SE9300758L - Förfarande för framställning av kavulansyrasalter - Google Patents

Förfarande för framställning av kavulansyrasalter

Info

Publication number: SE9300758L
Authority: SE; Sweden
Prior art keywords: cavulanic; preparation; acid salts; clavulanic acid; amino
Prior art date: 1992-03-10

Application number

SE9300758A

Other languages

English (en)

Other versions

SE9300758D0 (sv

SE508043C2 (sv

Inventor

Franz Krenmueller

Harald Summer

Original Assignee

Biochemie Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-03-10

Filing date

1993-03-08

Publication date

1993-09-11

1993-03-08 Application filed by Biochemie Gmbh filed Critical Biochemie Gmbh

1993-03-08 Publication of SE9300758D0 publication Critical patent/SE9300758D0/sv

1993-09-11 Publication of SE9300758L publication Critical patent/SE9300758L/sv

1998-08-17 Publication of SE508043C2 publication Critical patent/SE508043C2/sv

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Pharmacology & Pharmacy (AREA)
Communicable Diseases (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Cephalosporin Compounds (AREA)

SE9300758A 1992-03-10 1993-03-08 Förfarande för framställning och användning av 2-amino-2,4,4- trimetylpentansaltet av klavulansyra som mellanprodukt vid framställning av farmaceutiskt godtagbara salter av klavulansyra SE508043C2 (sv)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
AT0047292A AT400033B (de)	1992-03-10	1992-03-10	Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben

Publications (3)

Publication Number	Publication Date
SE9300758D0 SE9300758D0 (sv)	1993-03-08
SE9300758L true SE9300758L (sv)	1993-09-11
SE508043C2 SE508043C2 (sv)	1998-08-17

Family

ID=3491521

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE9300758A SE508043C2 (sv)	1992-03-10	1993-03-08	Förfarande för framställning och användning av 2-amino-2,4,4- trimetylpentansaltet av klavulansyra som mellanprodukt vid framställning av farmaceutiskt godtagbara salter av klavulansyra

Country Status (21)

Country	Link
US (4)	US20010036940A1 (sv)
JP (2)	JP2817563B2 (sv)
CN (3)	CN1045604C (sv)
AT (1)	AT400033B (sv)
AU (1)	AU659282B2 (sv)
CH (1)	CH685054A5 (sv)
CY (1)	CY1995A (sv)
DE (1)	DE4307422B4 (sv)
DK (1)	DK26093A (sv)
ES (1)	ES2058029B1 (sv)
FI (1)	FI101965B1 (sv)
FR (1)	FR2688506B1 (sv)
GB (1)	GB2264944B (sv)
GR (1)	GR1002329B (sv)
HK (1)	HK42696A (sv)
IE (1)	IE70926B1 (sv)
IT (1)	IT1261213B (sv)
NL (1)	NL9300430A (sv)
NO (1)	NO301372B1 (sv)
SE (1)	SE508043C2 (sv)
TW (1)	TW364907B (sv)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AT399155B (de) *	1992-03-26	1995-03-27	Lek Tovarna Farmacevtskih	Neue alkylendiammonium-diclavulanat-derivate, verfahren zu deren herstellung sowie deren verwendung
SI9300296B (sl) *	1992-06-11	1998-06-30	Smithkline Beecham P.L.C.	Postopek in intermedianti za pripravo klavulanske kisline
KR100200239B1 (ko) *	1992-10-21	1999-06-15	김충환	클라불란산 칼륨염의 제조방법
ES2155839T3 (es)	1993-11-17	2001-06-01	Biochemie Gmbh	Separacion de isomeros de cefalosporina.
GB9426261D0 (en) *	1994-12-24	1995-02-22	Spurcourt Ltd	Clavulanic acid salts
EE9700186A (et) *	1995-02-25	1998-02-16	Spurcourt Limited	Klavulaanhappe soolad
KR100200242B1 (ko) *	1995-05-16	1999-06-15	김충환	클라불란산염의 제조 방법
AT403375B (de) *	1995-11-15	1998-01-26	Biochemie Gmbh	Verfahren zur fällung von alkalisalzen der clavulansäure
CN1312814A (zh) *	1998-07-16	2001-09-12	Dsm公司	制备棒酸盐类及其酯类的改进方法
US6979735B1 (en) *	1999-04-01	2005-12-27	Dsm N.V.	Agglomerates by crystallization
SI1284978T2 (sl) *	2000-05-13	2008-12-31	Smithkline Beecham Plc	Postopek äśiĺ äśenja soli klavulanske kisline
US9180149B2 (en) *	2005-09-07	2015-11-10	Sillajen Biotherapeutics, Inc.	Systemic treatment of metastatic and/or systemically-disseminated cancers using GM-CSF-expressing poxviruses
JP7028064B2 (ja)	2018-05-30	2022-03-02	横河電機株式会社	機器保全装置、機器保全方法、機器保全プログラム及び記録媒体
KR20230038222A (ko)	2020-07-10	2023-03-17	카본 클린 솔루션스 리미티드	저급 열을 사용하여 용매에서 이산화탄소를 제거하는 방법 및 시스템

