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SI9620141B - Stanolni sestavki in njihova uporaba - Google Patents

Stanolni sestavki in njihova uporaba Download PDF

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Publication number
SI9620141B
SI9620141B SI9620141A SI9620141A SI9620141B SI 9620141 B SI9620141 B SI 9620141B SI 9620141 A SI9620141 A SI 9620141A SI 9620141 A SI9620141 A SI 9620141A SI 9620141 B SI9620141 B SI 9620141B
Authority
SI
Slovenia
Prior art keywords
fatty acid
acid ester
weight
composition according
composition
Prior art date
Application number
SI9620141A
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English (en)
Other versions
SI9620141A (sl
Inventor
Ingmar Wester
Tapio Palmu
Tatu Miettinen
Helena Gylling
Original Assignee
Raisio Benecol Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8546469&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI9620141(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Raisio Benecol Ltd filed Critical Raisio Benecol Ltd
Publication of SI9620141A publication Critical patent/SI9620141A/sl
Publication of SI9620141B publication Critical patent/SI9620141B/sl

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105Plant extracts, their artificial duplicates or their derivatives
    • A23L33/11Plant sterols or derivatives thereof, e.g. phytosterols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Botany (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Edible Oils And Fats (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Seasonings (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Ugotovljeno je bilo, da stanolni sestavek, ki vsebuje poleg sitostanola kot glavne komponente, tudiznatno količino vsaj 10% kampestanola, učinkovito znižuje nivoje serumskega holesterola, kadar ga vključimo v živila. Po zaestrenju je sestavek še zlasti uporaben v jedilnih maščobah in oljihin v živilih, ki vsebujejo maščobo.

Claims (15)

1 SI 9620141 - 20.08.2008-UO Patentni zahtevki 1. Sestavek rastlinskih stanolnih maščobnih kislinskih estrov, ki obsega sitostanolni maščobni kislinski ester in vsaj 20 mas.% kampestanolnega maščobnega kislinskega estra.
2. Sestavek rastlinskih stanolnih maščobnih kislinskih estrov za uporabo kot snov za zniževanje nivoja serumskega holesterola, pri čemer navedeni sestavek obsega sitostanolni maščobni kislinskih ester in vsaj 20 mas.% kampestanolnega maščobnega kislinskega estra.
3. Sestavek po zahtevku 1 ali 2, ki obsega od 20 mas.% do 40 mas. % kampestanolnega maščobnega kislinskega estra.
4. Sestavek po kateremkoli izmed zahtevkov od 1 do 3, ki obsega od 25 mas.% do 35 mas.% kampestanolnega maščobnega kislinskega estra.
5. Sestavek po kateremkoli izmed zahtevkov od 1 do 4, ki obsega 30 mas.% kampestanolnega maščobnega kislinskega estra.
6. Sestavek po kateremkoli izmed zahtevkov od 1 do 5, ki obsega od 50 mas.% do 80 mas.% sitostanolnega maščobnega kislinskega estra.
7. Sestavek po kateremkoli izmed zahtevkov od 1 do 6 za uporabo kot tak za zniževanje nivojev serumskega holesterola.
8. Sestavek po kateremkoli izmed zahtevkov od 1 do 6 za uporabo kot del diete za zniževanje nivojev serumskega holesterola. 2 SI 9620141 - 20.08.2008 - UO
9. Sestavek po kateremkoli izmed zahtevkov od 1 do 6 za uporabo kot del diete, ki obsega hrano, ki vsebuje maščobe, za zniževanje nivojev serumskega holesterola.
10. Uporaba sestavka po kateremkoli izmed zahtevkov od 1 do 6 za pripravo jedilnega proizvoda.
11. Prehrambna snov, ki vsebuje rastlinski stanolni maščobni kislinski estrski sestavek, ki je učinkovit v zniževanju nivojev serumskega holesterola, pri čemer navedeni sestavek obsega sitostanolni maščobni kislinski ester in vsaj 20 mas.% kampestanolnega maščobnega kislinskega estra.
12. Prehrambna snov po zahtevku 11, kjer navedeni sestavek obsega od 20 mas. % do 40 mas.% kampestanolnega maščobnega kislinskega estra.
13. Prehrambna snov po zahtevku 11 ali 12, kjer navedeni sestavek obsega od 25 mas.% do 35 mas.% kampestanolnega maščobnega kislinskega estra.
14. Prehrambna snov po kateremkoli izmed zahtevkov od 11 do 13, kjer navedeni sestavek obsega 30 mas. % kampestanolnega maščobnega kislinskega estra.
15. Prehrambna snov po kateremkoli izmed zahtevkov od 11 do 14, kjer navedeni sestavek obsega od 50 mas.% do 80 mas.% sitostanolnega maščobnega kislinskega estra.
SI9620141A 1996-08-09 1996-09-02 Stanolni sestavki in njihova uporaba SI9620141B (sl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI963126A FI107015B (fi) 1996-08-09 1996-08-09 Kasvistanolirasvahappoestereiden seos ja sen käyttö sekä elintarvike
PCT/FI1996/000465 WO1998006405A1 (en) 1996-08-09 1996-09-02 Stanol composition and the use thereof

