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HRP950358B1 - 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceuticals - Google Patents

2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceuticals

Info

Publication number
HRP950358B1
HRP950358B1 HR950358A HRP950358A HRP950358B1 HR P950358 B1 HRP950358 B1 HR P950358B1 HR 950358 A HR950358 A HR 950358A HR P950358 A HRP950358 A HR P950358A HR P950358 B1 HRP950358 B1 HR P950358B1
Authority
HR
Croatia
Prior art keywords
nervous system
central nervous
salts
pharmaceuticals
butyl nitrone
Prior art date
Application number
HR950358A
Other languages
English (en)
Inventor
John M Carney
Original Assignee
Oklahoma Med Res Found
Univ Kentucky Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oklahoma Med Res Found, Univ Kentucky Res Found filed Critical Oklahoma Med Res Found
Publication of HRP950358A2 publication Critical patent/HRP950358A2/xx
Publication of HRP950358B1 publication Critical patent/HRP950358B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/45—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
    • C07C309/46—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton having the sulfo groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HR950358A 1993-12-23 1995-06-23 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceuticals HRP950358B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/173,579 US5488145A (en) 1993-12-23 1993-12-23 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps

Publications (2)

Publication Number Publication Date
HRP950358A2 HRP950358A2 (en) 1997-08-31
HRP950358B1 true HRP950358B1 (en) 2001-04-30

Family

ID=22632663

Family Applications (1)

Application Number Title Priority Date Filing Date
HR950358A HRP950358B1 (en) 1993-12-23 1995-06-23 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceuticals

Country Status (28)

Country Link
US (4) US5488145A (xx)
EP (1) EP0736004B1 (xx)
JP (3) JP3412821B2 (xx)
KR (1) KR100370522B1 (xx)
CN (1) CN1070176C (xx)
AT (1) ATE192736T1 (xx)
AU (1) AU679835B2 (xx)
BR (2) BR9408378A (xx)
CA (1) CA2179521C (xx)
CZ (1) CZ289629B6 (xx)
DE (1) DE69424441T2 (xx)
DK (1) DK0736004T3 (xx)
ES (1) ES2145264T3 (xx)
FI (1) FI111718B (xx)
GR (1) GR3034134T3 (xx)
HR (1) HRP950358B1 (xx)
HU (1) HU221167B1 (xx)
MY (1) MY114178A (xx)
NO (1) NO306457B1 (xx)
NZ (1) NZ279025A (xx)
PL (1) PL185189B1 (xx)
PT (1) PT736004E (xx)
RU (1) RU2159231C2 (xx)
SG (1) SG64903A1 (xx)
SK (1) SK282403B6 (xx)
TW (1) TW299315B (xx)
UA (1) UA45964C2 (xx)
WO (1) WO1995017876A2 (xx)