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3288800A (en) *	1962-05-29	1966-11-29	Squibb & Sons Inc	Schiff's bases of 6-amino-penicillanic acid and purification of 6-aminopenicillanic acid by the use thereof
GB1508977A (en)	1974-04-20	1978-04-26	Beecham Group Ltd	Beta-lactam antibiotic from streptomyces clavuligerus
US4110165A (en) *	1974-04-20	1978-08-29	Beecham Group Limited	Process for the production of clavulanic acid
NZ177159A (en) *	1974-04-20	1978-03-06	Beecham Group Ltd	Clavulanic acid, salts, esters and preparation thereof from streptomyces clavuligerus: pharmaceutical compositions
US4144242A (en) *	1975-02-07	1979-03-13	Glaxo Laboratories Limited	Process for the purification of clavulanic acid
GB1543563A (en)	1975-02-07	1979-04-04	Glaxo Lab Ltd	Beta-lactam antibiotic in purified form
GB1561395A (en)	1976-02-26	1980-02-20	Beecham Group Ltd	-lactam antibiotic
GB1578739A (en) *	1976-07-23	1980-11-05	Beecham Group Ltd	Amine salts of clavulanic acid methods for their preparation and compositions containing them
GB2003863B (en)	1977-09-01	1982-03-31	Beecham Group Ltd	Chemical process
EP0002312B1 (en)	1977-11-26	1982-02-03	Beecham Group Plc	Derivatives of clavulanic acid and pharmaceutical compositions containing them
BE862211A (fr) *	1977-12-22	1978-06-22	Beecham Group Ltd	Agents antibacteriens
US4454069A (en) *	1979-08-24	1984-06-12	Beecham Group Limited	Clavulanic acid salts and their preparation from the tertiary butyl amine salt
EP0026044B1 (en) *	1979-08-24	1983-06-08	Beecham Group Plc	Amine salt of clavulanic acid, its preparation and use
AR245221A1 (es)	1984-10-27	1993-12-30	Beecham Group Plc	Un metodo para la produccion de acido clavulanico por fermentacion de s. clavuligerus
GB8618888D0 (en) *	1986-08-01	1986-09-10	Davy Mckee Ltd	Process
US5679789A (en) *	1987-01-29	1997-10-21	Beecham Group, P.L.C.	Pharmaceutical compositions comprising potassium clavulanate and methods of using them
ES2008418A6 (es)	1987-01-29	1989-07-16	Beecham Group Plc	Un procedimiento para la obtencioon de nueva forma cristalina del clavulanato de potasio y de composiciones del mismo.
ES2010143A6 (es) *	1989-03-01	1989-10-16	Pharma Mar S A Pharmar	Un nuevo procedimiento de obtencion del acido z(2r,5r)-3-(2-hiadroxietiliden)-7- oxo-4-oxa-1-azabiciclo(3,2,0) -heptano-2-carboxilico y de sales estares farmaceutiacamente aceptables del mismo,a partir de caldos de fermentacion de streptomyces, sp.
US5210296A (en) *	1990-11-19	1993-05-11	E. I. Du Pont De Nemours And Company	Recovery of lactate esters and lactic acid from fermentation broth
AT399155B (de) *	1992-03-26	1995-03-27	Lek Tovarna Farmacevtskih	Neue alkylendiammonium-diclavulanat-derivate, verfahren zu deren herstellung sowie deren verwendung
SI9300296B (sl)	1992-06-11	1998-06-30	Smithkline Beecham P.L.C.	Postopek in intermedianti za pripravo klavulanske kisline
SI9200139A (en) *	1992-07-08	1994-03-31	Lek Tovarna Farmacevtskih	New inclusion complex of clavulanic acid with hydrophylyc and hydropholyc beta-cyclodextrin derivates for production of them
KR100200239B1 (ko)	1992-10-21	1999-06-15	김충환	클라불란산 칼륨염의 제조방법
GB9401969D0 (en)	1994-02-02	1994-03-30	Smithkline Beecham Plc	Process
SI9400107A (en)	1994-03-02	1995-10-31	Lek Tovarna Farmacevtskih	New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
EE9700186A (et) *	1995-02-25	1998-02-16	Spurcourt Limited	Klavulaanhappe soolad
GB2298201B (en)	1995-02-25	1997-05-28	Spurcourt Ltd	Clavulanic acid salts
SI9500074A (en)	1995-03-10	1996-10-31	Lek Tovarna Farmacevtskih	Process for preparation of alkani salts of clavulanic acid.
SI9500134B (sl)	1995-04-20	2004-04-30	Lek,	Postopek za pripravo čistih alkalijskih soli klavulanske kisline
KR100200242B1 (ko)	1995-05-16	1999-06-15	김충환	클라불란산염의 제조 방법
GB9515809D0 (en)	1995-08-02	1995-10-04	Smithkline Beecham Plc	Process
SI9500265A1 (en)	1995-08-28	1997-02-28	Lek Tovarna Farmacevtskih	Process for purification of the aqueous fermented broth filtrate of streptomyces sp. p 6621 ferm p 2804 by ultrafiltration
US6414142B1 (en)	1996-06-13	2002-07-02	Smithkline Beecham Corporation	Process for preparing potassium clavulanate
CA2271847A1 (en)	1996-11-11	1998-05-22	Gist-Brocades B.V.	Process for the preparation of salts and esters of clavulanic acid

