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AU2705588A - New ciclosporin crystal form, processes for its production, pharmaceutical compositions containing it and its use. - Google Patents

New ciclosporin crystal form, processes for its production, pharmaceutical compositions containing it and its use.

Info

Publication number
AU2705588A
AU2705588A AU27055/88A AU2705588A AU2705588A AU 2705588 A AU2705588 A AU 2705588A AU 27055/88 A AU27055/88 A AU 27055/88A AU 2705588 A AU2705588 A AU 2705588A AU 2705588 A AU2705588 A AU 2705588A
Authority
AU
Australia
Prior art keywords
ciclosporin
processes
new
production
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU27055/88A
Other versions
AU626274B2 (en
Inventor
Danielle Giron
Martin List
Friedrich Richter
Yasuyuki Uike
Hans Peter Weber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Publication of AU2705588A publication Critical patent/AU2705588A/en
Application granted granted Critical
Publication of AU626274B2 publication Critical patent/AU626274B2/en
Assigned to NOVARTIS AG reassignment NOVARTIS AG Request to Amend Deed and Register Assignors: SANDOZ LTD.
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
AU27055/88A 1987-12-21 1988-12-19 New ciclosporin crystal form, processes for its production, pharmaceutical compositions containing it and its use. Expired AU626274B2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US13623087A 1987-12-21 1987-12-21
US136230 1987-12-21
US17261388A 1988-03-24 1988-03-24
US172613 1988-03-24
US21254888A 1988-06-28 1988-06-28
US212548 1988-06-28

Publications (2)

Publication Number Publication Date
AU2705588A true AU2705588A (en) 1989-06-22
AU626274B2 AU626274B2 (en) 1992-07-30

Family

ID=27384838

Family Applications (1)

Application Number Title Priority Date Filing Date
AU27055/88A Expired AU626274B2 (en) 1987-12-21 1988-12-19 New ciclosporin crystal form, processes for its production, pharmaceutical compositions containing it and its use.

Country Status (27)

Country Link
JP (1) JPH0791316B2 (en)
KR (1) KR100188305B1 (en)
AT (1) AT403163B (en)
AU (1) AU626274B2 (en)
BE (1) BE1002665A4 (en)
CA (1) CA1341396C (en)
CH (1) CH677926A5 (en)
CY (1) CY1799A (en)
DE (1) DE3843054C2 (en)
DK (1) DK175220B1 (en)
ES (1) ES2012580A6 (en)
FI (1) FI89065C (en)
FR (1) FR2624863B1 (en)
GB (1) GB2211848B (en)
GR (1) GR1002486B (en)
HK (1) HK102894A (en)
HU (1) HU203564B (en)
IE (1) IE62006B1 (en)
IL (1) IL88719A0 (en)
IT (1) IT1235356B (en)
LU (1) LU87409A1 (en)
MY (1) MY103943A (en)
NL (1) NL195096C (en)
NO (1) NO177228C (en)
NZ (1) NZ227384A (en)
SE (1) SE503174C2 (en)
SG (1) SG99494G (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU643750B2 (en) * 1989-12-20 1993-11-25 United States of America, as represented by the Secretary, U.S. Department of Commerce, The Method of treating ocular diseases by periocular administration of cyclosporine A or G

