SG55181A1 - 2-Substituted saccarin derivative proteolytic enzyme inhibitors - Google Patents
2-Substituted saccarin derivative proteolytic enzyme inhibitorsInfo
- Publication number
- SG55181A1 SG55181A1 SG1996008996A SG1996008996A SG55181A1 SG 55181 A1 SG55181 A1 SG 55181A1 SG 1996008996 A SG1996008996 A SG 1996008996A SG 1996008996 A SG1996008996 A SG 1996008996A SG 55181 A1 SG55181 A1 SG 55181A1
- Authority
- SG
- Singapore
- Prior art keywords
- saccarin
- substituted
- proteolytic enzyme
- enzyme inhibitors
- derivative
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
- C07F9/6539—Five-membered rings
- C07F9/6541—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/793,033 US5236917A (en) | 1989-05-04 | 1991-11-15 | Saccharin derivatives useful as proteolytic enzyme inhibitors and compositions and method of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG55181A1 true SG55181A1 (en) | 1998-12-21 |
Family
ID=25158880
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG1996008996A SG55181A1 (en) | 1991-11-15 | 1992-12-11 | 2-Substituted saccarin derivative proteolytic enzyme inhibitors |
Country Status (17)
| Country | Link |
|---|---|
| US (5) | US5236917A (es) |
| EP (1) | EP0542372A1 (es) |
| JP (1) | JPH05194444A (es) |
| KR (1) | KR930010015A (es) |
| AU (1) | AU654581B2 (es) |
| CA (1) | CA2079822A1 (es) |
| CZ (1) | CZ339092A3 (es) |
| FI (1) | FI925167L (es) |
| HU (2) | HUT66873A (es) |
| IL (1) | IL103748A (es) |
| MX (1) | MX9206008A (es) |
| MY (1) | MY107740A (es) |
| NO (1) | NO303119B1 (es) |
| NZ (1) | NZ244446A (es) |
| RU (1) | RU2101281C1 (es) |
| SG (1) | SG55181A1 (es) |
| TW (1) | TW221433B (es) |
Families Citing this family (91)
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| US5236917A (en) * | 1989-05-04 | 1993-08-17 | Sterling Winthrop Inc. | Saccharin derivatives useful as proteolytic enzyme inhibitors and compositions and method of use thereof |
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| AU656027B2 (en) * | 1991-11-15 | 1995-01-19 | Sanofi | Saccharin derivative proteolytic enzime inhibitors |
| US5378720A (en) * | 1991-12-19 | 1995-01-03 | Sterling Winthrop Inc. | Saccharin derivative proteolytic enzyme inhibitors |
| US5187173A (en) * | 1991-12-27 | 1993-02-16 | Sterling Winthrop Inc. | 2-saccharinylmethyl and 4,5,6,7-tetrahydro-2-saccharinylmethyl phosphates, phosphonates and phosphinates useful as proteolytic enzyme inhibitors and compositions and method of use thereof |
| US5296496A (en) * | 1991-12-27 | 1994-03-22 | Sterling Winthrop Inc. | 2-saccharinylmethyl phosphates, phosphonates and phosphinates useful as proteolytic enzyme inhibitors and compositions and method of use thereof |
| DE4427996A1 (de) * | 1994-08-08 | 1996-02-15 | Basf Ag | Verfahren zur Herstellung von Saccharincarbonsäuren und -carbonsäureestern |
| US5750546A (en) * | 1994-12-02 | 1998-05-12 | Sanofi Winthrop, Inc. | 2-(2, 3, 5, 6-tetrafluoro-4-pyridyl)-1, 2, 5-thiadiazolidin-3-one 1, 1-dioxides and compositions and method of use thereof |
| US5512576A (en) * | 1994-12-02 | 1996-04-30 | Sterling Winthrop Inc. | 2-substituted 1,2,5,-thiadiazolidin-3-one 1,1-dioxides and compositions and method of use thereof |
| US5541168A (en) * | 1994-12-02 | 1996-07-30 | Sterling Winthrop Inc. | Substituted 2-(phosphinyloxymethyl)-1,2,5-thiadiazolidin-3-one 1,1-dioxides and compositions and method of use thereof |
| US5494925A (en) * | 1994-12-02 | 1996-02-27 | Sterling Winthrop Inc. | 2-heterocyclyloxymethyl and 2-heterocyclylthiomethyl-1,2,5-thiadiazolidin-3-one 1,1-dioxides and compositions and method of use thereof |
| US5556909A (en) * | 1994-12-02 | 1996-09-17 | Sanofi Winthrop Inc. | Substituted 2-arylcarbonyloxymethyl-1,2,5-thiadiazolidin-3-one 1,1-dioxide derivatives and compositions and method of use thereof |
