SG164279A1 - Tricyclic thrombin receptor antagonists - Google Patents

Tricyclic thrombin receptor antagonists

Info

Publication number: SG164279A1
Authority: SG; Singapore
Prior art keywords: substituted; bond; receptor antagonists; optionally substituted; thrombin receptor
Prior art date: 2002-04-16

Application number

SG200607217-7A

Other languages

English (en)

Inventor

Samuel Chackalamannil

Martin C Clasby

William J Greenlee

Yuguang Wang

Yan Xia

Enrico P Veltri

Mariappan Chellian

Wenxue Wu

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-04-16

Filing date

2003-04-14

Publication date

2010-09-29

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29250954&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG164279(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2003-04-14 Application filed by Schering Corp filed Critical Schering Corp

2010-09-29 Publication of SG164279A1 publication Critical patent/SG164279A1/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

SG200607217-7A 2002-04-16 2003-04-14 Tricyclic thrombin receptor antagonists SG164279A1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US37307202P	2002-04-16	2002-04-16

Publications (1)

Publication Number	Publication Date
SG164279A1 true SG164279A1 (en)	2010-09-29

Family

ID=29250954

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SG200607217-7A SG164279A1 (en)	2002-04-16	2003-04-14	Tricyclic thrombin receptor antagonists

Country Status (33)

Country	Link
US (3)	US7304078B2 (de)
EP (5)	EP2062890B1 (de)
JP (2)	JP4558331B2 (de)
KR (1)	KR101026929B1 (de)
CN (1)	CN1659162B (de)
AR (1)	AR039570A1 (de)
AT (3)	ATE455774T1 (de)
AU (1)	AU2003221932B2 (de)
BR (1)	BRPI0309309B8 (de)
CA (1)	CA2482858C (de)
CY (3)	CY1107184T1 (de)
DE (3)	DE60317493T3 (de)
DK (2)	DK1495018T3 (de)
EC (1)	ECSP045368A (de)
ES (3)	ES2357876T3 (de)
FR (1)	FR15C0047I2 (de)
IL (1)	IL164585A (de)
LT (1)	LTC1495018I2 (de)
LU (1)	LU92759I2 (de)
MX (1)	MXPA04010308A (de)
MY (1)	MY144040A (de)
NL (1)	NL300746I2 (de)
NO (2)	NO330500B1 (de)
NZ (2)	NZ575139A (de)
PE (1)	PE20040412A1 (de)
PL (1)	PL214718B1 (de)
PT (2)	PT2065384E (de)
RU (2)	RU2329264C9 (de)
SG (1)	SG164279A1 (de)
SI (2)	SI1495018T1 (de)
TW (1)	TWI343919B (de)
WO (1)	WO2003089428A1 (de)
ZA (1)	ZA200408342B (de)

