SK10922000A3 - Triazolopyridazínové deriváty, spôsob ich výroby, farmaceutický prostriedok s ich obsahom a ich použitie - Google Patents

Triazolopyridazínové deriváty, spôsob ich výroby, farmaceutický prostriedok s ich obsahom a ich použitie Download PDF

Info

Publication number: SK10922000A3
Authority: SK; Slovakia
Prior art keywords: methyl; pyridazine; triazolo; triazol; ylmethoxy
Prior art date: 1998-01-21

Application number

SK1092-2000A

Other languages

English (en)

Slovak (sk)

Inventor

William Robert Carling

Pineiro Jose Luis Castro

Ian James Collins

Alexander Richard Guiblin

Timothy Harrison

Andrew Madin

Kevin William Moore

Michael Geoffrey Neil Russell

Gayle Scott

Leslie Joseph Street

Original Assignee

Merck Sharp & Dohme Limited

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-01-21

Filing date

1999-01-13

Publication date

2001-03-12

1998-01-21 Priority claimed from GBGB9801233.9A external-priority patent/GB9801233D0/en

1998-10-02 Priority claimed from GBGB9821517.1A external-priority patent/GB9821517D0/en

1999-01-13 Application filed by Merck Sharp & Dohme Limited filed Critical Merck Sharp & Dohme Limited

2001-03-12 Publication of SK10922000A3 publication Critical patent/SK10922000A3/sk

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

SK1092-2000A 1998-01-21 1999-01-13 Triazolopyridazínové deriváty, spôsob ich výroby, farmaceutický prostriedok s ich obsahom a ich použitie SK10922000A3 (sk)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB9801233.9A GB9801233D0 (en)	1998-01-21	1998-01-21	Therapeutic agents
GBGB9821517.1A GB9821517D0 (en)	1998-10-02	1998-10-02	Therapeutic agents
PCT/GB1999/000103 WO1999037644A1 (en)	1998-01-21	1999-01-13	Triazolo-pyridazine derivatives as ligands for gaba receptors

Publications (1)

Publication Number	Publication Date
SK10922000A3 true SK10922000A3 (sk)	2001-03-12

Family

ID=26312988

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK1092-2000A SK10922000A3 (sk)	1998-01-21	1999-01-13	Triazolopyridazínové deriváty, spôsob ich výroby, farmaceutický prostriedok s ich obsahom a ich použitie

Country Status (24)

