FI871087A0 - Förfarande för framställning av terapeutiskt användbara 1,2,3,4-tetrahydro-3-karbamoyl-2-tioxo/oxo-5-pyrimidinkarboxylsyraderivat - Google Patents

Förfarande för framställning av terapeutiskt användbara 1,2,3,4-tetrahydro-3-karbamoyl-2-tioxo/oxo-5-pyrimidinkarboxylsyraderivat

Info

Publication number: FI871087A0
Authority: FI; Finland
Prior art keywords: thioxo; carbamoyl; tetrahydro; oxo; preparation
Prior art date: 1986-03-14

Application number

FI871087A

Other languages

English (en)

Finnish (fi)

Other versions

FI96683C (sv

FI96683B (sv

FI871087A7 (sv

Inventor

Karnail Singh Atwal

George Charles Rovnyak

Original Assignee

Squibb & Sons Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-03-14

Filing date

1987-03-12

Publication date

1987-03-12

1987-02-09 Priority claimed from US07/008,037 external-priority patent/US4855301A/en

1987-03-12 Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc

1987-03-12 Publication of FI871087A0 publication Critical patent/FI871087A0/sv

1987-09-15 Publication of FI871087A7 publication Critical patent/FI871087A7/sv

1996-04-30 Application granted granted Critical

1996-04-30 Publication of FI96683B publication Critical patent/FI96683B/sv

1996-08-12 Publication of FI96683C publication Critical patent/FI96683C/sv

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

FI871087A 1986-03-14 1987-03-12 Förfarande för framställning av terapeutiskt användbara 1,2,3,4-tetrahydro-3-karbamoyl-2-tioxo/oxo-5-pyrimidinkarboxylsyraderivat FI96683C (sv)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
US83976786A	1986-03-14	1986-03-14
US83976786		1986-03-14
US91734986A	1986-10-09	1986-10-09
US91734986		1986-10-09
US07/008,037 US4855301A (en)	1986-10-09	1987-02-09	1,2,3,4-Tetrahydro-6-substituted-4-aryl(or heterocyclo)-3-((substituted amino)carbonyl)-2-thioxo (or oxo)-5-pyrimidinecarboxylic acids and esters
US803787		1997-02-24

Publications (4)

Publication Number	Publication Date
FI871087A0 true FI871087A0 (sv)	1987-03-12
FI871087A7 FI871087A7 (sv)	1987-09-15
FI96683B FI96683B (sv)	1996-04-30
FI96683C FI96683C (sv)	1996-08-12

Family

ID=27358497

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI871087A FI96683C (sv)	1986-03-14	1987-03-12	Förfarande för framställning av terapeutiskt användbara 1,2,3,4-tetrahydro-3-karbamoyl-2-tioxo/oxo-5-pyrimidinkarboxylsyraderivat

Country Status (17)

Country	Link
EP (1)	EP0237347B1 (sv)
JP (1)	JPH0819113B2 (sv)
KR (1)	KR900005014B1 (sv)
CA (1)	CA1337655C (sv)
DE (1)	DE3770661D1 (sv)
DK (1)	DK169031B1 (sv)
ES (1)	ES2039234T3 (sv)
FI (1)	FI96683C (sv)
GR (1)	GR3002715T3 (sv)
HU (1)	HU206091B (sv)
IE (1)	IE60114B1 (sv)
IL (1)	IL81800A0 (sv)
NO (1)	NO871044L (sv)
PH (1)	PH27052A (sv)
PL (1)	PL153727B1 (sv)
PT (1)	PT84479B (sv)
SU (1)	SU1713437A3 (sv)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS62267272A (ja) *	1986-05-15	1987-11-19	Sanwa Kagaku Kenkyusho Co Ltd	新規なジヒドロピリミジン化合物及びその塩、これらの製法並びに該化合物を有効成分とする循環器系作用剤
US4847379A (en) *	1987-11-30	1989-07-11	E. R. Squibb & Sons, Inc.	3,6-dihydro-1,5(2H)-pyrimidinecarboxylic acid esters
US6268369B1 (en)	1994-11-16	2001-07-31	Synaptic Pharmaceutical Corporation	5-(heterocyclic alkyl)-6-aryl-dihydropyrimidines
EE9700209A (et)	1994-11-16	1998-04-15	Synaptic Pharmaceutical Corporation	Dihüdropürimidiinid ja nende kasutamine
US6228861B1 (en)	1995-11-16	2001-05-08	Synaptic Pharmaceutical Corporation	Dihydropyrimidines and uses thereof
CA2237774A1 (en) *	1995-11-16	1997-05-22	Michael A. Patane	Dihydropyrimidines and uses thereof
US6172066B1 (en)	1996-05-16	2001-01-09	Synaptic Pharmaceutical Corporation	Dihydropyrimidines and uses thereof
US6245773B1 (en)	1996-05-16	2001-06-12	Synaptic Pharmaceutical Corporation	5-(heterocyclic alkyl)-6-aryl-dihydropyrimidines
EP0986553A4 (en) *	1997-02-04	2000-12-27	Bristol Myers Squibb Co	DIHYDROPYRIMIDONE DERIVATIVES AS NPY ANTAGONISTS
US6680323B2 (en)	1998-12-23	2004-01-20	Synaptic Pharmaceutical Corporation	Dihydropyrimidines and uses thereof
US6274585B1 (en)	1998-12-23	2001-08-14	Synaptic Pharmaceutical Corporation	Dihydropyrimidines and uses thereof
AU5568400A (en)	1999-06-23	2001-01-09	Ajinomoto Co., Inc.	Novel dihydropyrimidine derivatives
US6720324B2 (en)	2000-07-05	2004-04-13	Synaptic Pharmaceutical Corporation	Selective melanin concentrating hormone-1 (MCH1) receptor antagonists and uses thereof
AU2003270562B2 (en) *	2002-09-12	2010-09-16	Diakron Pharmaceuticals, Inc.	Calcium channel blockers
WO2005007124A2 (en)	2003-07-23	2005-01-27	Bristol-Myers Squibb Company	Substituted dihydropyrimidine inhibitors of calcium channel function
US7166603B2 (en)	2003-07-23	2007-01-23	Bristol-Myers Squibb Co.	Dihydropyrimidone inhibitors of calcium channel function

