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HRP20000492A2 - Triazolo-pyridazine derivatives as ligands for gaba receptors - Google Patents

Triazolo-pyridazine derivatives as ligands for gaba receptors Download PDF

Info

Publication number
HRP20000492A2
HRP20000492A2 HR20000492A HRP20000492A HRP20000492A2 HR P20000492 A2 HRP20000492 A2 HR P20000492A2 HR 20000492 A HR20000492 A HR 20000492A HR P20000492 A HRP20000492 A HR P20000492A HR P20000492 A2 HRP20000492 A2 HR P20000492A2
Authority
HR
Croatia
Prior art keywords
methyl
pyridazine
triazolo
ylmethoxy
triazol
Prior art date
Application number
HR20000492A
Other languages
English (en)
Croatian (hr)
Inventor
William Robert Carling
Jose Luis Castro Pineiro
Ian James Colins
Alexander Richard Guiblin
Timothy Harrison
Andrew Madin
Kevin William Moore
Michael Geoffrey Neil Russel
Gayle Scott
Leslie Joseph Street
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9801233.9A external-priority patent/GB9801233D0/en
Priority claimed from GBGB9821517.1A external-priority patent/GB9821517D0/en
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of HRP20000492A2 publication Critical patent/HRP20000492A2/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HR20000492A 1998-01-21 1999-01-13 Triazolo-pyridazine derivatives as ligands for gaba receptors HRP20000492A2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9801233.9A GB9801233D0 (en) 1998-01-21 1998-01-21 Therapeutic agents
GBGB9821517.1A GB9821517D0 (en) 1998-10-02 1998-10-02 Therapeutic agents
PCT/GB1999/000103 WO1999037644A1 (en) 1998-01-21 1999-01-13 Triazolo-pyridazine derivatives as ligands for gaba receptors

Publications (1)

Publication Number Publication Date
HRP20000492A2 true HRP20000492A2 (en) 2000-12-31

Family

ID=26312988

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20000492A HRP20000492A2 (en) 1998-01-21 1999-01-13 Triazolo-pyridazine derivatives as ligands for gaba receptors

Country Status (24)

Country Link
US (2) US6579875B1 (is)
EP (1) EP1049696A1 (is)
JP (1) JP2002501066A (is)
KR (1) KR20010034257A (is)
CN (1) CN1110498C (is)
AU (1) AU748737B2 (is)
BG (1) BG104671A (is)
BR (1) BR9906905A (is)
CA (1) CA2315763A1 (is)
CZ (1) CZ290883B6 (is)
EA (1) EA002755B1 (is)
EE (1) EE200000430A (is)
GE (1) GEP20032868B (is)
HR (1) HRP20000492A2 (is)
HU (1) HUP0100575A3 (is)
IL (1) IL136442A0 (is)
IS (1) IS5540A (is)
MX (1) MXPA00007135A (is)
NO (1) NO315516B1 (is)
NZ (1) NZ504870A (is)
PL (1) PL341652A1 (is)
SK (1) SK10922000A3 (is)
WO (1) WO1999037644A1 (is)
YU (1) YU43800A (is)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL341652A1 (en) * 1998-01-21 2001-04-23 Merck Sharp & Dohme Derivatives of triazolopyridazine as ligands for gaba receptors
GB9929685D0 (en) * 1999-12-15 2000-02-09 Merck Sharp & Dohme Therapeutic agents
GB0017543D0 (en) * 2000-07-17 2000-09-06 Merck Sharp & Dohme Therapeutic agents
JP4867350B2 (ja) * 2003-12-19 2012-02-01 宇部興産株式会社 ４−置換−４−シアノテトラヒドロピラン化合物の製法
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
EP1928437A2 (en) 2005-08-26 2008-06-11 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
JP2009512711A (ja) 2005-10-21 2009-03-26 ブレインセルス，インコーポレイティド Ｐｄｅ阻害による神経新生の調節
WO2007053596A1 (en) * 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
RS55630B1 (sr) * 2005-12-21 2017-06-30 Janssen Pharmaceutica Nv Triazolopiridazini kao modulatori tirozin kinaze
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
EP2026813A2 (en) 2006-05-09 2009-02-25 Braincells, Inc. 5 ht receptor mediated neurogenesis
WO2007134136A2 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
WO2008030651A1 (en) 2006-09-08 2008-03-13 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
EP2123619A1 (de) 2008-05-20 2009-11-25 Bayer Schering Pharma AG Neue [F-18]-Markierte L-Glutaminsäure-und L-Glutaminderivate (II), ihre Verwendung sowie Verfahren zu ihrer Herstellung
WO2010025407A1 (en) * 2008-08-29 2010-03-04 Concert Pharmaceuticals Inc. Substituted triazolo-pyridazine derivatives
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
WO2011005520A1 (en) 2009-06-23 2011-01-13 Concert Pharmaceuticals, Inc. Deuterium-modified triazolo-pyridazine derivatives as gaba-a receptor modulators
LT2464645T (lt) * 2009-07-27 2017-10-25 Gilead Sciences, Inc. Kondensuoti heterocikliniai junginiai, kaip jonų kanalų moduliatoriai
CN107050456B (zh) 2010-09-28 2022-08-12 加利福尼亚大学董事会 治疗代谢综合征相关疾病的gaba激动剂和治疗或预防i型糖尿病的gaba组合
KR20140033377A (ko) 2011-05-10 2014-03-18 길리애드 사이언시즈, 인코포레이티드 나트륨 채널 조절제로서의 융합된 헤테로시클릭 화합물
UY34171A (es) 2011-07-01 2013-01-31 Gilead Sciences Inc Compuestos heterocíclicos fusionados como moduladores del canal iónico
NO3175985T3 (is) 2011-07-01 2018-04-28
GB201321745D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
WO2017151617A1 (en) 2016-02-29 2017-09-08 Dana-Farber Cancer Institute, Inc. Stapled intracellular-targeting antimicrobial peptides to treat infection
CN107344936B (zh) * 2016-05-06 2022-06-03 上海赛默罗生物科技有限公司 三唑哒嗪类衍生物、其制备方法、药物组合物和用途
AU2018304230A1 (en) 2017-07-19 2020-02-06 Dana-Farber Cancer Institute, Inc. Stabilized anti-microbial peptides for the treatment of antibiotic-resistant bacterial infections