Country	Link
US (2)	US6579875B1 (is)
EP (1)	EP1049696A1 (is)
JP (1)	JP2002501066A (is)
KR (1)	KR20010034257A (is)
CN (1)	CN1110498C (is)
AU (1)	AU748737B2 (is)
BG (1)	BG104671A (is)
BR (1)	BR9906905A (is)
CA (1)	CA2315763A1 (is)
CZ (1)	CZ290883B6 (is)
EA (1)	EA002755B1 (is)
EE (1)	EE200000430A (is)
GE (1)	GEP20032868B (is)
HR (1)	HRP20000492A2 (is)
HU (1)	HUP0100575A3 (is)
IL (1)	IL136442A0 (is)
IS (1)	IS5540A (is)
MX (1)	MXPA00007135A (is)
NO (1)	NO315516B1 (is)
NZ (1)	NZ504870A (is)
PL (1)	PL341652A1 (is)
SK (1)	SK10922000A3 (is)
WO (1)	WO1999037644A1 (is)
YU (1)	YU43800A (is)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GEP20032868B (en) *	1998-01-21	2003-01-27	Merck Sharp & Dohme	Triazolo-Pyridazine Derivatives as Ligands for Gaba Receptors, Methods for Their Production, Pharmaceutical Compositions Containing the Same for Treatment and/or Prevention of disorders of Central Nervous System
GB9929685D0 (en)	1999-12-15	2000-02-09	Merck Sharp & Dohme	Therapeutic agents
GB0017543D0 (en)	2000-07-17	2000-09-06	Merck Sharp & Dohme	Therapeutic agents
WO2005058860A1 (ja) *	2003-12-19	2005-06-30	Ube Industries, Ltd.	４−置換又は非置換テトラヒドロピラン−４−カルボン酸化合物又はそのエステル化合物の製法
EP2258359A3 (en)	2005-08-26	2011-04-06	Braincells, Inc.	Neurogenesis by muscarinic receptor modulation with sabcomelin
CA2620333A1 (en)	2005-08-26	2007-03-01	Braincells, Inc.	Neurogenesis by muscarinic receptor modulation
AU2006304787A1 (en)	2005-10-21	2007-04-26	Braincells, Inc.	Modulation of neurogenesis by PDE inhibition
EP2314289A1 (en)	2005-10-31	2011-04-27	Braincells, Inc.	Gaba receptor mediated modulation of neurogenesis
MY159523A (en) *	2005-12-21	2017-01-13	Janssen Pharmaceutica Nv	Triazolopyridazines as tyrosine kinase modulators
US20100216734A1 (en)	2006-03-08	2010-08-26	Braincells, Inc.	Modulation of neurogenesis by nootropic agents
EP2021000A2 (en)	2006-05-09	2009-02-11	Braincells, Inc.	Neurogenesis by modulating angiotensin
JP2009536667A (ja)	2006-05-09	2009-10-15	ブレインセルス，インコーポレイティド	５ｈｔ受容体介在性の神経新生
MX2009002496A (es)	2006-09-08	2009-07-10	Braincells Inc	Combinaciones que contienen un derivado de 4-acilaminopiridina.
US20100184806A1 (en)	2006-09-19	2010-07-22	Braincells, Inc.	Modulation of neurogenesis by ppar agents
EP2123619A1 (de)	2008-05-20	2009-11-25	Bayer Schering Pharma AG	Neue [F-18]-Markierte L-Glutaminsäure-und L-Glutaminderivate (II), ihre Verwendung sowie Verfahren zu ihrer Herstellung
WO2010025407A1 (en) *	2008-08-29	2010-03-04	Concert Pharmaceuticals Inc.	Substituted triazolo-pyridazine derivatives
US20100216805A1 (en)	2009-02-25	2010-08-26	Braincells, Inc.	Modulation of neurogenesis using d-cycloserine combinations
EP2454259A1 (en)	2009-06-23	2012-05-23	Concert Pharmaceuticals Inc.	Deuterium-modified triazolo-pyridazine derivatives as gaba-a receptor modulators
DK2464645T3 (en) *	2009-07-27	2017-10-23	Gilead Sciences Inc	CONDENSED, HETEROCYCLIC COMPOUNDS AS IRON CHANNEL MODULATORS
CN107050456B (zh)	2010-09-28	2022-08-12	加利福尼亚大学董事会	治疗代谢综合征相关疾病的gaba激动剂和治疗或预防i型糖尿病的gaba组合
PL2707361T3 (pl)	2011-05-10	2018-01-31	Gilead Sciences Inc	Skondensowane związki heterocykliczne stosowane jako modulatory kanału sodowego
NO3175985T3 (is)	2011-07-01	2018-04-28
TWI622583B (zh)	2011-07-01	2018-05-01	基利科學股份有限公司	作為離子通道調節劑之稠合雜環化合物
GB201321745D0 (en) *	2013-12-09	2014-01-22	Ucb Pharma Sa	Therapeutic agents
US20170247423A1 (en)	2016-02-29	2017-08-31	Dana-Farber Cancer Institute, Inc.	Stapled intracellular-targeting antimicrobial peptides to treat infection
CN107344936B (zh) *	2016-05-06	2022-06-03	上海赛默罗生物科技有限公司	三唑哒嗪类衍生物、其制备方法、药物组合物和用途
WO2019018499A2 (en)	2017-07-19	2019-01-24	Dana-Farber Cancer Institute, Inc.	ANTIMICROBIAL PEPTIDES STABILIZED FOR THE TREATMENT OF ANTIBIOTIC-RESISTANT BACTERIAL INFECTIONS

