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MX2009003761A - Derivados biciclicos y triciclicos como antagonistas del receptor de trombina. - Google Patents

Derivados biciclicos y triciclicos como antagonistas del receptor de trombina.

Info

Publication number
MX2009003761A
MX2009003761A MX2009003761A MX2009003761A MX2009003761A MX 2009003761 A MX2009003761 A MX 2009003761A MX 2009003761 A MX2009003761 A MX 2009003761A MX 2009003761 A MX2009003761 A MX 2009003761A MX 2009003761 A MX2009003761 A MX 2009003761A
Authority
MX
Mexico
Prior art keywords
sup
bond
bicyclic
receptor antagonists
thrombin receptor
Prior art date
Application number
MX2009003761A
Other languages
English (en)
Inventor
Yan Xia
Samuel Chackalamannil
Mariappan V Chelliah
Yuguguang Wang
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of MX2009003761A publication Critical patent/MX2009003761A/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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Abstract

Los tricíclicos heterocíclicos-sustituidos de la fórmula (I): (ver fórmula (I)) o una sal o solvato farmacéuticamente aceptable de dicho compuesto, isómero o mezcla racémica, en donde representa un enlace doble opcional, la línea punteada es opcionalmente un enlace o no es un enlace, dando como resultado un enlace doble o un enlace sencillo, según lo permita el requerimiento de valencia y en donde E, A, G, M Het, B, X, R3, R10, R11, R32 y R33 son como se definen en la presente y los sustituyentes restantes son como se definen en la especificación, así como composiciones farmacéuticas que los contienen y un método para el tratamiento de enfermedades asociadas con trombosis, aterosclerosis, restenosis, hipertensión, angina de pecho, arritmia, paro cardíaco, cáncer, con la administración de dichos compuestos; también se reclama la terapia de combinación con otros agentes cardiovasculares.
MX2009003761A 2006-10-04 2007-10-02 Derivados biciclicos y triciclicos como antagonistas del receptor de trombina. MX2009003761A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84935406P 2006-10-04 2006-10-04
PCT/US2007/021277 WO2008042422A2 (en) 2006-10-04 2007-10-02 Bicyclic and tricyclic derivatives as thrombin receptor antagonists

Publications (1)

Publication Number Publication Date
MX2009003761A true MX2009003761A (es) 2009-06-30

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009003761A MX2009003761A (es) 2006-10-04 2007-10-02 Derivados biciclicos y triciclicos como antagonistas del receptor de trombina.

Country Status (13)

Country Link
US (2) US8153664B2 (es)
EP (1) EP2069326B1 (es)
JP (1) JP2010505842A (es)
KR (1) KR20090074219A (es)
CN (1) CN101541782A (es)
AR (1) AR063123A1 (es)
AU (1) AU2007305269A1 (es)
CA (1) CA2667082A1 (es)
IL (1) IL198009A0 (es)
MX (1) MX2009003761A (es)
TW (1) TW200823205A (es)
WO (1) WO2008042422A2 (es)
ZA (1) ZA200902362B (es)

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JP2019523279A (ja) 2016-07-29 2019-08-22 サノビオン ファーマシューティカルズ インクＳｕｎｏｖｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． 化合物および組成物ならびにそれらの使用
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MY208150A (en) 2018-02-16 2025-04-18 Sunovion Pharmaceuticals Inc Salts, crystal forms, and production methods thereof
CN110559294A (zh) * 2018-06-06 2019-12-13 杨仑 脂肪性肝病及其相关疾病的预防和治疗性药物
JP7703449B2 (ja) 2019-03-14 2025-07-07 スミトモ・ファーマ・アメリカ・インコーポレイテッド イソクロマニル化合物の塩およびその結晶体、ならびにそれらの製造方法、治療用途および医薬組成物
CN110627710B (zh) * 2019-09-29 2020-06-05 山东大学 一种新型par-1抑制剂及其制备方法和在预防和/或治疗血栓性疾病中的用途
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CN112759548B (zh) * 2020-12-31 2021-11-02 山东大学 一种par-1抑制剂及其制备方法
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US20120157403A1 (en) 2012-06-21
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KR20090074219A (ko) 2009-07-06
US8153664B2 (en) 2012-04-10
AR063123A1 (es) 2008-12-30
EP2069326A2 (en) 2009-06-17
US20080090830A1 (en) 2008-04-17
CA2667082A1 (en) 2008-04-10
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WO2008042422A2 (en) 2008-04-10
CN101541782A (zh) 2009-09-23

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