IT1235356B - CRYSTALLINE FORM OF CYCLOSPORINE, ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN IT - Google Patents

CRYSTALLINE FORM OF CYCLOSPORINE, ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN IT

Info

Publication number: IT1235356B
Authority: IT; Italy
Prior art keywords: cyclosporine; contain; preparation; pharmaceutical compositions; crystalline form
Prior art date: 1987-12-21

Application number

IT8848690A

Other languages

Italian (it)

Other versions

IT8848690A0 (en

Inventor

Giron Danielle

List Martin

Richter Friederich

Weber Hans Peter

Yasuyuki Uike

Original Assignee

Sandoz Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-12-21

Filing date

1988-12-20

Publication date

1992-06-30

1988-12-20 Application filed by Sandoz Ag filed Critical Sandoz Ag

1988-12-20 Publication of IT8848690A0 publication Critical patent/IT8848690A0/en

1992-06-30 Application granted granted Critical

1992-06-30 Publication of IT1235356B publication Critical patent/IT1235356B/en

Links

PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title 1
108010036949 Cyclosporine Proteins 0.000 title 1
229960001265 ciclosporin Drugs 0.000 title 1
229930182912 cyclosporin Natural products 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Immunology (AREA)
General Chemical & Material Sciences (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Dermatology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Epidemiology (AREA)
Transplantation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Peptides Or Proteins (AREA)

IT8848690A 1987-12-21 1988-12-20 CRYSTALLINE FORM OF CYCLOSPORINE, ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN IT IT1235356B (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date
US13623087A	1987-12-21	1987-12-21
US17261388A	1988-03-24	1988-03-24
US21254888A	1988-06-28	1988-06-28

Publications (2)

Publication Number	Publication Date
IT8848690A0 IT8848690A0 (en)	1988-12-20
IT1235356B true IT1235356B (en)	1992-06-30

Family

ID=27384838

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT8848690A IT1235356B (en)	1987-12-21	1988-12-20	CRYSTALLINE FORM OF CYCLOSPORINE, ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN IT

Country Status (27)