Publications (2)

Publication Number Publication Date
SI9620141A SI9620141A (sl) 1999-10-31
SI9620141B true SI9620141B (sl) 2008-10-31

Family

ID=8546469

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9620141A SI9620141B (sl) 1996-08-09 1996-09-02 Stanolni sestavki in njihova uporaba

Country Status (27)

Country Link
EP (2) EP0871451B2 (sl)
JP (3) JP2000513730A (sl)
KR (1) KR100440640B1 (sl)
CN (1) CN1165312C (sl)
AT (1) ATE266408T1 (sl)
AU (1) AU734418B2 (sl)
BR (1) BRPI9612693B8 (sl)
CA (1) CA2262600C (sl)
CZ (1) CZ290903B6 (sl)
DE (1) DE69632481T3 (sl)
DK (1) DK0871451T4 (sl)
EE (1) EE03747B1 (sl)
ES (1) ES2220986T5 (sl)
FI (1) FI107015B (sl)
HU (1) HU228301B1 (sl)
IL (1) IL128458A (sl)
LT (1) LT4649B (sl)
LV (1) LV12307B (sl)
NO (1) NO326262B1 (sl)
NZ (1) NZ334496A (sl)
PL (1) PL331515A1 (sl)
PT (1) PT871451E (sl)
SI (1) SI9620141B (sl)
SK (1) SK285849B6 (sl)
UA (1) UA66763C2 (sl)
WO (1) WO1998006405A1 (sl)
ZA (1) ZA967616B (sl)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU664827B2 (en) 1991-05-03 1995-12-07 Raisio Benecol Ltd. A substance for lowering high cholesterol level in serum and a method for preparing the same
US6544973B1 (en) 1995-07-28 2003-04-08 Raisio Benecol Ltd. Substance for lowering high cholesterol level in serum and methods for preparing and using the same
US6262277B1 (en) 1994-09-13 2001-07-17 G.D. Searle And Company Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US6642268B2 (en) 1994-09-13 2003-11-04 G.D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors
US20030104035A1 (en) 1996-08-09 2003-06-05 Raisio Benecol Ltd. Stanol composition and the use thereof
UA69378C2 (uk) * 1996-11-04 2004-09-15 Райзіо Бенекол Лтд. Текстуруюча композиція, текстуруючий агент, харчовий продукт, жирові суміші та способи їх одержання
US6929816B2 (en) 1998-01-21 2005-08-16 Raisio Benecol Ltd. Fat compositions for use in food
FI107538B (fi) 1997-02-26 2001-08-31 Raisio Benecol Oy Menetelmä stanoliesterien valmistamiseksi
ES2222553T3 (es) * 1997-08-22 2005-02-01 Unilever N.V. Producto alimenticio a base de grasa que comprende esteroles.
EP1440619B1 (en) * 1997-08-22 2006-11-02 Unilever N.V. Fat based food products comprising sterols
DE69818942T2 (de) 1997-08-22 2004-09-09 Unilever N.V. Stanolester enthaltende Zusammensetzungen
ES2231940T3 (es) * 1997-08-22 2005-05-16 Unilever N.V. Composicion de esteres de estanol.
EP0897971B1 (en) * 1997-08-22 2004-11-03 Unilever N.V. Stanol ester composition
DK0897970T3 (da) * 1997-08-22 2004-11-08 Unilever Nv Fremgangsmåde til fremstilling af stanolestere
FI974648A7 (fi) 1997-09-09 1999-05-06 Raisio Benecol Oy Hydroksihappo-, maitohappo- ja hydroksialkanoaattiesterit ja niiden käyttö
WO1999048907A1 (de) * 1998-03-23 1999-09-30 Cognis Deutschland Gmbh Verfahren zur herstellung von stanolen
US6025348A (en) * 1998-04-30 2000-02-15 Kao Corporation Oil and fat composition containing phytosterol
US6123978A (en) * 1998-08-31 2000-09-26 Mcneil-Ppc, Inc. Stable salad dressings
US6277431B1 (en) * 1998-10-14 2001-08-21 Redeem, Inc. Anticholesterolemic edible oil
FI115527B (fi) * 1998-10-16 2005-05-31 Upm Kymmene Oyj Kasvisterolijohdannaisten käyttö ja niitä sisältäviä tuotteita
NZ501169A (en) * 1998-11-26 2001-05-25 F Fatty acid esters of phytosterol and phytostanol
US6113972A (en) * 1998-12-03 2000-09-05 Monsanto Co. Phytosterol protein complex
DE69908643T2 (de) 1998-12-23 2004-05-13 G.D. Searle Llc, Chicago Kombinationen von cholesteryl ester transfer protein inhibitoren und nicotinsäure derivaten für kardiovaskuläre indikationen
