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SG64903A1 - 2,4-disulfonyl phenyl butyl nitrone its salts and their uses as pharmaceuticals - Google Patents

2,4-disulfonyl phenyl butyl nitrone its salts and their uses as pharmaceuticals

Info

Publication number
SG64903A1
SG64903A1 SG1996007103A SG1996007103A SG64903A1 SG 64903 A1 SG64903 A1 SG 64903A1 SG 1996007103 A SG1996007103 A SG 1996007103A SG 1996007103 A SG1996007103 A SG 1996007103A SG 64903 A1 SG64903 A1 SG 64903A1
Authority
SG
Singapore
Prior art keywords
nervous system
central nervous
salts
pharmaceuticals
butyl nitrone
Prior art date
Application number
SG1996007103A
Other languages
English (en)
Inventor
John M Carney
Original Assignee
Oklahoma Med Res Found
Univ Kentucky Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oklahoma Med Res Found, Univ Kentucky Res Found filed Critical Oklahoma Med Res Found
Publication of SG64903A1 publication Critical patent/SG64903A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/45—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
    • C07C309/46—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton having the sulfo groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SG1996007103A 1993-12-23 1994-12-22 2,4-disulfonyl phenyl butyl nitrone its salts and their uses as pharmaceuticals SG64903A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/173,579 US5488145A (en) 1993-12-23 1993-12-23 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps

Publications (1)

Publication Number Publication Date
SG64903A1 true SG64903A1 (en) 1999-05-25

Family

ID=22632663

Family Applications (1)

Application Number Title Priority Date Filing Date
SG1996007103A SG64903A1 (en) 1993-12-23 1994-12-22 2,4-disulfonyl phenyl butyl nitrone its salts and their uses as pharmaceuticals

Country Status (28)

Country Link
US (4) US5488145A (hu)
EP (1) EP0736004B1 (hu)
JP (3) JP3412821B2 (hu)
KR (1) KR100370522B1 (hu)
CN (1) CN1070176C (hu)
AT (1) ATE192736T1 (hu)
AU (1) AU679835B2 (hu)
BR (2) BR9408378A (hu)
CA (1) CA2179521C (hu)
CZ (1) CZ289629B6 (hu)
DE (1) DE69424441T2 (hu)
DK (1) DK0736004T3 (hu)
ES (1) ES2145264T3 (hu)
FI (1) FI111718B (hu)
GR (1) GR3034134T3 (hu)
HR (1) HRP950358B1 (hu)
HU (1) HU221167B1 (hu)
MY (1) MY114178A (hu)
NO (1) NO306457B1 (hu)
NZ (1) NZ279025A (hu)
PL (1) PL185189B1 (hu)
PT (1) PT736004E (hu)
RU (1) RU2159231C2 (hu)
SG (1) SG64903A1 (hu)
SK (1) SK282403B6 (hu)
TW (1) TW299315B (hu)
UA (1) UA45964C2 (hu)
WO (1) WO1995017876A2 (hu)

