[go: up one dir, main page]

ES2058029A1 - Proceso para la produccion de sales del acido clavulanico. - Google Patents

Proceso para la produccion de sales del acido clavulanico.

Info

Publication number
ES2058029A1
ES2058029A1 ES09300483A ES9300483A ES2058029A1 ES 2058029 A1 ES2058029 A1 ES 2058029A1 ES 09300483 A ES09300483 A ES 09300483A ES 9300483 A ES9300483 A ES 9300483A ES 2058029 A1 ES2058029 A1 ES 2058029A1
Authority
ES
Spain
Prior art keywords
clavulanic acid
production
acid salts
clavulanic
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09300483A
Other languages
English (en)
Other versions
ES2058029B1 (es
Inventor
Franz Krenmueller
Harald Summer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz GmbH
Original Assignee
Biochemie GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biochemie GmbH filed Critical Biochemie GmbH
Publication of ES2058029A1 publication Critical patent/ES2058029A1/es
Application granted granted Critical
Publication of ES2058029B1 publication Critical patent/ES2058029B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

PROCESO PARA LA PRODUCCION DE SALES DE ACIDO CLAVULANICO, EN PARTICULAR PARA LA PRODUCCION DE SALES FARMACEUTICAMENTE ACEPTABLES DEL REFERIDO ACIDO. COMPRENDE FORMAR LA SAL DE 2-AMINO-2,4,4-TRIMETILPENTANO DE ACIDO CLAVULANICO Y CONVERTIR ESTA SAL EN UNA SAL FARMACEUTICAMENTE ACEPTABLE DE ACIDO CLAVULANICO.
ES09300483A 1992-03-10 1993-03-10 Proceso para la produccion de sales del acido clavulanico. Expired - Fee Related ES2058029B1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT0047292A AT400033B (de) 1992-03-10 1992-03-10 Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben

Publications (2)

Publication Number Publication Date
ES2058029A1 true ES2058029A1 (es) 1994-10-16
ES2058029B1 ES2058029B1 (es) 1995-05-01

Family

ID=3491521

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09300483A Expired - Fee Related ES2058029B1 (es) 1992-03-10 1993-03-10 Proceso para la produccion de sales del acido clavulanico.

Country Status (21)

Country Link
US (4) US20010036940A1 (es)
JP (2) JP2817563B2 (es)
CN (3) CN1045604C (es)
AT (1) AT400033B (es)
AU (1) AU659282B2 (es)
CH (1) CH685054A5 (es)
CY (1) CY1995A (es)
DE (1) DE4307422B4 (es)
DK (1) DK26093A (es)
ES (1) ES2058029B1 (es)
FI (1) FI101965B1 (es)
FR (1) FR2688506B1 (es)
GB (1) GB2264944B (es)
GR (1) GR1002329B (es)
HK (1) HK42696A (es)
IE (1) IE70926B1 (es)
IT (1) IT1261213B (es)
NL (1) NL9300430A (es)
NO (1) NO301372B1 (es)
SE (1) SE508043C2 (es)
TW (1) TW364907B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT399155B (de) * 1992-03-26 1995-03-27 Lek Tovarna Farmacevtskih Neue alkylendiammonium-diclavulanat-derivate, verfahren zu deren herstellung sowie deren verwendung
SI9300296B (sl) * 1992-06-11 1998-06-30 Smithkline Beecham P.L.C. Postopek in intermedianti za pripravo klavulanske kisline
KR100200239B1 (ko) * 1992-10-21 1999-06-15 김충환 클라불란산 칼륨염의 제조방법
EP0658558B1 (en) 1993-11-17 2001-01-24 Biochemie Gesellschaft M.B.H. Separation of cephalosporin isomers
GB9426261D0 (en) 1994-12-24 1995-02-22 Spurcourt Ltd Clavulanic acid salts
AU691727B2 (en) * 1995-02-25 1998-05-21 Spurcourt Limited Clavulanic acid salts
KR100200242B1 (ko) * 1995-05-16 1999-06-15 김충환 클라불란산염의 제조 방법
AT403375B (de) * 1995-11-15 1998-01-26 Biochemie Gmbh Verfahren zur fällung von alkalisalzen der clavulansäure
CA2337072A1 (en) * 1998-07-16 2000-01-27 Dsm N.V. Improved process for the preparation of salts and esters of clavulanic acid
WO2000041478A2 (en) * 1999-04-01 2000-07-20 Dsm N.V. Agglomerates by crystallisation
KR100827898B1 (ko) * 2000-05-13 2008-05-07 스미스클라인비이참피이엘시이 클라불란산의 염의 정제 방법
EP1933857A2 (en) * 2005-09-07 2008-06-25 Jennerex Biotherapeutics ULC Systemic treatment of metastatic and/or systemically-disseminated cancers using gm-csf-expressing poxviruses
JP7028064B2 (ja) 2018-05-30 2022-03-02 横河電機株式会社 機器保全装置、機器保全方法、機器保全プログラム及び記録媒体
EP4178710A1 (en) 2020-07-10 2023-05-17 Carbon Clean Solutions Limited A method and system for the removal of carbon dioxide from solvents using low-grade heat