| DE19533643A1 (de) * | 1995-09-12 | 1997-03-13 | Nycomed Arzneimittel Gmbh | Neue cyclische Derivate von Benzolsulfonamiden |
| US5750550A (en) * | 1995-09-15 | 1998-05-12 | Sanofi | 2-(pyrazol-5-yl-oxymethyl)-1,2-benzisothiazol-3 (2H)-One 1, 1-dioxides and compositions and method of use thereof |
| US5670526A (en) * | 1995-12-21 | 1997-09-23 | Otsuka Pharmaceutical Co., Ltd. | 1,3,4-oxadiazoles |
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| AU2006200033B8 (en) * | 1998-10-30 | 2008-09-11 | Celgene Corporation | Substituted phenethylsulfones and methods of reducing TNF-alpha levels |
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| US11014884B2 (en) | 2018-10-01 | 2021-05-25 | Global Blood Therapeutics, Inc. | Modulators of hemoglobin |
| CN120379982A (zh) | 2022-12-02 | 2025-07-25 | 纽摩拉治疗公司 | 治疗神经障碍的方法 |
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| US3002884A (en) * | 1959-04-15 | 1961-10-03 | Rohm & Haas | Horticultural process with n-halomethyl-1,2-benzisothiazolin - 3 - one-1,1-dioxides for controlling fungus diseases |
| DE1302858B (es) * | 1962-09-21 | 1972-05-04 | ||
| US3314960A (en) * | 1964-08-25 | 1967-04-18 | American Home Prod | Benzisothiazol glutarimides |
| FR1451417A (fr) * | 1965-07-15 | 1966-01-07 | Roussel Uclaf | Nouveaux esters d'acides cycliques et leur procédé de préparation |
| US4195023A (en) * | 1975-08-20 | 1980-03-25 | Merck & Co., Inc. | 2-(2-Furoyl)1,2-benzisothiazole-3-one, 2-(2-furoyl) saccharin, and 2-(2-thenoyl) saccharin |
| NZ182325A (en) * | 1975-11-18 | 1979-03-16 | Beecham Group Ltd | 2-substituted-1,2-benzisothiazol-3-ones |
| US4135028A (en) * | 1976-06-25 | 1979-01-16 | Ciba-Geigy Corporation | Process for fireproofing synthetic fiber materials with sulphonamides |
| US4276298A (en) * | 1978-03-24 | 1981-06-30 | Merck & Co., Inc. | 2-Aryl-1,2-benzisothiazolinone-1,1-dioxides and their use as selective protease inhibitors |
| US4263393A (en) * | 1979-09-06 | 1981-04-21 | Eastman Kodak Company | Novel electron donor precursors and photographic element containing them |
| US4369183A (en) * | 1979-09-06 | 1983-01-18 | Merck & Co., Inc. | 2-Pyridyl-1,2-benzisothiazolinone-1,1-dioxides and their use as selective protease inhibitors |
| US4350752A (en) * | 1980-12-29 | 1982-09-21 | Eastman Kodak Company | Photographic elements and film units containing imidomethyl blocked photographic reagents |
| US4363865A (en) * | 1981-03-04 | 1982-12-14 | Eastman Kodak Company | Imido methyl blocked photographic dyes and dye releasing compounds |
| US4410618A (en) * | 1982-06-11 | 1983-10-18 | Eastman Kodak Company | Blocked photographic reagents |
| US4623645A (en) * | 1983-04-18 | 1986-11-18 | Merck & Co., Inc. | Substituted cephalosporin sulfoxides as anti-inflammatory and antidegenerative agents |
| US4547371A (en) * | 1983-04-18 | 1985-10-15 | Merck & Co., Inc. | Substituted cephalosporin sulfones as anti-inflammatory and anti-degenerative agents |
| EP0124067B1 (de) * | 1983-05-04 | 1986-12-17 | CASSELLA Aktiengesellschaft | 2-(Aminoalkyl)-pyrrol-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung |
| US4659855A (en) * | 1983-05-09 | 1987-04-21 | Georgia Tech Research Corporation | Aryl sulfonyl fluoride compounds |
| US5109018A (en) * | 1984-08-20 | 1992-04-28 | Georgia Tech Research Corporation | Use of heterocyclic inhibitors of serine proteases |
| DK153381C (da) * | 1985-10-21 | 1988-12-05 | Alliance Pentagon As | 3-lagsplade bestaaende af en plan polyurethanskumstofplade med paaklaebede metalyderlag samt fremgangsmaade til fremstilling deraf |
| US4748182A (en) * | 1986-03-05 | 1988-05-31 | Merrell Dow Pharmaceuticals Inc. | Aromatic 2-aminoalkyl-1,2-benzoisothiazol-3(2H)one-1,1-dioxide derivatives and their use as anti-hypertensive and anxiolytic agents |
| DE3639903A1 (de) * | 1986-11-22 | 1988-06-01 | Bayer Ag | Saccharin-salze von aminomethylheterocyclen |