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US7235567B2 (en) *	2000-06-15	2007-06-26	Schering Corporation	Crystalline polymorph of a bisulfate salt of a thrombin receptor antagonist
US7488742B2 (en) *	2000-06-15	2009-02-10	Schering Corporation	Thrombin receptor antagonists
CA2567981C (en) *	2004-05-28	2010-08-31	Schering Corporation	Constrained himbacine analogs as thrombin receptor antagonists
EP1799243B1 (de) *	2004-10-06	2015-07-15	University Of Rochester	Behandlung pulmonalen hochdrucks mit einem wirkstoff, der als gewebefaktorinhibitor fungiert
EP2399912B1 (de) *	2005-01-14	2015-02-25	Merck Sharp & Dohme Corp.	Exo-selektive Synthese von Himbacin-Analoga
CN102757423B (zh)	2005-01-14	2016-04-20	先灵公司	喜巴辛类似物的外型和非对映立体选择合成
US7541471B2 (en) *	2005-01-14	2009-06-02	Schering Corporation	Synthesis of himbacine analogs
MX2007008631A (es) *	2005-01-14	2007-09-12	Schering Corp	Sintesis de analogos de himbacina.
US20060172397A1 (en) *	2005-01-14	2006-08-03	Schering Corporation	Preparation of chiral propargylic alcohol and ester intermediates of himbacine analogs
WO2006105217A2 (en) *	2005-03-31	2006-10-05	Schering Corporation	Spirocyclic thrombin receptor antagonists
WO2007075808A2 (en) *	2005-12-20	2007-07-05	Schering Corporation	Methods for preventing and/or treating a cell proliferative disorder
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AR061727A1 (es) *	2006-06-30	2008-09-17	Schering Corp	Sintesis de dietil [[ 5- ( 3-fluorofenil) -piridin -2il] metil] fosfonato
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CN101553484A (zh) *	2006-10-04	2009-10-07	先灵公司	以喜巴辛的被改质三环单位为基础的凝血酶受体拮抗剂
EP2069326B1 (de) *	2006-10-04	2015-03-18	Merck Sharp & Dohme Corp.	Bizyklische und trizyklische derivate als thrombin-rezeptor-antagonisten
MX2009006873A (es) *	2006-12-22	2009-07-03	Schering Corp	Promotores de desintegracion en formulaciones de granulacion humeda de dosis solida.
MX2009010268A (es) *	2007-03-23	2009-11-09	Schering Corp	Reduccion de eventos adversos despues de intervencion percutanea mediante el uso de un antagonista del receptor de trombina.
NZ587142A (en)	2008-02-05	2012-04-27	Sanofi Aventis	Triazolium salts as par1 inhibitors, production thereof, and use as medicaments
MY152040A (en)	2008-02-05	2014-08-15	Sanofi Aventis	Triazolopyridazines as par1 inhibitors, production thereof, and use as medicaments
WO2009124103A2 (en) *	2008-04-02	2009-10-08	Schering Corporation	Combination therapies comprising par1 antagonists with par4 antagonists
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SI2438060T1 (sl) *	2009-06-04	2014-04-30	Merck Sharp & Dohme Corp.	Aktivni metabolit trombin receptorskega antagonista
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TWI393716B (zh)	2009-08-04	2013-04-21	Merck Sharp & Dohme	作為ｉｘａ因子抑制劑之雜環化合物
ES2532902T3 (es)	2010-04-16	2015-04-01	Sanofi	Piridil-vinil-pirroles tricíclicos como inhibidores de PAR1
PL2558462T3 (pl)	2010-04-16	2015-03-31	Sanofi Sa	Pirydylo-winylo-pirazolo-chinoliny jako inhibitory PAR1
