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PE20181519A1 - Compuestos de benzaldehido sustituidos y metodos para su uso en incrementar la oxigenacion del tejido - Google Patents

Compuestos de benzaldehido sustituidos y metodos para su uso en incrementar la oxigenacion del tejido

Info

Publication number
PE20181519A1
PE20181519A1 PE2018001322A PE2018001322A PE20181519A1 PE 20181519 A1 PE20181519 A1 PE 20181519A1 PE 2018001322 A PE2018001322 A PE 2018001322A PE 2018001322 A PE2018001322 A PE 2018001322A PE 20181519 A1 PE20181519 A1 PE 20181519A1
Authority
PE
Peru
Prior art keywords
halo
substitute
methods
tissue oxygenation
increasing tissue
Prior art date
Application number
PE2018001322A
Other languages
English (en)
Inventor
Brian W Metcalf
Chihyuan Chuang
Jeffrey Warrington
Kumar Paulvannan
Matthew P Jacobson
Lan Hua
Bradley MORGAN
Original Assignee
Global Blood Therapeutics Inc
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48698669&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20181519(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Global Blood Therapeutics Inc, Univ California filed Critical Global Blood Therapeutics Inc
Publication of PE20181519A1 publication Critical patent/PE20181519A1/es

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    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
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  • Vascular Medicine (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Se refiere a un compuesto de formula (I) o un tautomero, o sal farmaceuticamente aceptable del mismo donde Q es arilo, heteroarilo o heterociloalquilo cada uno opcionalmente sustituido con uno hasta tres Ra; Y es O o CR1aR1b donde R1a es H o halo, R1b es H, halo u OH; X es O, >CH(CH2)nR8 o C(R9)2 donde n es 0 o 1; R8 es OH; R9 es H o halo; R2, R3, R4 y R5 son H, halo, entre otros; R6 y R7 juntos forman oxo, o un grupo protector aldehido. Tambien se refiere a un metodo y una composicion farmaceutica que comprenden el compuesto de formula I. Dichos compuestos actuan como moduladores alostericos de hemoglobina y son utiles para el tratamiento de la enfermedad de celula falciforme, cancer, un trastorno pulmonar, entre otros.
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