| US4874760A (en) * | 1987-01-09 | 1989-10-17 | Toa Eiyo, Ltd. | 4,7-dihydroisothiazolo(5,4-b)pyridine derivatives and cardiovascular treating agents containing said derivatives |
| WO1990013549A1 (en) * | 1989-05-04 | 1990-11-15 | Sterling Winthrop Inc. | Saccharin derivatives useful as proteolytic enzyme inhibitors and preparation thereof |
| US5236917A (en) * | 1989-05-04 | 1993-08-17 | Sterling Winthrop Inc. | Saccharin derivatives useful as proteolytic enzyme inhibitors and compositions and method of use thereof |
| US5128339A (en) * | 1990-11-01 | 1992-07-07 | Sterling Winthrop Inc. | Proteolytic enzyme inhibition method |
| US5250696A (en) * | 1990-11-01 | 1993-10-05 | Sterling Winthrop Inc. | 2-saccharinylmethyl aryl carboxylate |
| US5187173A (en) * | 1991-12-27 | 1993-02-16 | Sterling Winthrop Inc. | 2-saccharinylmethyl and 4,5,6,7-tetrahydro-2-saccharinylmethyl phosphates, phosphonates and phosphinates useful as proteolytic enzyme inhibitors and compositions and method of use thereof |
| JPH07200419A (ja) * | 1993-12-28 | 1995-08-04 | Nec Corp | バスインタフェース装置 |
-
1991
- 1991-11-15 US US07/793,033 patent/US5236917A/en not_active Expired - Fee Related
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1992
- 1992-09-23 TW TW081107529A patent/TW221433B/zh active
- 1992-09-25 AU AU25340/92A patent/AU654581B2/en not_active Ceased
- 1992-10-05 CA CA002079822A patent/CA2079822A1/en not_active Abandoned
- 1992-10-19 MX MX9206008A patent/MX9206008A/es unknown
- 1992-11-12 EP EP92203469A patent/EP0542372A1/en not_active Withdrawn
- 1992-11-13 CZ CS923390A patent/CZ339092A3/cs unknown
- 1992-11-13 IL IL10374892A patent/IL103748A/xx not_active IP Right Cessation
- 1992-11-13 HU HU9203566A patent/HUT66873A/hu unknown
- 1992-11-13 FI FI925167A patent/FI925167L/fi unknown
- 1992-11-13 NO NO924401A patent/NO303119B1/no unknown
- 1992-11-13 NZ NZ244446A patent/NZ244446A/en unknown
- 1992-11-13 RU RU92004381A patent/RU2101281C1/ru active
- 1992-11-14 MY MYPI92002080A patent/MY107740A/en unknown
- 1992-11-14 KR KR1019920021437A patent/KR930010015A/ko not_active Ceased
- 1992-11-16 JP JP4305295A patent/JPH05194444A/ja not_active Withdrawn
- 1992-12-11 SG SG1996008996A patent/SG55181A1/en unknown
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1993
- 1993-05-24 US US08/067,637 patent/US5371074A/en not_active Expired - Fee Related
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1994
- 1994-07-05 US US08/270,964 patent/US5650422A/en not_active Expired - Fee Related
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1995
- 1995-05-24 US US08/449,152 patent/US5596012A/en not_active Expired - Fee Related
- 1995-06-30 HU HU95P/P00637P patent/HU211663A9/hu unknown
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1997
- 1997-02-20 US US08/803,297 patent/US5874432A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US5874432A (en) | 1999-02-23 |
| HU211663A9 (en) | 1995-12-28 |
| US5596012A (en) | 1997-01-21 |
| IL103748A0 (en) | 1993-04-04 |
| NZ244446A (en) | 1994-09-27 |
| CA2079822A1 (en) | 1993-05-16 |
| FI925167A7 (fi) | 1993-05-16 |
| FI925167L (fi) | 1993-05-16 |
| CZ339092A3 (en) | 1993-06-16 |
| AU2534092A (en) | 1993-05-20 |
| HUT66873A (en) | 1995-01-30 |
| EP0542372A1 (en) | 1993-05-19 |
| AU654581B2 (en) | 1994-11-10 |
| FI925167A0 (fi) | 1992-11-13 |
| US5236917A (en) | 1993-08-17 |
| HU9203566D0 (en) | 1993-01-28 |
| NO303119B1 (no) | 1998-06-02 |
| IL103748A (en) | 1997-02-18 |
| US5650422A (en) | 1997-07-22 |
| NO924401L (no) | 1993-05-18 |
| US5371074A (en) | 1994-12-06 |
| TW221433B (es) | 1994-03-01 |
| KR930010015A (ko) | 1993-06-21 |
| NO924401D0 (no) | 1992-11-13 |
| RU2101281C1 (ru) | 1998-01-10 |
| MX9206008A (es) | 1993-11-01 |
| JPH05194444A (ja) | 1993-08-03 |
| MY107740A (en) | 1996-05-30 |
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