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS60214778A (ja) *	1984-03-08	1985-10-28	Suntory Ltd	Ν置換３，４−ジヒドロピリミジン誘導体ならびにその製造法および用途
HUT42077A (en) *	1985-06-03	1987-06-29	Squibb & Sons Inc	Process for producing diesters of 2-tioxo- or 2-oxo-pyrimidine-1,5-dicarboxylic acid and 1-acyl-pyrimidine-5-carboxylic acids and esters
US4675321A (en) *	1986-02-07	1987-06-23	Merck & Co., Inc.	Substituted pyrimidines useful as calcium channel blockers
CA1275410C (en) *	1986-03-14	1990-10-23	Karnail S. Atwal	1,2,3,4-tetrahydro-6-substituted-4-aryl(or heterocyclo) -3-substituted-2-thioxo(or oxo)-5- pyrimidinecarboxylic acids and esters

1987
- 1987-03-05 IL IL81800A patent/IL81800A0/xx not_active IP Right Cessation
- 1987-03-06 PH PH34991A patent/PH27052A/en unknown
- 1987-03-11 IE IE63387A patent/IE60114B1/en not_active IP Right Cessation
- 1987-03-11 JP JP62057890A patent/JPH0819113B2/ja not_active Expired - Lifetime
- 1987-03-12 FI FI871087A patent/FI96683C/sv not_active IP Right Cessation
- 1987-03-12 ES ES198787302130T patent/ES2039234T3/es not_active Expired - Lifetime
- 1987-03-12 EP EP87302130A patent/EP0237347B1/en not_active Expired - Lifetime
- 1987-03-12 DE DE8787302130T patent/DE3770661D1/de not_active Expired - Fee Related
- 1987-03-13 PT PT84479A patent/PT84479B/pt not_active IP Right Cessation
- 1987-03-13 PL PL1987264629A patent/PL153727B1/pl unknown
- 1987-03-13 KR KR1019870002239A patent/KR900005014B1/ko not_active Expired
- 1987-03-13 SU SU874202205A patent/SU1713437A3/ru active
- 1987-03-13 DK DK131887A patent/DK169031B1/da not_active IP Right Cessation
- 1987-03-13 NO NO871044A patent/NO871044L/no unknown
- 1987-03-13 HU HU871127A patent/HU206091B/hu not_active IP Right Cessation
- 1987-03-16 CA CA000532125A patent/CA1337655C/en not_active Expired - Fee Related
1991
- 1991-09-12 GR GR91401319T patent/GR3002715T3/el unknown