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US5488145A (en) * 1993-12-23 1996-01-30 Oklahoma Medical Research Foundation 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps
CN1250528C (zh) * 1995-09-11 2006-04-12 阿温蒂斯药物公司 环状硝酮和含有它们的药用组合物
CA2235765C (en) * 1995-11-17 2006-04-04 David A. Becker Azulenyl nitrone spin trapping agents, methods of making and using same
EP0949915A4 (en) * 1996-04-17 2001-07-04 Oklahoma Med Res Found TREATMENT OF DEMENTIA ASSOCIATED WITH AIDS VIRUS INFECTION (HIV-1) USING NITRONE-FREE RADICAL TRAPS
KR20000067915A (ko) * 1996-07-19 2000-11-25 센토르 파마슈티칼스, 인크. 푸란 니트론 화합물
TW429241B (en) 1996-09-26 2001-04-11 Sumitomo Pharma Nitrone derivatives
US6046232A (en) * 1997-10-17 2000-04-04 Centaur Pharmaceuticals, Inc. α-aryl-N-alkylnitrones and pharmaceutical compositions containing the same
DE69904018D1 (en) * 1998-01-16 2003-01-02 Centaur Pharmaceuticals Inc Thiophennitronderivate
WO1999036415A1 (en) * 1998-01-16 1999-07-22 Centaur Pharmaceuticals, Inc. Thioether furan nitrone compounds
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US6730700B2 (en) * 1998-12-02 2004-05-04 Renovis, Inc. 3,4,5,-trisubstituted aryl nitrone compounds and pharmaceutical compositions containing the same
UA66401C2 (en) 1998-12-02 2004-05-17 Sentor Pharmaceuticals Inc 3,4,5-trisubstituted aryl nitrone compounds and pharmaceutical composition containing the same
NZ513164A (en) 1999-01-25 2006-03-31 Nat Jewish Med & Res Center Substituted porphyrins
MXPA01010835A (es) * 1999-04-28 2003-07-14 Univ Kingston Composiciones y metodos para tratar amiloidosis.
BR9904931A (pt) * 1999-10-18 2001-06-12 Sergio Teixeira Ferreira Inibição de amiloidoses
WO2001028578A2 (en) * 1999-10-22 2001-04-26 Wrair A PHARMACEUTICAL COMPOSITION CONTAINING pGLU-GLU-PRO-NH2 AND METHOD FOR TREATING DISEASES AND INJURIES TO THE BRAIN, SPINAL CORD AND RETINA USING SAME
US6815425B1 (en) 1999-10-22 2004-11-09 The United States Of America As Represented By The Secretary Of The Army Pharmaceutical composition containing pGLU-GLU-PRO-NH2 and method for treating diseases and injuries to the brain, spinal cord and retina using same
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AU2001236442A1 (en) * 2000-01-10 2001-07-24 Centaur Phamaceuticals, Inc. Method for the purification of aryl sulfonic acids and salts
SE0000056D0 (sv) * 2000-01-10 2000-01-10 Astrazeneca Ab Novel process
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US6664297B1 (en) 2000-10-18 2003-12-16 Universidade Federal Do Rio De Janeiro Methods for inhibition and dissolution of amyloidoses by administration of compositions comprising 2,4-dinitrophenol
WO2002065993A2 (en) 2001-01-08 2002-08-29 Centaur Pharmaceuticals, Inc. Use of aryl nitrone compounds in methods for treating neuropathic pain
WO2003010154A1 (en) * 2001-07-26 2003-02-06 Samsung Electronics Co. Ltd. Seleno compounds containing nitrone moiety, their preparation and their therapeutic uses
US20030045461A1 (en) * 2001-09-06 2003-03-06 Jen-Chang Hsia Composition and methods of esterified nitroxides gated with carboxylic acids
FR2846968B1 (fr) * 2002-11-08 2005-02-04 Salles Jean Pierre Nouveaux derives amphiphiles de l'alpha-c-phenyl-n-tert- butyl nitrone
US20070010573A1 (en) * 2003-06-23 2007-01-11 Xianqi Kong Methods and compositions for treating amyloid-related diseases
US7414076B2 (en) * 2003-06-23 2008-08-19 Neurochem (International) Limited Methods and compositions for treating amyloid-related diseases
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US20050059638A1 (en) * 2003-08-04 2005-03-17 Kelly Michael G. Aryl, heteroaromatic and bicyclic aryl nitrone compounds, prodrugs and pharmaceutical compositions of the same to treat human disorders
US20050182060A1 (en) * 2004-02-13 2005-08-18 Kelly Michael G. 2-Substituted and 4-substituted aryl nitrone compounds
EP1828111A2 (en) * 2004-11-12 2007-09-05 Neurochem (International) Limited Methods and fluorinated compositions for treating amyloid-related diseases
EP1817305A2 (en) * 2004-11-16 2007-08-15 Neurochem (International) Limited Compounds for the treatment of cns and amyloid associated diseases
CA2592320C (en) 2004-12-22 2015-11-24 Neurochem (International) Limited Methods and compositions for treating amyloid-related diseases
US20060235370A1 (en) * 2005-04-04 2006-10-19 Oblong John E Method of regulating mammalian keratinous tissue
TW200716088A (en) * 2005-04-15 2007-05-01 Neurochem Int Ltd Formulations and methods for treating amyloidosis
WO2007013843A1 (en) * 2005-07-26 2007-02-01 Astrazeneca Ab Use of 4-[(tert-butylimino)methyl]benzene-1,3-disulfonate n-oxide against myocardial ischaemia
WO2007013844A1 (en) * 2005-07-26 2007-02-01 Astrazeneca Ab Use of 4-[(tert-butylimino)benzene-1,3-disulfonate n-oxide against nausea
WO2007013842A1 (en) * 2005-07-26 2007-02-01 Astrazeneca Ab Use of 4-((tert-butylimino)methyl) benzene-1,3-disulfonate n-oxide against maemorrhagic changes in the brain
WO2007013841A1 (en) * 2005-07-26 2007-02-01 Astrazeneca Ab Use of 4-((tert-butylimine)methyl) benzene-1,3-disulfonate n-oxide against cerebral oedema
EP1968561B8 (en) * 2005-12-22 2010-10-20 Kiacta Sàrl Treatment of diabetic nephropathy
WO2008013866A2 (en) * 2006-07-25 2008-01-31 Hough Ear Institute Methods for treating acute acoustic trauma
ES2533463T3 (es) 2006-10-12 2015-04-10 Bhi Limited Partnership Métodos, compuestos, composiciones y vehículos para suministrar ácido 3-amino-1-propanosulfónico
US20080262088A1 (en) * 2006-12-22 2008-10-23 Wendy Hauck Methods, compounds, and compositions for treating metabolic disorders and diabetes
US20090082454A1 (en) * 2007-09-25 2009-03-26 Protia, Llc Deuterium-enriched disufenton
ES2571740T3 (es) 2007-09-26 2016-05-26 St Jude Medical Válvulas cardiacas protésicas colapsables
CN102006775B (zh) * 2008-02-12 2015-02-25 托斯克公司 减少毒性的多柔比星助剂及其使用方法
ES2600469T3 (es) 2008-05-23 2017-02-09 National Jewish Health Un compuesto para su uso en el tratamiento de lesiones asociadas con la exposición al gas fosgeno o al gas de cloro
CA2735859C (en) * 2008-09-02 2016-08-30 Oklahoma Medical Research Foundation 2,4-disulfonyl phenyl tert-butyl nitrone for the treatment of gliomas
ES2563777T3 (es) * 2009-08-24 2016-03-16 Hough Ear Institute Compuestos de nitrona para tratar la pérdida auditiva sensorineural
CA2826602C (en) 2011-02-04 2019-06-11 Hough Ear Institute Methods for treating brain injury
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US10829441B2 (en) 2017-11-14 2020-11-10 The University Of Toledo Reactive oxygen species-sensitive nitric oxide synthase inhibitors for the treatment of ischemic stroke
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DE3914650A1 (de) * 1989-05-03 1990-11-08 Basf Ag Neue phenylendiamine sowie ein verfahren zur herstellung von phenylendiaminen
DK0496796T3 (da) * 1989-10-17 1994-10-03 Oklahoma Med Res Found Fremgangsmåde og præparater til inhibering af sygdomme i forbindelse med oxidativ beskadigelse
US5025032A (en) * 1989-10-17 1991-06-18 Oklahoma Medical Research Foundation Phenyl butyl nitrone compositions and methods for treatment of oxidative tissue damage
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CA2111836C (en) * 1991-06-18 2006-08-29 John M. Carney Spin-trapping pharmaceutical compositions and methods for use thereof
US5488145A (en) * 1993-12-23 1996-01-30 Oklahoma Medical Research Foundation 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps

