SE8205533L - Forfarande for framstellning av aminoalkylfuranderivat med terapeutisk verkan - Google Patents
Forfarande for framstellning av aminoalkylfuranderivat med terapeutisk verkanInfo
- Publication number
- SE8205533L SE8205533L SE8205533A SE8205533A SE8205533L SE 8205533 L SE8205533 L SE 8205533L SE 8205533 A SE8205533 A SE 8205533A SE 8205533 A SE8205533 A SE 8205533A SE 8205533 L SE8205533 L SE 8205533L
- Authority
- SE
- Sweden
- Prior art keywords
- group
- denotes
- formula
- alk
- alkyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 2
- 238000002360 preparation method Methods 0.000 title claims 2
- 238000001816 cooling Methods 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 6
- 150000003839 salts Chemical class 0.000 claims abstract 5
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 4
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 2
- 150000001412 amines Chemical class 0.000 claims 2
- 125000004391 aryl sulfonyl group Chemical group 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 125000004430 oxygen atom Chemical group O* 0.000 claims 2
- 150000003335 secondary amines Chemical class 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 241000276420 Lophius piscatorius Species 0.000 claims 1
- 238000006683 Mannich reaction Methods 0.000 claims 1
- 150000001204 N-oxides Chemical class 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 239000012467 final product Substances 0.000 claims 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 150000004677 hydrates Chemical class 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
- 230000007306 turnover Effects 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 102000003710 Histamine H2 Receptors Human genes 0.000 abstract 1
- 108090000050 Histamine H2 Receptors Proteins 0.000 abstract 1
- 239000012458 free base Substances 0.000 abstract 1
- 230000027119 gastric acid secretion Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
- C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/64—Sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
Claims (1)
1. Firfarande fir framstallning as fbreningar med den formeln R2 N-A 1k0' (CH2)nX(CH2)mNHCNHR3 samt fysiologiskt godtagbara salter soh N-oxider och hydrat darav, dar symbolerna RI och g2, mom kan vara like eller alike, vardera betecknar en vateatom, en lagalkygrupp, en cykoalkylgrupp, en lAgalkenylgrupp, en aralky]grupp eller en lagalkylgrupp avbruten as en syreatom eller en grupp, dar 114betecknar , site eller lagalkyl, eller • A4 dar symbolerna Ri och R2 tillsammans med den kvaveatom, till silken de Ur bundna, bildar on heterocyklisk ring, vilken dessutom ken innehalla en syreatom eller en grupp -114-; dar 113 betecknar en vateatom, en lagal- Ry kylgrupp, en V',galkenylgrupp eller en alkoxialkylgrupp; (tar X betecknar 0112, 0 eller 8; dar Ytecknar =S, NR eller -CRR6; dar Alk be- teeknar en rak ellerrenad alkyle.la innehtillande 1-6 kolatomer; underkastas en Mannich-reaktion med en 1iimplig aldehyd och en sekundar amin eller ett salt as en primal, amin eller en sekundar amin till bild,ning as foreningar med formeln I, dar Y betecknar en =11I och Alk betecknar an metylengrupp eller enjargrenad alkylengrupp; eller alt (f) en farening med formein N17-Alk 410,3_ (C11)X(C112)NCI(IV) dar R1 R. •och n har de oven angivna betydelserna, omsatten , 2 Alk X, m med en amin med formeln 11311H2, clar R3 bar oVan anglers betydelse, till bildning as foreningar med fcrmeln I, dir Y betecknar svavel; varvid 