SK130098A3 - Method of treating heart failure with endothelin antagonists - Google Patents

Method of treating heart failure with endothelin antagonists Download PDF

Info

Publication number: SK130098A3
Authority: SK; Slovakia
Prior art keywords: carboxy; pyridine; methoxyphenyl; cyclopenteno; methylenedioxyphenyl
Prior art date: 1996-04-04

Application number

SK1300-98A

Other languages

English (en)

Slovak (sk)

Inventor

Joseph J Lynch Jr

You-Tang Shen

Original Assignee

Banyu Pharma Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-04-04

Filing date

1997-03-19

Publication date

1999-05-07

1997-03-19 Application filed by Banyu Pharma Co Ltd filed Critical Banyu Pharma Co Ltd

1999-05-07 Publication of SK130098A3 publication Critical patent/SK130098A3/sk

Links

206010019280 Heart failures Diseases 0.000 title claims abstract description 62
ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 title abstract description 34
102000002045 Endothelin Human genes 0.000 title abstract description 33
108050009340 Endothelin Proteins 0.000 title abstract description 33
239000005557 antagonist Substances 0.000 title abstract description 9
238000000034 method Methods 0.000 title description 4
150000001875 compounds Chemical class 0.000 claims abstract description 25
230000002265 prevention Effects 0.000 claims abstract description 5
-1 benzofuranoyl group Chemical group 0.000 claims description 1237
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 799
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims description 398
125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims description 121
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 73
125000000217 alkyl group Chemical group 0.000 claims description 41
230000002861 ventricular Effects 0.000 claims description 34
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 26
125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 25
241001465754 Metazoa Species 0.000 claims description 24
125000002947 alkylene group Chemical group 0.000 claims description 24
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 21
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 20
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125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims description 17
125000001072 heteroaryl group Chemical group 0.000 claims description 16
239000008194 pharmaceutical composition Substances 0.000 claims description 16
150000003839 salts Chemical class 0.000 claims description 16
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125000003118 aryl group Chemical group 0.000 claims description 15
229910052757 nitrogen Inorganic materials 0.000 claims description 15
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 14
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239000002308 endothelin receptor antagonist Substances 0.000 claims description 13
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125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 11
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IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 9
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230000006815 ventricular dysfunction Effects 0.000 claims description 9
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229910052736 halogen Inorganic materials 0.000 claims description 8
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FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical group C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims description 2
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BPICBUSOMSTKRF-UHFFFAOYSA-N xylazine Chemical compound CC1=CC=CC(C)=C1NC1=NCCCS1 BPICBUSOMSTKRF-UHFFFAOYSA-N 0.000 description 1
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Classifications

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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pulmonology (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)
Materials For Photolithography (AREA)
Photosensitive Polymer And Photoresist Processing (AREA)

SK1300-98A 1996-04-04 1997-03-19 Method of treating heart failure with endothelin antagonists SK130098A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US1488296P	1996-04-04	1996-04-04
PCT/US1997/003737 WO1997037665A1 (en)	1996-04-04	1997-03-19	Method of treating heart failure with endothelin antagonists

Publications (1)

Publication Number	Publication Date
SK130098A3 true SK130098A3 (en)	1999-05-07

Family

ID=21768326

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK1300-98A SK130098A3 (en)	1996-04-04	1997-03-19	Method of treating heart failure with endothelin antagonists

Country Status (25)

