SV1997000035A - Acetilenos de biaril como inhibisores de matrices metaloproteasas - Google Patents

Acetilenos de biaril como inhibisores de matrices metaloproteasas

Info

Publication number: SV1997000035A
Authority: SV; El Salvador
Prior art keywords: biaril; metaloprotease; acetylene; matrix inhibitors; matrix
Prior art date: 1996-05-15

Application number

SV1997000035A

Other languages

English (en)

Spanish (es)

Inventor

Brian R Dixon

Jinshan Chen

Original Assignee

Bayer Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-05-15

Filing date

1997-05-12

Publication date

1999-01-14

1997-05-12 Application filed by Bayer Corp filed Critical Bayer Corp

1999-01-14 Publication of SV1997000035A publication Critical patent/SV1997000035A/es

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Rheumatology (AREA)
Oncology (AREA)
Physical Education & Sports Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Ophthalmology & Optometry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Hematology (AREA)
Dermatology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Enzymes And Modification Thereof (AREA)
Steroid Compounds (AREA)

SV1997000035A 1996-05-15 1997-05-12 Acetilenos de biaril como inhibisores de matrices metaloproteasas SV1997000035A (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US64502896A	1996-05-15	1996-05-15

Publications (1)

Publication Number	Publication Date
SV1997000035A true SV1997000035A (es)	1999-01-14

Family

ID=24587368

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SV1997000035A SV1997000035A (es)	1996-05-15	1997-05-12	Acetilenos de biaril como inhibisores de matrices metaloproteasas

Country Status (18)

Country	Link
EP (1)	EP0912496A1 (pt)
JP (1)	JP3090957B2 (pt)
CN (1)	CN1139570C (pt)
AR (1)	AR007097A1 (pt)
AU (1)	AU710759B2 (pt)
BR (1)	BR9709077A (pt)
CA (1)	CA2253796C (pt)
CO (1)	CO5080759A1 (pt)
HN (1)	HN1997000088A (pt)
HR (1)	HRP970245B1 (pt)
ID (1)	ID16910A (pt)
PA (1)	PA8429301A1 (pt)
SV (1)	SV1997000035A (pt)
TN (1)	TNSN97084A1 (pt)
TW (1)	TW381079B (pt)
WO (1)	WO1997043245A1 (pt)
YU (1)	YU18697A (pt)
ZA (1)	ZA974031B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6288063B1 (en)	1998-05-27	2001-09-11	Bayer Corporation	Substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives as matrix metalloprotease inhibitors
AR035478A1 (es) *	1999-01-27	2004-06-02	Wyeth Corp	Acido amida-hidroxamico, acido acetilenico, beta-sulfonamido y fosfinico como inhibidores de la tace, uso de los mismos para la manufactura de un medicamento y composicion farmaceutica que los contiene
US6326516B1 (en)	1999-01-27	2001-12-04	American Cyanamid Company	Acetylenic β-sulfonamido and phosphinic acid amide hydroxamic acid TACE inhibitors
EP1031349A1 (en) *	1999-02-25	2000-08-30	Bayer Aktiengesellschaft	Use of substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives for the treatment of cerebral diseases
US7141607B1 (en)	2000-03-10	2006-11-28	Insite Vision Incorporated	Methods and compositions for treating and inhibiting retinal neovascularization
DK2597084T3 (en)	2010-07-08	2016-08-15	Kaken Pharma Co Ltd	N-HYDROXYFORMAMIDE DERIVATIVE AND MEDICINAL CONTAINING SAME
CA2944614A1 (en)	2014-04-03	2015-10-08	Bayer Pharma Aktiengesellschaft	2,5-disubstituted cyclopentane carboxylic acids for the treatment of respiratoy tract diseases
CN106458938A (zh)	2014-04-03	2017-02-22	拜耳制药股份公司	手性2,5‑二取代的环戊烷甲酸衍生物及其用途
EP3126339A1 (de)	2014-04-03	2017-02-08	Bayer Pharma Aktiengesellschaft	2,5-disubstituierte cyclopentancarbonsäuren und ihre verwendung

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3784701A (en) *	1970-09-21	1974-01-08	American Cyanamid Co	Compositions containing substituted benzoylpropionic acids and method of use to treat inflammation and pain
DE2112716A1 (de) *	1971-03-17	1972-10-05	Thomae Gmbh Dr K	Neue 4-(4-Biphenylyl)-4-oxobuttersaeuren,ihre Salze und ihre Ester
FR2378741A1 (fr)	1977-02-01	1978-08-25	Fabre Sa Pierre	Acides garyl goxo isovaleriques doues de proprietes antiphlogistiques et antalgiques
US5789434A (en) *	1994-11-15	1998-08-04	Bayer Corporation	Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors
HRP970247B1 (en)	1996-05-15	2002-02-28	Bayer Ag	Substituted 4-arylbutric acid derivatives as matrix metalloprotease inhibitors

1997
- 1997-05-09 CO CO97025172A patent/CO5080759A1/es unknown
- 1997-05-09 ZA ZA9704031A patent/ZA974031B/xx unknown
- 1997-05-09 HR HR970245A patent/HRP970245B1/xx not_active IP Right Cessation
- 1997-05-09 TN TNTNSN97084A patent/TNSN97084A1/fr unknown
- 1997-05-12 TW TW086106283A patent/TW381079B/zh not_active IP Right Cessation
- 1997-05-12 CN CNB971964564A patent/CN1139570C/zh not_active Expired - Fee Related
- 1997-05-12 JP JP09540980A patent/JP3090957B2/ja not_active Expired - Fee Related
- 1997-05-12 BR BR9709077A patent/BR9709077A/pt not_active Application Discontinuation
- 1997-05-12 CA CA002253796A patent/CA2253796C/en not_active Expired - Fee Related
- 1997-05-12 PA PA19978429301A patent/PA8429301A1/es unknown
- 1997-05-12 AU AU29386/97A patent/AU710759B2/en not_active Ceased
- 1997-05-12 HN HN1997000088A patent/HN1997000088A/es unknown
- 1997-05-12 SV SV1997000035A patent/SV1997000035A/es unknown
- 1997-05-12 YU YU18697A patent/YU18697A/sr unknown
- 1997-05-12 EP EP97923622A patent/EP0912496A1/en not_active Withdrawn
- 1997-05-12 WO PCT/US1997/007921 patent/WO1997043245A1/en not_active Ceased
- 1997-05-12 AR ARP970101977A patent/AR007097A1/es unknown
- 1997-05-14 ID IDP971606A patent/ID16910A/id unknown

Also Published As

Publication number	Publication date
WO1997043245A1 (en)	1997-11-20
JPH11511179A (ja)	1999-09-28
BR9709077A (pt)	1999-08-03
EP0912496A1 (en)	1999-05-06
TW381079B (en)	2000-02-01
CN1225623A (zh)	1999-08-11
ZA974031B (en)	1998-02-19
TNSN97084A1 (fr)	2005-03-15
AU2938697A (en)	1997-12-05
ID16910A (id)	1997-11-20
PA8429301A1 (es)	2000-05-24
YU18697A (en)	1999-11-22
AU710759B2 (en)	1999-09-30
CA2253796A1 (en)	1997-11-20
JP3090957B2 (ja)	2000-09-25
CA2253796C (en)	2003-10-28
HN1997000088A (es)	1997-06-18
CO5080759A1 (es)	2001-09-25
AR007097A1 (es)	1999-10-13
HRP970245A2 (en)	1998-04-30
CN1139570C (zh)	2004-02-25
HRP970245B1 (en)	2002-06-30

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