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1080712A (en) *	1976-09-22	1980-07-01	Jay D. Albright	Hypotensive agents
US4230705A (en) *	1976-09-22	1980-10-28	American Cyanamid Company	6-Phenyl-1,2,4-triazolo[4,3-b]pyridazines and their uses in treating anxiety
US4112095A (en) *	1976-10-07	1978-09-05	American Cyanamid Company	6-Phenyl-1,2,4-triazolo[4,3-b]pyridazine hypotensive agents
PH12424A (en) *	1976-10-26	1979-02-15	American Cyanamid Co	Method of treating anxiety in mammals
US4260755A (en)	1979-10-31	1981-04-07	American Cyanamid Company	Novel 6-phenyl and substituted 6-phenyl-1,2,4-triazolo[4,3-b]pyridazines
US4260756A (en)	1979-11-15	1981-04-07	American Cyanamid Company	6- And 8-heteroaryl-1,2,4-triazolo[4,3-b]pyridazines
FI81350C (fi)	1982-01-18	1990-10-10	Lepetit Spa	Analogfoerfarande foer framstaellning av nya, farmakologiskt aktiva 6-substituerade s-triatsolo/3,4-a/ ftalazinderivat.
IT1194310B (it)	1983-07-12	1988-09-14	Lepetit Spa	Derivati triazolo (3,4-a) ftalazinici 3,6-disostituiti
US4654343A (en) *	1985-10-31	1987-03-31	American Cyanamid Company	N-substituted-N[3-(1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]alkanamides, carbamates and ureas
YU2899A (sh)	1996-07-25	2000-03-21	Merck Sharp & Dohme Limited	Supstituisani triazolo-piridazin derivati kao ligandi za gaba receptore
GEP20032868B (en) *	1998-01-21	2003-01-27	Merck Sharp & Dohme	Triazolo-Pyridazine Derivatives as Ligands for Gaba Receptors, Methods for Their Production, Pharmaceutical Compositions Containing the Same for Treatment and/or Prevention of disorders of Central Nervous System

1999
- 1999-01-13 GE GEAP19995511A patent/GEP20032868B/en unknown
- 1999-01-13 US US09/582,589 patent/US6579875B1/en not_active Expired - Fee Related
- 1999-01-13 YU YU43800A patent/YU43800A/sh unknown
- 1999-01-13 EA EA200000783A patent/EA002755B1/ru not_active IP Right Cessation
- 1999-01-13 CA CA002315763A patent/CA2315763A1/en not_active Abandoned
- 1999-01-13 SK SK1092-2000A patent/SK10922000A3/sk unknown
- 1999-01-13 EE EEP200000430A patent/EE200000430A/xx unknown
- 1999-01-13 PL PL99341652A patent/PL341652A1/xx not_active Application Discontinuation
- 1999-01-13 KR KR1020007007937A patent/KR20010034257A/ko not_active Withdrawn
- 1999-01-13 HR HR20000492A patent/HRP20000492A2/hr not_active Application Discontinuation
- 1999-01-13 MX MXPA00007135A patent/MXPA00007135A/es unknown
- 1999-01-13 AU AU20657/99A patent/AU748737B2/en not_active Ceased
- 1999-01-13 CN CN99802249A patent/CN1110498C/zh not_active Expired - Fee Related
- 1999-01-13 JP JP2000528565A patent/JP2002501066A/ja not_active Withdrawn
- 1999-01-13 WO PCT/GB1999/000103 patent/WO1999037644A1/en not_active Ceased
- 1999-01-13 IL IL13644299A patent/IL136442A0/xx unknown
- 1999-01-13 CZ CZ20002691A patent/CZ290883B6/cs not_active IP Right Cessation
- 1999-01-13 EP EP99901025A patent/EP1049696A1/en not_active Withdrawn
- 1999-01-13 NZ NZ504870A patent/NZ504870A/xx unknown
- 1999-01-13 HU HU0100575A patent/HUP0100575A3/hu unknown
- 1999-01-13 BR BR9906905-9A patent/BR9906905A/pt not_active IP Right Cessation
2000
- 2000-06-16 IS IS5540A patent/IS5540A/is unknown
- 2000-07-20 NO NO20003730A patent/NO315516B1/no not_active IP Right Cessation
- 2000-08-07 BG BG104671A patent/BG104671A/xx unknown
2003
- 2003-06-17 US US10/463,075 patent/US6828322B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EE200000430A (et)	2001-12-17
MXPA00007135A (es)	2002-11-07
EA200000783A1 (ru)	2000-12-25
EA002755B1 (ru)	2002-08-29
GEP20032868B (en)	2003-01-27
HUP0100575A3 (en)	2003-03-28
KR20010034257A (ko)	2001-04-25
NZ504870A (en)	2002-11-26
WO1999037644A1 (en)	1999-07-29
CN1110498C (zh)	2003-06-04
PL341652A1 (en)	2001-04-23
CN1288465A (zh)	2001-03-21
HRP20000492A2 (en)	2000-12-31
AU748737B2 (en)	2002-06-13
US6579875B1 (en)	2003-06-17
IS5540A (is)	2000-06-16
JP2002501066A (ja)	2002-01-15
EP1049696A1 (en)	2000-11-08
BG104671A (en)	2001-05-31
CZ290883B6 (cs)	2002-11-13
YU43800A (sh)	2002-12-10
NO315516B1 (no)	2003-09-15
CA2315763A1 (en)	1999-07-29
US6828322B2 (en)	2004-12-07
HUP0100575A2 (hu)	2001-09-28
CZ20002691A3 (cs)	2000-12-13
IL136442A0 (en)	2001-06-14
NO20003730D0 (no)	2000-07-20
BR9906905A (pt)	2000-10-10
US20040063714A1 (en)	2004-04-01
AU2065799A (en)	1999-08-09
NO20003730L (no)	2000-09-20

