES, THEIR PREPARATION METHOD AND MEDICAMENTS CONTAINING THEM
IT1173445B (en) *	1984-03-16	1987-06-24	Guidotti & C Spa Labor	AGENTS WITH ANTIBRONCOSPASTIC ACTIVITY AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM

1991
- 1991-08-07 IT ITMI912225A patent/IT1251161B/en active IP Right Grant
1992
- 1992-08-03 WO PCT/EP1992/001759 patent/WO1993003029A1/en not_active Ceased
- 1992-08-03 FI FI940530A patent/FI940530L/en not_active Application Discontinuation
- 1992-08-03 AU AU24173/92A patent/AU2417392A/en not_active Abandoned
- 1992-08-03 CZ CS94248A patent/CZ24894A3/en unknown
- 1992-08-03 BR BR9206339A patent/BR9206339A/en not_active Application Discontinuation
- 1992-08-03 MA MA22900A patent/MA22611A1/en unknown
- 1992-08-03 CA CA002114844A patent/CA2114844A1/en not_active Abandoned
- 1992-08-03 SK SK115-94A patent/SK11594A3/en unknown
- 1992-08-03 JP JP5503276A patent/JPH06509570A/en active Pending
- 1992-08-03 HU HU9400273A patent/HUT66570A/en unknown
- 1992-08-03 EP EP92916942A patent/EP0599896A1/en not_active Ceased
- 1992-08-04 EC EC1992000859A patent/ECSP920859A/en unknown
- 1992-08-04 ZA ZA925852A patent/ZA925852B/en unknown
- 1992-08-05 MX MX9204539A patent/MX9204539A/en unknown
- 1992-08-05 TN TNTNSN92073A patent/TNSN92073A1/en unknown
- 1992-08-06 CN CN92109021A patent/CN1071667A/en active Pending
- 1992-08-07 PT PT100765A patent/PT100765A/en not_active Application Discontinuation
1994
- 1994-02-07 BG BG98439A patent/BG98439A/en unknown

Also Published As

Publication number	Publication date
EP0599896A1 (en)	1994-06-08
CA2114844A1 (en)	1993-02-18
TNSN92073A1 (en)	1993-06-08
ECSP920859A (en)	1993-08-03
MA22611A1 (en)	1993-04-01
WO1993003029A1 (en)	1993-02-18
PT100765A (en)	1993-10-29
ZA925852B (en)	1993-03-05
FI940530A0 (en)	1994-02-04
BG98439A (en)	1994-09-30
FI940530A7 (en)	1994-02-04
BR9206339A (en)	1994-11-08
HUT66570A (en)	1994-12-28
CN1071667A (en)	1993-05-05
SK11594A3 (en)	1994-12-07
MX9204539A (en)	1993-02-01
FI940530L (en)	1994-02-04
JPH06509570A (en)	1994-10-27
ITMI912225A0 (en)	1991-08-07
IT1251161B (en)	1995-05-04
AU2417392A (en)	1993-03-02
HU9400273D0 (en)	1994-05-30
CZ24894A3 (en)	1994-07-13

Publication	Publication Date	Title
ITMI913324A0 (en)	1991-12-11	PHARMACEUTICAL AGENTS
DK160557C (en)	1991-09-09	1,8-NAPHTHYRIDE COMPOUNDS AND PHARMACEUTICAL PREPARATIONS CONTAINING SUCH PRODUCTS
IT1178947B (en)	1987-09-16	PHARMACEUTICAL PREPARATIONS HAVING REDUCED TOXICITY
DK163923C (en)	1992-09-14	2-PHENYL-3-AMINOMETHYL-IMIDAZOOE1,2-AAAPYRIDINE DERIVATIVES AND PHARMACEUTICAL PREPARATIONS CONTAINING SUCH COMPOUNDS
FI933122L (en)	1993-07-07	FOERBAETTRAD HERBICIDISK FORMULATION
MX9203099A (en)	1992-07-31	N-HETEROCICLICO-N- (4-PIPERIDIA) AMIDES AND PHARMACEUTICAL COMPOSITIONS AND METHODS USING SUCH COMPOUNDS.
BR9200058A (en)	1992-09-08	PHARMACEUTICAL COMPOUND AND COMPOSITION
ITRM910952A0 (en)	1991-12-18	PHARMACEUTICAL COMPOSITIONS CONTAINING GONADATROPINES
IT8820386A0 (en)	1988-04-29	OROSOLUBLE PHARMACEUTICAL COMPOSITIONS CONTAINING ACETYLCISTEINE.
FI931023A7 (en)	1993-09-11	New b-amino acid derivatives
FI921718L (en)	1992-10-18	AMINO ACID DERIVATIVES
FI906361A7 (en)	1991-06-30	Eliminating the adverse effects of imidazolinone herbicides
KR900012897A (en)	1990-09-03	Guanidine derivatives and pharmaceutical compositions containing them
ITMI912225A1 (en)	1993-02-07	QUATERNARY AMMONIUM DERIVATIVES OF (-) AND (+) - 3- (10 H-PHENOTHIAZIN-10- ILMETHYL) -L-AZABICYCLE (2. 2. 2.) OCT AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FI940003L (en)	1994-03-02	Amino acid derivatives
DK0508334T3 (en)	1998-09-07	Aminophenol derivatives and pharmaceutical compositions containing them
DK635988D0 (en)	1988-11-15	1,3-BUTANDIOLACETOACETATE DERIVATIVES AND USE OF 1,3-BUTANDIOLACETOACETATE COMPOUNDS FOR THE PREPARATION OF PHARMACEUTICAL PREPARATIONS
DK253585D0 (en)	1985-06-06	HETEROCYCLIC SUBSTITUTED 1,4-DIHYDROPYRIDINE DERIVATIVES AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE DERIVATIVES
DK269289D0 (en)	1989-06-02	CYCLOPENTAND DERIVATIVES AND PHARMACEUTICAL PREPARATIONS CONTAINING SUCH COMPOUNDS
DK0511991T3 (en)	1996-11-11	Pharmaceutical formulation
DK449188A (en)	1989-02-13	2'-DEOXY-5-FLUORURIDIN DERIVATIVES AND PHARMACEUTICAL PREPARATIONS CONTAINING SUCH COMPOUNDS
FI915930A7 (en)	1992-06-19	Novel 15-nitro-2B, 3B-dihydro- and nitro-2B, 3B, 6,7-tetrahydrotaversonine derivatives, pharmaceutical compositions containing them and method of their preparation
KR900700471A (en)	1990-08-13	New 2,3-thiomorpholine dione-2-oxime derivatives, pharmaceutical compositions and preparations containing them
FI925068A7 (en)	1993-05-20	Amino acid derivatives
DK60187A (en)	1987-03-20	BIS-DIOZOPIPERAZINE DERIVATIVES AND PHARMACEUTICAL FORMULATIONS CONTAINING SUCH COMPOUNDS

Legal Events

Date	Code	Title	Description
1995-05-04	0001	Granted
1999-10-27	TA	Fee payment date (situation as of event date), data collected since 19931001	Effective date: 19970828