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1578739A (en) * 1976-07-23 1980-11-05 Beecham Group Ltd Amine salts of clavulanic acid methods for their preparation and compositions containing them
ES8106157A1 (es) * 1979-08-24 1981-07-16 Beecham Group Ltd Un procedimiento para la preparacion de acido clavulanico
ES2010143A6 (es) * 1989-03-01 1989-10-16 Pharma Mar S A Pharmar Un nuevo procedimiento de obtencion del acido z(2r,5r)-3-(2-hiadroxietiliden)-7- oxo-4-oxa-1-azabiciclo(3,2,0) -heptano-2-carboxilico y de sales estares farmaceutiacamente aceptables del mismo,a partir de caldos de fermentacion de streptomyces, sp.

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3288800A (en) 1962-05-29 1966-11-29 Squibb & Sons Inc Schiff's bases of 6-amino-penicillanic acid and purification of 6-aminopenicillanic acid by the use thereof
GB1508977A (en) 1974-04-20 1978-04-26 Beecham Group Ltd Beta-lactam antibiotic from streptomyces clavuligerus
IE41109B1 (en) 1974-04-20 1979-10-24 Beecham Group Ltd Novel -lactam antibiotic from streptomyces clavuligerus
US4110165A (en) 1974-04-20 1978-08-29 Beecham Group Limited Process for the production of clavulanic acid
GB1543563A (en) 1975-02-07 1979-04-04 Glaxo Lab Ltd Beta-lactam antibiotic in purified form
US4144242A (en) 1975-02-07 1979-03-13 Glaxo Laboratories Limited Process for the purification of clavulanic acid
GB1561395A (en) 1976-02-26 1980-02-20 Beecham Group Ltd -lactam antibiotic
GB2003863B (en) 1977-09-01 1982-03-31 Beecham Group Ltd Chemical process
DE2861607D1 (en) 1977-11-26 1982-03-11 Beecham Group Plc Derivatives of clavulanic acid and pharmaceutical compositions containing them
BE862211A (fr) * 1977-12-22 1978-06-22 Beecham Group Ltd Agents antibacteriens
US4454069A (en) 1979-08-24 1984-06-12 Beecham Group Limited Clavulanic acid salts and their preparation from the tertiary butyl amine salt
AR245221A1 (es) 1984-10-27 1993-12-30 Beecham Group Plc Un metodo para la produccion de acido clavulanico por fermentacion de s. clavuligerus
GB8618888D0 (en) 1986-08-01 1986-09-10 Davy Mckee Ltd Process
US5679789A (en) 1987-01-29 1997-10-21 Beecham Group, P.L.C. Pharmaceutical compositions comprising potassium clavulanate and methods of using them
GB2200355B (en) 1987-01-29 1990-08-01 Beecham Group Plc Potassium clavulanate
US5210296A (en) 1990-11-19 1993-05-11 E. I. Du Pont De Nemours And Company Recovery of lactate esters and lactic acid from fermentation broth