Publication	Publication Date	Title
SK10922000A3 (sk)	2001-03-12	Triazolopyridazínové deriváty, spôsob ich výroby, farmaceutický prostriedok s ich obsahom a ich použitie
US6500828B1 (en)	2002-12-31	Triazolo-pyridazine derivatives as ligands for gaba receptors
EA021504B1 (ru)	2015-07-30	Производные 1-гетероциклил-1,5-дигидропиразоло[3,4-d]пиримидин-4-она и их применение в качестве модуляторов pde9a
CN101647802A (zh)	2010-02-17	具有PDE-5抑制活性的5,7-二氨基吡唑并[4,3-d]嘧啶及其组合物
JP2004501109A (ja)	2004-01-15	Ｇａｂａ受容体に対するリガンドとしての３−フェニル−イミダゾ−ピリミジン誘導体
WO2002081474A1 (en)	2002-10-17	Triazolophthalazine / quinoline / isoquinoline derivatives which are ligands for gaba-a receptors containing the alpha 5 subtype
US6608062B1 (en)	2003-08-19	Imidazo-triazine derivatives as ligands for GABA receptors
JP2002501067A (ja)	2002-01-15	Ｇａｂａ受容体に対するリガンドとしてのトリアゾロ−ピリダジン誘導体
US6337331B1 (en)	2002-01-08	Triazolo-pyrimidine as ligands for GABA receptors
US6303597B1 (en)	2001-10-16	Triazolo-pyridazine derivatives as ligands for GABA receptors
US6730676B2 (en)	2004-05-04	Pyrazino-pyridazine derivatives as ligands for GABA receptors
JP2002501070A (ja)	2002-01-15	Ｇａｂａ受容体のリガンドとしてのトリアゾロ−ピリダジン誘導体
US6297235B1 (en)	2001-10-02	Triazolopyridazine derivatives for treating anxiety and enhancing cognition
US6291460B1 (en)	2001-09-18	Triazolo-pyridazine derivatives as ligands for GABA receptors
WO2004014891A1 (en)	2004-02-19	Pyridazine derivatives as ligands for gaba receptors
US6699859B1 (en)	2004-03-02	Triazolo-pyridazine derivatives as ligands for GABA receptors
US6444666B1 (en)	2002-09-03	Triazolopyridazine Derivatives for treating anxiety and enhancing cognition