1992
- 1992-03-10 AT AT0047292A patent/AT400033B/de not_active IP Right Cessation
1993
- 1993-03-05 CH CH670/93A patent/CH685054A5/de not_active IP Right Cessation
- 1993-03-08 NO NO930829A patent/NO301372B1/no unknown
- 1993-03-08 JP JP5046691A patent/JP2817563B2/ja not_active Expired - Fee Related
- 1993-03-08 GB GB9304704A patent/GB2264944B/en not_active Expired - Fee Related
- 1993-03-08 SE SE9300758A patent/SE508043C2/sv not_active IP Right Cessation
- 1993-03-09 CN CN93102897A patent/CN1045604C/zh not_active Expired - Fee Related
- 1993-03-09 DE DE4307422A patent/DE4307422B4/de not_active Expired - Fee Related
- 1993-03-09 DK DK026093A patent/DK26093A/da not_active Application Discontinuation
- 1993-03-09 IE IE930172A patent/IE70926B1/en not_active IP Right Cessation
- 1993-03-09 GR GR930100090A patent/GR1002329B/el not_active IP Right Cessation
- 1993-03-09 AU AU34070/93A patent/AU659282B2/en not_active Ceased
- 1993-03-09 FI FI931032A patent/FI101965B1/sv active
- 1993-03-09 FR FR9302720A patent/FR2688506B1/fr not_active Expired - Fee Related
- 1993-03-10 NL NL9300430A patent/NL9300430A/nl active Search and Examination
- 1993-03-10 IT ITRM930147A patent/IT1261213B/it active IP Right Grant
- 1993-03-10 ES ES09300483A patent/ES2058029B1/es not_active Expired - Fee Related
- 1993-05-04 TW TW082103491A patent/TW364907B/zh not_active IP Right Cessation
1996
- 1996-03-14 HK HK42696A patent/HK42696A/xx not_active IP Right Cessation
- 1996-06-29 CN CN96108278A patent/CN1150153A/zh active Pending
- 1996-06-29 CN CN96108276A patent/CN1145906A/zh active Pending
1997
- 1997-08-13 JP JP9218732A patent/JPH1067785A/ja active Pending
- 1997-09-05 CY CY199597A patent/CY1995A/en unknown
2001
- 2001-06-26 US US09/892,179 patent/US20010036940A1/en not_active Abandoned
2002
- 2002-02-08 US US10/071,364 patent/US20020072513A1/en not_active Abandoned
- 2002-09-20 US US10/251,948 patent/US20030022882A1/en not_active Abandoned
2003
- 2003-05-13 US US10/437,097 patent/USH2158H1/en not_active Abandoned