KR101303348B1 (ko)	2010-06-25	2013-09-03	한국화학연구원	트롬빈 수용체 길항제인 ［6＋5］접합 바이사이클, 그의 제조방법 및 그를 포함하는 약제학적 조성물
EP2822557B1 (de)	2012-03-06	2017-08-23	Merck Sharp & Dohme Corp.	Herstellung und verwendung bicyclischer himbacinderivate als par-rezeptor-antagonisten
US9604971B2 (en)	2013-07-22	2017-03-28	Aralez Pharmaceuticals Trading Dac	Co-crystal of the PAR-1 receptor antagonists vorapaxar and aspirin
EP3035929B1 (de) *	2013-08-22	2024-07-03	Merck Sharp & Dohme LLC	7a-amid-substituierte bicyclische 6,6-difluorhimbacinderivate
US9808473B2 (en)	2013-08-22	2017-11-07	Merck Sharp & Dohme Corp.	Preparation and use of 3-pyridyl substituted-6,6-difluoro bicyclic himbacine derivatives as par-1 receptor antagonists
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FR3014693B1 (fr)	2013-12-16	2016-01-08	Pf Medicament	Utilisation de la 3-(2-chloro-phenyl)-1-[4-(4-fluoro-benzyl)-piperazin-1-yl]-propenone pour la prevention et/ou le traitement des pathologies fonctionnelles pelvi-perineales
WO2015160636A1 (en)	2014-04-16	2015-10-22	Merck Sharp & Dohme Corp.	Factor ixa inhibitors
DE102014108210A1 (de)	2014-06-11	2015-12-17	Dietrich Gulba	Rodentizid
CN105985303B (zh) *	2015-02-13	2020-08-14	上海彩迩文生化科技有限公司	抗凝血剂的制备方法、中间体及其制备方法
CN106478608A (zh) *	2015-09-01	2017-03-08	博瑞生物医药（苏州）股份有限公司	沃拉帕沙的硫酸盐的结晶多晶型物
CN106749201A (zh) *	2015-11-25	2017-05-31	博瑞生物医药（苏州）股份有限公司	一种沃拉帕沙及其中间体的制备方法
TR201601548A2 (tr) *	2016-02-05	2018-03-21	Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi	Vorapaksar ve metoprololün bi̇r farmasöti̇k kompozi̇syonu
WO2017134200A1 (en) *	2016-02-05	2017-08-10	Sanovel Ilac Sanayi Ve Ticaret A.S.	A novel pharmaceutical composition of vorapaxar and metoprolol
TW201738221A (zh) *	2016-04-22	2017-11-01	Jiangsu Tasly Diyi Pharmaceutical Co Ltd	新的喜巴辛類似物、其藥物組合物及其在醫藥中的應用
CN106236779A (zh) *	2016-08-22	2016-12-21	孔五	一种脐带血富血小板血浆prp的制备方法
FR3090317B1 (fr)	2018-12-19	2021-05-07	Cvasthera	Utilisation d’un antagoniste de par-1 pour le traitement d’une maladie inflammatoire chronique intestinale
CN110407819B (zh) *	2019-08-02	2020-06-26	牡丹江医学院	一种作为预防外科手术并发症的凝血酶受体拮抗剂
US20210113536A1 (en) *	2019-10-21	2021-04-22	United States Government as Represented by the Department of Veteran Affairs	Methods and compositions for detecting and treating venous thromboembolism
FR3109089B1 (fr)	2020-04-08	2023-04-14	Cvasthera	Composition pharmaceutique pour le traitement des maladies inflammatoires intestinales
ES3048448T3 (en)	2020-07-22	2025-12-10	Janssen Pharmaceutica Nv	Compounds useful as factor xia inhibitors
US11814364B2 (en)	2021-03-18	2023-11-14	Janssen Pharmaceutica Nv	Pyridine N-oxide derivatives useful as factor XIa inhibitors
US11845748B2 (en)	2021-03-18	2023-12-19	Janssen Pharmaceutica Nv	Bicyclic pyridine N-oxide derivatives useful as a factor XIa inhibitors
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WO2001096330A2 (en) *	2000-06-15	2001-12-20	Schering Corporation	Thrombin receptor antagonists