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5639724A (en) 1984-07-24 1997-06-17 Sandoz Ltd. Cyclosporin galenic forms
KR0148748B1 (en) * 1988-09-16 1998-08-17 장 크라메르, 한스 루돌프 하우스 Pharmaceutical composition containing cyclosporin
US6007840A (en) * 1988-09-16 1999-12-28 Novartis Ag Pharmaceutical compositions comprising cyclosporins
US7081445B2 (en) 1989-02-20 2006-07-25 Novartis Ag Cyclosporin galenic forms
GB9105705D0 (en) * 1991-03-18 1991-05-01 Sandoz Ltd Improvements in or relating to organic compounds
US6262022B1 (en) 1992-06-25 2001-07-17 Novartis Ag Pharmaceutical compositions containing cyclosporin as the active agent
EP0642332B1 (en) * 1992-05-13 1997-01-15 Sandoz Ltd. Ophthalmic compositions containing a cyclosporin
ES2168271T3 (en) 1992-09-25 2002-06-16 Novartis Ag PHARMACEUTICAL COMPOSITIONS CONTAINING CYCLOSPORINS.
EP0789580B1 (en) 1994-11-03 2002-06-05 Novartis AG Novel cyclosporine preparation forms for oral administration of simple composition and high bio-availability, and process for producing them
US5962019A (en) * 1995-08-25 1999-10-05 Sangstat Medical Corporation Oral cyclosporin formulations
US5766629A (en) 1995-08-25 1998-06-16 Sangstat Medical Corporation Oral cyclosporin formulations
DE19544507B4 (en) 1995-11-29 2007-11-15 Novartis Ag Cyclosporin containing preparations
US6262054B1 (en) 1996-02-01 2001-07-17 Sloan-Kettering Institute Of Cancer Research Combination therapy method for treating breast cancer using edatrexate
KR20000069900A (en) 1997-01-30 2000-11-25 한스 루돌프 하우스, 헨리테 브룬너, 베아트리체 귄터 Oil-Free Pharmaceutical Compositions Containing Cyclosporin A
TW581681B (en) 1998-02-20 2004-04-01 Nektar Therapeutics Liquid crystal forms of cyclosporin
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
BRPI0506983A (en) 2004-01-20 2007-07-03 Allergan Inc localized eye therapy compositions, preferably comprising triamcinolone acetonide and hyaluronic acid
CN1763084B (en) * 2005-10-11 2010-04-21 山东新时代药业有限公司 Preparation method of high-purity cyclosporine A
BR112013030554B1 (en) * 2011-05-27 2020-12-15 Allergan, Inc. CRYSTALLINE FORM OF CYCLOSPORIN A, METHODS OF PREPARATION AND METHODS FOR USE OF THE SAME
CN108175742B (en) * 2011-11-15 2021-10-22 阿勒根公司 Sustained-acting formulation of cyclosporine form 2
AU2012339693B2 (en) * 2011-11-15 2017-09-07 Allergan, Inc. Cyclosporine A Form 2 and method of making same
JP6368244B2 (en) * 2011-11-15 2018-08-01 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ Autoclavable cyclosporin A2 suspension
ES2791751T3 (en) * 2011-11-15 2020-11-05 Allergan Inc Suspensions of cyclosporin A form 2
CN120051479A (en) * 2022-10-20 2025-05-27 中外制药株式会社 Method for producing cyclic peptide crystals

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH614931A5 (en) * 1975-11-04 1979-12-28 Sandoz Ag
CH640519A5 (en) * 1976-04-09 1984-01-13 Sandoz Ag Process for preparing a modified form of the antibiotic S 7481/F-1
US4117118A (en) * 1976-04-09 1978-09-26 Sandoz Ltd. Organic compounds
DE2819094A1 (en) * 1977-05-10 1978-11-23 Sandoz Ag CYCLOSPORIN DERIVATIVES, THEIR USE AND MANUFACTURING
CH637124A5 (en) * 1978-10-18 1983-07-15 Sandoz Ag Antibiotic, its preparation and use

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU643750B2 (en) * 1989-12-20 1993-11-25 United States of America, as represented by the Secretary, U.S. Department of Commerce, The Method of treating ocular diseases by periocular administration of cyclosporine A or G

Also Published As

Publication number Publication date
SE503174C2 (en) 1996-04-15
LU87409A1 (en) 1989-07-07
ES2012580A6 (en) 1990-04-01
FI89065C (en) 1993-09-30
IE883779L (en) 1989-06-21
IL88719A0 (en) 1989-07-31
BE1002665A4 (en) 1991-04-30
NO885625L (en) 1989-06-22
FI885869A0 (en) 1988-12-19
DK705488A (en) 1989-06-22
SG99494G (en) 1994-10-28
GR1002486B (en) 1996-12-09
GR880100850A (en) 1994-03-31
NL8803125A (en) 1989-07-17
CY1799A (en) 1995-02-17
DK175220B1 (en) 2004-07-12
DK705488D0 (en) 1988-12-19
FR2624863B1 (en) 1991-04-26
KR890009975A (en) 1989-08-05
NO885625D0 (en) 1988-12-19
CA1341396C (en) 2002-11-05
GB2211848B (en) 1991-11-06
HK102894A (en) 1994-09-30
DE3843054C2 (en) 2003-08-21
MY103943A (en) 1993-10-30
KR100188305B1 (en) 1999-06-01
NO177228C (en) 1995-08-09
HU203564B (en) 1991-08-28
NZ227384A (en) 1991-09-25
AT403163B (en) 1997-11-25
HUT49893A (en) 1989-11-28
IE62006B1 (en) 1994-12-14
FR2624863A1 (en) 1989-06-23
JPH01211598A (en) 1989-08-24
GB2211848A (en) 1989-07-12
JPH0791316B2 (en) 1995-10-04
CH677926A5 (en) 1991-07-15
DE3843054A1 (en) 1989-07-27
FI885869L (en) 1989-06-22
FI89065B (en) 1993-04-30
ATA309588A (en) 1997-04-15
NO177228B (en) 1995-05-02
GB8829556D0 (en) 1989-02-08
SE8804570D0 (en) 1988-12-19
IT1235356B (en) 1992-06-30
IT8848690A0 (en) 1988-12-20
SE8804570L (en) 1989-06-22
AU626274B2 (en) 1992-07-30
NL195096C (en) 2004-02-09

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