MX2007008631A - Sintesis de analogos de himbacina. - Google Patents
Sintesis de analogos de himbacina.Info
- Publication number
- MX2007008631A MX2007008631A MX2007008631A MX2007008631A MX2007008631A MX 2007008631 A MX2007008631 A MX 2007008631A MX 2007008631 A MX2007008631 A MX 2007008631A MX 2007008631 A MX2007008631 A MX 2007008631A MX 2007008631 A MX2007008631 A MX 2007008631A
- Authority
- MX
- Mexico
- Prior art keywords
- synthesis
- improved process
- analogs
- himbacine
- himbacine analogs
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- FMPNFDSPHNUFOS-LPJDIUFZSA-N himbacine Chemical class C(/[C@@H]1[C@H]2CCCC[C@@H]2C[C@@H]2C(=O)O[C@H]([C@H]12)C)=C\[C@H]1CCC[C@H](C)N1C FMPNFDSPHNUFOS-LPJDIUFZSA-N 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 239000003856 thrombin receptor antagonist Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
- C07D307/885—3,3-Diphenylphthalides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/92—Naphthofurans; Hydrogenated naphthofurans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Furan Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
La presente invencion se refiere a un procedimiento mejorado para preparar analogos de himbacina; los compuestos son utiles como antagonistas de los receptores de trombina; el procedimiento mejorado puede permitir al menos una purificacion mediante cristalizacion, escalabilidad o rendimiento de procedimiento mejorado del enantiomero deseado mas sencillo; un ejemplo de una etapa en la sintesis de ese tipo de analogo de himbacina es el siguiente: Formula (I).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64393205P | 2005-01-14 | 2005-01-14 | |
| PCT/US2006/001208 WO2006076564A1 (en) | 2005-01-14 | 2006-01-12 | Synthesis of himbacine analogs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2007008631A true MX2007008631A (es) | 2007-09-12 |
Family
ID=36228637
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2007008631A MX2007008631A (es) | 2005-01-14 | 2006-01-12 | Sintesis de analogos de himbacina. |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP1853592B1 (es) |
| JP (2) | JP4681617B2 (es) |
| CN (1) | CN101137647A (es) |
| AR (1) | AR052870A1 (es) |
| AT (1) | ATE500249T1 (es) |
| CA (1) | CA2594741A1 (es) |
| DE (1) | DE602006020414D1 (es) |
| ES (1) | ES2360721T3 (es) |
| MX (1) | MX2007008631A (es) |
| PT (1) | PT1853592E (es) |
| SG (1) | SG158885A1 (es) |
| WO (1) | WO2006076564A1 (es) |
| ZA (1) | ZA200705792B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE458726T1 (de) * | 2005-01-14 | 2010-03-15 | Schering Corp | Exo- und diastereoselektive synthese von himbacin-analoga |
| EP2558465B1 (de) | 2010-04-16 | 2014-12-17 | Sanofi | Trizyklische pyridyl-vinyl-pyrrole als par1-inhibitoren |
| PL2558462T3 (pl) | 2010-04-16 | 2015-03-31 | Sanofi Sa | Pirydylo-winylo-pirazolo-chinoliny jako inhibitory PAR1 |
| WO2015013083A1 (en) * | 2013-07-22 | 2015-01-29 | Merck Sharp & Dohme Corp. | Co-crystal of the par-1 receptor antagonist vorapaxar and aspirin |
| CN105330689B (zh) * | 2014-08-08 | 2018-08-17 | 博瑞生物医药（苏州）股份有限公司 | 制备Himbacine类似物中间体的制备方法 |
| CN105985303B (zh) * | 2015-02-13 | 2020-08-14 | 上海彩迩文生化科技有限公司 | 抗凝血剂的制备方法、中间体及其制备方法 |
| CN106478608A (zh) * | 2015-09-01 | 2017-03-08 | 博瑞生物医药（苏州）股份有限公司 | 沃拉帕沙的硫酸盐的结晶多晶型物 |
| CN105348241B (zh) * | 2015-12-11 | 2017-09-05 | 南京华威医药科技开发有限公司 | 一种硫酸沃拉帕沙中间体的合成方法 |
| ITUB20160876A1 (it) | 2016-02-19 | 2017-08-19 | Dambrosio Enzo Maria | Combinazione di un agente antiallergico con un antagonista muscarinico e/o un agonista dopaminergico per l'uso in prevenzione/ arresto di miopia assiale nell’uomo |
| CN107129477A (zh) * | 2016-02-26 | 2017-09-05 | 上海星泰医药科技有限公司 | ((1R,3aR,4aR,6R,8aR,9S,9aR)-9-甲酰基-1-甲基-3-氧杂十二氢萘[2,3-c]-6-呋喃基)羧酸乙酯的制备方法 |
| CN106749138B (zh) * | 2016-12-07 | 2019-08-16 | 扬子江药业集团四川海蓉药业有限公司 | 一种硫酸沃拉帕沙中间体醛的制备方法 |
| CN107955014B (zh) * | 2017-11-10 | 2019-06-28 | 南阳师范学院 | 萘并呋喃酮类化合物及制备与在制备抗肿瘤药物中的应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6063847A (en) * | 1997-11-25 | 2000-05-16 | Schering Corporation | Thrombin receptor antagonists |
| WO1999026943A1 (en) * | 1997-11-25 | 1999-06-03 | Schering Corporation | Thrombin receptor antagonists |
| US7235567B2 (en) * | 2000-06-15 | 2007-06-26 | Schering Corporation | Crystalline polymorph of a bisulfate salt of a thrombin receptor antagonist |