Country	Link
US (3)	US5834483A (pt)
EP (1)	EP0906108B1 (pt)
JP (2)	JP3345891B2 (pt)
KR (1)	KR20000005178A (pt)
CN (1)	CN1215335A (pt)
AT (1)	ATE297739T1 (pt)
AU (1)	AU723351B2 (pt)
BG (1)	BG102716A (pt)
BR (1)	BR9708525A (pt)
CA (1)	CA2249330C (pt)
CZ (1)	CZ296098A3 (pt)
DE (1)	DE69733557T2 (pt)
EA (1)	EA003587B1 (pt)
EE (1)	EE9800315A (pt)
ES (1)	ES2241047T3 (pt)
HU (1)	HUP9903893A3 (pt)
IL (1)	IL126175A (pt)
IS (1)	IS4847A (pt)
NO (1)	NO984564L (pt)
NZ (1)	NZ331789A (pt)
PL (1)	PL329077A1 (pt)
SK (1)	SK130098A3 (pt)
TR (1)	TR199801988T2 (pt)
UA (1)	UA50761C2 (pt)
WO (1)	WO1997037665A1 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PL329077A1 (en) *	1996-04-04	1999-03-15	Banyu Pharma Co Ltd	Method of treating cardiac insufficiency by means of endotelin antagonists
AU711936B2 (en) *	1996-08-09	1999-10-28	Banyu Pharmaceutical Co., Ltd.	Stereoselective deoxygenation reaction
AU742423B2 (en)	1998-01-21	2002-01-03	Msd K.K.	Substituted 5-(2,2-difluoro-1,3-benzodioxol-5-yl) cyclopentenopyridine derivative
US8168616B1 (en)	2000-11-17	2012-05-01	Novartis Ag	Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension
US20060089503A1 (en) *	2002-12-27	2006-04-27	Kaneka Corporation	Processes for producing optically active 2-thiomethyl-3-phenylpropionic acid derivative and for producing intermediate therefor
WO2005049022A2 (en)	2003-11-17	2005-06-02	Novartis Ag	Use of dipeptidyl peptidase iv inhibitors
GB0327839D0 (en)	2003-12-01	2003-12-31	Novartis Ag	Organic compounds
WO2005089731A2 (en)	2004-03-17	2005-09-29	Novartis Ag	Use of renin inhibitors in therapy
EP1894582A1 (en)	2005-06-24	2008-03-05	Tokyo Medical and Dental University	Method for control of drug elution rate and composition for coating of drug-eluting stent
AR080683A1 (es)	2010-03-16	2012-05-02	Novartis Ag	Composiciones farmaceuticas de aliskiren y metodos de administracion

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4971959A (en) *	1987-04-14	1990-11-20	Warner-Lambert Company	Trisubstituted phenyl analogs having activity for congestive heart failure
GB9007762D0 (en) *	1990-04-05	1990-06-06	Beecham Group Plc	Novel compounds
US5565485A (en) *	1993-03-19	1996-10-15	Merck & Co., Inc.	Biphenyl compounds useful or endothelin antagonists
HU9503067D0 (en)	1993-04-27	1995-12-28	Smithkline Beecham Corp	Endotheline receptor antagonists
US5571813A (en) *	1993-06-10	1996-11-05	Beiersdorf-Lilly Gmbh	Fused pyrimidine compounds and their use as pharmaceuticals
US5389620A (en) *	1993-08-18	1995-02-14	Banyu Pharmaceutical Co., Ltd.	Endothelin antagonistic heteroaromatic ring-fused cyclopentene derivatives
AU675870B2 (en) *	1993-08-18	1997-02-20	Msd K.K.	Endothelin antagonistic heteroaromatic ring-fused cyclopentene derivatives
US5658943A (en) *	1995-01-05	1997-08-19	Warner-Lambert Company	Phenylalanine derivatives as endothelin antagonists
PL329077A1 (en) *	1996-04-04	1999-03-15	Banyu Pharma Co Ltd	Method of treating cardiac insufficiency by means of endotelin antagonists