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US5622994A (en) * 1989-10-17 1997-04-22 Oklahoma Medical Research Foundation Spin trapping pharmaceutical compositions and methods for use thereof
AU653921B2 (en) * 1989-10-17 1994-10-20 Oklahoma Medical Research Foundation Method and compositions for inhibition of disorders associated with oxidative damage
US20050107366A1 (en) * 1991-06-18 2005-05-19 Carney John M. Spin trapping pharmaceutical compositions and methods for use thereof
US6002001A (en) * 1991-06-18 1999-12-14 Oklahoma Medical Research Foundation Spin trapping pharmaceutical compositions and methods for use thereof
US20040208875A1 (en) * 1995-03-15 2004-10-21 Queen's University At Kingston Method for treating amyloidosis
US5488145A (en) * 1993-12-23 1996-01-30 Oklahoma Medical Research Foundation 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps
ATE230731T1 (de) * 1995-09-11 2003-01-15 Aventis Pharma Inc Cyclische nitrone und pharmazeutische zusammensetzungen die sie enthalten
DE69636795D1 (de) 1995-11-17 2007-02-08 Florida Internat University Azulenylnitrone als radikal fanger (spin trapping agents), verfahren zu ihrer herstellung und ihre anwendung
AU725432B2 (en) * 1996-04-17 2000-10-12 Centaur Pharmaceuticals, Inc. Nitrone free radical trap treatment of dementia associated with AIDS virus (HIV-1) infection
KR20000067915A (ko) * 1996-07-19 2000-11-25 센토르 파마슈티칼스, 인크. 푸란 니트론 화합물
TW429241B (en) 1996-09-26 2001-04-11 Sumitomo Pharma Nitrone derivatives
MA26553A1 (fr) * 1997-10-17 2004-12-20 Centaur Pharmaceuticals Inc Alpha-aryl-n-alkylnitrones et compositions pharmaceutiques contenant ceux-la
AU742768B2 (en) * 1998-01-16 2002-01-10 Renovis, Inc. Thioether furan nitrone compounds
ZA99255B (en) * 1998-01-16 1999-07-14 Centaur Pharmaceuticals Inc Thiopene nitrone compounds.
CA2323490A1 (en) * 1998-03-13 1999-09-16 Lowell D. Waterbury Inhibition of angiogenesis
AU3985799A (en) * 1998-05-19 1999-12-06 Centaur Pharmaceuticals, Inc. Furan nitrone therapeutics for the treatment of inflammatory bowel disease
US6083989A (en) * 1999-05-18 2000-07-04 Centaur Pharmaceuticals, Inc. Aryl nitrone therapeutics for the treatment of inflammatory bowel disease
UA66401C2 (en) 1998-12-02 2004-05-17 Sentor Pharmaceuticals Inc 3,4,5-trisubstituted aryl nitrone compounds and pharmaceutical composition containing the same
US6730700B2 (en) * 1998-12-02 2004-05-04 Renovis, Inc. 3,4,5,-trisubstituted aryl nitrone compounds and pharmaceutical compositions containing the same
CN1156478C (zh) 1999-01-25 2004-07-07 国家犹太医疗及研究中心 取代的卟啉
ATE441421T1 (de) * 1999-04-28 2009-09-15 Bellus Health Int Ltd Zusammensetzungen und verfahren zur behandlung von amyloidosis mit sulphonatderivaten
BR9904931A (pt) * 1999-10-18 2001-06-12 Sergio Teixeira Ferreira Inibição de amiloidoses
AU1574701A (en) * 1999-10-22 2001-04-30 Wrair Walter Reed Army Institute Of Research A pharmaceutical composition containing pglu-glu-pro-nh2 and method for treating diseases and injuries to the brain, spinal cord and retina using same
US6815425B1 (en) 1999-10-22 2004-11-09 The United States Of America As Represented By The Secretary Of The Army Pharmaceutical composition containing pGLU-GLU-PRO-NH2 and method for treating diseases and injuries to the brain, spinal cord and retina using same
SE0000055D0 (sv) * 2000-01-10 2000-01-10 Centaur Pharmaceuticals Inc Novel process
US20020022743A1 (en) * 2000-01-10 2002-02-21 Sergei Pouhov Method for the purification of aryl sulfonic acids and salts
SE0000056D0 (sv) * 2000-01-10 2000-01-10 Astrazeneca Ab Novel process
SE0001916D0 (sv) * 2000-05-23 2000-05-23 Astrazeneca Ab Novel formulation
US6664297B1 (en) 2000-10-18 2003-12-16 Universidade Federal Do Rio De Janeiro Methods for inhibition and dissolution of amyloidoses by administration of compositions comprising 2,4-dinitrophenol
US6835754B2 (en) 2001-01-08 2004-12-28 Renovis, Inc. Use of aryl nitrone compounds in methods for treating neuropathic pain
