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GB1543563A - Beta-lactam antibiotic in purified form - Google Patents

Beta-lactam antibiotic in purified form

Info

Publication number
GB1543563A
GB1543563A GB540975A GB540975A GB1543563A GB 1543563 A GB1543563 A GB 1543563A GB 540975 A GB540975 A GB 540975A GB 540975 A GB540975 A GB 540975A GB 1543563 A GB1543563 A GB 1543563A
Authority
GB
United Kingdom
Prior art keywords
beta
purified form
lactam antibiotic
lactam
antibiotic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB540975A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Laboratories Ltd
Original Assignee
Glaxo Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Laboratories Ltd filed Critical Glaxo Laboratories Ltd
Priority to GB540975A priority Critical patent/GB1543563A/en
Priority to ES76444948A priority patent/ES444948A1/en
Priority to AU10891/76A priority patent/AU509313B2/en
Priority to CH148776A priority patent/CH624956A5/en
Priority to BE164139A priority patent/BE838330A/en
Priority to IT7647988A priority patent/IT1059403B/en
Priority to DE19762604697 priority patent/DE2604697A1/en
Priority to YU290/76A priority patent/YU40452B/en
Priority to AT83476A priority patent/AT353409B/en
Priority to FR7603281A priority patent/FR2368276A1/en
Priority to IE245/76A priority patent/IE43790B1/en
Priority to DK49876AA priority patent/DK141099B/en
Priority to SE7601337A priority patent/SE421796B/en
Priority to NL7601227A priority patent/NL7601227A/en
Priority to FI760285A priority patent/FI63580C/en
Priority to JP51012156A priority patent/JPS51101994A/ja
Priority to IT7648002A priority patent/IT1066098B/en
Priority to US05/751,341 priority patent/US4144242A/en
Priority to US05/888,496 priority patent/US4490294A/en
Priority to DK207378A priority patent/DK146764C/en
Publication of GB1543563A publication Critical patent/GB1543563A/en
Priority to US06/147,614 priority patent/US4367175A/en
Priority to US06/147,584 priority patent/US4490295A/en
Priority to FI802142A priority patent/FI64600C/en
Priority to JP1046384A priority patent/JPH0222281A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
GB540975A 1975-02-07 1975-02-07 Beta-lactam antibiotic in purified form Expired GB1543563A (en)

Priority Applications (24)

Application Number Priority Date Filing Date Title
GB540975A GB1543563A (en) 1975-02-07 1975-02-07 Beta-lactam antibiotic in purified form
DK49876AA DK141099B (en) 1975-02-07 1976-02-06 Process for purifying clavulanic acid or a salt thereof with a base.
NL7601227A NL7601227A (en) 1975-02-07 1976-02-06 PROCESS FOR PREPARING A NEW ANTIBIOTIC.
CH148776A CH624956A5 (en) 1975-02-07 1976-02-06 METHOD FOR REMOVING IMPURITIES FROM CLAVULANIC ACID.
BE164139A BE838330A (en) 1975-02-07 1976-02-06 NEW ANTIBIOTIC FROM STREPTOMYCES CLAVULIGERUS AND ITS OBTAINING.
IT7647988A IT1059403B (en) 1975-02-07 1976-02-06 PROCEDURE FOR PRODUCING CLAVULANIC ACID AND ITS DERIVATIVES AS WELL AS COMPOSITIONS CONTAINING IT
DE19762604697 DE2604697A1 (en) 1975-02-07 1976-02-06 ANTIBIOTICS
YU290/76A YU40452B (en) 1975-02-07 1976-02-06 Process for the elimination of contaminating impurities from clavulinic acid
AT83476A AT353409B (en) 1975-02-07 1976-02-06 METHOD OF REMOVING CONTAMINATION FROM CLAVULANIC ACID OR THEIR SALT
FR7603281A FR2368276A1 (en) 1975-02-07 1976-02-06 NEW ANTIBIOTIC FROM STREPTOMYCES CLAVULIGERUS AND ITS PREPARATION PROCESS
AU10891/76A AU509313B2 (en) 1975-02-07 1976-02-06 Clavulanic acid
ES76444948A ES444948A1 (en) 1975-02-07 1976-02-06 Pure potassium salt of clavulanic acid
SE7601337A SE421796B (en) 1975-02-07 1976-02-06 PROCEDURE FOR PURIFICATION OF CLAVULANIC ACID AND ITS SALTS
JP51012156A JPS51101994A (en) 1975-02-07 1976-02-06
IE245/76A IE43790B1 (en) 1975-02-07 1976-02-06 -lactam antibiotic in purified form
FI760285A FI63580C (en) 1975-02-07 1976-02-06 FOERFARANDE FOER RENING AV FOERORENAD KLAVULANSYRA OCH FOER FRMSTAELLNING AV RENA KLAVULANATSALTER
IT7648002A IT1066098B (en) 1975-02-07 1976-02-09 PROCEDURE FOR PRODUCING CLAVULANIC ACID AND ITS SALTS AT STATOPURO
US05/751,341 US4144242A (en) 1975-02-07 1976-12-16 Process for the purification of clavulanic acid
US05/888,496 US4490294A (en) 1975-02-07 1978-03-20 Pure salts of clavulanic acid, e.g. lithium clavulanate
DK207378A DK146764C (en) 1975-02-07 1978-05-11 ALKALIMETAL CLAVULANATE USED AS INTERMEDIATE IN THE PREPARATION OF CLAVULANIC ACID OR OTHER DERIVATIVES THEREOF, AND MIXTURE USED FOR THE PREPARATION OF CLAVULANIC ACID OR DERIVATIVES THEREOF
US06/147,614 US4367175A (en) 1975-02-07 1980-05-07 Pure potassium salt of clavulanic acid
US06/147,584 US4490295A (en) 1975-02-07 1980-05-07 Pure sodium salt of clavulanic acid
FI802142A FI64600C (en) 1975-02-07 1980-07-03 LITHUANIAN CLAVULANATE FOR OIL DEVELOPMENT OF RAVING AV KLAVULANSYRA OCH DESS DERIVAT
JP1046384A JPH0222281A (en) 1975-02-07 1989-02-27 Purification of kurabaranic acid and salt thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB540975A GB1543563A (en) 1975-02-07 1975-02-07 Beta-lactam antibiotic in purified form

