SE8804570L - CICLOSPORINE CRYSTAL FORM, PROCEDURE FOR ITS PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING ITS SAME AND ITS USE - Google Patents
CICLOSPORINE CRYSTAL FORM, PROCEDURE FOR ITS PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING ITS SAME AND ITS USEInfo
- Publication number
- SE8804570L SE8804570L SE8804570A SE8804570A SE8804570L SE 8804570 L SE8804570 L SE 8804570L SE 8804570 A SE8804570 A SE 8804570A SE 8804570 A SE8804570 A SE 8804570A SE 8804570 L SE8804570 L SE 8804570L
- Authority
- SE
- Sweden
- Prior art keywords
- crystal form
- pharmaceutical compositions
- ciclosporine
- procedure
- preparation
- Prior art date
Links
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 3
- 229960001265 ciclosporin Drugs 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 108010036949 Cyclosporine Proteins 0.000 abstract 2
- 239000013078 crystal Substances 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Abstract
Novel pharmaceutical compositions, in particular topical forms, e.g. for intra-lesional or intra-articular injection, comprising Ciclosporin as active ingredient in orthorhombic crystal form. Ciclosporin in non-solvate orthorhombic crystal form is preferred for use in the compositions of the invention, is new and also part of the invention together with its use and processes for its production.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13623087A | 1987-12-21 | 1987-12-21 | |
| US17261388A | 1988-03-24 | 1988-03-24 | |
| US21254888A | 1988-06-28 | 1988-06-28 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| SE8804570D0 SE8804570D0 (en) | 1988-12-19 |
| SE8804570L true SE8804570L (en) | 1989-06-22 |
| SE503174C2 SE503174C2 (en) | 1996-04-15 |
Family
ID=27384838
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8804570A SE503174C2 (en) | 1987-12-21 | 1988-12-19 | Ciclosporin crystal forms, process for its preparation, pharmaceutical compositions containing the same and its use |
Country Status (27)
| Country | Link |
|---|---|
| JP (1) | JPH0791316B2 (en) |
| KR (1) | KR100188305B1 (en) |
| AT (1) | AT403163B (en) |
| AU (1) | AU626274B2 (en) |
| BE (1) | BE1002665A4 (en) |
| CA (1) | CA1341396C (en) |
| CH (1) | CH677926A5 (en) |
| CY (1) | CY1799A (en) |
| DE (1) | DE3843054C2 (en) |
| DK (1) | DK175220B1 (en) |
| ES (1) | ES2012580A6 (en) |
| FI (1) | FI89065C (en) |
| FR (1) | FR2624863B1 (en) |
| GB (1) | GB2211848B (en) |
| GR (1) | GR1002486B (en) |
| HK (1) | HK102894A (en) |
| HU (1) | HU203564B (en) |
| IE (1) | IE62006B1 (en) |
| IL (1) | IL88719A0 (en) |
| IT (1) | IT1235356B (en) |
| LU (1) | LU87409A1 (en) |
| MY (1) | MY103943A (en) |
| NL (1) | NL195096C (en) |
| NO (1) | NO177228C (en) |
| NZ (1) | NZ227384A (en) |
| SE (1) | SE503174C2 (en) |
| SG (1) | SG99494G (en) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5639724A (en) * | 1984-07-24 | 1997-06-17 | Sandoz Ltd. | Cyclosporin galenic forms |
| US6007840A (en) * | 1988-09-16 | 1999-12-28 | Novartis Ag | Pharmaceutical compositions comprising cyclosporins |
| GB2222770B (en) | 1988-09-16 | 1992-07-29 | Sandoz Ltd | Pharmaceutical compositions containing cyclosporins |
| US7081445B2 (en) | 1989-02-20 | 2006-07-25 | Novartis Ag | Cyclosporin galenic forms |
| US5294604A (en) * | 1989-12-20 | 1994-03-15 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method of treating ocular diseases by periocular administration of cyclosporine A or G |
| GB9105705D0 (en) * | 1991-03-18 | 1991-05-01 | Sandoz Ltd | Improvements in or relating to organic compounds |
| US6262022B1 (en) | 1992-06-25 | 2001-07-17 | Novartis Ag | Pharmaceutical compositions containing cyclosporin as the active agent |
| EP0642332B1 (en) * | 1992-05-13 | 1997-01-15 | Sandoz Ltd. | Ophthalmic compositions containing a cyclosporin |
| ES2168271T3 (en) | 1992-09-25 | 2002-06-16 | Novartis Ag | PHARMACEUTICAL COMPOSITIONS CONTAINING CYCLOSPORINS. |
| PT789580E (en) | 1994-11-03 | 2002-09-30 | Novartis Ag | CYCLOSPORINE FORMULATIONS FOR ORAL ADMINISTRATION WITH SIMPLE COMPOSITION AND HIGH BIODISPONIBILITY AND PROCESS FOR ITS PRODUCTION |
| US5962019A (en) * | 1995-08-25 | 1999-10-05 | Sangstat Medical Corporation | Oral cyclosporin formulations |