1 samtliga fall slutprodukten eventuellt isoleras Sa50M ett fysiologiskt godtagbart salt eller omvandlas frdn ett dylikt salt till ett annat. allmanna (I) RI -oi- 1 7 dar R. betecknar en vgteatoM, en nitrogrupp, en cyangrupp, en lfigalkyi. grupp, en arylgrupp, en alkylsulfonylgrupp eller en arylsulfonylgrupp; dgr 26 betecknar en nitrogrupp, en arylsulfonylgrupp eller en alkylsulfonylgrupp; ddr m betecknar ett heltal frgn 2 till 4 och db.r n betecknar 1 eller 2, eller dal n betecknar 0,1 eller 2 ngr X betecknar 3 elier CE2; med den begrgnsningen att Y joke ban beteckna gruppen CHNO2 ngr R2, R2 och R3 betecknar metyl, Alk betecknar metylen, X betecknar S,nbetecknar 1 ochmbetecknar 2,1<11nnetec1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB32465/76A GB1565966A (en) | 1976-08-04 | 1976-08-04 | Aminoalkyl furan derivatives |
| GB5068576 | 1976-12-06 | ||
| GB2018777 | 1977-05-13 | ||
| KR7701808A KR810000355B1 (ko) | 1977-05-13 | 1977-08-04 | 아미노 알킬푸란 유도체의 제조방법 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| SE8205533D0 SE8205533D0 (sv) | 1982-09-28 |
| SE8205533L true SE8205533L (sv) | 1982-09-28 |
| SE454882B SE454882B (sv) | 1988-06-06 |
Family
ID=27448487
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7708521A SE437373B (sv) | 1976-08-04 | 1977-07-25 | Forfarande for framstellning av ett aminoalkylfuranderivat med terapeutisk verkan |
| SE8205533A SE454882B (sv) | 1976-08-04 | 1982-09-28 | Forfarande for framstellning av aminoalkylfuranderivat med terapeutisk verkan |
| SE8206556A SE454883B (sv) | 1976-08-04 | 1982-11-17 | Aminoalkylfuranderivat till anvendning som mellanprodukter vid framstellning av aminoalkylfuranderivat med terapeutisk verkan |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7708521A SE437373B (sv) | 1976-08-04 | 1977-07-25 | Forfarande for framstellning av ett aminoalkylfuranderivat med terapeutisk verkan |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8206556A SE454883B (sv) | 1976-08-04 | 1982-11-17 | Aminoalkylfuranderivat till anvendning som mellanprodukter vid framstellning av aminoalkylfuranderivat med terapeutisk verkan |
Country Status (16)
| Country | Link |
|---|---|
| AT (1) | AT375931B (sv) |
| CH (2) | CH642072A5 (sv) |
| CY (1) | CY1077A (sv) |
| DE (2) | DE2759959C2 (sv) |
| DK (2) | DK148258C (sv) |
| ES (2) | ES461334A1 (sv) |
| FI (1) | FI72318C (sv) |
| HK (1) | HK55780A (sv) |
| IE (1) | IE45456B1 (sv) |
| IT (2) | IT1126759B (sv) |
| KE (1) | KE3080A (sv) |
| NZ (2) | NZ184759A (sv) |
| PH (1) | PH13540A (sv) |
| PT (1) | PT66874B (sv) |
| SE (3) | SE437373B (sv) |
| YU (2) | YU40006B (sv) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4203909A (en) * | 1978-09-26 | 1980-05-20 | Bristol-Myers Company | Furan compounds |
| YU52598A (sh) * | 1998-11-19 | 2001-05-28 | D.D. Zdravlje- sektor za istraživanje i razvoj | POSTUPAK ZA sintezu N-[2[[[5=[(DIALKILAMINO)METIL]-2= FURANIL]METIL]TIO]ETIL]-N'-ALKIL-2-NITRO 1,1 ALKENDIAMINA I NJIHOVIH HIDROHLORIDA |
-
1977
- 1977-07-22 FI FI772264A patent/FI72318C/sv not_active IP Right Cessation
- 1977-07-22 CY CY1277A patent/CY1077A/xx unknown
- 1977-07-25 IE IE1536/77A patent/IE45456B1/en not_active IP Right Cessation
- 1977-07-25 SE SE7708521A patent/SE437373B/sv not_active IP Right Cessation
- 1977-07-26 DK DK337977A patent/DK148258C/da not_active IP Right Cessation
- 1977-07-27 NZ NZ184759A patent/NZ184759A/en unknown
- 1977-07-27 NZ NZ191383A patent/NZ191383A/xx unknown