Also Published As

Publication number	Publication date
CN1045604C (zh)	1999-10-13
FR2688506A1 (fr)	1993-09-17
US20030022882A1 (en)	2003-01-30
GB2264944A (en)	1993-09-15
NO930829L (no)	1993-09-13
DE4307422A1 (de)	1993-09-30
GR1002329B (el)	1996-05-15
IE930172A1 (en)	1993-09-22
CN1145906A (zh)	1997-03-26
CN1150153A (zh)	1997-05-21
JPH1067785A (ja)	1998-03-10
FI931032L (fi)	1993-09-11
ATA47292A (de)	1995-01-15
US20030203886A1 (en)	2003-10-30
US20010036940A1 (en)	2001-11-01
HK42696A (en)	1996-03-22
IT1261213B (it)	1996-05-09
FI101965B (sv)	1998-09-30
AU659282B2 (en)	1995-05-11
DK26093D0 (da)	1993-03-09
DE4307422B4 (de)	2004-11-25
CY1995A (en)	1997-09-05
SE9300758D0 (sv)	1993-03-08
GB9304704D0 (en)	1993-04-28
US20020072513A1 (en)	2002-06-13
GB2264944B (en)	1995-09-06
FI101965B1 (sv)	1998-09-30
CN1079743A (zh)	1993-12-22
TW364907B (en)	1999-07-21
AU3407093A (en)	1993-09-16
USH2158H1 (en)	2006-06-06
NL9300430A (nl)	1993-10-01
ES2058029A1 (es)	1994-10-16
JP2817563B2 (ja)	1998-10-30
JPH0641143A (ja)	1994-02-15
NO930829D0 (no)	1993-03-08
DK26093A (da)	1993-09-11
GR930100090A (el)	1993-11-30
ITRM930147A0 (it)	1993-03-10
ITRM930147A1 (it)	1994-09-10
NO301372B1 (no)	1997-10-20
ES2058029B1 (es)	1995-05-01
IE70926B1 (en)	1997-01-15
FI931032A0 (fi)	1993-03-09
SE508043C2 (sv)	1998-08-17
AT400033B (de)	1995-09-25
CH685054A5 (de)	1995-03-15
FR2688506B1 (fr)	1995-06-23

Publication	Publication Date	Title
GEP20032965B (en)	2003-05-12	Pharmaceutical Compound
MX9300014A (es)	1993-07-01	Nuevos derivados de 1,2,4-triaminobenceno y procedimiento para su elaboracion.
NO178194C (no)	1996-02-07	Analogifremgangsmåte for fremstilling av terapeutisk aktive naftyridin-derivater
HU913760D0 (en)	1992-02-28	Process for the production of new dihydro-iso-kynoline derivatives
SE9300758L (sv)	1993-09-11	Förfarande för framställning av kavulansyrasalter
ES2042534T3 (es)	1993-12-16	Un proceso para la preparacion de una preparacion topica en forma de un hidrogel.
ATE155469T1 (de)	1997-08-15	Verfahren zur herstellung von cephemderivaten
FI871087A0 (sv)	1987-03-12	Förfarande för framställning av terapeutiskt användbara 1,2,3,4-tetrahydro-3-karbamoyl-2-tioxo/oxo-5-pyrimidinkarboxylsyraderivat
NO301767B1 (no)	1997-12-08	Salt av clavulansyre
DE69233249D1 (de)	2003-12-11	Verfahren zur Herstellung von einem 3-Cephem-4-Carbonsäurederivat
MA21122A1 (fr)	1988-07-01	Procede de preparation de derives d'acides aminocarboxyliques bicycliques .
TR28873A (tr)	1997-08-04	N-sübstitüe edilmis, N,N'-kaynasik heterosiklik benzoik asit üretmeye mahsus yöntem.
FI892684A0 (sv)	1989-06-01	Förfarande för framställning av terapeutiskt aktiva 4-oxo-imidazo/1,5-a/kinoxalinderivat
MY103210A (en)	1993-05-29	Arylpiperazinyl-alkylene-phenyl-heterocyclic compounds.
ES2163038T3 (es)	2002-01-16	Procedimiento para la preparacion de clavulanato de potasio.
FI900145A0 (sv)	1990-01-11	Förfarande för framställning av farmaceutiskt användbara 1,1-dioxo-cefem-4-karbotiolsyraderivat
FI893121A0 (sv)	1989-06-27	Förfarande för framställning av terapeutiskt aktiva 6,21-dimetyl-19-norprogestronderivat
FI93216C (sv)	1995-03-10	Analogiförfarande för framställning av terapeutiskt användbara 1,3-dioxanalkensyraderivat
BG42676A3 (en)	1988-01-15	Method for preparang derivatives of 6- aminoalkyl- penicillanic acid
IT1247034B (it)	1994-12-12	Acidi dimetilamino-idrossi alchil difosfonici e loro sali, loro procedimento produttivo e composizioni farmaceutiche che li comprendono
DE3887174D1 (de)	1994-03-03	Verfahren zur Herstellung von 2,3-Dihydro-1H-imidazolylalkoxyinden-Derivaten und ihren pharmazeutisch annehmbaren Salzen, und Zwischenprodukte hierfür.
FI913161A7 (sv)	1991-06-28	Förfarande för framställning av N-(3',4'-dimetoxikinnamoyl)antranilsyr a
FI934054A0 (sv)	1993-09-15	Förfarande för framställning av mellanprodukter, som är användbara vid framställning av antibakteriella karboxylsyraderivat
PH25092A (en)	1991-02-19	A method of preventing and treating renal diseases

Legal Events

Date	Code	Title	Description
2010-11-02	NUG	Patent has lapsed