Country	Link
JP (1)	JPH0791316B2 (en)
KR (1)	KR100188305B1 (en)
AT (1)	AT403163B (en)
AU (1)	AU626274B2 (en)
BE (1)	BE1002665A4 (en)
CA (1)	CA1341396C (en)
CH (1)	CH677926A5 (en)
CY (1)	CY1799A (en)
DE (1)	DE3843054C2 (en)
DK (1)	DK175220B1 (en)
ES (1)	ES2012580A6 (en)
FI (1)	FI89065C (en)
FR (1)	FR2624863B1 (en)
GB (1)	GB2211848B (en)
GR (1)	GR1002486B (en)
HK (1)	HK102894A (en)
HU (1)	HU203564B (en)
IE (1)	IE62006B1 (en)
IL (1)	IL88719A0 (en)
IT (1)	IT1235356B (en)
LU (1)	LU87409A1 (en)
MY (1)	MY103943A (en)
NL (1)	NL195096C (en)
NO (1)	NO177228C (en)
NZ (1)	NZ227384A (en)
SE (1)	SE503174C2 (en)
SG (1)	SG99494G (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5639724A (en) *	1984-07-24	1997-06-17	Sandoz Ltd.	Cyclosporin galenic forms
US6007840A (en) *	1988-09-16	1999-12-28	Novartis Ag	Pharmaceutical compositions comprising cyclosporins
GB2222770B (en)	1988-09-16	1992-07-29	Sandoz Ltd	Pharmaceutical compositions containing cyclosporins
US7081445B2 (en)	1989-02-20	2006-07-25	Novartis Ag	Cyclosporin galenic forms
US5294604A (en) *	1989-12-20	1994-03-15	The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services	Method of treating ocular diseases by periocular administration of cyclosporine A or G
GB9105705D0 (en) *	1991-03-18	1991-05-01	Sandoz Ltd	Improvements in or relating to organic compounds
US6262022B1 (en)	1992-06-25	2001-07-17	Novartis Ag	Pharmaceutical compositions containing cyclosporin as the active agent
EP0642332B1 (en) *	1992-05-13	1997-01-15	Sandoz Ltd.	Ophthalmic compositions containing a cyclosporin
ES2168271T3 (en)	1992-09-25	2002-06-16	Novartis Ag	PHARMACEUTICAL COMPOSITIONS CONTAINING CYCLOSPORINS.
PT789580E (en)	1994-11-03	2002-09-30	Novartis Ag	CYCLOSPORINE FORMULATIONS FOR ORAL ADMINISTRATION WITH SIMPLE COMPOSITION AND HIGH BIODISPONIBILITY AND PROCESS FOR ITS PRODUCTION
US5962019A (en) *	1995-08-25	1999-10-05	Sangstat Medical Corporation	Oral cyclosporin formulations
US5766629A (en)	1995-08-25	1998-06-16	Sangstat Medical Corporation	Oral cyclosporin formulations
DE19549852B4 (en)	1995-11-29	2009-06-04	Novartis Ag	Cyclosporin containing preparations
US6262054B1 (en) *	1996-02-01	2001-07-17	Sloan-Kettering Institute Of Cancer Research	Combination therapy method for treating breast cancer using edatrexate
EP0988046B1 (en)	1997-01-30	2004-09-15	Novartis AG	Oil-free pharmaceutical compositions containing cyclosporin a
TW581681B (en)	1998-02-20	2004-04-01	Nektar Therapeutics	Liquid crystal forms of cyclosporin
US7732404B2 (en)	1999-12-30	2010-06-08	Dexcel Ltd	Pro-nanodispersion for the delivery of cyclosporin
JP2007518804A (en)	2004-01-20	2007-07-12	アラーガン、インコーポレイテッド	Composition for topical ophthalmic treatment preferably containing triamcinolone acetonide and hyaluronic acid
CN1763084B (en) *	2005-10-11	2010-04-21	山东新时代药业有限公司	Preparation method of high-purity cyclosporine A
CA2836946C (en) *	2011-05-27	2017-08-01	Allergan, Inc.	A crystalline form of cyclosporine a, methods of preparation, and methods for use thereof
BR112014011744A2 (en)	2011-11-15	2017-05-02	Allergan Inc	sustainable action formulation of cyclosporine form 2
RU2630970C2 (en)	2011-11-15	2017-09-15	Аллерган, Инк.	Autoclavable form 2 cyclosporin a portion
EP2779994B1 (en) *	2011-11-15	2020-02-19	Allergan, Inc.	Suspensions of cyclosporin a form 2
WO2013074608A1 (en)	2011-11-15	2013-05-23	Allergan, Inc.	Cyclosporine a form 2 and method of making same
WO2024085235A1 (en) *	2022-10-20	2024-04-25	中外製薬株式会社	Method for producing cyclic peptide crystals

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH614931A5 (en) *	1975-11-04	1979-12-28	Sandoz Ag
CH640519A5 (en) *	1976-04-09	1984-01-13	Sandoz Ag	Process for preparing a modified form of the antibiotic S 7481/F-1
US4117118A (en) *	1976-04-09	1978-09-26	Sandoz Ltd.	Organic compounds
DE2819094A1 (en) *	1977-05-10	1978-11-23	Sandoz Ag	CYCLOSPORIN DERIVATIVES, THEIR USE AND MANUFACTURING
CH637124A5 (en) *	1978-10-18	1983-07-15	Sandoz Ag	Antibiotic, its preparation and use