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2003
- 2003-04-14 JP JP2003586149A patent/JP4558331B2/ja not_active Expired - Fee Related
- 2003-04-14 AR ARP030101302A patent/AR039570A1/es active IP Right Grant
- 2003-04-14 KR KR1020047016409A patent/KR101026929B1/ko not_active Expired - Fee Related
- 2003-04-14 PT PT09150995T patent/PT2065384E/pt unknown
- 2003-04-14 NZ NZ575139A patent/NZ575139A/en not_active IP Right Cessation
- 2003-04-14 EP EP09150996A patent/EP2062890B1/de not_active Expired - Lifetime
- 2003-04-14 AT AT07016461T patent/ATE455774T1/de not_active IP Right Cessation
- 2003-04-14 AT AT03718393T patent/ATE378330T1/de active
- 2003-04-14 AU AU2003221932A patent/AU2003221932B2/en not_active Ceased
- 2003-04-14 DK DK03718393T patent/DK1495018T3/da active
- 2003-04-14 ES ES09150995T patent/ES2357876T3/es not_active Expired - Lifetime
- 2003-04-14 ES ES07016461T patent/ES2338171T3/es not_active Expired - Lifetime
- 2003-04-14 WO PCT/US2003/011510 patent/WO2003089428A1/en not_active Ceased
- 2003-04-14 EP EP09150995A patent/EP2065384B1/de not_active Expired - Lifetime
- 2003-04-14 EP EP03718393A patent/EP1495018B3/de not_active Expired - Lifetime
- 2003-04-14 PL PL373332A patent/PL214718B1/pl unknown
- 2003-04-14 PE PE2003000375A patent/PE20040412A1/es active IP Right Grant
- 2003-04-14 BR BRPI0309309A patent/BRPI0309309B8/pt not_active IP Right Cessation
- 2003-04-14 SG SG200607217-7A patent/SG164279A1/en unknown
- 2003-04-14 SI SI200331110T patent/SI1495018T1/sl unknown
- 2003-04-14 CA CA2482858A patent/CA2482858C/en not_active Expired - Lifetime
- 2003-04-14 SI SI200331969T patent/SI2065384T1/sl unknown
- 2003-04-14 CN CN038131129A patent/CN1659162B/zh not_active Expired - Fee Related
- 2003-04-14 NZ NZ535880A patent/NZ535880A/en not_active IP Right Cessation
- 2003-04-14 PT PT03718393T patent/PT1495018E/pt unknown
- 2003-04-14 DE DE60317493.0T patent/DE60317493T3/de not_active Expired - Lifetime
- 2003-04-14 EP EP08012015A patent/EP1982984B1/de not_active Expired - Lifetime
- 2003-04-14 EP EP07016461A patent/EP1860106B1/de not_active Expired - Lifetime
- 2003-04-14 RU RU2004133375/04A patent/RU2329264C9/ru active
- 2003-04-14 DE DE60335679T patent/DE60335679D1/de not_active Expired - Lifetime
- 2003-04-14 MX MXPA04010308A patent/MXPA04010308A/es active IP Right Grant
- 2003-04-14 DK DK09150995.0T patent/DK2065384T3/da active
- 2003-04-14 DE DE60331114T patent/DE60331114D1/de not_active Expired - Lifetime
- 2003-04-14 AT AT09150995T patent/ATE494284T1/de active
- 2003-04-14 MY MYPI20031400A patent/MY144040A/en unknown
- 2003-04-14 ES ES03718393T patent/ES2297150T7/es active Active
- 2003-04-14 US US10/412,982 patent/US7304078B2/en active Active
- 2003-04-15 TW TW092108648A patent/TWI343919B/zh not_active IP Right Cessation
2004
- 2004-10-14 IL IL164585A patent/IL164585A/en active IP Right Grant
- 2004-10-14 ZA ZA200408342A patent/ZA200408342B/xx unknown
- 2004-10-15 EC EC2004005368A patent/ECSP045368A/es unknown
- 2004-11-15 NO NO20044963A patent/NO330500B1/no not_active IP Right Cessation
2007
- 2007-04-10 US US11/733,635 patent/US7713999B2/en not_active Expired - Lifetime
- 2007-07-06 US US11/774,358 patent/US20070270439A1/en not_active Abandoned
2008
- 2008-02-07 CY CY20081100152T patent/CY1107184T1/el unknown
- 2008-02-21 RU RU2008106401/04A patent/RU2008106401A/ru not_active Application Discontinuation
2010
- 2010-03-05 JP JP2010049903A patent/JP2010132710A/ja not_active Withdrawn
2011
- 2011-03-30 CY CY20111100338T patent/CY1111363T1/el unknown
2015
- 2015-06-29 LU LU92759C patent/LU92759I2/xx unknown
- 2015-06-29 NL NL300746C patent/NL300746I2/nl unknown
- 2015-07-01 LT LTPA2015027C patent/LTC1495018I2/lt unknown
- 2015-07-03 FR FR15C0047C patent/FR15C0047I2/fr active Active
- 2015-07-09 NO NO2015016C patent/NO2015016I1/no not_active IP Right Cessation
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WO2001096330A2 (en) *	2000-06-15	2001-12-20	Schering Corporation	Thrombin receptor antagonists