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4230705A (en) * 1976-09-22 1980-10-28 American Cyanamid Company 6-Phenyl-1,2,4-triazolo[4,3-b]pyridazines and their uses in treating anxiety
CA1080712A (en) * 1976-09-22 1980-07-01 Jay D. Albright Hypotensive agents
US4112095A (en) 1976-10-07 1978-09-05 American Cyanamid Company 6-Phenyl-1,2,4-triazolo[4,3-b]pyridazine hypotensive agents
PH12424A (en) * 1976-10-26 1979-02-15 American Cyanamid Co Method of treating anxiety in mammals
US4260755A (en) 1979-10-31 1981-04-07 American Cyanamid Company Novel 6-phenyl and substituted 6-phenyl-1,2,4-triazolo[4,3-b]pyridazines
US4260756A (en) * 1979-11-15 1981-04-07 American Cyanamid Company 6- And 8-heteroaryl-1,2,4-triazolo[4,3-b]pyridazines
FI81350C (fi) 1982-01-18 1990-10-10 Lepetit Spa Analogfoerfarande foer framstaellning av nya, farmakologiskt aktiva 6-substituerade s-triatsolo/3,4-a/ ftalazinderivat.
IT1194310B (it) * 1983-07-12 1988-09-14 Lepetit Spa Derivati triazolo (3,4-a) ftalazinici 3,6-disostituiti
US4654343A (en) * 1985-10-31 1987-03-31 American Cyanamid Company N-substituted-N[3-(1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]alkanamides, carbamates and ureas
WO1998004559A2 (en) * 1996-07-25 1998-02-05 Merck Sharp & Dohme Limited Substituted triazolo-pyridazine derivatives as ligands for gaba receptors
PL341652A1 (en) * 1998-01-21 2001-04-23 Merck Sharp & Dohme Derivatives of triazolopyridazine as ligands for gaba receptors

Also Published As

Publication number Publication date
AU748737B2 (en) 2002-06-13
NO315516B1 (no) 2003-09-15
US6579875B1 (en) 2003-06-17
EA200000783A1 (ru) 2000-12-25
CN1110498C (zh) 2003-06-04
NO20003730D0 (no) 2000-07-20
EE200000430A (et) 2001-12-17
EP1049696A1 (en) 2000-11-08
IL136442A0 (en) 2001-06-14
US6828322B2 (en) 2004-12-07
HUP0100575A2 (hu) 2001-09-28
EA002755B1 (ru) 2002-08-29
IS5540A (is) 2000-06-16
HUP0100575A3 (en) 2003-03-28
PL341652A1 (en) 2001-04-23
CN1288465A (zh) 2001-03-21
CZ290883B6 (cs) 2002-11-13
US20040063714A1 (en) 2004-04-01
NZ504870A (en) 2002-11-26
NO20003730L (no) 2000-09-20
JP2002501066A (ja) 2002-01-15
GEP20032868B (en) 2003-01-27
WO1999037644A1 (en) 1999-07-29
SK10922000A3 (sk) 2001-03-12
KR20010034257A (ko) 2001-04-25
CA2315763A1 (en) 1999-07-29
MXPA00007135A (es) 2002-11-07
AU2065799A (en) 1999-08-09
CZ20002691A3 (cs) 2000-12-13
BR9906905A (pt) 2000-10-10
BG104671A (en) 2001-05-31
YU43800A (sh) 2002-12-10

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Payment date: 20021223

Year of fee payment: 6

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