1988
- 1988-12-09 HU HU886374A patent/HU203564B/en unknown
- 1988-12-19 FR FR888816886A patent/FR2624863B1/en not_active Expired - Lifetime
- 1988-12-19 AU AU27055/88A patent/AU626274B2/en not_active Expired
- 1988-12-19 NZ NZ227384A patent/NZ227384A/en unknown
- 1988-12-19 SE SE8804570A patent/SE503174C2/en not_active IP Right Cessation
- 1988-12-19 CH CH4687/88A patent/CH677926A5/de not_active IP Right Cessation
- 1988-12-19 IE IE377988A patent/IE62006B1/en not_active IP Right Cessation
- 1988-12-19 NO NO885625A patent/NO177228C/en unknown
- 1988-12-19 FI FI885869A patent/FI89065C/en not_active IP Right Cessation
- 1988-12-19 IL IL88719A patent/IL88719A0/en unknown
- 1988-12-19 DK DK198807054A patent/DK175220B1/en not_active IP Right Cessation
- 1988-12-19 GB GB8829556A patent/GB2211848B/en not_active Expired - Lifetime
- 1988-12-20 AT AT0309588A patent/AT403163B/en not_active IP Right Cessation
- 1988-12-20 KR KR1019880017194A patent/KR100188305B1/en not_active Expired - Lifetime
- 1988-12-20 IT IT8848690A patent/IT1235356B/en active
- 1988-12-20 LU LU87409A patent/LU87409A1/en unknown
- 1988-12-20 JP JP63321857A patent/JPH0791316B2/en not_active Expired - Lifetime
- 1988-12-20 GR GR880100850A patent/GR1002486B/en not_active IP Right Cessation
- 1988-12-20 BE BE8801421A patent/BE1002665A4/en not_active IP Right Cessation
- 1988-12-21 NL NL8803125A patent/NL195096C/en active Search and Examination
- 1988-12-21 CA CA000586611A patent/CA1341396C/en not_active Expired - Fee Related
- 1988-12-21 ES ES8803887A patent/ES2012580A6/en not_active Expired - Lifetime
- 1988-12-21 DE DE3843054A patent/DE3843054C2/en not_active Expired - Lifetime
- 1988-12-21 MY MYPI88001495A patent/MY103943A/en unknown
1994
- 1994-07-21 SG SG99494A patent/SG99494G/en unknown
- 1994-09-22 HK HK102894A patent/HK102894A/en not_active IP Right Cessation
1995
- 1995-02-17 CY CY179995A patent/CY1799A/en unknown

Also Published As

Publication number	Publication date
IE883779L (en)	1989-06-21
IE62006B1 (en)	1994-12-14
NO177228B (en)	1995-05-02
DK705488A (en)	1989-06-22
GB2211848B (en)	1991-11-06
SE8804570D0 (en)	1988-12-19
CH677926A5 (en)	1991-07-15
FR2624863B1 (en)	1991-04-26
DK705488D0 (en)	1988-12-19
AT403163B (en)	1997-11-25
HUT49893A (en)	1989-11-28
FR2624863A1 (en)	1989-06-23
JPH0791316B2 (en)	1995-10-04
GR1002486B (en)	1996-12-09
HU203564B (en)	1991-08-28
ES2012580A6 (en)	1990-04-01
KR100188305B1 (en)	1999-06-01
GB2211848A (en)	1989-07-12
NL195096C (en)	2004-02-09
AU2705588A (en)	1989-06-22
NO885625L (en)	1989-06-22
IT8848690A0 (en)	1988-12-20
AU626274B2 (en)	1992-07-30
GR880100850A (en)	1994-03-31
SG99494G (en)	1994-10-28
HK102894A (en)	1994-09-30
GB8829556D0 (en)	1989-02-08
IL88719A0 (en)	1989-07-31
MY103943A (en)	1993-10-30
JPH01211598A (en)	1989-08-24
NL8803125A (en)	1989-07-17
CY1799A (en)	1995-02-17
KR890009975A (en)	1989-08-05
NO177228C (en)	1995-08-09
ATA309588A (en)	1997-04-15
SE503174C2 (en)	1996-04-15
NZ227384A (en)	1991-09-25
BE1002665A4 (en)	1991-04-30
DE3843054A1 (en)	1989-07-27
DE3843054C2 (en)	2003-08-21
NO885625D0 (en)	1988-12-19
CA1341396C (en)	2002-11-05
FI89065C (en)	1993-09-30
LU87409A1 (en)	1989-07-07
SE8804570L (en)	1989-06-22
DK175220B1 (en)	2004-07-12
FI885869L (en)	1989-06-22
FI89065B (en)	1993-04-30
FI885869A0 (en)	1988-12-19