Publications (1)

Publication Number Publication Date
GB1543563A true GB1543563A (en) 1979-04-04

Family

ID=9795646

Family Applications (1)

Application Number Title Priority Date Filing Date
GB540975A Expired GB1543563A (en) 1975-02-07 1975-02-07 Beta-lactam antibiotic in purified form

Country Status (2)

Country Link
BE (1) BE838330A (en)
GB (1) GB1543563A (en)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK156069B (en) * 1979-08-24 1989-06-19 Beecham Group Ltd USE OF THE TERT.BUTYLAMINE SALT OF CLAVULANIC ACID AS INTERMEDIATE IN THE PREPARATION OF CLAVULANIC ACID AND PHARMACEUTICAL TOLERABLE SALTS AND ESTERS THEREOF
EP0312813A3 (en) * 1984-10-27 1989-12-13 Beecham Group p.l.c. Preparation of clavulanic acid and its salts and esters
EP0594099A1 (en) * 1992-10-21 1994-04-27 Pharma Development Ltd. Process for the purification of crude clavulanic acid
EP0672670A1 (en) 1992-06-11 1995-09-20 Smithkline Beecham Plc Process for the preparation of clavulanic acid
WO1996028452A1 (en) 1995-03-10 1996-09-19 Lek Pharmaceutical And Chemical Co. D.D. Process for the preparation of pharmaceutically acceptable salts of clavulanic acid
US5726170A (en) * 1995-02-25 1998-03-10 Spurcourt Limited Clavulanic acid salts
US5734048A (en) * 1995-05-16 1998-03-31 Chong Kun Dang Corp. Process for manufacturing clavulanic acid salt
RU2140418C1 (en) * 1994-02-02 1999-10-27 Смитклайн Бичам Плс Method of preparing clavulanic acid salt
EP0387178B2 (en) † 1989-03-01 2001-04-18 Smithkline Beecham Plc Process for the preparation of clavulinic acid and pharmaceutically acceptable salts from fermentation broths of Streptomyces sp.
WO2002032847A1 (en) * 2000-10-16 2002-04-25 Sankyo Company, Limited Method of purifying pravastatin or its pharmacologically acceptable salt
US6414142B1 (en) * 1996-06-13 2002-07-02 Smithkline Beecham Corporation Process for preparing potassium clavulanate
USH2158H1 (en) 1992-03-10 2006-06-06 Sandoz Ag Process for the production of clavulanic acid salts

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK156069B (en) * 1979-08-24 1989-06-19 Beecham Group Ltd USE OF THE TERT.BUTYLAMINE SALT OF CLAVULANIC ACID AS INTERMEDIATE IN THE PREPARATION OF CLAVULANIC ACID AND PHARMACEUTICAL TOLERABLE SALTS AND ESTERS THEREOF
EP0312813A3 (en) * 1984-10-27 1989-12-13 Beecham Group p.l.c. Preparation of clavulanic acid and its salts and esters
EP0387178B2 (en) † 1989-03-01 2001-04-18 Smithkline Beecham Plc Process for the preparation of clavulinic acid and pharmaceutically acceptable salts from fermentation broths of Streptomyces sp.
USH2158H1 (en) 1992-03-10 2006-06-06 Sandoz Ag Process for the production of clavulanic acid salts
EP0672670A1 (en) 1992-06-11 1995-09-20 Smithkline Beecham Plc Process for the preparation of clavulanic acid
DE4345311C1 (en) * 1992-06-11 1996-02-01 Smithkline Beecham Plc Process for the production and / or purification of clavulanic acid
EP0699682A1 (en) 1992-06-11 1996-03-06 Smithkline Beecham P.L.C. Process for the preparation and/or purification of clavulanic acid
EP0594099A1 (en) * 1992-10-21 1994-04-27 Pharma Development Ltd. Process for the purification of crude clavulanic acid
RU2140418C1 (en) * 1994-02-02 1999-10-27 Смитклайн Бичам Плс Method of preparing clavulanic acid salt
US5726170A (en) * 1995-02-25 1998-03-10 Spurcourt Limited Clavulanic acid salts
WO1996028452A1 (en) 1995-03-10 1996-09-19 Lek Pharmaceutical And Chemical Co. D.D. Process for the preparation of pharmaceutically acceptable salts of clavulanic acid
US5734048A (en) * 1995-05-16 1998-03-31 Chong Kun Dang Corp. Process for manufacturing clavulanic acid salt
US6414142B1 (en) * 1996-06-13 2002-07-02 Smithkline Beecham Corporation Process for preparing potassium clavulanate
WO2002032847A1 (en) * 2000-10-16 2002-04-25 Sankyo Company, Limited Method of purifying pravastatin or its pharmacologically acceptable salt

Also Published As

Publication number Publication date
BE838330A (en) 1976-08-06

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Legal Events

Date Code Title Description
PS Patent sealed
49 Proceeding under section 9 patents act 1949
SP Amendment (slips) printed
732 Registration of transactions, instruments or events in the register (sect. 32/1977)
704A Declaration that licence is not available as of right for an excepted use (par. 4a/1977)
PE20 Patent expired after termination of 20 years

Effective date: 19960205