WO2003010154A1 (en) * 2001-07-26 2003-02-06 Samsung Electronics Co. Ltd. Seleno compounds containing nitrone moiety, their preparation and their therapeutic uses
US20030045461A1 (en) * 2001-09-06 2003-03-06 Jen-Chang Hsia Composition and methods of esterified nitroxides gated with carboxylic acids
FR2846968B1 (fr) * 2002-11-08 2005-02-04 Salles Jean Pierre Nouveaux derives amphiphiles de l'alpha-c-phenyl-n-tert- butyl nitrone
US20070010573A1 (en) * 2003-06-23 2007-01-11 Xianqi Kong Methods and compositions for treating amyloid-related diseases
US7244764B2 (en) * 2003-06-23 2007-07-17 Neurochem (International) Limited Methods and compositions for treating amyloid-related diseases
US7414076B2 (en) * 2003-06-23 2008-08-19 Neurochem (International) Limited Methods and compositions for treating amyloid-related diseases
US20050059638A1 (en) * 2003-08-04 2005-03-17 Kelly Michael G. Aryl, heteroaromatic and bicyclic aryl nitrone compounds, prodrugs and pharmaceutical compositions of the same to treat human disorders
US20050182060A1 (en) * 2004-02-13 2005-08-18 Kelly Michael G. 2-Substituted and 4-substituted aryl nitrone compounds
CA2586111A1 (en) * 2004-11-12 2006-06-08 Neurochem (International) Limited Methods and fluorinated compositions for treating amyloid-related diseases
WO2006059245A2 (en) * 2004-11-16 2006-06-08 Neurochem (International) Limited Compounds for the treatment of cns and amyloid associated diseases
CA2592320C (en) 2004-12-22 2015-11-24 Neurochem (International) Limited Methods and compositions for treating amyloid-related diseases
US20060235370A1 (en) * 2005-04-04 2006-10-19 Oblong John E Method of regulating mammalian keratinous tissue
TW200716088A (en) * 2005-04-15 2007-05-01 Neurochem Int Ltd Formulations and methods for treating amyloidosis
WO2007013841A1 (en) * 2005-07-26 2007-02-01 Astrazeneca Ab Use of 4-((tert-butylimine)methyl) benzene-1,3-disulfonate n-oxide against cerebral oedema
WO2007013842A1 (en) * 2005-07-26 2007-02-01 Astrazeneca Ab Use of 4-((tert-butylimino)methyl) benzene-1,3-disulfonate n-oxide against maemorrhagic changes in the brain
WO2007013843A1 (en) * 2005-07-26 2007-02-01 Astrazeneca Ab Use of 4-[(tert-butylimino)methyl]benzene-1,3-disulfonate n-oxide against myocardial ischaemia
WO2007013844A1 (en) * 2005-07-26 2007-02-01 Astrazeneca Ab Use of 4-[(tert-butylimino)benzene-1,3-disulfonate n-oxide against nausea
AU2006342958A1 (en) * 2005-12-22 2007-11-08 Bellus Health (International) Limited Treatment of renal disorders, diabetic nephropathy and dyslipidemias
EP2054047B1 (en) * 2006-07-25 2014-12-17 Hough Ear Institute Methods for treating acute acoustic trauma
CN101600730B (zh) 2006-10-12 2014-01-29 Bhi有限合资公司 递送3-氨基-1-丙磺酸的方法、化合物、组合物和载体
CN101730529A (zh) * 2006-12-22 2010-06-09 贝鲁斯健康(国际)有限公司 用于治疗代谢疾病和糖尿病的方法、化合物和组合物
US20090082454A1 (en) * 2007-09-25 2009-03-26 Protia, Llc Deuterium-enriched disufenton
US8425593B2 (en) 2007-09-26 2013-04-23 St. Jude Medical, Inc. Collapsible prosthetic heart valves
JP5611056B2 (ja) 2008-02-12 2014-10-22 トスク インコーポレーティッド 毒性を低減するためのドキソルビシンアジュバントおよびその使用法
US11382895B2 (en) 2008-05-23 2022-07-12 National Jewish Health Methods for treating injury associated with exposure to an alkylating species
WO2010028058A1 (en) * 2008-09-02 2010-03-11 Oklahoma Medical Research Foundation 2, 4-disulfonyl pheny tert-butyl nitrone for the treatment of gliomas
WO2011028503A1 (en) * 2009-08-24 2011-03-10 Hough Ear Institute Methods for treating acute acoustic trauma
ES2893825T3 (es) 2011-02-04 2022-02-10 Hough Ear Inst Métodos de tratamiento de lesiones cerebrales
EP3532042A4 (en) 2016-10-31 2020-06-24 Hough Ear Institute METHOD FOR IMPROVING SYNAPTOGENESIS AND NEURITOGENESIS
CN110392568A (zh) 2017-01-19 2019-10-29 耳科制药公司 N-乙酰半胱氨酸的制剂及其用途
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US10829441B2 (en) 2017-11-14 2020-11-10 The University Of Toledo Reactive oxygen species-sensitive nitric oxide synthase inhibitors for the treatment of ischemic stroke
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JP2023514742A (ja) * 2020-02-24 2023-04-07 オブラート，インコーポレーテッド がん及び腫瘍を処置する組成物及び方法