- 1977-07-28 DE DE2759959A patent/DE2759959C2/de not_active Expired
- 1977-07-28 DE DE2760097A patent/DE2760097C2/de not_active Expired
- 1977-07-29 CH CH938077A patent/CH642072A5/de not_active IP Right Cessation
- 1977-08-01 PT PT66874A patent/PT66874B/pt unknown
- 1977-08-02 PH PH20057A patent/PH13540A/en unknown
- 1977-08-03 YU YU1911/77A patent/YU40006B/xx unknown
- 1977-08-03 IT IT50551/77A patent/IT1126759B/it active Protection Beyond IP Right Term
- 1977-08-03 ES ES461334A patent/ES461334A1/es not_active Expired
- 1977-08-04 AT AT0574077A patent/AT375931B/de not_active IP Right Cessation
-
1978
- 1978-06-15 ES ES470836A patent/ES470836A1/es not_active Expired
-
1980
- 1980-08-30 KE KE3080A patent/KE3080A/xx unknown
- 1980-10-02 HK HK557/80A patent/HK55780A/xx unknown
-
1982
- 1982-08-27 CH CH509282A patent/CH641176A5/de not_active IP Right Cessation
- 1982-09-03 YU YU2000/82A patent/YU40088B/xx unknown
- 1982-09-28 SE SE8205533A patent/SE454882B/sv not_active IP Right Cessation
- 1982-11-17 SE SE8206556A patent/SE454883B/sv not_active IP Right Cessation
-
1984
- 1984-08-30 DK DK416384A patent/DK149952C/da not_active IP Right Cessation
-
1985
- 1985-08-01 IT IT48437/85A patent/IT1221058B/it active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US3763156A (en) | 2-heterocyclic amino-4-morpholinothieno(3,2-d)pyrimidines | |
| AU668901B2 (en) | Piperazine derivatives as 5-HT receptors antagonists | |
| AU594739B2 (en) | Thieno-1,4-diazepines | |
| AU2001272476A1 (en) | Piperidines for use as orexin receptor antagonists | |
| IE47701B1 (en) | Amine derivatives,their preparation and pharmaceutical compositions containing them | |
| IE41539L (en) | Chroman derivatives. | |
| KR830009773A (ko) | 1,2-디아미노 시클로부텐-3,4-디온의 제조방법 | |
| KR840004107A (ko) | 1,4-디히드로피리딘-3,5-디카르복실산 에스테르 유도체의 제법 | |
| ATE26263T1 (de) | 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepine, verfahren zur herstellung derselben und ihre verwendung als heilmittel. | |
| KR830000694A (ko) | 헤테로싸이클 유도체의 제조방법 | |
| ZA8742B (en) | Derivatives of decahydroquinoline,their preparation process,the preparation intermediates,their use as medicaments and the compositions containing them | |
| ES8207148A1 (es) | Un procedimiento para la preparacion de imidazolilfenilami- dinas. | |
| EP0000220A1 (de) | Dihydrouracile, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel | |
| ES486824A1 (es) | Procedimiento para la preparacion de nuevos derivados de 4- (naftilmetil) piperidinas | |
| AU644295B2 (en) | 2-aminopyrimidine-4-carboxamide derivatives, their preparation and their use in therapeutics | |
| AU554976B2 (en) | 1-phenyl-2-aminocarbonylindole compounds | |
| SE8205533L (sv) | Forfarande for framstellning av aminoalkylfuranderivat med terapeutisk verkan | |
| ES486071A1 (es) | Un procedimiento para la preparacion de derivados de amina | |
| ATE42295T1 (de) | Penem-derivate, verfahren zu deren herstellung, ihre verwendung und pharmazeutische zusammensetzungen. | |
| KR880002889A (ko) | 일차 복조환식아민의 디세레노비스 벤조산아민과 그 제조방법 및 약제화합물 | |
| KR860002507A (ko) | 치환 7-옥소미토산의 제조방법 | |
| DE3689762D1 (de) | Antibakterielle Verbindungen, ihre Herstellung und Verwendung. | |
| NO844778L (no) | Fremgangmsmaate for fremstilling av 2-hydroksy-propiofenom-derivater | |
| IE801382L (en) | Piperidines. | |
| KR910007939A (ko) | 헤테로사이클릭 화합물 및 이의 제조방법 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NUG | Patent has lapsed |
Ref document number: 8205533-6 Effective date: 19930204 Format of ref document f/p: F |