| US5766629A (en) | 1995-08-25 | 1998-06-16 | Sangstat Medical Corporation | Oral cyclosporin formulations |
| DE19549852B4 (en) | 1995-11-29 | 2009-06-04 | Novartis Ag | Cyclosporin containing preparations |
| US6262054B1 (en) * | 1996-02-01 | 2001-07-17 | Sloan-Kettering Institute Of Cancer Research | Combination therapy method for treating breast cancer using edatrexate |
| EP0988046B1 (en) | 1997-01-30 | 2004-09-15 | Novartis AG | Oil-free pharmaceutical compositions containing cyclosporin a |
| TW581681B (en) | 1998-02-20 | 2004-04-01 | Nektar Therapeutics | Liquid crystal forms of cyclosporin |
| US7732404B2 (en) | 1999-12-30 | 2010-06-08 | Dexcel Ltd | Pro-nanodispersion for the delivery of cyclosporin |
| JP2007518804A (en) | 2004-01-20 | 2007-07-12 | アラーガン、インコーポレイテッド | Composition for topical ophthalmic treatment preferably containing triamcinolone acetonide and hyaluronic acid |
| CN1763084B (en) * | 2005-10-11 | 2010-04-21 | 山东新时代药业有限公司 | Preparation method of high-purity cyclosporine A |
| CA2836946C (en) * | 2011-05-27 | 2017-08-01 | Allergan, Inc. | A crystalline form of cyclosporine a, methods of preparation, and methods for use thereof |
| BR112014011744A2 (en) | 2011-11-15 | 2017-05-02 | Allergan Inc | sustainable action formulation of cyclosporine form 2 |
| RU2630970C2 (en) | 2011-11-15 | 2017-09-15 | Аллерган, Инк. | Autoclavable form 2 cyclosporin a portion |
| EP2779994B1 (en) * | 2011-11-15 | 2020-02-19 | Allergan, Inc. | Suspensions of cyclosporin a form 2 |
| WO2013074608A1 (en) | 2011-11-15 | 2013-05-23 | Allergan, Inc. | Cyclosporine a form 2 and method of making same |
| WO2024085235A1 (en) * | 2022-10-20 | 2024-04-25 | 中外製薬株式会社 | Method for producing cyclic peptide crystals |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH614931A5 (en) * | 1975-11-04 | 1979-12-28 | Sandoz Ag | |
| CH640519A5 (en) * | 1976-04-09 | 1984-01-13 | Sandoz Ag | Process for preparing a modified form of the antibiotic S 7481/F-1 |
| US4117118A (en) * | 1976-04-09 | 1978-09-26 | Sandoz Ltd. | Organic compounds |
| DE2819094A1 (en) * | 1977-05-10 | 1978-11-23 | Sandoz Ag | CYCLOSPORIN DERIVATIVES, THEIR USE AND MANUFACTURING |
| CH637124A5 (en) * | 1978-10-18 | 1983-07-15 | Sandoz Ag | Antibiotic, its preparation and use |
-
1988
- 1988-12-09 HU HU886374A patent/HU203564B/en unknown
- 1988-12-19 FR FR888816886A patent/FR2624863B1/en not_active Expired - Lifetime
- 1988-12-19 AU AU27055/88A patent/AU626274B2/en not_active Expired
- 1988-12-19 NZ NZ227384A patent/NZ227384A/en unknown
- 1988-12-19 SE SE8804570A patent/SE503174C2/en not_active IP Right Cessation
- 1988-12-19 CH CH4687/88A patent/CH677926A5/de not_active IP Right Cessation
- 1988-12-19 IE IE377988A patent/IE62006B1/en not_active IP Right Cessation
- 1988-12-19 NO NO885625A patent/NO177228C/en unknown
- 1988-12-19 FI FI885869A patent/FI89065C/en not_active IP Right Cessation
- 1988-12-19 IL IL88719A patent/IL88719A0/en unknown
- 1988-12-19 DK DK198807054A patent/DK175220B1/en not_active IP Right Cessation
- 1988-12-19 GB GB8829556A patent/GB2211848B/en not_active Expired - Lifetime
- 1988-12-20 AT AT0309588A patent/AT403163B/en not_active IP Right Cessation
- 1988-12-20 KR KR1019880017194A patent/KR100188305B1/en not_active Expired - Lifetime
- 1988-12-20 IT IT8848690A patent/IT1235356B/en active
- 1988-12-20 LU LU87409A patent/LU87409A1/en unknown
- 1988-12-20 JP JP63321857A patent/JPH0791316B2/en not_active Expired - Lifetime
- 1988-12-20 GR GR880100850A patent/GR1002486B/en not_active IP Right Cessation
- 1988-12-20 BE BE8801421A patent/BE1002665A4/en not_active IP Right Cessation
- 1988-12-21 NL NL8803125A patent/NL195096C/en active Search and Examination
- 1988-12-21 CA CA000586611A patent/CA1341396C/en not_active Expired - Fee Related
- 1988-12-21 ES ES8803887A patent/ES2012580A6/en not_active Expired - Lifetime
- 1988-12-21 DE DE3843054A patent/DE3843054C2/en not_active Expired - Lifetime
- 1988-12-21 MY MYPI88001495A patent/MY103943A/en unknown
-
1994
- 1994-07-21 SG SG99494A patent/SG99494G/en unknown
- 1994-09-22 HK HK102894A patent/HK102894A/en not_active IP Right Cessation
-
1995
- 1995-02-17 CY CY179995A patent/CY1799A/en unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NUG | Patent has lapsed |