| AR036832A1 (es) * | 2001-10-18 | 2004-10-06 | Schering Corp | Compuestos derivados de himbacina, agonistas receptores de trombina, composiciones farmaceuticas y el uso de dichos compuestos para la preparacion de medicamentos |
| PT1495018E (pt) * | 2002-04-16 | 2008-02-19 | Schering Corp | Antagonistas tricíclicos de receptores de trombina |
| ATE458726T1 (de) * | 2005-01-14 | 2010-03-15 | Schering Corp | Exo- und diastereoselektive synthese von himbacin-analoga |
-
2006
- 2006-01-12 AT AT06718299T patent/ATE500249T1/de active
- 2006-01-12 DE DE602006020414T patent/DE602006020414D1/de not_active Expired - Lifetime
- 2006-01-12 CA CA002594741A patent/CA2594741A1/en not_active Abandoned
- 2006-01-12 SG SG201000275-6A patent/SG158885A1/en unknown
- 2006-01-12 CN CNA2006800080207A patent/CN101137647A/zh active Pending
- 2006-01-12 AR ARP060100125A patent/AR052870A1/es not_active Application Discontinuation
- 2006-01-12 WO PCT/US2006/001208 patent/WO2006076564A1/en not_active Ceased
- 2006-01-12 ES ES06718299T patent/ES2360721T3/es not_active Expired - Lifetime
- 2006-01-12 JP JP2007551396A patent/JP4681617B2/ja not_active Expired - Fee Related
- 2006-01-12 MX MX2007008631A patent/MX2007008631A/es active IP Right Grant
- 2006-01-12 PT PT06718299T patent/PT1853592E/pt unknown
- 2006-01-12 EP EP06718299A patent/EP1853592B1/en not_active Expired - Lifetime
-
2007
- 2007-07-13 ZA ZA200705792A patent/ZA200705792B/xx unknown
-
2010
- 2010-12-09 JP JP2010275168A patent/JP2011046751A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008526981A (ja) | 2008-07-24 |
| WO2006076564A1 (en) | 2006-07-20 |
| SG158885A1 (en) | 2010-02-26 |
| ATE500249T1 (de) | 2011-03-15 |
| EP1853592A1 (en) | 2007-11-14 |
| CN101137647A (zh) | 2008-03-05 |
| DE602006020414D1 (en) | 2011-04-14 |
| ZA200705792B (en) | 2008-08-27 |
| PT1853592E (pt) | 2011-05-10 |
| EP1853592B1 (en) | 2011-03-02 |
| ES2360721T3 (es) | 2011-06-08 |
| AR052870A1 (es) | 2007-04-11 |
| JP2011046751A (ja) | 2011-03-10 |
| JP4681617B2 (ja) | 2011-05-11 |
| CA2594741A1 (en) | 2006-07-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| WO2011015522A3 (en) | Process for the manufacture of pharmaceutically active compounds | |
| PL1888541T3 (pl) | Związki benzo[d]izoksazol-3-iloaminy i ich zastosowanie jako ligandów receptora waniloidowego | |
| SG158885A1 (en) | Synthesis of himbacine analogs | |
| WO2008035212A3 (en) | Processes for preparing intermediate compounds useful for the preparation of cinacalcet | |
| NZ586187A (en) | Processes for the synthesis of sinomenine derivatives and their intermediate | |
| MX2009013212A (es) | Proceso para la sintesis de intermediarios de los inhibidores de renina tales como alisquireno. | |
| MA30079B1 (fr) | Procede de synthese de ferri-succinylcaseine | |
| TW200619215A (en) | Asymmetric synthesis of dihydrobenzofuran derivatives | |
| MX2007004698A (es) | Sintesis asimetrica de dihidrobenzofuranos sustituidos. | |
| MY171292A (en) | Synthesis of polymer conjugates of indolocarbazole compounds | |
| PL376896A1 (pl) | Sposoby wytwarzania 5-androstenów podstawionych w pozycji C-7 | |
| EP3020704A3 (en) | Crystalline polymorphs of clevidipine butyrate | |
| EA201000464A1 (ru) | Способ получения очищенного синтез-газа из синтез-газа, содержащего следовые количества примеси сернистых соединений, с помощью металлорганической структуры | |
| SG158884A1 (en) | An exo-selective synthesis of himbacine analogs | |
| MX2007007446A (es) | Procesos para la produccion de 4-aminoquinazolinas. | |
| MX2007003922A (es) | Nuevas propenonas ciclicas y aciclicas para tratar trastornos del sistema nervioso central. | |
| MY143324A (en) | Process for preparing phosphorus compounds having phosphate-phosphonate bond | |
| WO2010012797A3 (en) | Synthesis of 3,4-diaryl-4,5-dihydro-(1h)-pyrazole-1- carboxamidine derivatives | |
| TW200624435A (en) | Process for preparing iridium(Ⅲ) ketoketonates | |
| MX2008000011A (es) | Procesos para preparar derivados de pirazol-o-glucosido y nuevos intermediarios de dichos procesos. | |
| TW200630369A (en) | Process for preparing purine compounds | |
| EA200701862A1 (ru) | Улучшенный способ очистки периндоприла | |
| IL178228A0 (en) | A process for the semisynthesis of deserpidine | |
| MY141734A (en) | Methods for producing quinazoline alkaloids | |
| TW200621734A (en) | Process for preparing diarylcycloalkyl derivatives |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration | ||
| HC | Change of company name or juridical status |