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US5036097A (en) * 1989-10-17 1991-07-30 Oklahoma Medical Research Foundation Phenylbutyl nitrone compositions and methods for prevention of gastric ulceration
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US5488145A (en) * 1993-12-23 1996-01-30 Oklahoma Medical Research Foundation 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps

Also Published As

Publication number Publication date
HU221167B1 (en) 2002-08-28
AU1552795A (en) 1995-07-17
JP2001010953A (ja) 2001-01-16
EP0736004B1 (en) 2000-05-10
PL185189B1 (pl) 2003-03-31
DE69424441T2 (de) 2000-10-12
US5475032A (en) 1995-12-12
HK1001768A1 (en) 1998-07-10
CZ177596A3 (en) 1996-12-11
TW299315B (xx) 1997-03-01
ATE192736T1 (de) 2000-05-15
AU679835B2 (en) 1997-07-10
HRP950358A2 (en) 1997-08-31
CN1156447A (zh) 1997-08-06
CZ289629B6 (cs) 2002-03-13
HK1008294A1 (en) 1999-05-07
WO1995017876A3 (en) 1995-08-10
HUT76788A (en) 1997-11-28
FI962589A0 (fi) 1996-06-20
ES2145264T3 (es) 2000-07-01
NZ279025A (en) 1998-02-26
CA2179521A1 (en) 1995-07-06
NO306457B1 (no) 1999-11-08
UA45964C2 (uk) 2002-05-15
CN1070176C (zh) 2001-08-29
FI111718B (fi) 2003-09-15
NO962637D0 (no) 1996-06-20
BR9408378A (pt) 1997-08-19
WO1995017876A2 (en) 1995-07-06
JP2004075696A (ja) 2004-03-11
PT736004E (pt) 2000-09-29
US5508305A (en) 1996-04-16
HU9601739D0 (en) 1996-08-28
NO962637L (no) 1996-08-13
SG64903A1 (en) 1999-05-25
SK78896A3 (en) 1997-09-10
PL315154A1 (en) 1996-10-14
BR1100626A (pt) 1999-11-23
RU2159231C2 (ru) 2000-11-20
KR100370522B1 (ko) 2003-05-16
FI962589L (fi) 1996-08-20
CA2179521C (en) 2002-03-19
DK0736004T3 (da) 2000-10-09
JPH09507232A (ja) 1997-07-22
JP3412821B2 (ja) 2003-06-03
MY114178A (en) 2002-08-30
US5780510A (en) 1998-07-14
DE69424441D1 (de) 2000-06-15
SK282403B6 (sk) 2002-01-07
EP0736004A1 (en) 1996-10-09
US5488145A (en) 1996-01-30
GR3034134T3 (en) 2000-11-30

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