WO2000047701A2 (en) 1999-02-10 2000-08-17 Eastman Chemical Company Corn fiber for the production of advanced chemicals and materials
EP1169462B1 (en) 1999-04-12 2009-10-21 Monsanto Technology LLC Oil comprising brassicastanol
FI991533L (fi) * 1999-07-05 2001-01-06 Sohkar Oy Menetelmä orgaanisten aineiden käsittelemiseksi
US6998501B1 (en) 1999-08-30 2006-02-14 Ocean Nutrition Canada Limited Nutritional supplement for lowering serum triglyceride and cholesterol levels
US7157619B1 (en) 1999-08-30 2007-01-02 Monsanto Technology, L.L.C. Plant sterol acyltransferases
WO2001015552A1 (en) * 1999-08-30 2001-03-08 Ocean Nutrition Canada Ltd. A nutritional supplement for lowering serum triglyceride and cholesterol levels
US6677327B1 (en) 1999-11-24 2004-01-13 Archer-Daniels-Midland Company Phytosterol and phytostanol compositions
ATE323714T1 (de) * 2000-01-21 2006-05-15 Forbes Medi Tech Inc Krystalline zusammensetzungen enthaltend phytosterole und phytostanole oder derivate davon
CA2395447A1 (en) 2000-01-28 2001-08-02 Robert Joseph Sarama Palatable arginine compounds and uses thereof for cardiovascular health
ES2298197T3 (es) * 2000-01-31 2008-05-16 Harting S.A. Composiciones que contienen esteres de acidos grasos de fitosterol y de policosanol para reducir el colesterol y los trigliceridos de la sangre.
AU2001253294A1 (en) 2000-04-14 2001-10-30 Mars, Incorporated Compositions and methods for improving vascular health
FI20010780A0 (fi) * 2001-04-12 2001-04-12 Raisio Benecol Oy Parannetut koostumukset
JP2005521653A (ja) 2002-01-17 2005-07-21 ファルマシア コーポレイション 先端ナトリウム同時依存性胆汁酸輸送(asbt)およびタウロコール酸塩取込みの阻害剤としての新規アルキル/アリールヒドロキシまたはケトチエピン化合物
US20080182801A1 (en) 2003-12-22 2008-07-31 Btg International Limited Core 2 glcnac-t inhibitors
GB0513881D0 (en) 2005-07-06 2005-08-10 Btg Int Ltd Core 2 GLCNAC-T Inhibitors III
GB0329667D0 (en) 2003-12-22 2004-01-28 King S College London Core 2 GlcNAc-T inhibitor
US8158184B2 (en) 2004-03-08 2012-04-17 Bunge Oils, Inc. Structured lipid containing compositions and methods with health and nutrition promoting characteristics
GB0513883D0 (en) 2005-07-06 2005-08-10 Btg Int Ltd Diagnosis of Atherosclerosis
GB0513888D0 (en) 2005-07-06 2005-08-10 Btg Int Ltd Core 2 GLCNAC-T Inhibitors II
IE20060710A1 (en) * 2005-09-28 2007-07-25 Alltracel Dev Services Ltd Use of polyanhydroglucronic acid
CA2673005A1 (en) * 2005-12-20 2007-06-28 Forbes Medi-Tech Inc. Emulsions comprising non-esterified phytosterols in the aqueous phase
US20070148311A1 (en) 2005-12-22 2007-06-28 Bunge Oils, Inc. Phytosterol esterification product and method of make same
DE102006041302A1 (de) * 2006-03-08 2007-09-13 Cognis Ip Management Gmbh Sterolester mit kurzkettigen Fettsäuren
AU2007222697B2 (en) * 2006-03-08 2012-07-05 Cognis Ip Management Gmbh Powder containing sterol
US20080124387A1 (en) 2006-11-27 2008-05-29 Kapac, Llc Methods and formulations for enhancing the absorption and decreasing the absorption variability of orally administered drugs, vitamins and nutrients
FI123374B (fi) 2011-03-25 2013-03-15 Ravintoraisio Oy Uusi syötävä koostumus
PL3287014T3 (pl) * 2016-08-22 2020-08-24 Verbio Vereinigte Bioenergie Ag Sposób wytwarzania kompozycji fitosteroli-fitostanoli
WO2021170873A1 (en) * 2020-02-27 2021-09-02 Basf Se Composition for the treatment of (pre)hypercholesterolemia and/or associated morbidities thereto
GB202110358D0 (en) * 2021-07-19 2021-09-01 Meda Pharma S P A Composition