Also Published As

Publication number Publication date
CN1070176C (zh) 2001-08-29
SK78896A3 (en) 1997-09-10
SK282403B6 (sk) 2002-01-07
BR1100626A (pt) 1999-11-23
JPH09507232A (ja) 1997-07-22
KR100370522B1 (ko) 2003-05-16
HU9601739D0 (en) 1996-08-28
GR3034134T3 (en) 2000-11-30
US5780510A (en) 1998-07-14
NZ279025A (en) 1998-02-26
JP2001010953A (ja) 2001-01-16
US5508305A (en) 1996-04-16
WO1995017876A3 (en) 1995-08-10
UA45964C2 (uk) 2002-05-15
AU679835B2 (en) 1997-07-10
CZ289629B6 (cs) 2002-03-13
CA2179521C (en) 2002-03-19
FI962589A0 (fi) 1996-06-20
HK1008294A1 (en) 1999-05-07
PL185189B1 (pl) 2003-03-31
HU221167B1 (en) 2002-08-28
NO962637L (no) 1996-08-13
EP0736004B1 (en) 2000-05-10
MY114178A (en) 2002-08-30
CA2179521A1 (en) 1995-07-06
US5475032A (en) 1995-12-12
HRP950358A2 (en) 1997-08-31
PL315154A1 (en) 1996-10-14
DK0736004T3 (da) 2000-10-09
HUT76788A (en) 1997-11-28
NO962637D0 (no) 1996-06-20
FI111718B (fi) 2003-09-15
HRP950358B1 (en) 2001-04-30
DE69424441D1 (de) 2000-06-15
CN1156447A (zh) 1997-08-06
ATE192736T1 (de) 2000-05-15
DE69424441T2 (de) 2000-10-12
RU2159231C2 (ru) 2000-11-20
TW299315B (hu) 1997-03-01
WO1995017876A2 (en) 1995-07-06
NO306457B1 (no) 1999-11-08
HK1001768A1 (en) 1998-07-10
PT736004E (pt) 2000-09-29
FI962589L (fi) 1996-08-20
CZ177596A3 (en) 1996-12-11
US5488145A (en) 1996-01-30
JP3412821B2 (ja) 2003-06-03
AU1552795A (en) 1995-07-17
EP0736004A1 (en) 1996-10-09
BR9408378A (pt) 1997-08-19
JP2004075696A (ja) 2004-03-11
ES2145264T3 (es) 2000-07-01

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