AT399155B (de) 1992-03-26 1995-03-27 Lek Tovarna Farmacevtskih Neue alkylendiammonium-diclavulanat-derivate, verfahren zu deren herstellung sowie deren verwendung
SI9300296B (sl) 1992-06-11 1998-06-30 Smithkline Beecham P.L.C. Postopek in intermedianti za pripravo klavulanske kisline
SI9200139A (en) 1992-07-08 1994-03-31 Lek Tovarna Farmacevtskih New inclusion complex of clavulanic acid with hydrophylyc and hydropholyc beta-cyclodextrin derivates for production of them
KR100200239B1 (ko) 1992-10-21 1999-06-15 김충환 클라불란산 칼륨염의 제조방법
GB9401969D0 (en) 1994-02-02 1994-03-30 Smithkline Beecham Plc Process
SI9400107A (en) 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
GB2298201B (en) 1995-02-25 1997-05-28 Spurcourt Ltd Clavulanic acid salts
AU691727B2 (en) 1995-02-25 1998-05-21 Spurcourt Limited Clavulanic acid salts
SI9500074A (en) 1995-03-10 1996-10-31 Lek Tovarna Farmacevtskih Process for preparation of alkani salts of clavulanic acid.
SI9500134B (sl) 1995-04-20 2004-04-30 Lek, Postopek za pripravo čistih alkalijskih soli klavulanske kisline
KR100200242B1 (ko) 1995-05-16 1999-06-15 김충환 클라불란산염의 제조 방법
GB9515809D0 (en) 1995-08-02 1995-10-04 Smithkline Beecham Plc Process
SI9500265A1 (en) 1995-08-28 1997-02-28 Lek Tovarna Farmacevtskih Process for purification of the aqueous fermented broth filtrate of streptomyces sp. p 6621 ferm p 2804 by ultrafiltration
ZA975198B (en) 1996-06-13 1997-12-15 Smithkline Beecham Corp Improved process for preparing potassium clavulanate.
JP2001503763A (ja) 1996-11-11 2001-03-21 ギスト ブロカデス ベスローテン フェンノートシャップ クラバラン酸の塩及びエステルの調製法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1578739A (en) * 1976-07-23 1980-11-05 Beecham Group Ltd Amine salts of clavulanic acid methods for their preparation and compositions containing them
US4650795A (en) * 1976-07-23 1987-03-17 Beecham Group P.L.C. Amine salts of clavulanic acid as antibacterial agents
ES8106157A1 (es) * 1979-08-24 1981-07-16 Beecham Group Ltd Un procedimiento para la preparacion de acido clavulanico
ES2010143A6 (es) * 1989-03-01 1989-10-16 Pharma Mar S A Pharmar Un nuevo procedimiento de obtencion del acido z(2r,5r)-3-(2-hiadroxietiliden)-7- oxo-4-oxa-1-azabiciclo(3,2,0) -heptano-2-carboxilico y de sales estares farmaceutiacamente aceptables del mismo,a partir de caldos de fermentacion de streptomyces, sp.

