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NO303119B1 - 2-substituerte sakkarinderivater med proteolytisk enzyminhiberende aktivitet, farmas÷ytisk preparat inneholdende disse derivatene, samt anvendelse derav - Google Patents

2-substituerte sakkarinderivater med proteolytisk enzyminhiberende aktivitet, farmas÷ytisk preparat inneholdende disse derivatene, samt anvendelse derav Download PDF

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Publication number
NO303119B1
NO303119B1 NO924401A NO924401A NO303119B1 NO 303119 B1 NO303119 B1 NO 303119B1 NO 924401 A NO924401 A NO 924401A NO 924401 A NO924401 A NO 924401A NO 303119 B1 NO303119 B1 NO 303119B1
Authority
NO
Norway
Prior art keywords
isopropyl
oxymethyl
methoxysaccharin
phenyl
isopropylsaccharin
Prior art date
Application number
NO924401A
Other languages
English (en)
Norwegian (no)
Other versions
NO924401L (no
NO924401D0 (no
Inventor
Richard Paul Dunlap
Albert Joseph Mura
Dennis John Hlasta
Ranjit Chimanlal Desai
Chakrapani Subramanyam
Lee Hamilton Latimer
Neil Warren Boaz
Eric Piatt Lodge
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of NO924401D0 publication Critical patent/NO924401D0/no
Publication of NO924401L publication Critical patent/NO924401L/no
Publication of NO303119B1 publication Critical patent/NO303119B1/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
    • C07F9/6539—Five-membered rings
    • C07F9/6541—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
NO924401A 1991-11-15 1992-11-13 2-substituerte sakkarinderivater med proteolytisk enzyminhiberende aktivitet, farmas÷ytisk preparat inneholdende disse derivatene, samt anvendelse derav NO303119B1 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/793,033 US5236917A (en) 1989-05-04 1991-11-15 Saccharin derivatives useful as proteolytic enzyme inhibitors and compositions and method of use thereof

Publications (3)

Publication Number Publication Date
NO924401D0 NO924401D0 (no) 1992-11-13
NO924401L NO924401L (no) 1993-05-18
NO303119B1 true NO303119B1 (no) 1998-06-02

Family

ID=25158880

Family Applications (1)

Application Number Title Priority Date Filing Date
NO924401A NO303119B1 (no) 1991-11-15 1992-11-13 2-substituerte sakkarinderivater med proteolytisk enzyminhiberende aktivitet, farmas÷ytisk preparat inneholdende disse derivatene, samt anvendelse derav

Country Status (17)

Country Link
US (5) US5236917A (es)
EP (1) EP0542372A1 (es)
JP (1) JPH05194444A (es)
KR (1) KR930010015A (es)
AU (1) AU654581B2 (es)
CA (1) CA2079822A1 (es)
CZ (1) CZ339092A3 (es)
FI (1) FI925167L (es)
HU (2) HUT66873A (es)
IL (1) IL103748A (es)
MX (1) MX9206008A (es)
MY (1) MY107740A (es)
NO (1) NO303119B1 (es)
NZ (1) NZ244446A (es)
RU (1) RU2101281C1 (es)
SG (1) SG55181A1 (es)
TW (1) TW221433B (es)

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EP0542372A1 (en) 1993-05-19
HU211663A9 (en) 1995-12-28
HU9203566D0 (en) 1993-01-28
NO924401L (no) 1993-05-18
FI925167A0 (fi) 1992-11-13
US5236917A (en) 1993-08-17
US5650422A (en) 1997-07-22
JPH05194444A (ja) 1993-08-03
IL103748A0 (en) 1993-04-04
US5596012A (en) 1997-01-21
MY107740A (en) 1996-05-30
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US5371074A (en) 1994-12-06
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FI925167A7 (fi) 1993-05-16
US5874432A (en) 1999-02-23
AU2534092A (en) 1993-05-20
FI925167L (fi) 1993-05-16
NO924401D0 (no) 1992-11-13
HUT66873A (en) 1995-01-30
KR930010015A (ko) 1993-06-21
IL103748A (en) 1997-02-18
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AU654581B2 (en) 1994-11-10
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