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU664827B2 (en) * 1991-05-03 1995-12-07 Raisio Benecol Ltd. A substance for lowering high cholesterol level in serum and a method for preparing the same
US5244887A (en) * 1992-02-14 1993-09-14 Straub Carl D Stanols to reduce cholesterol absorption from foods and methods of preparation and use thereof

Also Published As

Publication number Publication date
HUP0001020A3 (en) 2001-10-29
CN1165312C (zh) 2004-09-08
JP2009102421A (ja) 2009-05-14
LV12307A (lv) 1999-07-20
FI963126A0 (fi) 1996-08-09
CZ290903B6 (cs) 2002-11-13
FI107015B (fi) 2001-05-31
BRPI9612693B1 (pt) 2016-04-12
EP1452180A1 (en) 2004-09-01
CZ34699A3 (cs) 1999-07-14
JP2000513730A (ja) 2000-10-17
CA2262600A1 (en) 1998-02-19
JP4554915B2 (ja) 2010-09-29
EE9900040A (et) 1999-08-16
BR9612693A (pt) 1999-12-28
BRPI9612693B8 (pt) 2016-04-26
DE69632481T2 (de) 2005-05-12
UA66763C2 (en) 2004-06-15
HUP0001020A2 (hu) 2000-08-28
SI9620141A (sl) 1999-10-31
HU228301B1 (en) 2013-03-28
ES2220986T3 (es) 2004-12-16
ZA967616B (en) 1997-04-16
IL128458A (en) 2004-07-25
ES2220986T5 (es) 2008-11-01
DK0871451T3 (da) 2004-09-20
FI963126L (fi) 1998-02-10
LT4649B (lt) 2000-04-25
KR20000029884A (ko) 2000-05-25
EP0871451B2 (en) 2008-07-09
WO1998006405A1 (en) 1998-02-19
CN1228025A (zh) 1999-09-08
SK285849B6 (sk) 2007-09-06
LV12307B (en) 1999-10-20
DE69632481T3 (de) 2008-11-27
LT99018A (lt) 1999-12-27
AU6823096A (en) 1998-03-06
IL128458A0 (en) 2000-01-31
SK11299A3 (en) 1999-09-10
ATE266408T1 (de) 2004-05-15
PL331515A1 (en) 1999-07-19
EP0871451B1 (en) 2004-05-12
JP2004143181A (ja) 2004-05-20
PT871451E (pt) 2004-09-30
DK0871451T4 (da) 2008-11-10
NO990559D0 (no) 1999-02-05
KR100440640B1 (ko) 2004-07-19
AU734418B2 (en) 2001-06-14
NZ334496A (en) 2000-07-28
CA2262600C (en) 2009-11-17
NO990559L (no) 1999-02-05
DE69632481D1 (de) 2004-06-17
NO326262B1 (no) 2008-10-27
EP0871451A1 (en) 1998-10-21
EE03747B1 (et) 2002-06-17

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OU02 Decision according to article 73(2) ipa 1992, publication of decision on partial fulfilment of the invention and change of patent claims

Effective date: 20080826