1997
- 1997-03-19 PL PL97329077A patent/PL329077A1/xx unknown
- 1997-03-19 IL IL12617597A patent/IL126175A/xx not_active IP Right Cessation
- 1997-03-19 SK SK1300-98A patent/SK130098A3/sk unknown
- 1997-03-19 HU HU9903893A patent/HUP9903893A3/hu unknown
- 1997-03-19 AT AT97914955T patent/ATE297739T1/de not_active IP Right Cessation
- 1997-03-19 BR BR9708525A patent/BR9708525A/pt not_active Application Discontinuation
- 1997-03-19 KR KR1019980707850A patent/KR20000005178A/ko not_active Ceased
- 1997-03-19 TR TR1998/01988T patent/TR199801988T2/xx unknown
- 1997-03-19 CN CN97193645A patent/CN1215335A/zh active Pending
- 1997-03-19 EP EP97914955A patent/EP0906108B1/en not_active Expired - Lifetime
- 1997-03-19 JP JP53619497A patent/JP3345891B2/ja not_active Expired - Fee Related
- 1997-03-19 ES ES97914955T patent/ES2241047T3/es not_active Expired - Lifetime
- 1997-03-19 WO PCT/US1997/003737 patent/WO1997037665A1/en not_active Ceased
- 1997-03-19 NZ NZ331789A patent/NZ331789A/xx unknown
- 1997-03-19 CA CA002249330A patent/CA2249330C/en not_active Expired - Fee Related
- 1997-03-19 AU AU22025/97A patent/AU723351B2/en not_active Ceased
- 1997-03-19 EE EE9800315A patent/EE9800315A/xx unknown
- 1997-03-19 CZ CZ982960A patent/CZ296098A3/cs unknown
- 1997-03-19 DE DE69733557T patent/DE69733557T2/de not_active Expired - Lifetime
- 1997-03-19 EA EA199800889A patent/EA003587B1/ru not_active IP Right Cessation
- 1997-03-19 UA UA98105222A patent/UA50761C2/uk unknown
- 1997-03-26 US US08/824,848 patent/US5834483A/en not_active Expired - Fee Related
1998
- 1998-08-11 US US09/132,514 patent/US6087360A/en not_active Expired - Lifetime
- 1998-08-21 BG BG102716A patent/BG102716A/xx unknown
- 1998-09-15 IS IS4847A patent/IS4847A/is unknown
- 1998-09-30 NO NO984564A patent/NO984564L/no not_active Application Discontinuation
2000
- 2000-02-22 US US09/507,666 patent/US6380195B1/en not_active Expired - Fee Related
2001
- 2001-12-07 JP JP2001374870A patent/JP2002220337A/ja active Pending

Also Published As

Publication number	Publication date
EP0906108A1 (en)	1999-04-07
IS4847A (is)	1998-09-15
CA2249330A1 (en)	1997-10-16
UA50761C2 (uk)	2002-11-15
NO984564D0 (no)	1998-09-30
JP2000510824A (ja)	2000-08-22
EA003587B1 (ru)	2003-06-26
BR9708525A (pt)	1999-08-03
US6380195B1 (en)	2002-04-30
TR199801988T2 (xx)	2000-08-21
BG102716A (en)	1999-09-30
IL126175A (en)	2003-05-29
EP0906108A4 (en)	2000-12-06
US5834483A (en)	1998-11-10
JP3345891B2 (ja)	2002-11-18
NZ331789A (en)	2000-05-26
CZ296098A3 (cs)	1999-06-16
CA2249330C (en)	2005-08-09
DE69733557T2 (de)	2005-11-03
ES2241047T3 (es)	2005-10-16
PL329077A1 (en)	1999-03-15
WO1997037665A1 (en)	1997-10-16
ATE297739T1 (de)	2005-07-15
EE9800315A (et)	1999-06-15
DE69733557D1 (de)	2005-07-21
EA199800889A1 (ru)	1999-04-29
AU723351B2 (en)	2000-08-24
NO984564L (no)	1998-12-04
CN1215335A (zh)	1999-04-28
IL126175A0 (en)	1999-05-09
US6087360A (en)	2000-07-11
HUP9903893A3 (en)	2001-05-28
KR20000005178A (ko)	2000-01-25
HUP9903893A2 (hu)	2001-04-28
EP0906108B1 (en)	2005-06-15
JP2002220337A (ja)	2002-08-09
AU2202597A (en)	1997-10-29

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