Also Published As

Publication number	Publication date
TWI343919B (en)	2011-06-21
IL164585A0 (en)	2005-12-18
EP1860106B1 (de)	2010-01-20
AU2003221932B2 (en)	2007-11-22
PE20040412A1 (es)	2004-07-12
EP1860106A1 (de)	2007-11-28
HK1070887A1 (en)	2005-06-30
DE60317493T3 (de)	2018-07-12
KR101026929B1 (ko)	2011-04-04
ATE494284T1 (de)	2011-01-15
BRPI0309309B1 (pt)	2018-09-04
DE60317493D1 (en)	2011-01-13
US7713999B2 (en)	2010-05-11
ES2297150T7 (es)	2012-03-16
FR15C0047I2 (fr)	2016-05-06
DE60317493T2 (de)	2008-09-18
JP4558331B2 (ja)	2010-10-06
LTC1495018I2 (lt)	2017-04-10
US20070270439A1 (en)	2007-11-22
NO330500B1 (no)	2011-05-02
NO20044963L (no)	2004-11-15
CA2482858C (en)	2010-11-30
ATE378330T1 (de)	2007-11-15
EP1495018A1 (de)	2005-01-12
NO2015016I1 (no)	2015-07-20
BRPI0309309B8 (pt)	2021-05-25
PL373332A1 (en)	2005-08-22
ATE455774T1 (de)	2010-02-15
RU2004133375A (ru)	2005-07-10
CY1111363T1 (el)	2015-08-05
TW200404068A (en)	2004-03-16
CN1659162B (zh)	2011-08-31
RU2329264C9 (ru)	2009-04-20
ECSP045368A (es)	2005-01-03
AU2003221932A1 (en)	2003-11-03
PT1495018E (pt)	2008-02-19
JP2010132710A (ja)	2010-06-17
PT2065384E (pt)	2011-03-16
PL214718B1 (pl)	2013-09-30
ES2297150T3 (es)	2008-05-01
CY2015029I1 (el)	2016-04-13
RU2008106401A (ru)	2009-08-27
BR0309309A (pt)	2005-02-15
DK2065384T3 (da)	2011-05-02
ES2338171T3 (es)	2010-05-04
RU2329264C2 (ru)	2008-07-20
NZ535880A (en)	2007-11-30
SI1495018T1 (sl)	2008-04-30
CY2015029I2 (el)	2016-04-13
EP1495018B3 (de)	2011-03-16
NL300746I1 (de)	2016-01-21
US7304078B2 (en)	2007-12-04
EP1495018B1 (de)	2007-11-14
NO2015016I2 (no)	2015-07-09
EP2065384B1 (de)	2011-01-05
US20030216437A1 (en)	2003-11-20
KR20040099441A (ko)	2004-11-26
SI2065384T1 (sl)	2011-05-31
NZ575139A (en)	2010-08-27
EP2065384A1 (de)	2009-06-03
DK1495018T3 (da)	2008-02-18
LU92759I2 (en)	2015-08-31
DE60331114D1 (de)	2010-03-11
MY144040A (en)	2011-07-29
ES2357876T3 (es)	2011-05-03
CA2482858A1 (en)	2003-10-30
EP2062890A1 (de)	2009-05-27
AR039570A1 (es)	2005-02-23
FR15C0047I1 (de)	2015-08-28
NL300746I2 (de)	2016-01-21
JP2005528406A (ja)	2005-09-22
EP1982984B1 (de)	2013-02-13
HK1129893A1 (en)	2009-12-11
WO2003089428A1 (en)	2003-10-30
ZA200408342B (en)	2006-05-31
DE60335679D1 (de)	2011-02-17
EP1982984A3 (de)	2008-10-29
EP1982984A2 (de)	2008-10-22
CN1659162A (zh)	2005-08-24
IL164585A (en)	2010-11-30
CY1107184T1 (el)	2012-10-24
HK1123302A1 (en)	2009-06-12
EP2062890B1 (de)	2011-01-05
MXPA04010308A (es)	2005-02-03
US20070179187A1 (en)	2007-08-02

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