Also Published As

Publication number	Publication date
PL153727B1 (en)	1991-05-31
EP0237347A3 (en)	1988-11-02
PH27052A (en)	1993-02-01
FI96683C (sv)	1996-08-12
EP0237347B1 (en)	1991-06-12
JPS62265271A (ja)	1987-11-18
DK169031B1 (da)	1994-08-01
PL264629A1 (en)	1988-07-21
EP0237347A2 (en)	1987-09-16
DE3770661D1 (de)	1991-07-18
CA1337655C (en)	1995-11-28
SU1713437A3 (ru)	1992-02-15
PT84479A (en)	1987-04-01
ES2039234T3 (es)	1993-09-16
IL81800A0 (en)	1987-10-20
NO871044L (no)	1987-09-15
DK131887D0 (da)	1987-03-13
NO871044D0 (no)	1987-03-13
FI96683B (sv)	1996-04-30
GR3002715T3 (en)	1993-01-25
FI871087A7 (sv)	1987-09-15
DK131887A (da)	1987-09-15
HUT43832A (en)	1987-12-28
IE870633L (en)	1987-09-14
KR900005014B1 (ko)	1990-07-16
PT84479B (pt)	1990-08-31
KR870008856A (ko)	1987-10-21
JPH0819113B2 (ja)	1996-02-28
HU206091B (en)	1992-08-28
IE60114B1 (en)	1994-06-01

Publication	Publication Date	Title
FI890282A0 (sv)	1989-01-19	Förfarande för framställning av terapeutiskt användbara 23,24-didehydro-25-hydroxikalciferolderivat
FI873467A7 (sv)	1988-02-14	Förfarande för framställning av 5-amino-4-hydroxi-valeriansyraderivat
FI875660L (sv)	1987-12-22	Förfarande för framställning av terapeutiskt användbara 5-fenyl-2-pyrimidinonderivat
FI875024A7 (sv)	1988-05-15	Förfarande för framställning av terapeutiskt användbara 1-alkyl-6-halogentetrahydronaftalenderivat
FI892881A0 (sv)	1989-06-13	Förfarande för framställning av terapeutiskt användbara aminosyraderivat
PT87754A (pt)	1988-07-01	Process for the preparation of new amino acid derivatives
FI92934B (sv)	1994-10-14	Analogiförfarande för framställning av terapeutiskt användbara 1-deoxinojirimycinderivat
FI97297C (sv)	1996-11-25	Förfarande för framställning av terapeutiskt användbara boraminosyraderivat
FI873205A0 (sv)	1987-07-21	Förfarande för framställning av terapeutiskt aktiva bensimidazolderivat
FI874459A0 (sv)	1987-10-09	Förfarande för framställning av terapeutiskt användbara piperidinderivat
FI90769C (sv)	1994-03-25	Förfarande för framställning av terapeutiskt användbara triazolföreningar
FI850654A0 (sv)	1985-02-15	Förfarande för framställning av terapeutiskt användbara pleuromutilinderivator
FI94752C (sv)	1995-10-25	Förfarande för framställning av terapeutiskt användbara propenonoximetrar
FI871087A0 (sv)	1987-03-12	Förfarande för framställning av terapeutiskt användbara 1,2,3,4-tetrahydro-3-karbamoyl-2-tioxo/oxo-5-pyrimidinkarboxylsyraderivat
PT87153A (pt)	1988-05-01	Process for the preparation of acid ribofuranuronic derivatives
FI93215C (sv)	1995-03-10	Förfarande för framställning av terapeutiskt användbara aminoalkoxifenylderivat
FI880467A0 (sv)	1988-02-02	Förfarande för framställning av terapeutiskt användbara substituerade 3,4-dihydro-2H-benzopyraner
FI93444B (sv)	1994-12-30	Förfarande för framställning av terapeutiskt aktiva dihydropyridinföreningar
FI881892A7 (sv)	1988-10-25	Förfarande för framställning av nya, terapeutiskt användbara 1,2,5,6-tetrahydropyridinderivat
FI104075B1 (sv)	1999-11-15	Förfarande för framställning av terapeutiskt användbara 2-karboxitienylkarbamoylpyrrolidin-4-ylkarbapenem-3-karboxylsyraderivat
FI903077A0 (sv)	1990-06-19	Förfarande för framställning av terapeutiskt aktiva R(-)-3-kinuklidinolderivat
FI893003A0 (sv)	1989-06-19	Förfarande för framställning av terapeutiskt användbara neplanocinderivat
FI884660A0 (sv)	1988-10-11	Förfarande för framställning av terapeutiskt aktiva 2,2-dimetylkromenderivat
FI900145A0 (sv)	1990-01-11	Förfarande för framställning av farmaceutiskt användbara 1,1-dioxo-cefem-4-karbotiolsyraderivat
FI892946A7 (sv)	1989-12-16	Förfarande för framställning av nya terapeutiskt användbara 2,3,4,5-tetrahydro-1H-3-bensazepinderivat

Legal Events

Date	Code	Title	Description
1996-04-01	BB	Publication of examined application
1997-10-16	MM	Patent lapsed
2004-08-31	MM	Patent lapsed	Owner name: E.R. SQUIBB & SONS, INC.