Also Published As

Publication number Publication date
US20030203886A1 (en) 2003-10-30
FR2688506B1 (fr) 1995-06-23
HK42696A (en) 1996-03-22
IT1261213B (it) 1996-05-09
ES2058029B1 (es) 1995-05-01
ATA47292A (de) 1995-01-15
IE930172A1 (en) 1993-09-22
FI101965B (fi) 1998-09-30
DK26093A (da) 1993-09-11
JP2817563B2 (ja) 1998-10-30
ITRM930147A0 (it) 1993-03-10
GR1002329B (el) 1996-05-15
SE9300758L (sv) 1993-09-11
CN1145906A (zh) 1997-03-26
USH2158H1 (en) 2006-06-06
CY1995A (en) 1997-09-05
US20020072513A1 (en) 2002-06-13
GR930100090A (el) 1993-11-30
TW364907B (en) 1999-07-21
AT400033B (de) 1995-09-25
CN1079743A (zh) 1993-12-22
DE4307422B4 (de) 2004-11-25
SE9300758D0 (sv) 1993-03-08
CH685054A5 (de) 1995-03-15
FR2688506A1 (fr) 1993-09-17
US20010036940A1 (en) 2001-11-01
ITRM930147A1 (it) 1994-09-10
DE4307422A1 (de) 1993-09-30
GB9304704D0 (en) 1993-04-28
AU3407093A (en) 1993-09-16
JPH0641143A (ja) 1994-02-15
NO301372B1 (no) 1997-10-20
NL9300430A (nl) 1993-10-01
FI101965B1 (fi) 1998-09-30
FI931032L (fi) 1993-09-11
CN1150153A (zh) 1997-05-21
FI931032A0 (fi) 1993-03-09
CN1045604C (zh) 1999-10-13
DK26093D0 (da) 1993-03-09
JPH1067785A (ja) 1998-03-10
GB2264944B (en) 1995-09-06
US20030022882A1 (en) 2003-01-30
SE508043C2 (sv) 1998-08-17
NO930829D0 (no) 1993-03-08
NO930829L (no) 1993-09-13
IE70926B1 (en) 1997-01-15
AU659282B2 (en) 1995-05-11
GB2264944A (en) 1993-09-15

Similar Documents

Publication Publication Date Title
GEP20032965B (en) Pharmaceutical Compound
HU914073D0 (en) New 5-chloro-quinoline-8-oxy-alkane-carboxylic acid derivatives, process for producing them and their utilization as antidote
HU9501214D0 (en) New process for producing clavulanic acid, and pharmaceutically acceptable salts and esters thereof and/or their purification
ES2058029A1 (es) Proceso para la produccion de sales del acido clavulanico.
ES2042534T3 (es) Un proceso para la preparacion de una preparacion topica en forma de un hidrogel.
LV10256B (en) Novel acylale of imidazole-5-carboxylic acid derivatives, process for producing thereof and using same
NZ224706A (en) Amino acid 1,2-diketo derivatives as renin inhibitors
HUT69372A (en) Diamine salts of clarulanic acid, pharmaceutical compositions containing the same and process for their production
MY103210A (en) Arylpiperazinyl-alkylene-phenyl-heterocyclic compounds.
PL300747A1 (en) Method of obtaining substantially pure clavulanic acid
GB9515809D0 (en) Process
HU912097D0 (en) Process for the production of amino acid derivatives
KR0156581B1 (en) 1,4-benzothiazine-2-acetic acid derivatives and process for production
HUT49846A (en) Process for producing n-(3',4'-dimethoxycinnamoyl)-anthranilic acid (tranilast)
HUT50476A (en) Process for producing 3-pyrrolidinyl-thio-1-azabicyclo/3,2,0/hept-2-ene-2-carboxylic acid derivatives
HU914020D0 (en) Process for the production of d1, d, and 1/1,2,3,4/tetrahydro-izokynoline-1-carbonic acid and its uretane type derivatives with n-protection group
EG19465A (en) Process for the production of basically substituted benzylphthalazone derivatives and acid addition salts thereof.
GR3021347T3 (en) Diamine salts of clavulanic acid.
ZA886870B (en) L-dopa derivatives or their acid addition salts,process for producing same and their use
HU912133D0 (en) Process for the production of octa hydroindolo(2,3-a)kynolyzine-phenyl-sulphonamide derivatives and their acido-additional salts
HU9200895D0 (en) Process for the production of n-(aryl-sulphonyl)-carbamide acid derivatives

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20101018