Publication	Publication Date	Title
IT1235356B (en)	1992-06-30	CRYSTALLINE FORM OF CYCLOSPORINE, ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN IT
DK89090A (en)	1990-04-09	PHARMACEUTICAL PREPARATION
SE8801813D0 (en)	1988-05-13	PHARMACEUTICAL COMPOSITION
KR890701101A (en)	1989-12-19	Pharmaceutical composition
DK159688D0 (en)	1988-03-23	ANTIMICROBIAL DELAYED PREPARATION
DK130287D0 (en)	1987-03-13	ORAL PREPARATION
TR23964A (en)	1991-01-11	YOENTEM FOR DETERGENT POWDER AND ITS PREPARATION.
IT1240605B (en)	1993-12-17	SOLID PHARMACEUTICAL COMPOSITION AND PROCEDURE FOR ITS PREPARATION
IT8748544A0 (en)	1987-10-28	SUBSTITUTED ALPHA-AMINO ACIDS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM
TR24553A (en)	1991-11-21	PHARMACEUTICAL ITEMS WITHOUT PHOSPHOR IN THE EVENT OF GRANUES
IT8222768A0 (en)	1982-08-06	PEPTIDE ALKALOIDS OF ERGOTS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.
IT8922164A0 (en)	1989-10-27	PHARMACEUTICAL COMPOSITION AND PROCEDURE FOR ITS PREPARATION
IT8719165A0 (en)	1987-01-26	THIAZOLIDIN-4-CARBOXYLIC ACID DERIVATIVE, ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN IT.
IT1226586B (en)	1991-01-24	PHARMACEUTICAL COMPOSITIONS THAT ENHANCE THE WOUND CICATRIZATION AND PROCEDURE TO PREPARE THEM
IT1216139B (en)	1990-02-22	DIETARY COMPOSITION AND PROCEDURE FOR ITS PREPARATION.
IT1204306B (en)	1989-03-01	(-) - 1BETA-ETHYL-1ALPHA-HYDROXIMENTYL-1,2,3,4,6,7,12,12BALPHA-OCTAHYDROINDOL (2,3-A) QUINOLIZINE, PROCEDURE FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN IT
ITMI912002A0 (en)	1991-07-19	SOLID PHARMACEUTICAL COMPOSITION AND PROCEDURE FOR ITS PREPARATION
DK276288D0 (en)	1988-05-20	PHARMACEUTICAL PREPARATION
IT8548964A0 (en)	1985-12-20	8ALFA-ACYLAMINOERGOLINES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM
IT8721958A0 (en)	1987-09-18	TAURINE DERIVATIVE, ITS PREPARATION AND RELATED PHARMACEUTICAL COMPOSITIONS
IT1216814B (en)	1990-03-14	PHARMACEUTICAL COMPOSITIONS
BR8807102A (en)	1989-10-17	PREPARATION OF NEW PROTEIN SWEETS
IT8522364A0 (en)	1985-10-04	DIHYDROPYRIDINE DERIVATIVE, PROCEDURE FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN IT.
DK138888A (en)	1988-09-19	PHARMACEUTICAL PREPARATION
IT8747852A0 (en)	1987-04-15	SUBSTITUTED BENZAMIDS, PROCEDURE FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM

Legal Events

Date	Code	Title	Description
1999-10-27	TA	Fee payment date (situation as of event date), data collected since 19931001	Effective date: 19971205